Analysis of Sexual Plasticity in Gonads by AMH System
| Project/Area Number |
21370101
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
TANAKA Minoru 基礎生物学研究所, 生殖遺伝学研究室, 准教授 (80202175)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 生殖細胞 / 性分化 / sox9 / 生殖腺 / メダカ / AMH / 性転換 / 性的可塑性 / 性決定分化 / ミュラー管 / メダカ変異体 / MIS |
|---|
| Research Abstract |
With support of this budget, we firstly clarified the molecular and cellular mechanism of sexual plasticity in the gonads and AMH system is involved in this mechanism. We discovered that this system functions in what we named 'Germinal Cradle' in the ovary, in which germline stem cells are present. This was the first successful demonstration of stem cells and niche structure in vertebrate ovary. The AMH system functions in interfollicular manner in the Germinal Cradles and indirectly regulates proliferation of subpopulation of stem cells. The sexual plasticity is also controlled through the regulation of germ cells. This indicates that Germinal Cradles is not only for regulation of the egg number but also for sexual plasticity.
The function of AMH system differs in medaka and mammals. We also revealed that sox9, another important gene for testis formation in mammals, does not functions in masculinization of medaka gonads. Together with functional analysis, our studies collectively indicate that different species in vertebrates develop their own system of sex determination.
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Report
(4 results)
Research Products
(82 results)
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[Journal Article] Hyperproliferation of mitotically active germ cells dues to defective anti-Mullerian hormone signaling mediates sex reversal in medaka2012
Author(s)
Nakamura, S., Watanabe, I., Nishimura, T., Picard, J-Y., Toyoda, A., Taniguchi, Y., di Clemente, N. and Tanaka, M
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Journal Title
Development
Volume: (in press)
Pages: 139-139
Related Report
Peer Reviewed
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[Journal Article] Analysis of medaka sox9 orthologue reveals a concerved role in germ cell maintenance2012
Author(s)
Nakamura, S., Watanabe, I., Nishimura, T., Toyoda, A., Taniguchi, Y. and Tanaka, M
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Journal Title
PLoS ONE
Volume: 7(1)
Issue: 1
Pages: e29982-e29982
DOI
Related Report
Peer Reviewed
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[Journal Article] Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements2010
Author(s)
Herpin, A., Braasch, I., Kraeusslling, M., Schmidt, C., Thoma, E. C., Nakamura, S., Tanaka, M. and Schartl, M
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Journal Title
PLoS Genetics
Volume: 6
Issue: 2
Pages: e1000844-e1000844
DOI
Related Report
Peer Reviewed
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