Inhibitory mechanism of p53 transactivation by anaplastic lymphoma kinase(ALK) through direct p53 tyrosine phosphorylation
| Project/Area Number |
21370083
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
ENARI Masato 独立行政法人国立がん研究センター, 研究所, ユニット長 (90294058)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 転写 / 癌 / 遺伝子 / シグナル伝達 |
|---|
| Research Abstract |
Certain chromosomal translocations have been found in lymphomas and lung cancers and their translocations are known to promote tumor formation. We found that translocated genes have both abilities to activate oncogenic factors and to inactivate tumor suppressors. Moreover, we found that pathologically activated genes by translocations inhibit an important tumor suppressor through its direct phosphorylations and that these phosphorylations inactivate the tumor-suppressive function through enhancement of cytoplasmic retention of the tumor suppressor.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] KIF5B-RET fusions in lung adenocarcinoma2012
Author(s)
Takashi Kohno, Hitoshi Ichikawa, Yasushi Totoki, Kazuki Yasuda, Masaki Hiramoto, Takao Nammo, Hiromi Sakamoto, Koji Tsuta, Koh Furuta, Yoko Shimada, Reika Iwakawa, Hideaki Ogiwara, Takahiro Oike, Masato Enari, Aaron J. Schetter, Hirokazu Okayama, Aage Haugen, Vidar Skaug, Suenori Chiku, Itaru Yamanaka, Shun-ichi Watanabe, Ikuo Sekine, Seishi Ogawa, Curtis C. Harris, Hitoshi Tsuda, Teruhiko Yoshida, Jun Yokota and Tatsuhiro Shibata
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Journal Title
Nat. Med.
Volume: 18
Pages: 375-377
Related Report
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[Journal Article] Overexpression of DNA sensor proteins, AIM2 and IFI16, contributes to tumorigenesis of OSCC with p53 inactivation2012
Author(s)
Yuudai Kondo, Kentaro Nagai, Shingo Nakahata, Yusuke Saito, Tomonaga Ichikawa, Akira Suekane, Tomohiko Taki, Reika Iwakawa, Masato Enari, Masafumi Taniwaki, Jun Yokota, Sumio Sakoda and Kazuhiro Morishita
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Journal Title
Cancer Sci.
Volume: 103
Pages: 782-790
Related Report
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