Large-scale syntheses of multi-bridged peptides that require complicated synthetic processes
| Project/Area Number |
21380072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
CHIBA Kazuhiro 東京農工大学, 大学院・農学研究院, 教授 (20227325)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | ペプチド / 化学合成 / 立体構造 / 生体分子 / 生物活性 / 生物活性物質 / 分子内架橋 / 化学修飾 / ジスルフィド結合 / 逆ミセル / 液相合成法 |
|---|
| Research Abstract |
Large-scale synthetic method for multi-bridged peptides was investigated to overcome their synthetic difficulties. By introducing reverse-micelle reaction field, condensation reactions and selective intramolecular bridge-formations took place efficiently to achieve the chemical synthetic method of the peptides with high-purity, high-yield, and ease of handling.
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions2009
Author(s)
Iijima, Motoyuki, Mikami, Yuzuru, Yoshioka, Tomohiko, Kim, Shokaku, Kamiya, Hidehiro, Chiba, Kazuhiro
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Journal Title
Langmuir 25(18)
Pages: 11043-11047
Related Report
Peer Reviewed
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