| Project/Area Number |
21380059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
SUZUKI Hideyuki 京都工芸繊維大学, 工芸科学研究科, 教授 (10202136)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Keiichi 大阪大学, 理学研究科, 教授 (80032283)
HIRSATAKE Jyun 京都大学, 化学研究所, 教授 (80199075)
IZAWA Shingo 京都工芸繊維大学, 工芸科学研究科, 准教授 (10273517)
WADA Kei 大阪大学, 理学研究科, 助教 (80379304)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | グルタチオン / ポリアミン / 大腸菌 / 結晶構造 / 代謝経路 |
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| Research Abstract |
Regulation mechanisms of glutathione metabolism and polyamine metabolism were studied from the point of view that both metabolic pathways met at glutathionylspermidine. We studied extensively on the regulation of the Puu pathway, which is a catabolic pathway of putrescine. The affinity for putrescine of the repressor PuuR and PuuA, which is the first enzyme of the Puu pathway, are very low. This indicates that the Puu pathway is regulated, so that the pathway is active only in the presence of high putrescine concentration.
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