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Structural polymorphism and functional differentiation of actin filaments

Research Project

Project/Area Number 21370061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

UYEDA Taro  独立行政法人産業技術総合研究所, バイオメディカル研究部門, 部門付 (90356551)

Co-Investigator(Kenkyū-buntansha) TOKURAKU Kiyotaka  室蘭工業大学, 大学院・工学研究科, 准教授 (00332106)
KATAYAMA Eisaku  千葉大学, 大学院・工学研究科, 研究員 (50111505)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsアクチンフィラメント / ミオシン / コフィリン / 協同的結合 / 張力 / メカノセンサー / 細胞極性 / アクチン / アクチン結合タンパク質 / 協同的構造変化 / GFP
Research Abstract

The goal of this project is to understood how different actin filaments within a cell perform different functions. We found that stretched actin filaments with a longer helical pitch have higher affinity for myosin II. We also found that myosin II and cofilin, two major actin binding proteins, bound to actin filaments in a mutually exclusive manner, even though the two proteins do not compete for a binding site on actin. These results support our hypothesis that actin filaments of different atomic structures have different affinities for different actin binding proteins, leading to functional differentiation within cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (52 results)

All 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (32 results) Remarks (1 results)

  • [Journal Article] G146V mutation at the hinge region of actin reveals a myosin class-specific requirement of actin conformations for motility2012

    • Author(s)
      Noguchi, T. Q. P., T. Komori, N. Umeki N. Demizu, K. Ito, A. Hikikoshi-Iwane, K. Tokuraku, T. Yanagida and T. Q. P.Noguchi, T. Q. P., T. Komori, N. Umeki N. Demizu, K. Ito, A. Hikikoshi-Iwane, K. Tokuraku, T. Yanagida and T. Q. P. Uyeda
    • Journal Title

      J. Biol. Chem.

      Volume: (in press)

    • URL

      http://www.jbc.org/content/early/2012/05/27/jbc.M111.321752.long

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microtubule-associated protein 4 binds to actin filaments and modulates their properties2012

    • Author(s)
      Matsushima, K., K. Tokuraku, M. R. Hasan, and S. Kotani
    • Journal Title

      J. Biochem

      Volume: 151 Issue: 1 Pages: 99-108

    • DOI

      10.1093/jb/mvr119

    • NAID

      10031166047

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stretching actin filaments within cells enhances their affinity for the myosin II motor domain2011

    • Author(s)
      Uyeda, T. Q. P., Y. Iwadate, N. Umeki, A. Nagasaki, and S. Yumura
    • Journal Title

      PLoS One

      Volume: 6

    • URL

      http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fractal dimension analysis and mathematical morphology of structural changes in actin filaments imaged by electron microscopy2011

    • Author(s)
      Kimori, Y., E. Katayama, N. Morone, and T. Kodama
    • Journal Title

      J. Struct. Biol

      Volume: 176 Issue: 1 Pages: 1-8

    • DOI

      10.1016/j.jsb.2011.07.007

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single restriction enzyme-assisted megaprimer polymerase chain reaction to fuse two DNA sequences on separate cloning vectors2011

    • Author(s)
      Umeki, N., Uyeda, T.Q.P.
    • Journal Title

      Anal.Biochem.

      Volume: 414 Issue: 2 Pages: 309-311

    • DOI

      10.1016/j.ab.2011.03.023

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stretching actin filaments within cells enhances their affinity for the myosin II motor domain2011

    • Author(s)
      Uyeda, T.Q.P., Iwadate, Y., Umeki, N., Nagasaki, A., Yumura, S.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 10 Pages: e26200-e26200

    • DOI

      10.1371/journal.pone.0026200

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New versatile staining reagents for biological transmission electron microscopy that substitutes for uranyl acetate2011

    • Author(s)
      Nakakoshi, M., Nishioka, H., Katayama, E.
    • Journal Title

      J.Electron Microsc.

      Volume: 60 Issue: 6 Pages: 401-407

    • DOI

      10.1093/jmicro/dfr084

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single, restriction enzyme-assisted megaprimer PCR to fuse two DNA sequences on separate cloning vectors.2011

    • Author(s)
      Uyeda, T.Q.P., Umeki, N.
    • Journal Title

      Analytical Biochemistry

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actin interaction and regulation of cyclin-dependent kinase 5/P35 complex activity.2011

    • Author(s)
      Xu, J., Tsutsumi, K., Tokuraku, K., Estes, K.A., Hisanaga, S., Ikezu, T.
    • Journal Title

      Journal of Neurochemistry

      Volume: 116 Pages: 192-204

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electron microscopic evidence for the myosin head lever arm mechanism in hydrated myosin filaments using the gas environmental chamber.2011

    • Author(s)
      Minoda, H., Okabe, T., Inayoshi, Y., Miyakawa, T., Miyauchi, Y., Tanokura, M., Katayama, E., Wakabayashi, T., Akimoto, T., Sugi, H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 405 Pages: 651-656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis for Actin Assembly, Activation of ATP Hydrolysis, and Delayed Phosphate Release2010

    • Author(s)
      Murakami, K., T. Yasunaga, T. Q. P. Noguchi, Y. Gomibuchi, K. X. Ngo, T. Q. P. Uyeda, and T. Wakabayashi
    • Journal Title

      Cell

      Volume: 143 Issue: 2 Pages: 275-287

    • DOI

      10.1016/j.cell.2010.09.034

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myosin-actin Interaction in Dictyostelium Cells Revealed by GFP-based Strain Sensor and Validated Linear Spectral Unmixing2010

    • Author(s)
      Iwai, S., and T. Q. P. Uyeda
    • Journal Title

      Cytometry A

      Volume: 77 Issue: 8 Pages: 743-750

    • DOI

      10.1002/cyto.a.20900

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of novel dominant negative mutant actins using glycine targeted scanning identified G146V actin that cooperatively inhibits cofilin binding2010

    • Author(s)
      Noguchi, T. Q. P., R. Toya, H. Ueno, K. Tokuraku, and T. Q. P. Uyeda
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 396 Issue: 4 Pages: 1006-1011

    • DOI

      10.1016/j.bbrc.2010.05.047

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dominant negative mutant actins identified in flightless Drosophila can be classified into three classes, including perturbation of the tropomyosin-troponin system2010

    • Author(s)
      Noguchi, T. Q. P., Y. Gomibuchi, K. Murakami, H. Ueno, K. Hirose, T. Wakabayashi, and T. Q. P. Uyeda
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Issue: 7 Pages: 4337-4347

    • DOI

      10.1074/jbc.m109.059881

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Actin interaction and regulation of cyclin-dependent kinase 5/P35 complex activity2010

    • Author(s)
      Xu, J., K. Tsutsumi, K. Tokuraku, K. A. Estes, S. Hisanaga, T. Ikezu
    • Journal Title

      J. Neurochem

      Volume: 116 Issue: 2 Pages: 192-204

    • DOI

      10.1111/j.1471-4159.2010.06824.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-dimensional Brownian motion of charged nanoparticles along microtubules : a model system for weak binding interactions2010

    • Author(s)
      Minoura, I., E. Katayama, K. Sekimoto, and E. Muto
    • Journal Title

      Biophys. J

      Volume: 98 Issue: 8 Pages: 1589-1597

    • DOI

      10.1016/j.bpj.2009.12.4323

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-dimensional Brownian motion of charged nanoparticles along microtubules : a model system for weak binding interactions.2010

    • Author(s)
      Minoura, I., Katayama, E., Sekimoto, K., Muto, E.
    • Journal Title

      Biophysical Journal

      Volume: 98 Pages: 1589-1597

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of novel dominant negative mutant actins using glycine targeted scanning identifies G146V actin that cooperatively inhibits cofilin binding2010

    • Author(s)
      Noguchi, T.Q.P., Toya, R., Ueno, H., Tokuraku, K., Uyeda, T.Q.P.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 396 Pages: 1006-1011

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stabilization of Anaphase Midzone Microtubules is Regulated by Rho during Cytokinesis in Human Fibrosarcoma Cells2009

    • Author(s)
      Kanada, M., A. Nagasaki, and T. Q. P. Uyeda
    • Journal Title

      Exp. Cell Res.

      Volume: 315 Issue: 16 Pages: 2705-2714

    • DOI

      10.1016/j.yexcr.2009.06.027

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] FRET analyses of WT and G146V actin filaments identify a conformational state necessary for myosin motility and cofilin binding2011

    • Author(s)
      Noguchi, T. M. Morimatsu, T. Komori, A. Iwane, T. Yanagida, T. Q. P. Uyeda
    • Organizer
      International Symposium "Actin, the cytoskeleton, and the nucleus"
    • Place of Presentation
      National Singapore University, Singapore
    • Year and Date
      2011-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ミオシンHMMとコフィリンのアクチンフィラメントに対する協同的結合は相互排他的である2011

    • Author(s)
      貴嶋紗久、梅木伸久、中嶋潤、野口太郎、徳楽清孝、上田太郎
    • Organizer
      第一回日本細胞性粘菌学会
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Exclusive binding of myosin and cofilin to F-actin2011

    • Author(s)
      Kijima, S., Noguchi, T., Uyeda, T.Q.P., Tokuraku, K.
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      姫路工業大学(兵庫県)
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stretching actin filaments within cells enhances their affinity for the myosin II motor domain2011

    • Author(s)
      Uyeda, T. Q. P., Y. Iwadate, N. Umeki, A. Nagasaki, S. Yumura
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県、姫路工業大学
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Unidirectional conformational changes of actin filaments : possible implications in force generation by myosin2011

    • Author(s)
      Kien, N. X., E. Katayama, S. Iwai, M. Suzuki, T. Q. P. Uyeda
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県、姫路工業大学
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Exclusive binding of myosin and cofilin to F-actin2011

    • Author(s)
      Kijima, S., T. Noguchi, T. Q. P. Uyeda, K. Tokuraku
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県、姫路工業大学
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Unidirectional conformational changes of actin filaments : possible implications in force generation by myosin2011

    • Author(s)
      Kien, N.X., Katayama, E., Iwai, S., Suzuki, M., Uyeda, T.Q.P.
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      姫路工業大学(兵庫県)(招待講演)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 優性阻害となるAsp11変異アクチンの解析2011

    • Author(s)
      中嶋潤、梅木伸久、野口太郎、徳楽清孝、長崎晃、上田太郎
    • Organizer
      2012年生体運動研究合同班会議
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2011-01-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Acto-cofilin融合蛋白質によって誘導される、アクチンフィラメントの協同的構造変化2011

    • Author(s)
      梅木伸久、長崎晃、上田太郎
    • Organizer
      2012年生体運動研究合同班会議
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2011-01-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミオシンとコフィリンはF-アクチンに対して排他的に結合する2011

    • Author(s)
      貴嶋紗久、梅木伸久、上田太郎、徳楽清孝、長崎晃、野口太郎
    • Organizer
      2012年生体運動研究合同班会議
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2011-01-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] アクチンの生化学的性質へのチロシン143変異の影響2011

    • Author(s)
      五味渕由貴、上田太郎、若林健之
    • Organizer
      2012年生体運動研究合同班会議
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2011-01-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 力学的刺激部位へのGFP-ミオシンIIS1の局在2010

    • Author(s)
      上田太郎、岩楯好昭
    • Organizer
      第13回細胞性粘菌研究会
    • Place of Presentation
      富山
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stretched actin filaments in cells have a high affinity for S1 of myosin II2010

    • Author(s)
      Uyeda, T. Q. P., Y. Iwadate, S. Yumura, A. Nagasaki
    • Organizer
      International Symposium "Actin, the cytoskeleton, and the nucleus"
    • Place of Presentation
      National Singapore University, Singapore
    • Year and Date
      2010-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] FRET analyses of WT and G146V actin filaments identify a conformational state necessary for myosin motility and cofilin binding.2010

    • Author(s)
      野口太郎、森松賢順、小森智貴、岩根敦子、柳田敏雄、上田太郎
    • Organizer
      International Symposium "Actin, the cytoskeleton, and the nucleus"
    • Place of Presentation
      Singapore
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stretched actin filaments in cells have a high affinity for S1 of myosin II.2010

    • Author(s)
      上田太郎、岩楯好昭、祐村恵彦、長崎晃
    • Organizer
      International Symposium "Actin, the cytoskeleton, and the nucleus"
    • Place of Presentation
      Singapore
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cooperative binding of cofilin to actin filaments observed by fluorescence microscopy2010

    • Author(s)
      Nakajima, J., N. Umeki, T. Q. P. Uyeda
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台、東北大学
    • Year and Date
      2010-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] The binding of heavy meromyosin to G146V actin mutant that cooperatively inhibits cofilin binding2010

    • Author(s)
      Demizu, N., T. Noguchi, T. Q. P. Uyeda, K. Tokuraku
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台、東北大学
    • Year and Date
      2010-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] G146V subunits in actin filaments are predominantly in a flat, slow-O depolymerizing conformation.2010

    • Author(s)
      野口太郎、上田太郎
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cooperative binding of cofilin to actin filaments observed by fluorescence microscopy.2010

    • Author(s)
      中嶋潤、梅木伸久、上田太郎
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] The binding of heavy meromyosin to G146V actin mutant that cooperatively inhibits cofilin binding.2010

    • Author(s)
      出水紀行、野口太郎、上田太郎、徳楽清孝
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] G146V MUTANT ACTIN IS DEFECTIVE IN CONFORMATIONAL CHANGES, ACCOMPANIED BY IMPAIRED MOTILITY WITH SKELETAL MYOSIN.2010

    • Author(s)
      野口太郎、森松賢順、小森智貴、伊藤光二、岩根敦子、柳田敏雄、上田太郎
    • Organizer
      国際シンポジウム「水を主役としたATPエネルギー変換」
    • Place of Presentation
      仙台
    • Year and Date
      2010-03-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] G146V mutant actin is defective in conformational changes, accompanied by impaired motility with skeletal myosin2010

    • Author(s)
      Noguchi, T. M. Morimatsu, T. Komori, K. Ito, A. Iwane, T. Yanagida, T. Q. P. Uyeda
    • Organizer
      Biophysical Society 54th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-02-21
    • Related Report
      2011 Final Research Report
  • [Presentation] G146V MUTANT ACTIN IS DEFECTIVE IN CONFORMATIONAL CHANGES, ACCOMPANIED BY IMPAIRED MOTILITY WITH SKELETAL MYOSIN.2010

    • Author(s)
      野口太郎、森松賢順、小森智貴、伊藤光二、岩根敦子、柳田敏雄、上田太郎
    • Organizer
      Biophysical Society 54th Annual Meeting
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2010-02-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクチンフィラメントとミオシンIIモータードメインの選択的親和性に依存した新奇ミオシンII局在化機構.2010

    • Author(s)
      上田太郎、祐村恵彦、徳楽清孝、岩楯好昭、長崎晃
    • Organizer
      2010年生体運動研究合同班会議
    • Place of Presentation
      東京
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクチンのG146V変異はミオシン運動とアクチンの構造変化を阻害する.2010

    • Author(s)
      野口太郎、森松賢順、伊藤光二、岩根敦子、柳田敏雄、上田太郎
    • Organizer
      2010年生体運動研究合同班会議
    • Place of Presentation
      東京
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Localization of myosin II to the cleavage furrow is driven by multiple mechanisms including direct recognition of specific subsets of actin filaments by the motor domain of myosin II2009

    • Author(s)
      Uyeda, T. Q. P., S. Yumura, A. Nagasaki
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Localization of myosin II to the cleavage furrow is driven by multiple mechanisms including direct recognition of specific subsets of actin filaments by the motor domain of myosin II.2009

    • Author(s)
      上田太郎、祐村恵彦、長崎晃
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Specific subsets of actin filaments in cells have a high affinity for myosin II S12009

    • Author(s)
      上田太郎、長崎晃、市原昭、平野隆
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      徳島
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dictyostelium discoideum変異アクチンとミオシンとの相互作用解析2009

    • Author(s)
      野口太郎、小森智貴、森松賢順、岩根敦子、柳田敏雄、上田太郎
    • Organizer
      第12回細胞性粘菌研究会
    • Place of Presentation
      山口
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクチンフィラメントとミオシンIIモータードメインの選択的親和性に依存した新奇ミオシンII局在化機構2009

    • Author(s)
      上田太郎、祐村恵彦、岩楯好昭、長崎晃
    • Organizer
      第12回細胞性粘菌研究会
    • Place of Presentation
      山口
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] メカノセンサーとしてのアクチンフィラメント?2009

    • Author(s)
      上田太郎、祐村恵彦、長崎晃
    • Organizer
      第4回細胞運動研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity2009

    • Author(s)
      J. Xu, K. Tokuraku, L-H Tsai, T. Ikezu
    • Organizer
      Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://staff.aist.go.jp/t-uyeda/HP/CEB8A6F4-E4BC-11DA-9287-000A95B8DB8E/A9D295CE-E035-11DC-A6FB-000A95B8DB8E.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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