Analyses of the left-right asymmetric development in Drosophila

• Project/Area Number: 21370099
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Tokyo University of Science
• Principal Investigator: MATSUNO Kenji 東京理科大学, 基礎工学部, 教授 (60318227)
• Co-Investigator(Renkei-kenkyūsha): MAEDA Reo 東京理科大学, 基礎工学部, 助教 (40453831) ; OKUMURA Takashi 東京理科大学, 基礎工学部, 研究員 (20449234) ; NAKAYAMA Minoro 東京理科大学, 総合研究機構, ポストドクトラル研究員 (40449236)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 器官形成 / 左右非対称性 / 左右軸 / ミオシンI / E-カドヘリン / アクチン / 遺伝的スクリーニング / Wntシグナル / 消化管 / ショウジョウバエ / 質量分析

Research Abstract

Our group is interested in the left-right(LR) asymmetric development in Drosophila. To address this issue, we focused on the directional LR asymmetry of the Drosophila embryonic gut. We found that the activation of Wnt signaling and Rho GTPase pathway are required for the LR asymmetric development of the embryonic gut. We developed a computer modeling that recuperates the RL asymmetric development and obtained imaging data to improve our model.

Research Products

• [Journal Article] A novel Cre/loxP system for mosaic gene expression in the Drosophila embryo (2012)
  • Author(s): Nakazawa, N., Taniguchi, K., Okumura, T., Maeda, R., and Matsuno, K
  • Journal Title: Dev. Dyn Volume: 241 Pages: 965-974
• [Journal Article] Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut (2012)
  • Author(s): Kuroda, J., Nakamura, M., Yoshida, M., Yamamoto, H., Maeda, T., Taniguchi, K., Nakazawa, N., Hatori, R., Ishio, A., Ozaki, A., Shimaoka, S., Ito, T., Iida, H., Okumura, T., Maeda, R., and Matsuno, K
  • Journal Title: Mech. Dev Volume: 128 Pages: 625-629
• [Journal Article] Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila (2012)
  • Author(s): Yamakawa, T., Yamada, K., Sasamura, T., Nakazawa, N., Kanai, M., Suzuki, E., Fortini, M. E., and Matsuno, K
  • Journal Title: Development Volume: 139 Pages: 558-567
• [Journal Article] Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosopbila midgut (2012)
  • Author(s): Junpei Kuroda, Mitsutoshi Nakamura, Masashi Yoshida, Haruka Yamamoto, Takaaki Maeda, Kiichiro Taniguchi, Naotaka Nakazawa, Ryo Hatori, Akira Ishio, Ayumi Ozaki, Shunsuke Shimaoka, Tamiko Ito, Hironao Iida, Takashi Okumura, Reo Maeda, Kenji Matsuno
  • Journal Title: Mechanisms of Development Volume: 128 Issue: 11-12 Pages: 625-639
  • DOI: 10.1016/j.mod.2011.12.002
  • Peer Reviewed
• [Journal Article] Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis (2011)
  • Author(s): Taniguchi, K., Maeda, R., Ando, T., Okumura, T., Nakazawa, N., Hatori, R., Nakamura, M., Hozumi, S., Fujiwara, H., Matsuno, K
  • Journal Title: Science Volume: 333 Pages: 339-341
• [Journal Article] Drosophila carrying Pex3 or Pex16 mutations are models of zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes (2011)
  • Author(s): Nakayama, M., Sato, H., Okuda, T., Fujisawa, N., Kono, N., Arai, H., Suzuki, E., Umeda, M., Ishikawa, H. O., and Matsuno, K
  • Journal Title: PLoS ONE Volume: 6(8)
  • NAID: 120004996597
• [Journal Article] Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation (2011)
  • Author(s): Yamada, K., Fuwa, T. J., Ayukawa, T., Tanaka, T., Nakamura, A., Wilkin, M. B., Baron, M., and Matsuno, K
  • Journal Title: Genes to Cells Volume: 16 Pages: 261-272
• [Journal Article] Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation. (2011)
  • Author(s): Kenta Yamada
  • Journal Title: Genes to Cells Volume: 16 Pages: 261-272
  • Peer Reviewed
• [Journal Article] Introgression of Drosophila simulans Nup160(nuclear pore protein 160) in Drosophila melanogaster Alone Does Not Cause Inviability but Does Cause Female Sterility (2010)
  • Author(s): Sawamura, K., Maeharam, K., Mashino, S., Kagesawa, T., Kajiwara, M., Matsuno, K., Takahashi, A., Takano-shimizu, T
  • Journal Title: Genetics Volume: 186 Pages: 669-678
• [Journal Article] Two pathways for importing GDP-fucose into the ER lumen function redundantly in the O-fucosylation of Notch in Drosophila (2010)
  • Author(s): Ishikawa, H. O., Ayukawa, T., Nakayama, N., Higashi, S., Kamiyama, S., Nishihara, S., Aoki, K., Ishida, N., Sanai, Y., and Matsuno, K
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 4122-4129
• [Journal Article] Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila (2010)
  • Author(s): Okumura, T., Fujiwara, H., Taniguchi, K., Kuroda, J., Nakazawa, N., Nakamura, M., Hatori, R., Ishio, A., Maeda, R., and Matsuno, K
  • Journal Title: Dev. Biol Volume: 344 Pages: 693-706
• [Journal Article] Introgression of Drosophila simulans Nup160 (nuclear pore protein 160) in Drosophila melanogaster Alone Does Not Cause Inviability but Does Cause Female Sterility. (2010)
  • Author(s): Kyouichi Sawamura
  • Journal Title: Genetics Volume: 186 Pages: 669-678
  • Peer Reviewed
• [Journal Article] Two pathways for importing GDP-fucose into the ER lumen function redundantly in the O-fucosylation of Notch in Drosophila. (2010)
  • Author(s): Hiroyuki O.Ishikawa
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 4122-4129
  • Peer Reviewed
• [Journal Article] Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila. (2010)
  • Author(s): Takashi Okumura
  • Journal Title: Dev.Biol. Volume: 344 Pages: 693-706
  • Peer Reviewed
• [Journal Article] Two pathways for importing GDP-fucose into the ER lumen function redundantly in the O-fucosylation of Notch in Drosophila (2010)
  • Author(s): Hiroyuki Ishikawa
  • Journal Title: J.Biol.Chem. 285 Pages: 4122-4129
  • Peer Reviewed
• [Journal Article] Notch 受容体活性化の場としてのリソソーム様小器官 (2009)
  • Author(s): 山田健太
  • Journal Title: 実験医学 27 Pages: 1251-1254
• [Presentation] 細胞の左右非対称な歪みが生み出す「力」による器官形態の新しい形成機構 (2012)
  • Author(s): 松野健治
  • Organizer: 第153回日本獣医学会学術集会
  • Place of Presentation: 大宮
• [Presentation] Function of a neurogenic gene, pecanex in Notch signaling (2012)
  • Author(s): Tomoko Yamakawa, Kenta Yamada, Takeshi Sasamura, Naotaka Nakazawa, Maiko Kanai, Emiko Suzuki, Mark E. Fortini, Kenji Matsuno
  • Organizer: 53th Annual Drosophila Conference
  • Place of Presentation: 米国シカゴ
• [Presentation] Functions of a Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left-Right Asymmetry in the Drosophila Embryonic Hindgut (2011)
  • Author(s): Ryo Hatori
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: 台北、台湾
  • Year and Date: 2011-05-24
• [Presentation] Wnt signal plays an essential role in the left-right asymmetric development of the embryonic gut in Drosophila (2011)
  • Author(s): Junpei Kuroda
  • Organizer: 52^<nd> Annual Drosophila research conference
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2011-04-01
• [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut (2011)
  • Author(s): Ryo Hatori
  • Organizer: 52^<nd> Annual Drosophila research conference
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2011-04-01
• [Presentation] Genetic screens of mutants on the second and third chromosomes to identify genes involved in the left-right asymmetric development of the embryonic gut in Drosophila (2011)
  • Author(s): Mitsutoshi Nakamura
  • Organizer: 52^<nd> Annual Drosophila research conference
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2011-04-01
• [Presentation] Functions of a Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left Right Asymmetry in the Drosophila Embryonic Hindgut (2011)
  • Author(s): Ryo Hatori, Kiichiro Taniguchi, Takashi Okumura, Naotaka Nakazawa, Mitsutoshi Nakamura, Kenji Matsuno
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Function of a neurogenic gene, pecanex in Notch signaling (2011)
  • Author(s): Tomoko Yamakawa, Kenta Yamada, Takeshi Sasamura, Naotaka Nakazawa, Maiko Kanai, Emiko Suzuki, Mark E. Fortini, Kenji Matsuno
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] ショウジョウバエ神経上皮における平面内の細胞極性はsingle-minded遺伝子に依存して形成された正中線細胞によって制御されている (2011)
  • Author(s): 伊藤多美子, 前田礼男, 松野健治
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis (2011)
  • Author(s): Reo Maeda, Kiichiro Taniguchi, Tadashi Ando, Takashi Okumura, Naotaka Nakazawa, Ryo Hatori, Mitsutoshi Nakamura, Shunya Hozumi, Hiroo Fujiwara, Kenji Matsuno
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] A RhoGEF encoded by pebble is involved in the asymmetric development of the embryonic gut in Drosophila (2011)
  • Author(s): Takeshi Muguruma, Mitsutoshi Nakamura, Kenjiroo Matsumoto, Naotaka Nakazawa, Reo Maeda, Ryo Hatori, Akira Ishio, Kenji Matsuno
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] ギャップ結合によるGDP-フコースの供給はNotchのO-フコシル化に十分である (2011)
  • Author(s): 松野健治
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
• [Presentation] Mechanisms of left-right asymmetric development in Drosophila : approaches involving genome-wide genetic screens and computer simulations (2011)
  • Author(s): Kenji Matsuno
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 札幌
• [Presentation] Functions of a Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left Right Asymmetry in the Drosophila Embryonic Hindgut (2011)
  • Author(s): Ryo Hatori, Kiichiro Taniguchi, Naotaka Nakazawa, Reo Maeda, Kenji Matsuno
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: 台湾台北
• [Presentation] Genetic Screens of Mutants on the Second and Third Chromosomes to Identify Genes Involved in the Left-Right Asymmetric Development of the Embryonic Gut in Drosophila (2011)
  • Author(s): Mitsutoshi Nakamura, Naotaka Nakazawa, Kiichiro Taniguchi, Takashi Okumura, Reo Maeda, Ryo Hatori, Akira Ishio, Ayumi Ozaki, Kenji Matsuno
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: 台湾台北
• [Presentation] Function of a Neurogenic Gene, pecanex in Notch Signaling (2011)
  • Author(s): Tomoko Yamakawa, Takeshi Sasamura, Maiko Kanai, Emiko Suzuki, Mark E. Fortini, Kenji Matsuno
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: 台湾台北
• [Presentation] A Novel Method for Mosaic Gene Expression with Cre-loxP System in Drosophila Embryos (2011)
  • Author(s): Naotaka Nakazawa, Kiichiro Taniguchi, Takashi Okumura, Reo Maeda, Kenji Matsuno
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: 台湾台北
• [Presentation] Planar cell chirality contributes to left-right asymmetric epithelial morphogenesis in Drosophila (2011)
  • Author(s): Reo Maeda, Kiichiro Taniguchi, Tadashi Ando, Naotaka Nakazawa, Ryo Hatori, Mitsutoshi Nakamura, Takashi Okumura, Kenji Matsuno
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄
• [Presentation] Monosaccharide O-fucose modification of Notch contributes to the folding of Notch receptor in Drosophila (2011)
  • Author(s): Akira Ishio, Tomonori Ayukawa, Naoki Aoyama, Tetsuya Okajima, Kenji Matsuno
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄
• [Presentation] Wnt signal plays an essential role in the left-right asymmetric development of the embryonic gut in Drosophila (2011)
  • Author(s): Junpei Kuroda, Reo Maeda, Yasuhiro Kawakatsu, Mitsutoshi Nakamura, Naotaka Nakazawa, Ayumi Ozaki, Akira Ishio, Ryo Hatori, Shigenori Nonaka, Kenji Matsuno
  • Organizer: 52th Annual Drosophila Conference
  • Place of Presentation: 米国サンディエゴ
• [Presentation] Role of Monosaccharide O-fucose modification of Notch for the folding of Notch receptor in Drosophila (2011)
  • Author(s): Akira Ishio, Tomonori Ayukawa, Naoki Aoyama, Tetsuya Okajima, Kenji Matsuno
  • Organizer: 52th Annual Drosophila Conference
  • Place of Presentation: 米国サンディエゴ
• [Presentation] Planar cell chirality contributes to left-right asymmetric epithelial morphogenesis in Drosophila (2011)
  • Author(s): Reo Maeda, Kiichiro Taniguchi, Tadashi Ando, Naotaka Nakazawa, Ryo Hatori, Mitsutoshi Nakamura, Takashi Okumura, Kenji Matsuno
  • Organizer: 52th Annual Drosophila Conference
  • Place of Presentation: 米国サンディエゴ
• [Presentation] Functions of a helix-loop-helix transcription factor (2011)
  • Author(s): Ryo Hatori, Kiichiro Taniguchi, Naotaka Nakazawa, Mitsutoshi Nakamura, Reo Maeda, Kenji Matsuno
  • Organizer: Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut
  • Place of Presentation: 米国サンディエゴ
• [Presentation] Genetic screens of mutants on the second and third chromosomes to identify genes involved in the left-right asymmetric development of the embryonic gut in Drosophila (2011)
  • Author(s): Mitsutoshi Nakamura, Naotaka Nakazawa, Kiichiro Taniguchi, Reo Maeda, Takashi Okumura, Ryo Hatori, Akira Ishio, Ayumi Ozaki, Kenji Matsuno
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 米国サンディエゴ
• [Presentation] Genetic Screens of Mutants on the Second and Third Chromosomes to Identify Genes Involved in the Left-Right Asymmetric Development of the Embryonic Gut in Drosophila (2011)
  • Author(s): Mitsutoshi Nakamura
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: 台北、台湾
• [Presentation] Functions of Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left Right Asymmetry in the Drosophila Embryonic Hindgut (2011)
  • Author(s): Ryo Hatori
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Enzymatic activity-independent functions of O-fucosyltransferase 1 in the folding and endocytic trafficking of the Notch receptor in Drosophila (2010)
  • Author(s): Tomonori Ayukawa
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-10
• [Presentation] Notch deficiency implicated in the pathogenesis of congenital disorders of glycosylation llc (2010)
  • Author(s): Naoki Aoyama
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] ショウジョウバエ杯消化管の左右非対称形成に関与する第2染色体遺伝子の遺伝的スクリーニングによる網羅的同定 (2010)
  • Author(s): 尾崎あゆみ
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] A genetic screen to identify genes on the 3^<rd> chromosome involved in the left-right asymmetric development of the embryonic gut in Drosophila (2010)
  • Author(s): Mitsutoshi Nakamura
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut (2010)
  • Author(s): Ryo Hatori
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] Analysis of mechanical force controlled by MyosinlD during the left-right asymmetric morphogenesis of epithelia in Drosophila (2010)
  • Author(s): Naotaka Nakazawa
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] A Novel role of Notch monosaccharide O-fucose modification is required for Notch signaling in Drosophila (2010)
  • Author(s): Akira Ishio
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] Wnt signal plays essential roles in the left-right asymmetric development of the embryonic gut Drosophila (2010)
  • Author(s): Jyupei Kuroda
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] SUMO化たんぱく質をユビキチン化するRNF4のショウジョウバエ初期胚核分裂における機能に関する研究 (2010)
  • Author(s): 橋本珠子
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] ヒラマキガイを用いた冠輪動物順遺伝学モデルの創出の試み (2010)
  • Author(s): 植竹啓介
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] Diversity in the functions of the negative regulators of EGFR signaling may underlie the evolution of eggshell morphology in genus Drosophila (2010)
  • Author(s): Yota Akiyama
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut (2010)
  • Author(s): Ryo Hatori
  • Organizer: The 16^<th> International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
  • Place of Presentation: 奈良
  • Year and Date: 2010-11-16
• [Presentation] Wnt signal plays essential in the left-right asymmetric development of the embryonic gut in Drosophila (2010)
  • Author(s): Jyunpei Kuroda
  • Organizer: The 16^<th> International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
  • Place of Presentation: 奈良
  • Year and Date: 2010-11-16
• [Presentation] Function of a neurogenic gene pecanex in Notch signaling. (2010)
  • Author(s): Tomoko Yamakawa
  • Organizer: 第5回Notch研究会
  • Place of Presentation: 東京理科大学野田キャンパスセミナーハウス
  • Year and Date: 2010-11-09
• [Presentation] Monosaccharide O-fucose modification of Notch is required for Notch signaling in the folding of the Notch receptor in Drosophila (2010)
  • Author(s): Akira Ishio
  • Organizer: 第5回Notch研究会
  • Place of Presentation: 東京理科大学野田キャンパスセミナーハウス
  • Year and Date: 2010-11-08
• [Presentation] A genome-wide RNAi screen to identity the genes regulating vesicular trafficking of Notch in Drosophila melanogaster (2010)
  • Author(s): Naoki Aoyama
  • Organizer: 第5回Notch研究会
  • Place of Presentation: 東京理科大学野田キャンパスセミナーハウス
  • Year and Date: 2010-11-08
• [Presentation] Two Enzymatic Activity-Independent Functions of O-Fucosyltransferase 1 Separately Contribute to the Folding and Trafficking of the Notch. (2010)
  • Author(s): Kenji Matsuno
  • Organizer: THE 28^<th> NAITO CONFERRENCE
  • Place of Presentation: Shonan Village Center
  • Year and Date: 2010-07-30
• [Presentation] Planar cell chirality contributes to the left-right asymmetric morphogenesis of the hindgut epithelium in Drosophila. (2010)
  • Author(s): Kenji Matsuno
  • Organizer: The molecular and developmental biology of Drosophila
  • Place of Presentation: CRETE GREECE
  • Year and Date: 2010-06-24
• [Presentation] Functions of helix loop transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut (2010)
  • Author(s): Ryo Hatori
  • Organizer: 第43回日本発生生物学会年回
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-06-20
• [Presentation] E3ユビキチンリガーゼNeuralizedは、ショウジョウバエ後腸の左右非対称形成の必須である (2010)
  • Author(s): Akira Ishio
  • Organizer: 第43回日本発生生物学会年回
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-06-20
• [Presentation] Planar cell chirality contributes to the left-right asymmetric morphogenesis of epithelium in Drosophila. (2010)
  • Author(s): Kenji Matsuno
  • Organizer: 2^<nd> joint Meeting of the French and Japanese Societies for Development
  • Place of Presentation: Institut Pasteur, Paris
  • Year and Date: 2010-05-26
• [Presentation] Wnt signal plays essential roles in the Left-right asymmetric development of the embryonic gut in Drosophila. (2010)
  • Author(s): Junpei Kuroda
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-21
• [Presentation] A genetic screen of the Drosophila second chromosome to identify genes involved in the left-right asymmetric development of the embryonic gut. (2010)
  • Author(s): Naotaka Nakazawa
  • Organizer: 51^<st> Annual Drosophila Research Conference
  • Place of Presentation: WASHINGTON, DC
  • Year and Date: 2010-04-10
• [Presentation] A noncanonical role septate junction proteins in the visceral mesoderm essential for mesodermal closure in Drosophila. (2010)
  • Author(s): Yasuhiro Kawakatsu
  • Organizer: 51^<st> Annual Drosophila Research Conference
  • Place of Presentation: WASHINGTON, DC
  • Year and Date: 2010-04-10
• [Presentation] Notch deficiency implicated in the pathogenesis of congenital disorders of glycosylation IIc (2010)
  • Author(s): Naoki Aoyama, Tomonori Ayukawa, Hiroyuki O. Ishikawa, Takuya Suzuki, Kenji Matsuno
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Wnt signal plays essential roles in the left-right asymmetric development of the embryonic gut in Drosophila (2010)
  • Author(s): Junpei Kuroda, Reo Maeda, Yasuhiro Kawakatsu, Mitsutoshi Nakamura, Naotaka Nakazawa, Akira Ishio, Ayumi Ozaki, Ryo Hatori, Kenji Matsuno
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Diversity in the functions of the negative regulators of EGFR signaling may underlie the evolution of eggshell morphology in genus Drosophila (2010)
  • Author(s): Yota Akiyama, Tatsuo Kagesawa, Yukio Nakamura, Minori Nishikawa, Miyuki Kajiwara, Kenji Matsuno
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] ショウジョウバエ胚消化管の左右非対称性形成に関与する第2染色体遺伝子の遺伝的スクリーニングによる網羅的同定 (2010)
  • Author(s): 尾崎あゆみ, 中村充利, 中澤直高, 谷口喜一郎, 奥村高志, 前田礼男, 羽鳥僚, 石尾彬, 松野健治
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] A genetic screen to identify genes on the 3rd chromosome involved in the left-right asymmetric development of the embryonic gut in Drosophila (2010)
  • Author(s): Mitsutoshi Nakamura, Naotaka Nakazawa, Reo Maeda, Ryo Hatori, Akira Ishio, Ayumi Ozaki, Kenji Matsuno
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut (2010)
  • Author(s): Ryo Hatori, Kiichiro Taniguchi, Takashi Okumura, Naotaka Nakazawa, Mitsutoshi Nakamura, Reo Maeda, Kenji Matsuno
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Analysis of mechanical force controlled by MyosinlD during the left-right asymmetric morphogenesis of epithelia in Drosophila (2010)
  • Author(s): Naotaka Nakazawa, Kiichiro Taniguchi, Ryo Hatri, Mitsutoshi Nakamura, Reo Maeda, Kenji Matsuno
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut (2010)
  • Author(s): Ryo Hatori, Kiichiro Taniguchi, Takashi Okumura, Naotaka Nakazawa, Mitsutoshi Nakamura, Reo Maeda, Kenji Matsuno
  • Organizer: The 16th International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
  • Place of Presentation: 奈良
• [Presentation] Wnt signal plays essential in the left-right asymmetric development of the embryonic gut in Drosophila (2010)
  • Author(s): Junpei Kuroda, Reo Maeda, Yasuhiro Kawakatsu, Mitsutoshi Nakamura, Naotaka Nakazawa, Akira Ishio, Ayumi Ozaki, Ryo Hatori, Kenji Matsuno
  • Organizer: The 16th International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
  • Place of Presentation: 奈良
• [Presentation] Two Enzymatic Activity-Independent Functions of O-Fucosyltransferase l Separately Contribute to the Folding and Trafficking of the Notch Receptor in Drosophila (2010)
  • Author(s): Kenji Matsuno
  • Organizer: THE 28th NAITO CONFERRENCE
  • Place of Presentation: 神奈川
• [Presentation] Planar cell chirality contributes to the left-right asymmetric morphogenesis of the hindgut epithelium in Drosophila (2010)
  • Author(s): Kenji Matsuno
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: ギリシャクレタ島
• [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut (2010)
  • Author(s): Ryo Hatori, Kiichiro Taniguchi, Takashi Okumura, Naotaka Nakazawa, Reo Maeda, Kenji Matsuno
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都
• [Presentation] A genetic screen to identify genes involved in the left-right asymmetric development of the embryonic gut in Drosophila (2010)
  • Author(s): Mitsutoshi Nakamura, Naotaka Nakazawa, Kiichiro Taniguchi, Takashi Okumura, Reo Maeda, Haruka Yamamoto, Ryo Hatori, Akira Ishio, Ayumi Ozaki, Kenji Matsuno
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都
• [Presentation] Planar cell chirality contributes to the left-right asymmetric morphogenesis of the hindgut epithelium in Drosophila (2010)
  • Author(s): Kenji Matsuno
  • Organizer: 2nd joint Meeting of the French and Japanese Societies for Deveropment
  • Place of Presentation: フランスパリ
• [Presentation] RNA干渉法を用いたショウジョウバエ Notch の細胞内小胞輸送に関する遺伝子の網羅的検索 (2009)
  • Author(s): 青山尚規
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] ショウジョウバエ胚消化管の左右非対称性形成におけるWntシグナル機能 (2009)
  • Author(s): 黒田純平
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] A genetic screen of the third chromosome to identify genes involved In the Left-right asymmetric development of the embryonic gut in Drosophila (2009)
  • Author(s): 中村充利
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] Neuralized, an E3 ubquitin liase, is required for the asymmetric Development of hindgut in the Drosophila (2009)
  • Author(s): 石尾彬
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] A Genetic Screen of the Drosophila Second Chromosome to Identify Genes Involved in the Left-Right Asymmetric Development of the Embryonic Gut (2009)
  • Author(s): 中澤尚高
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] Functions of a Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left-Right asymmetry in the Drosophila Embryonic Hindgut (2009)
  • Author(s): 羽鳥僚
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] Doctor no and ken and Barbie are involved in the left-right asymmetric Development of the Drosophila embryonic gut (2009)
  • Author(s): 前田礼男
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] Pecanex 遺伝子のショウジョウバエ Notch 情報伝達における機能 (2009)
  • Author(s): 松野健治
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] ショウジョウバエをモデル系としたペルオキシソーム形成異常症の病理研究 (2009)
  • Author(s): 中山実
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] 小胞体形成に必須な新規因子 Pecanex の Notch 情報伝達における機能の分析 (2009)
  • Author(s): 山川智子
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-09
• [Presentation] Deltex promotes endocytic transport of Notch to lysosome-related Organelles that are alternative compartments for Notch activation (2009)
  • Author(s): 山田健太
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-09
• [Presentation] ショウジョウバエ Notch のO-フコシル化の機能発現に関与する新規遺伝子の遺伝的検索 (2009)
  • Author(s): 渡利和美
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-09
• [Presentation] ショウジョウバエをモデルとした肢根型点状軟骨異形成症治療に向けた脂質代謝経路 (2009)
  • Author(s): 藤澤奈穂
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-09
• [Presentation] Roles of O-fucosyltransferasel in the trafficking and activation of Notch In Drosophila (2009)
  • Author(s): Kenji Matsuno
  • Organizer: The Notch Meeting
  • Place of Presentation: Athens, Greece
  • Year and Date: 2009-10-01
• [Presentation] A RNAi Screen to identify the genes regulating vesicular trafficking Of Notch in Drosophila (2009)
  • Author(s): 青山尚規
  • Organizer: The Notch Meeting
  • Place of Presentation: Athens, Greece
  • Year and Date: 2009-09-29
• [Presentation] A Genetic Screen of the Drosophila Second Chromosome to Identify Genes Involved in the Left-Right Asymmetric Development of the Embryonic Gut (2009)
  • Author(s): 中澤尚高
  • Organizer: The American Society for Cell Biology/Japan Society for Biology/Developmental Biology Meeting
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2009-09-21
• [Presentation] Functions of a Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left-Right asymmetry in the Drosophila Embryonic Hindgut (2009)
  • Author(s): 羽鳥僚
  • Organizer: The American Society for Cell Biology/Japan Society for Biology/Developmental Biology Meeting
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2009-09-21
• [Presentation] Heartless, Encoding a Receptor of Drosophila, HGF8/17/18-Like Growth Factor, Is Required for the Left-Right Asymmetric Development of the Embryonic Gut in Drosophila (2009)
  • Author(s): 石尾彬
  • Organizer: The American Society for Cell Biology/Japan Society for Biology/Developmental Biology Meeting
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2009-09-21
• [Presentation] A Genetic Screen of Mutants on the Third Chromosome to Identify Genes involved in the Left-right Asymmetric Development of the Embryonic Gut in Drosophila (2009)
  • Author(s): M.Nakamaru
  • Organizer: The American Society for Cell Biology/Japan Society for Biology/Developmental Biology Meeting
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2009-09-21
• [Presentation] Notch のO-フコース単糖装飾の新規な機能に関する研究 (2009)
  • Author(s): 鮎川友紀
  • Organizer: 第29回 日本糖質学会年会
  • Place of Presentation: 飛騨・世界生活文化センター(岐阜県)
  • Year and Date: 2009-09-10
• [Presentation] 上皮細胞のキラリティによる組織形態の形成 (2009)
  • Author(s): 松野健治
  • Organizer: 第6回 日本病理学会カンファレンス
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2009-07-31
• [Presentation] Doctor no and ken and Barbie are involved in the left-right asymmetric Development of the Drosophila embryonic gut (2009)
  • Author(s): 前田礼男
  • Organizer: The 9^<th> Japanese Drosophila Research Conference
  • Place of Presentation: Yamaha Resort TUMAGOI(静岡県)
  • Year and Date: 2009-07-07
• [Presentation] Notch signaling is involved in the left-right asymmetric rotation of the Embryonic midget in Drosophila (2009)
  • Author(s): Naotaka Nakazawa
  • Organizer: 第61回 日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-06-02
• [Presentation] ショウジョウバエをモデル系としたペルオキシソーム病の病態研究 (2009)
  • Author(s): 中山実
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] ショウジョウバエの卵殻形態の進化をもたらしたEGFR情報伝達機構の多様化に関する研究 (2009)
  • Author(s): Tatsuo Kagesawa
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] 選択的エンドサイトーシスを介した Notch 下流シグナルの二分岐機構の研究 (2009)
  • Author(s): 山田健太
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] ショウジョウバエの発生過程における3つのクラスIミオシン遺伝子の役割 (2009)
  • Author(s): Takashi Okumura
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] ショウジョウバエ生体内におけるRNAiを用いた Notch の小胞輸送因子の遺伝学的検索 (2009)
  • Author(s): Naoki Akiyama
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] ショウジョウバエ消化管の左右非対称性形成におけるWnt4シグナルの機能 (2009)
  • Author(s): 黒田純平
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] Septate junctions are required for left-right asymmetric development Of the embryonic gut in Drosophila melanogaster (2009)
  • Author(s): Yasuhiro Kawakatsu
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] Functions of a neurogenic gene, pecanex in Notch signaling (2009)
  • Author(s): 山川智子
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-29
• [Presentation] A novel role of Notch monosaccharide O-fucose modification is required For Delta-Notch but not Sarrate-Notch signaling Drosophila (2009)
  • Author(s): 鮎川友紀
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-29
• [Presentation] ショウジョウバエ胚消化管における左右非対称な形態形成に関わる遺伝子の網羅的スクリーニング (2009)
  • Author(s): 中澤尚高
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-29
• [Presentation] ショウジョウバエ Drn と Ken はJAK/STATシグナルを介して消化管の左右非対称を制御する (2009)
  • Author(s): 前田礼男
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-29
• [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, In development of left-right asymmetry in the Drosophila embryonic Hindgut (2009)
  • Author(s): 羽鳥僚
  • Organizer: 第42回 日本発生生物学会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-05-29
• [Book] 上皮細胞の平面内細胞形状のキラリティによる左右非対称な組織形態形成の新たな機構.実験医学 (2012)
  • Author(s): 中澤直高, 前田礼男, 谷口喜一郎, 安藤格士, 松野健治
• [Book] 細胞のキラルな形状が上皮組織の左右非対称な形態変化を誘発する,細胞工学 (2011)
  • Author(s): 前田礼男, 谷口喜一郎, 安藤格士, 松野健治
• [Book] キラルな細胞形状の変化による左右非対称な形態形成, FIRST AUTHORSライフサイエンス (2011)
  • Author(s): 前田礼男, 谷口喜一郎, 安藤格士, 松野健治
• [Book] Notch Signaling in Embryology and Cancer (2011)
  • Author(s): Tomoko Yamakawa
  • Total Pages: 15
  • Publisher: Landes Bioscience
• [Remarks]
  • URL: http://www.bio.sci.osaka-u.ac.jp/dbs01/re-paper-temp.php?id=81
• [Remarks]
  • URL: http://matsuno-lab.homeip.net/frame.html