| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
Notch signaling is an evolutionary conserved pathway that plays an important role in the development of various organs. In this study, physiological functions of Notch ligands and the mechanism by which Notch activity is regulated were analyzed using zebrafish. We found a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signaling. Furthermore, using a biochemical screen, we identified Notch as a new substrate of NLK. NLK-phosphorylated Notch1 intercellular domain is impaired in its ability to form a transcriptionally active ternary complex.
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