| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
Lectin-like oxidized LDL receptor-1(LOX-1) recognizes oxidized LDL and initiates endothelial dysfunction, which is believed to be a crucial early step in atherosclerosis. Here we show how LOX-1 forms the functional unit, and succeed to reconstitute the binding ability of LOX-1.Moreover, we develop molecular device to evaluate the OxLDL formation and molecular species, which produced on OxLDL as the results of oxidative stress.
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