Dynamics of histones during DNA replication, repair, and chromosome segregation

• Project/Area Number: 21370075
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Molecular biology
• Research Institution: Tohoku University
• Principal Investigator: SEKI Masayuki 東北大学, 大学院・薬学研究科, 准教授 (70202140)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 染色体構築 / 機能 / 分配 / クロマチン / ヒストン / DNA複製 / DNA修復 / ヒストンシャペロン / ヒストンバリアント / 染色体分配 / 点突然変異 / 出芽酵母

Research Abstract

The nucleosome is a histone octamer which is wrapped by 146 bp eukaryotic DNA. Dynamics of histones during DNA replication/repair remains elusive. We proposed here that FACT facilitates DNA replication elongation by promoting efficient pre-replicative nucleosome disassembly. Furthermore, we showed that acetylation of histone H3 on lysine 56 is required for homologous recombination.

Research Products

• [Journal Article] Nucleosome surface containing nucleosomal DNA entry/exit site regulates H3-K36me3 via association with RNA polymerase II and Set2 (2012)
  • Author(s): Endo, H., Nakabayashi, Y., Kawashima, S., Enomoto, T., Seki, M., Horikoshi, M.
  • Journal Title: Genes Cells Volume: 17 Pages: 65-81
  • Peer Reviewed
• [Journal Article] The roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication (2011)
  • Author(s): Ishikawa, K., Ohsumi, T., Tada, S., Natsume, R., Kundu, L-R., Nozaki, N., Senda, T., Enomoto, T., Horikoshi, M., Seki, M.
  • Journal Title: Genes Cells Volume: 16 Pages: 1050-1062
• [Journal Article] The histone chaperone FACT maintains normal replication fork rates (2011)
  • Author(s): Abe, T., Sugimura, K., Hosono, Y., Takami, Y., Akita, M., Yoshimura, A., Tada, S., Nakayama, T., Murofushi, H., Okumura, K., Takeda, S., Horikoshi, M., Seki, M., Enomoto, T.
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 30504-30512
  • Peer Reviewed
• [Journal Article] Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation (2011)
  • Author(s): Kawashima, S., Nakabayashi, Y., Matsubara, K., Sano, N., Enomoto, T., Tanaka, K., Seki, M., Horikoshi, M.
  • Journal Title: EMBO J Volume: 30 Pages: 3353-3367
  • Peer Reviewed
• [Journal Article] The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells (2011)
  • Author(s): Abe, T., Yoshimura, A., Hosono, Y., Tada, S., Seki, M., Enomoto. T.
  • Journal Title: Biochim. Biophys. Acta Volume: 1813 Pages: 473-479
  • Peer Reviewed
• [Journal Article] Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication (2011)
  • Author(s): Kundu, L. R., Seki, M., Watanabe, N., Murofushi, H., Furukohri, A., Waga, S., Score, A. J., Blow, J. J., Horikoshi, M., Enomoto, T., Tada, S.
  • Journal Title: Biochim. Biophys. Acta Volume: 1813 Pages: 1129-1136
  • Peer Reviewed
• [Journal Article] The histone chaperone FACT maintains replication fork rates (2011)
  • Author(s): T.Abe, K.Sugimura, Y.Hosono, Y.Takami, M.Akita, A.Yoshimura, S.Tada, T.Nakayama, H.Murofushi, K.Okumura, S.Takeda, M.Horikoshi, M.Seki & T.Enomoto
  • Journal Title: J.Biol.Chem. Volume: 286 Issue: 35 Pages: 30504-30512
  • DOI: 10.1074/jbc.m111.264721
  • Peer Reviewed
• [Journal Article] Global analysis of core histones reveals nucleosomal surfaces required for chromosomebi-orientation (2011)
  • Author(s): S.Kawashima, Y.Nakabayashi, K.Matsubara, N.Sano, T.Enomoto, K.Tanaka, M.Seki & M.Horikoshi
  • Journal Title: EMBO J. Volume: 30 Issue: 16 Pages: 3353-3367
  • DOI: 10.1038/emboj.2011.241
  • Peer Reviewed
• [Journal Article] Functional relationship between Claspin and Rad17 (2011)
  • Author(s): Yoshimura, A., Akita, M., Hosono, Y., Abe, T., Kobayashi, M., Yamamoto, K.I., Tada, S., Seki, M., Enomoto, T.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 414 Issue: 2 Pages: 298-303
  • DOI: 10.1016/j.bbrc.2011.09.037
  • Peer Reviewed
• [Journal Article] Werner Interacting Protein 1 Promotes Binding of Werner Protein to Template-Primer DNA (2011)
  • Author(s): Kanamori M, Seki, M, Yoshimura A, Tsurimoto T, Tada S, Enomoto T
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 34 Issue: 8 Pages: 1314-1318
  • DOI: 10.1248/bpb.34.1314
  • NAID: 130000936605
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] The role of SNM1 family nucleases in etoposide-induced apoptosis (2011)
  • Author(s): Hosono, Y., Abe, T., Ishiai, M., Takata, M., Enomoto, T., Seki, M.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 410 Issue: 3 Pages: 568-573
  • DOI: 10.1016/j.bbrc.2011.06.027
  • Peer Reviewed
• [Journal Article] Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells : LAT1 is a promising molecular target for human cancer therapy (2011)
  • Author(s): Ohkawa, M., Ohno, Y., Masuko, K., Takeuchi, A., Suda, K., Kubo, A., Kawahara, R., Okazaki, S., Tanaka, T., Saya, H., Seki, M., Enomoto, T., Yagi, H., Hashimoto, Y., Masuko, T.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 406 Issue: 4 Pages: 649-655
  • DOI: 10.1016/j.bbrc.2011.02.135
  • Peer Reviewed
• [Journal Article] The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells (2011)
  • Author(s): Abe, T., Yoshimura, A., Hosono, Y., Tada, S., Seki, M., Enomoto. T
  • Journal Title: Biochim.Biophys.Acta Volume: 1813 Issue: 3 Pages: 473-479
  • DOI: 10.1016/j.bbamcr.2011.01.001
  • Peer Reviewed
• [Journal Article] Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication (2011)
  • Author(s): L.R.Kundu, M.Seki, H.Murofushi,A.Furukohri, S.Waga, A.J.Score, J.J.Blow, M.Horikoshi, T.Enomoto & S.Tada
  • Journal Title: Biochim.Biophys.Acta Volume: 1813 Issue: 6 Pages: 1129-36
  • DOI: 10.1016/j.bbamcr.2011.01.002
  • Peer Reviewed
• [Journal Article] Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells : LAT1 is a promising molecular target for human cancer therapy. (2011)
  • Author(s): Ohkawa, M., Ohno, Y., Masuko, K., Takeuchi, A., Suda, K., Kubo, A., kawahara, R., Okazaki, S., Tanaka, T., Saya, H., Seki, M., Enomoto, T., Yagi, H., Hashimoto, Y., Masuko, T.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 406 Pages: 649-655
  • Peer Reviewed
• [Journal Article] The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells. (2011)
  • Author(s): Abe, T., Yoshimura, A., Hosono, Y., Tada, S., Seki, M., Enomoto, T.
  • Journal Title: Biochim.Biophys.Acta Volume: 1813 Pages: 473-479
  • Peer Reviewed
• [Journal Article] Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. (2011)
  • Author(s): Kundu, L.R., Seki, M., Watanabe, N., Murofushi, H., Furukohri, A., Waga, S., Score, A.J., Blow, J.J., Horikoshi, M., Enomoto, T., Tada, S.
  • Journal Title: Biochim.Biophys.Acta Volume: (未定,印刷中)
  • Peer Reviewed
• [Journal Article] Chromatin dynamics mediated by histone modifiers and histone chaperones in post-replicative recombination (2010)
  • Author(s): Endo, H., Kawashima, S., Sato, L., Lai, M. S., Enomoto, T., Seki, M., Horikoshi, M.
  • Journal Title: Genes Cells Volume: 15 Pages: 945-958
  • Peer Reviewed
• [Journal Article] SOD1 is essential for the viability of DT40 cells and nuclear SOD1 functions as a guardian of genomic DNA. (2010)
  • Author(s): Inoue, E., Tano, K., Yoshii, H., Nakamura, J., Tada, S., Watanabe, M., Seki, M., Enomoto, T.
  • Journal Title: J.Nucleic Acid Volume: pii : 795946(電子媒体のみで頁の表記はない。)
  • Peer Reviewed
• [Journal Article] Chromatin dynamics mediated by histone modifiers and histone chape rones in post-replicative recombination. (2010)
  • Author(s): Endo, H., Kawashima, S., Sato, L., Lai, M.S., Enomoto, T., Seki, M., Horikoshi, M.
  • Journal Title: Genes Cells Volume: 15 Pages: 945-958
  • Peer Reviewed
• [Journal Article] Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. (2010)
  • Author(s): Kundu, L.R., Kumata, Y., Kakusho, N., Watanabe, S., Furukohri, A., Waga, S., Seki, M., Masai, H., Enomoto, T., Tada S.
  • Journal Title: Nucleic Acids Res. Volume: 38 Pages: 5409-5418
  • Peer Reviewed
• [Journal Article] Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants (2009)
  • Author(s): Sakamoto, M., Noguchi, S., Kawashima, S., Okada, Y., Enomoto, T., Seki, M., Horikoshi, M.
  • Journal Title: Genes Cells Volume: 14 Pages: 1271-1330
  • Peer Reviewed
• [Journal Article] Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants. (2009)
  • Author(s): Sakamoto, M., Noguchi, S., Kawashima, S., Okada, Y., Enomoto, T., Seki, M., Horikoshi, M.
  • Journal Title: Genes Cells 14 Pages: 1271-1330
  • Peer Reviewed
• [Journal Article] Physical and functional interaction between WRNIP1 and RAD18. (2009)
  • Author(s): Yoshimura, A., Seki, M., Kanamori, M., Tateishi, S., Tsurimoto, T., Tada, S., Enomoto, T.
  • Journal Title: Genes Genet.System 84 Pages: 171-178
  • NAID: 10024791852
  • Peer Reviewed
• [Journal Article] Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication. (2009)
  • Author(s): Ohuchi, T., Seki, M., Kugou, K., Tada, S., Ohta, K., Enomoto, T.
  • Journal Title: DNA Repair 8 Pages: 690-696
  • Peer Reviewed
• [Journal Article] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2. (2009)
  • Author(s): Takada, S., Inoue, E., Tano, K., Yoshii, H., Abe, T., Yoshimura, A., Akita, M., Tada, S., Watanabe, M., Seki, M., Enomoto, T.
  • Journal Title: Biochem.Biophys.Res.Commun. 379 Pages: 233-238
  • Peer Reviewed
• [Journal Article] Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts. (2009)
  • Author(s): Tsuyama, T., Watanabe, S., Aoki, A., Cho, Y., Seki, M., Enomoto, T., Tada, S.
  • Journal Title: Mol.Biol.Cell 20 Pages: 937-947
  • Peer Reviewed
• [Presentation] Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells (2012)
  • Author(s): Keizo Tano, Eri Inoue, Yuki Tamari, Hisakatsu Nawata, Akari Yoshimura, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe
  • Organizer: Sugahara Memorial International Symposium
  • Place of Presentation: 京都市稲森ホール(招待)
• [Presentation] Studies on chromatin regulation by utilizing histone-GLibrary (2012)
  • Author(s): Masayuki Seki, Masami Horikoshi
  • Organizer: Keystone Symposia Epigenomics (J3)
  • Place of Presentation: Keystone, Colorado, USA
• [Presentation] Global analysis of functional relationships between histone H2A and its variant Htz1 (2011)
  • Author(s): 上野岳、岡田裕介、吉田隼人、榎本武美、堀越正美、関政幸
  • Organizer: 第34回分子生物会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation (2011)
  • Author(s): Yu Nakabayashi, Satoshi Kawashima, Kazuko Matsubara, Norihiko Sano, Takemi Enomoto, Kozo Tanaka, Masayuki Seki and Masami Horikoshi
  • Organizer: 第34回分子生物会年会2011年12月15日
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation (2011)
  • Author(s): Yu Nakabayashi, Satoshi Kawashima, Kazuko Matsubara, Norihiko Sano, Takemi Enomoto, Kozo Tanaka, Masayuki Seki, Masami Horikoshi
  • Organizer: 第10回核ダイナミクス研究会
  • Place of Presentation: 札幌
  • Year and Date: 2011-10-27
• [Presentation] アスコルビン酸は細胞内局在性を異にするSOD活性枯渇による酸素代謝異常を正常化する (2011)
  • Author(s): 田野恵三, 玉利勇樹, 縄田寿克, 菓子野元郎, 関政幸, 榎本武美, 渡邉正己
  • Organizer: 日本放射線影響学会第54回大会
  • Place of Presentation: 神戸市神戸商工会議所会館
• [Presentation] Ascorbic acid suppress oxidative stress induced by depletion of superoxide dismutase in chicken DT40 cells (2011)
  • Author(s): Yuki Tamari, Hisakatsu Nawata, Eri Inoue, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe
  • Organizer: 日本環境変異原学会第40回大会
  • Place of Presentation: 東京学術総合センター
• [Presentation] ニワトリDT40 Tipin遺伝子破壊株の性状解析 (2011)
  • Author(s): 樋口優人、阿部拓也、細野嘉史、櫻場秀一、榎本武美、関政幸
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市パシフィコ横浜
• [Presentation] Analysis of the functional relationship between WRNIP1 and DNA polymerase etha in the cell (2011)
  • Author(s): 吉村明、関政幸、榎本武美
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市パシフィコ横浜
• [Presentation] Global analysis of functional relationships between H2A and its variant Htz1 (2011)
  • Author(s): 上野岳、岡田裕介、吉田隼人、榎本武美、堀越正美、関政幸
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市パシフィコ横浜
• [Presentation] Glabal analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation (2011)
  • Author(s): Yu Nakabayashi, Satoshi Kawashima, Kazuo Matsubara, Norihiko Sano, Takemi Enomoto, Kozo Tanaka, Masayuki Seki, Masami Horikoshi
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市パシフィコ横浜
• [Presentation] Ascorbic acid suppress oxidative stress induced by depletion of superoxide dismutase in chicken DT40 cells (2011)
  • Author(s): Yuki Tamari, Hisakatsu Nawata, Eri Inoue, Akari Yoshimura, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市パシフィコ横浜
• [Presentation] DNAヘリカーゼRecQL5の相同組換え機構における機能の解析 (2011)
  • Author(s): 細野嘉史、阿部拓也、関政幸、榎本武美
  • Organizer: 第21回DNA複製・組換え・ゲノム安定性制御ワークショップ
  • Place of Presentation: 福岡県福津市サンピア福岡
• [Presentation] 包括的なコアヒストンの解析による染色体分配に必要なヌクレオソーム上の3種類の機能領域の同定 (2011)
  • Author(s): 中林悠、川嶋聡、松原和子、佐野徳彦、榎本武美、田中耕三、関政幸、堀越正美
  • Organizer: 第10回核ダイナミクス研究会
  • Place of Presentation: 北海道北広島市クラッセホテル北広島
• [Presentation] ヒストンから迫るDNA介在反応制御機構 (2010)
  • Author(s): 関政幸
  • Organizer: BMB2010 (第33回分子生物会年会 ; 第83回生化学会大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Mechanistic models on eukaryotic gene regulation (2010)
  • Author(s): Yohei Hayashi, Lui Sato, Satoshi Kawashima, Yusuke Akai, Naruhiko Adachi, Ryo Natsume, Toshiya Senda, Masayuki Seki, Masami Horikoshi
  • Organizer: BMB2010 (第33回分子生物会年会 ; 第83回生化学会大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication (2010)
  • Author(s): Lena R. Kundu, Masayuki Seki, Nanae Watanabe, Hiromu Murofushi, Asako Furukohri, Shou Waga, Alan J. Score, Julian J. Blow, Masami Horikoshi, Takemi Enomoto, Shusuke Tada
  • Organizer: BMB2010 (第33回分子生物会年会 ; 第83回生化学会大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Analysis of novel histone chaperone Cdc45 interacting with histone H3-H4 (2010)
  • Author(s): Tatsuya Ohsumi, Takanori Hirano, Satoshi Kawashima, Gaku Ueno, Hiriki Kurihara, Takemi Enomoto, Masami Horikoshi, Masayuki Seki
  • Organizer: BMB2010 (第33回分子生物会年会 ; 第83回生化学会大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] The nucleosome entry site regulates H3-K36me3 through the association of RNA polymerase II and Set2 on chromatin (2010)
  • Author(s): Hirohito Endo, Satoshi Kawashima, Tomonori Mitsuki, Takemi Enomoto, Masayuki Seki, Masami Horikoshi
  • Organizer: BMB2010 (第33回分子生物会年会 ; 第83回生化学会大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] In vivo analisis of histone variant exchange with H2B-H2A and H2B-Htz1 fusion proteins (2010)
  • Author(s): Yu Nakabayashi, Lui Sato, Satoshi Kawashima, Gaku Ueno, Masayuki Seki, Masami Horikoshi
  • Organizer: BMB2010 (第33回分子生物会年会 ; 第83回生化学会大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] The nucleosome entry site regulates H3-K36me3 through the association of RNA polymerase II and Set2 on chromatin (2010)
  • Author(s): Hirohito Endo, Satoshi Kawashima, Tomonori Mitsuki, Takemi Enomoto, Masayuki Seki, Masami Horikoshi
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] Mechanistic models on eukaryotic gene regulation (2010)
  • Author(s): Yohei Hayashi, Lui Sato, Satoshi Kawashima, Yusuke Akai, Naruhiko Adachi, Ryo Natsume, Toshiya Senda, Masayuki Seki, Masami Horikoshi
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] In vivo analysis of histone variant exchange with H"B-H2A and H"B-Htzl fusion proteins (2010)
  • Author(s): Yu Nakahayashi, Lui Sato, Satoshi Kawashima, Gaku Ueno, Masayuki Seki, Masami Horikoshi
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] The N-terminal region of RECQL4 lacking the helicase domain in both essential and sufficient for the viability of vertebrate cells. (2010)
  • Author(s): 吉村明、阿部拓也、多田周右、関政幸、榎本武美
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ボートアイランド
  • Year and Date: 2010-12-08
• [Presentation] SOD1枯渇細胞とPRDX1枯渇細胞の抗酸化剤に対する挙動の違い (2010)
  • Author(s): 樋口優人、井上絵里、田野恵三、吉村明、渡邉正巳、榎本武美、関政幸
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication (2010)
  • Author(s): Lena R.Kundu, Masayuki Seki, Nanae Watanabe, Hiromu Murofushi, Asako Furukohri, Shou Waga, Alan J.Score, Julian J.Blow, Masami Horikoshi, Takemi Enomoto, Shusuke Tada
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] DNAヘリカーゼRECQL5のDNA組換え、修復における機能の解析 (2010)
  • Author(s): 細野嘉史、阿部拓也、石合正道、多田周右、武田俊一、高田穣、関政幸、榎本武美
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] ヒストンから迫るDNA介在反応制御機構 (2010)
  • Author(s): 関政幸
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] Analysis of novel histone chaperone Cdc45 interacting with histone H3-H4 (2010)
  • Author(s): Tatsuya Ohsumi, Takanori Hirano, Satoshi Kawashima, Gaku Ueno, Hiriki Kurihara, Takemi Enomoto, Masami Horikoshi, Masayuki Seki
  • Organizer: BMB2010(第33回分子生物会年会;第83回生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] ヒストンシャペロンFACTは複製フォークの進行を促す (2010)
  • Author(s): 江戸崇人、阿部拓也、細野嘉史、多田周右、堀越正美、榎本武美、関政幸
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 奥羽大学薬学部
  • Year and Date: 2010-10-24
• [Presentation] ヌクレオソームと複製フォークの進行 (2010)
  • Author(s): 関政幸
  • Organizer: 国立遺伝学研究所研究会「ユビキチン・SUMOによるDNA複製およびDNA修復系の制御」
  • Place of Presentation: 三島
  • Year and Date: 2010-10-01
• [Presentation] コアヒストンから迫る核内反応機構の解明へ (2010)
  • Author(s): 関政幸
  • Organizer: 第62回生命機能研究科コロキウム
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-15
• [Presentation] A mutant protein of histone chaperone CIA/Asf1 defective in disrupting histone (H3-H4)2 tetramer accelerates rate of DNA replication (2009)
  • Author(s): 大隅達也、石川勝幸、多田周右、夏目亮、Lena R. Kundu、野崎直仁、千田俊哉、榎本武美、堀越正美、関政幸
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Acetylation of histone H3-K56 regulates homologous recombination (2009)
  • Author(s): 遠藤博人、関政幸、川嶋聡、佐藤塁、榎本武美、堀越正美
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Acetylation of histone H3-K56 regulates homologous recombination (2009)
  • Author(s): 遠藤博人、関政幸、川嶋聡、佐藤塁、榎本武美、堀越正美
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-11
• [Presentation] A mutant protein of histone chaperone CIA/Asf1 defective in disrupting histone(H3-H4)_2 tetramer accelerates rate of DNA replication (2009)
  • Author(s): 大隅達也、石川勝幸、多田周右、夏目亮、Lena R.Kundu、野崎直仁、千田俊哉、榎本武美、堀越正美、関政幸
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-11
• [Presentation] Analysis of DNA replication repression by excess Cdt1 (2009)
  • Author(s): 牛田磨理、津山崇、渡辺沙里、青木彩子、関政幸、榎本武美、多田周右
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-10
• [Presentation] Nuclear superoxide may trigger spontaneous sister chromatid exchanges(招待講演) (2009)
  • Author(s): Eri Inoue, Keizo Tano, Hanako Yoshii, Syunya Takada, Akari Yoshimura, Nawata Hisakatsu, Jun Nakamura, Shusuke Tada, Masami Watanabe, Masayuki Seki, Takemi Enomoto
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-09
• [Presentation] 親鎖ヌクレオソーム中のヒストン成分の娘鎖への分配機構解明に向けて(招待講演) (2009)
  • Author(s): 石川勝幸、大隅達也、阿部拓也、夏目亮、多田周右、千田俊哉、榎本武美、堀越正美、関政幸
  • Organizer: 第48回日本薬学会東北支部大会
  • Place of Presentation: ポートアイランド(神戸)
  • Year and Date: 2009-10-23
• [Presentation] DNA複製に必須なCdc45の新規機能の解析 (2009)
  • Author(s): 大隅達也、石川勝幸、多田周右、榎本武美、堀越正美、関政幸
  • Organizer: 第48回日本薬学会東北支部大会
  • Place of Presentation: 東北薬科大学(仙台)
  • Year and Date: 2009-10-18
• [Presentation] 親鎖ヌクレオソーム中のヒストン成分の娘鎖への分配機構解明にむけて (2009)
  • Author(s): 石川勝幸、大隅達也、阿部拓也、夏目亮、多田周右、千田俊哉、榎本武美、堀越正美、関政幸
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-10
• [Presentation] 染色体分配におけるヒストンの機能的役割とクロマチン制御機構の解析 (2009)
  • Author(s): 川嶋聡、佐野徳彦、松原和子、榎本武美、田中耕三、関政幸、堀越正美
  • Organizer: 第6回 東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2009-06-16