• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A challenge to "homochirality in sugar metabolism"Analysis of L-glucose catabolic pathway

Research Project

Project/Area Number 21380054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionUniversity of Tsukuba

Principal Investigator

NAKAMURA Akira  筑波大学, 生命環境系, 准教授 (10207863)

Co-Investigator(Renkei-kenkyūsha) TAKAYA Naoki  筑波大学, 生命環境系, 教授 (50282322)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywordsホモキラリティー / L-グルコース / Paracoccus / 糖代謝 / L-glucose代謝 / L-glucose dehydrogenase / lgn operon / 転写調節 / lgn gene cluster / inositol dehydrogenase / inosose reductase / L-gluconate dehydrogenase / L-glucose 代謝 / L-eluconate dehydrogenase
Research Abstract

Most organisms on the Earth can utilize D-glucose as carbon and energy sources, but utilization of its enantiomer, L-glucose, was not reported so far. Therefore it is generally recognized that there is a homochirality issue in sugar utilization. In this study we have analyzed, at enzyme and genetic levels, an L-glucose catabolic pathway in Paracoccus sp. 43P, an L-glucose utilizing bacterium isolated from soil, and succeeded in its elucidation for the first time. The results may contribute further understanding of homochirality issues of living organisms.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (23 results)

  • [Journal Article] L-グルコース代謝機構の発見2013

    • Author(s)
      中村 顕
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 71 Pages: 150-152

    • NAID

      10031159699

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] An L-glucose catabolic pathway in Paracoccusspecies 43P.2012

    • Author(s)
      T. Shimizu, N. Takaya and A. Nakamura
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 40448-40456

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An L-glucose catabolic pathway in Paracoccus species 43P.2012

    • Author(s)
      T. Shimizu, N. Takaya, and A. Nakamura
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 48 Pages: 40448-40456

    • DOI

      10.1074/jbc.m112.403055

    • NAID

      120007136866

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Paracoccus sp. 43P株のL-gluconate 代謝関連遺伝子の発現制御機構の解析2013

    • Author(s)
      清水哲、中村顕
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Paracoccus sp. 43P 株のL-gluconate 代謝関連遺伝子の発現制御機構の解析2012

    • Author(s)
      清水哲、中村顕
    • Organizer
      日本農芸化学会関東支部2012年度大会
    • Place of Presentation
      新潟薬科大学(新潟)
    • Year and Date
      2012-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Paracoccus属細菌43P株のL-グルコース代謝経路2012

    • Author(s)
      清水哲、高谷直樹、中村顕
    • Organizer
      第2回モデル生物丸ごと一匹学会
    • Place of Presentation
      理研SPring-8(兵庫県佐用町)
    • Year and Date
      2012-09-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Paracoccus属細菌43P株のL-グルコース代謝経路2012

    • Author(s)
      清水哲、高谷直樹、中村顕
    • Organizer
      2012年度グラム陽性菌ゲノム機能会議
    • Place of Presentation
      焼津グランドホテル(焼津)
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] L-glucose catabolic pathway in Paracoccus sp. 4 3P.2012

    • Author(s)
      T. Shimizu, N. Takaya, and A. Nakamura.
    • Organizer
      American Society for Microbiology 112th general meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2012-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] An L-glucose metabolic pathway in Paracoccus sp. 43P2011

    • Author(s)
      T. Shimizu, N. Takaya and A. Nakamura
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター (札幌)
    • Year and Date
      2011-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] L-グルコース代謝の初発酵素L-GDHの結晶構造解析2011

    • Author(s)
      深野和紘、清水哲、佐々木康幸、中村顕、矢嶋俊介
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都女子大学 (京都)
    • Year and Date
      2011-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Paracoccus sp. 43PのL-グルコース代謝経路2011

    • Author(s)
      清水哲、高谷直樹、中村顕
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都女子大学 (京都)
    • Year and Date
      2011-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Paracoccus sp.43PのL-グルコース代謝経路2011

    • Author(s)
      清水哲、高谷直樹、中村顕
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] L°グルコース代謝の初発酵素L-GDHの結晶構造解析2011

    • Author(s)
      深野和紘、清水哲、佐々木康幸、中村顕、矢嶋俊介
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Paracoccus sp. 43P由来L-グルコース代謝経路酵素の立体構造解析2011

    • Author(s)
      深野 和紘、清水哲、牧遼、佐々木康幸、中村顕、矢嶋俊介
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学 (京都)
    • Year and Date
      2011-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Paracoccus sp. 43P株のL-グルコース代謝経路2011

    • Author(s)
      清水 哲、高谷直樹、中村顕
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学 (京都)
    • Year and Date
      2011-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] L-glucose dehydrogenase, the first enzyme for L-glucose metabolism in Paracoccus sp. 43P.2010

    • Author(s)
      T. Shimizu, N. Takaya, A. Nakamura.
    • Organizer
      110th General Meeting, American Society for Microbiology
    • Place of Presentation
      San Diego Convention Center, San Diego (USA)
    • Year and Date
      2010-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] L-glucose dehydrogenase, the first enzyme for L-glucose metabolism in Paracoccus sn.43P.2010

    • Author(s)
      T.Shimizu, N.Takaya, A.Nakamura
    • Organizer
      110th General Meeting, American Society for Microbiology
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] L-glucose dehydrogenase, the first enzyme for L-glucose metabolism in Paracoccus sp. 43P.2010

    • Author(s)
      T.Shimizu, N.Takaya, A.Nakamura
    • Organizer
      110th General Meeting, American Society for Microbiology
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Year and Date
      2010-05-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] L-グルコース代謝の初発酵素L-GDHの酵素学的解析2010

    • Author(s)
      清水哲、中村顕、高谷直樹
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2010-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] L-グルコース資化細菌の代謝機構の解明2009

    • Author(s)
      清水哲、高谷直樹、中村顕
    • Organizer
      2009年度日本農芸化学会関東支部大会
    • Place of Presentation
      玉川大学(東京)
    • Year and Date
      2009-10-31
    • Related Report
      2012 Final Research Report
  • [Presentation] L-glucose catabolic pathway in Paracoccus sp. 43P.

    • Author(s)
      T. Shimizu, N. Takaya, and A. Nakamura
    • Organizer
      American Society for Microbiology 112th general meeting
    • Place of Presentation
      San Francisco (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Paracoccus属細菌43P株のL-グルコース代謝経路

    • Author(s)
      清水哲、高谷直樹、中村顕
    • Organizer
      2012年度グラム陽性菌ゲノム機能会議
    • Place of Presentation
      焼津グランドホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Paracoccus属細菌43P株のL-グルコース代謝経路

    • Author(s)
      清水哲、高谷直樹、中村顕
    • Organizer
      第2回モデル生物丸ごと一匹学会
    • Place of Presentation
      理研SPring-8
    • Related Report
      2012 Annual Research Report
  • [Presentation] Paracoccus sp. 43P株のL-gluconate代謝関連遺伝子の発現制御機構の解析

    • Author(s)
      清水哲、中村顕
    • Organizer
      日本農芸化学会関東支部2012年度大会
    • Place of Presentation
      新潟薬科大学(新潟)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Paracoccus sp. 43P株のL-gluconate代謝関連遺伝子の発現制御機構の解析

    • Author(s)
      清水哲、中村顕
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2012 Annual Research Report
  • [Presentation] An L-glucose metabolic pathway in Paracoccus sp. 43P.

    • Author(s)
      T. Shimizu, N. Takaya and A. Nakamura
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi