| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
Post-transcriptional regulation of gene expression has a significant role in various cellular processes such as cell growth, cell differentiation, adaptation to stress, and cell death. In our study, we are focusing on understanding the molecular mechanism and the physiological function of the post-transcriptional regulation by RNA-binding proteins using yeast and mammalian cells. We have revealed that RNA-binding protein Khd1 and cytoplasmic deadenylase Ccr4 modulate a signal from Rho1 in the yeast cell wall integrity pathway by regulating the expression of RhoGEF and RhoGAP. We have also revealed that RNA-binding protein Stau1 coordinates myogenesis through the regulation of Dvl2 mRNA encoding a central mediator of Wnt pathway.
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