Research on a disturbance mechanism of endocrine system of host by an insect virus.
| Project/Area Number |
21380038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied entomology
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| Research Institution | Forestry and Forest Products Research Institute |
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Principal Investigator |
TAKATSUKA Jun 独立行政法人森林総合研究所, 森林昆虫研究領域, 主任研究員 (80399378)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAI Madoka 東京農工大学, 共生科学技術研究科(研究院), 准教授 (60302907)
SHINODA Tetsuro 独立行政法人農業生物資源研究所, 昆虫科学研究領域制御剤標的遺伝子研究, ユニット長 (10355620)
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| Co-Investigator(Renkei-kenkyūsha) |
TOKORO Masahiko 独立行政法人森林総合研究所, 林昆虫研究領域, 室長 (70343796)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Keywords | 昆虫 / ウイルス / 内分泌 / ウィルス |
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| Research Abstract |
Whole genome sequences of entomopoxviruses revealed the viruses had an important gene for manipulation of the host endocrine. Using cultured cell that was found to support an entomopoxvirus replication in present research, knock-out mutant lacking this gene function was constructed. Juvenile hormone(JH) titer of the hosts infected with wild type virus was maintained to be high, resulting in host's death in larval stage. On the other hand, JH titer of the hosts infected with the gene function-defective virus was similar to that of healthy hosts, which allowed infected hosts to develop toward pupation. These findings indicate that entomopoxviruses have a gene that disturbs JH titer to manipulate hosts development.
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Report
(4 results)
Research Products
(7 results)
