Gene networks underlying development of the Drosophila central nervous system

• Project/Area Number: 21370096
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: The University of Tokyo
• Principal Investigator: TABATA Tetsuya 東京大学, 分子細胞生物学研究所, 教授 (10183865)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: ショウジョウバエ / 視覚中枢 / 嗅覚中枢 / キノコ体 / EGF / Notch / PCP / アクチン / 軸索投射 / 軸索伸長 / マイクロアレイ / 視覚系神経 / 発生分化 / 軸索形成 / アクチン重合 / sickie / Wnt5 / ラミナ / メダラ / マッシュルームボディ / EGFR

Research Abstract

The molecular mechanisms underlying development of Drosophila lamina and medulla optic ganglia have been studied. We have identified(1) cell surface molecules that are required for recognition between lamina precursor cells and retinal axons,(2) coordinated sequential action of the EGFR and Notch signaling pathways that induce medulla neuroblasts formation in a precisely ordered manner. We have also identified genes involved in planer cell polarity and actin remodeling as important players that regulate axon elongation and guidance of the mushroom body, the center of the olfactory memory formation.

Research Products

• [Journal Article] Concentric zones, cell migration and neuronal circuits in the Drosophila visual center (2011)
  • Author(s): Hasegawa*, E., Kitada*, Y., Kaido, M., Takayama, R., Awasaki, T., Tabata, T. and Sate, M.
  • Journal Title: Development Volume: 138 Pages: 983-993
  • NAID: 120002924884
  • Peer Reviewed
• [Journal Article] The Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe (2011)
  • Author(s): Kawamori, H., Tai, M., Sato, M., Yasugi, T., Tabata, T.
  • Journal Title: Growth Diff Volume: 53 Pages: 653-667
  • NAID: 10029006107
  • Peer Reviewed
• [Journal Article] The Wnts/Planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron (2011)
  • Author(s): Shimizu, K., Sate, M. and Tabata, T.
  • Journal Title: J. Neuroscience Volume: 31 Pages: 4944-4954
  • Peer Reviewed
• [Journal Article] The Wnt5/Planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron. (2011)
  • Author(s): Shimizu, K., Sato, M, Tabata, T.
  • Journal Title: J.Neuroscience Volume: 31 Pages: 4944-4954
  • Peer Reviewed
• [Journal Article] Recognition of pre-and postsynaptic neurons via nephrin/NEPHl homologs is a basis for the formation of the Drosophila retinotopic map (2010)
  • Author(s): Sugie, A., Umetsu, D., Yasugi, T., Fischbach, K.-F. and Tabata. T.
  • Journal Title: Development Volume: 137 Pages: 3303-3313
  • Peer Reviewed
• [Journal Article] Coordinated sequential action of EGFR and Notch signaling pathways regulates pro neural wave progression in the Drosophila optic lobe (2010)
  • Author(s): Yasugi, T., Sugie, A., Umetsu, D. and Tabata, T.
  • Journal Title: Development Volume: 137 Pages: 3193-3203
  • Peer Reviewed
• [Journal Article] Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. (2010)
  • Author(s): Hasegawa, E., Kitada, Y., Kaido, M., Takayama, R., Awasaki, T.Tabata T, Sate M
  • Journal Title: Development Volume: 138 Pages: 983-993
  • NAID: 120002924884
  • Peer Reviewed
• [Journal Article] Recognition of pre-and postsynaptic neurons via nephrin/NEPH1 homologs is a basis for the formation of the Drosophila retinotopic map. (2010)
  • Author(s): Sugie, A., Umetsu, D., Yasugi, T., Fischbach, K.-F., Tabata, T.
  • Journal Title: Development Volume: 137 Pages: 3303-3313
  • Peer Reviewed
• [Journal Article] Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave nrngression in the Drosonbila ontic lobe (2010)
  • Author(s): Yasugi, T., Sugie, A., Umetsu, D., Tabata, T.
  • Journal Title: Development Volume: 137 Pages: 3193-3203
  • Peer Reviewed
• [Journal Article] The Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe.
  • Author(s): Kawamori, H., Tai, M., Sato, M., Yasugi, T., Tabata, T.
  • Journal Title: Development Growth Diff Volume: (掲載確定)(in press)
  • NAID: 10029006107
  • Peer Reviewed
• [Presentation] Cellular and molecular mechanisms underlying neural formation in Drosophila visual system development (2010)
  • Author(s): Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
• [Presentation] Roles of Wnt Signal in Development of Drosophila Mushroom Body (2010)
  • Author(s): Shimizu, K., Sate, M. and Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
• [Presentation] Sickle, a Neuron navigator homolog, is required for the axonal development of Drosophila mushroom body neurons (2010)
  • Author(s): Abe, T., Maeyama, Y., Yasugi, T., Murakami, S. and Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
• [Presentation] RNA interference screening for genes involved in the development of Drosophila mushroom body (2010)
  • Author(s): Nitta, Y., Shimizu, K., Ohtsubo, M. and Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
• [Presentation] Mechanisms underlying Drosophila memory formation (2010)
  • Author(s): Tabata, T., Murakami, S.
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Mechanisms underlying Drosophila memory formation. (2010)
  • Author(s): Tetsuya Tabata, Satoshi Murakami
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Nephrin/NEPH1 homolog proteins play a role in the specific interaction between pre-and post-synaptic neurons during development of Drosophila visual system (2010)
  • Author(s): Atsushi Sugie, Daiki Umetsu, Tetsuo Yasugi, Karl-Friedrich, Fischbach
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都国際会館
• [Presentation] Sickie, a NEURON NAVIGATOR homolog, is required for the axonal development of Drosophila mushroom body neurons. (2010)
  • Author(s): 阿部崇志
  • Organizer: 第43回発生生物学会
  • Place of Presentation: 京都国際会館
• [Presentation] Sickie, a NEURON NAVIGATOR homolog, is required for the axonal development of Drosophila mushroom body neurons. (2010)
  • Author(s): 阿部崇志
  • Organizer: 発生学会 夏季シンポジウム2010
  • Place of Presentation: 東京八王子セミナーハゥス
• [Presentation] Sickie, a NEURON NAVIGATOR homolog, is required for the axonal development of Drosophila mushroom body neurons. (2010)
  • Author(s): 阿部崇志
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Cellular and molecular mechanisms underlying neural formation in Drosophila visual system development. (2010)
  • Author(s): Tabata Tetsuya
  • Organizer: International Symposium on Drosophila Bio-Resource : -Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: 京都
• [Presentation] Roles of Wnt Signal in Development of Drosophila Mushroom Body. (2010)
  • Author(s): Kazumichi Shimizu, Makoto Sato, Tetsuya Tabata
  • Organizer: International Symposium on Drosophila Bio-Resource : -Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: 京都
• [Presentation] Sickie, a Neuron navigator homolog, is required for the axonal development of Drosophila mushroom body neurons. (2010)
  • Author(s): Takashi Abe, Yuko Maeyama, Tetsuo Yasugi, Satoshi Murakami, Tetsuya Tabata
  • Organizer: International Symposium on Drosophila Bio-Resource : -Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: 京都
• [Presentation] RNA interference screening for genes involved in the development of Drosophila mushroom body. (2010)
  • Author(s): Yohei Nitta, Kazumichi Shimizu, Maki Ohtsubo, Tetsuya Tabata
  • Organizer: International Symposium on Drosophila Bio-Resource : -Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: 京都
• [Presentation] EGFR and Notch Signaling Regulates the Progression of the Proneural Wave in the Drosophila Optic Lobe Development (2009)
  • Author(s): Yasugi, T., Umetsu, D. and Tabata, T.
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Nephl/Nephrin homolog proteins play a role in the specific interaction between pie-and post-synaptic neurons during development of Drosophila visual system (2009)
  • Author(s): Sugie, A., Fischbach, K.-F. and Tabata, T.
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Spatio-temporal regulation of DER and Notch signaling pathways organizes the pro neural wave progression in medulla neuroblast development (2009)
  • Author(s): Tabata, T.
  • Organizer: Neurobiology of Drosophila
  • Place of Presentation: Cold Spring Harbor Laboratory, U. S. A
• [Presentation] Role for the EGFR and JAK/STAT Signaling Pathway in the Drosophila Optic Lobe Development (2009)
  • Author(s): Yasugi, T., Umetsu, D., Murakami, S., Sate, M., and Tabata, T.
  • Organizer: 16th International Society of Developmental Biologists Congress 2009
  • Place of Presentation: Edinburgh, UK
• [Presentation] Identification of cell surface moleculesunderlying the specific interaction between pre-and post-synaptic neurons during development of Drosophila visual system (2009)
  • Author(s): Sugie, A., Fischbach, K.-F. and Tabata, T.
  • Organizer: ショウジョウバエ研究会第9回研究会
  • Place of Presentation: 静岡
• [Presentation] Atypical protocadherin Fat contributes to the neurogenesis of medulla neurons in the Drosophila Opitc Lobe (2009)
  • Author(s): Kawamori, H., Tat, M., Sate, M. and Tabata, T.
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
• [Presentation] Cellular and molecular mechanisms underlying neural circuit formation in Drosophila visual system development (2009)
  • Author(s): Tabata. T., Yasugi, T., Sugie, A., Umetsu, D. and Fischbach, K.-F.
  • Organizer: Neural development, 42^<nd> Annual meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: Niigata
• [Presentation] Spatio-temporal regulation of DER and Notch signaling pathways organizes the proneur〓 wave progression in medulla neuroblast development. (2009)
  • Author(s): Tabata Tetsuya
  • Organizer: Neurobiology of Drosophila, Cold Spring Harbor Laboratory
  • Place of Presentation: Cold Spring Harbor, U.S.A
• [Presentation] EGFR and Notch Signaling Regulates the Progression of the Proneural Wave in the Drosophila Optic Lobe Development. (2009)
  • Author(s): Tetsuo Yasugi, Umetsu Daiki, Tetsuya Tabata
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Role for the EGFR and JAK/STAT Signaling Pathway in the Drosophila Optic Lobe Development. (2009)
  • Author(s): Tetsuo Yasugi, Umetsu Daiki, Satoshi Murakami, Makoto Sato, Tetsuya Tabata
  • Organizer: 16th International Society of Developmental Biologists Congress 2009
  • Place of Presentation: Edinburgh, UK
• [Presentation] Nephl/Nephrin homolog proteins play a role in the specific interaction between pre- and post-synaptic neurons during development of Drosophila visual system. (2009)
  • Author(s): Atsushi Sugie, Karl-Friedrich Fischbach, Tetsuya Tabata
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Identification of cell surface molecules underlying the specific interaction between pre- and post-synaptic neurons during development of Drosophila visual system. (2009)
  • Author(s): Atsushi Sugie, Karl-Friedrich Fischbach, Tetsuya Tabata
  • Organizer: ショウジョウバエ研究会第9回研究会
  • Place of Presentation: 静岡
• [Presentation] Atypical protocadherin Fat contributes to the neurogenesis of medulla neurons in the Drosophila Opitc Lobe. (2009)
  • Author(s): Haruhiko Kawamori, Miyako Tai, Makoto Sato, Tetsuya Tabata.
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
• [Presentation] Roles of Wnt Signal in Development of Drosophila Mushroom Body. (2009)
  • Author(s): Kazumichi Shimizu, Makoto Sato, Tetsuya Tabata
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Roles of Wnt signal in development of Drosophila mushroom body. (2009)
  • Author(s): Kazumichi Shimizu, Makoto Sato, Tetsuya Tabata
  • Organizer: 第32回神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Sickie, a Neuron Navigator homolog, is required for axon development of Drosophila mushroom body neurons. (2009)
  • Author(s): Takashi Abe, Yuko Maeyama, Tetsuo Yasugi, Satoshi Murakami, Tetsuya Tabata
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Sickie, a neuron navigator homolog, is required for proper axonal elongation of the Drosophila mushroom body. (2009)
  • Author(s): Takashi Abe, Yuko Maeyama, Tetsuo Yasugi, Satoshi Murakami, Tetsuya Tabata
  • Organizer: 第32回神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Sickie, a Neuron Navigator homolog, is required for axon development of Drosophila mushroom body neurons. (2009)
  • Author(s): Takashi Abe, Yuko Maeyama, Tetsuo Yasugi, Satoshi Murakami, Tetsuya Tabata
  • Organizer: ショウジョウバエ研究会第9回研究会
  • Place of Presentation: 静岡
• [Presentation] RNA interference screening for genes involved in the development of Drosophila mushroom body (2009)
  • Author(s): Yohei Nitta, Kazumichi Shimizu, Maki Ohtsubo, Tetsuya Tabata
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜