Large-scale syntheses of multi-bridged peptides that require complicated synthetic processes

• Project/Area Number: 21380072
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: CHIBA Kazuhiro 東京農工大学, 大学院・農学研究院, 教授 (20227325)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
• Keywords: ペプチド / 化学合成 / 立体構造 / 生体分子 / 生物活性 / 生物活性物質 / 分子内架橋 / 化学修飾 / ジスルフィド結合 / 逆ミセル / 液相合成法

Research Abstract

Large-scale synthetic method for multi-bridged peptides was investigated to overcome their synthetic difficulties. By introducing reverse-micelle reaction field, condensation reactions and selective intramolecular bridge-formations took place efficiently to achieve the chemical synthetic method of the peptides with high-purity, high-yield, and ease of handling.

Research Products

• [Journal Article] Intermolecular Olefin Cross-Metathesis Initiated by the Umpolung of Enol Ethers (2012)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Journal Title: Journal of Synthetic Organic Chemistry Volume: (in press)
  • NAID: 10030835258
• [Journal Article] Cycloalkane-based thermomorphic systems for organic electrochemistry : An application to Kolbe-coupling (2012)
  • Author(s): Yohei Okada, Kazuya Kamimura, Kazuhiro Chiba
  • Journal Title: Tetrahedron Volume: 68(29) Issue: 29 Pages: 5857-5862
  • DOI: 10.1016/j.tet.2012.04.112
  • Peer Reviewed
• [Journal Article] Electrochemically Active Crosslinking Reaction for Fluorescent Labeling of Aliphatic Alkenes (2012)
  • Author(s): Shokaku Kim, Kumi Hirose, Jumpei Uematsu, Yuzuru Mikami, Kazuhiro Chiba
  • Journal Title: Chemistry-A European Journal Volume: 18(20) Issue: 20 Pages: 6284-6288
  • DOI: 10.1002/chem.201103630
  • Peer Reviewed
• [Journal Article] Efficient Intermolecular Carbon-Carbon Bond-Formation Reactions Assisted by Surface-Condensed Electrodes (2012)
  • Author(s): Okada, Y.; Yamaguchi, Y.; Chiba, K.
  • Journal Title: European Journal of Organic Chemistry Volume: 2 Issue: 2 Pages: 243-246
  • DOI: 10.1002/ejoc.201101313
  • Peer Reviewed
• [Journal Article] A Cycloalkane-based Thermomorphic System for Organocatalytic Cyclopropanation Using Ammonium Ylides (2011)
  • Author(s): Shokaku Kim, Naoki Ikuhisa, Kazuhiro Chiba
  • Journal Title: Chemistry Letters Volume: 40(10) Issue: 10 Pages: 1077-1078
  • DOI: 10.1246/cl.2011.1077
  • NAID: 130004426054
• [Journal Article] Heterogeneous continuous flow synthetic system using cyclohexane-based multiphase electrolyte solutions (2011)
  • Author(s): Okada, Y.; Yoshioka, T.; Koike, M.; Chiba, K.
  • Journal Title: Tetrahedron Letters Volume: 52 Issue: 36 Pages: 4690-4693
  • DOI: 10.1016/j.tetlet.2011.07.007
  • Peer Reviewed
• [Journal Article] Demonstration of On-line Desalination for LC-MS Using Phosphate Adsorption onto TiO_2-coated Magnetic Microparticles within a Microchannel (2011)
  • Author(s): Yoshitake Akiyama, Yutaka Takahashi, Issei Akutagawa, Akira Ono, Keisuke Morishima, Kazuhiro Chiba
  • Journal Title: International Journal of Mass Spectrometry Volume: 306(1) Issue: 1 Pages: 37-43
  • DOI: 10.1016/j.ijms.2011.06.005
• [Journal Article] Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-in hibiting peptide somatostatin (2011)
  • Author(s): Kitada, S.; Fujita, S.; Okada, Y.; Kim, S.; Chiba, K.
  • Journal Title: Bioorganic Medicinal Chemistry Letters Volume: 21 Issue: 15 Pages: 4476-4479
  • DOI: 10.1016/j.bmcl.2011.06.004
  • Peer Reviewed
• [Journal Article] Electron Transfer-Induced Intermolecular[ 2+2] Cycloaddition Reactions Based on the Aromatic "Redox Tag" Strategy (2011)
  • Author(s): Yohei Okada, Asaki Nishimoto, Ryoichi Akaba, Kazuhiro Chiba
  • Journal Title: J. Org. Chem Volume: 74 Issue: 9 Pages: 3470-3476
  • DOI: 10.1021/jo200490q
  • Peer Reviewed
• [Journal Article] Thermal history indicators for cook-chill foods : Effect of particle size on cold triggering time (2011)
  • Author(s): Tatsuya Mizoguchi, Makoto Kitsunai, Kumi Hirose, Akira Hirasawa, Svetlana Rodgers, Kazuhiro Chiba
  • Journal Title: Food Australia Volume: 63(3) Pages: 77-80
• [Journal Article] Rate acceleration of Diels-Alder reactions utilizing a fluorous micellar system in water (2011)
  • Author(s): Kohsuke Nishimoto, Yohei Okada, Kazuhiro Chiba
  • Journal Title: Electrochimica Acta Volume: 56 Issue: 28 Pages: 10626-10631
  • DOI: 10.1016/j.electacta.2011.02.087
• [Journal Article] Electron transfer-induced four-membered cyclic intermediate : olefin cross-coupling vs. olefin cross-metathesis (2011)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Journal Title: Electrochimica Acta Volume: 56 Issue: 3 Pages: 1037-1042
  • DOI: 10.1016/j.electacta.2010.10.042
• [Journal Article] Practical Intramolecular Disulfide Formation Based on Hydrophobic Tag Strategy (2011)
  • Author(s): Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba
  • Journal Title: Peptide Science Pages: 139-140
  • NAID: 10030204156
  • Peer Reviewed
• [Journal Article] Electron transfer-induced four-membered cyclic intermediate : olefin cross-coupling vs.olefin cross-metathesis (2011)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Journal Title: Electrochimica Acta Volume: 56 Pages: 1037-1042
  • Peer Reviewed
• [Journal Article] Electro Tranfer-induced Intermolecular [2+2] Cycloaddition Reactions Based on the Aromatic "Redox Tag" Strategy (2011)
  • Author(s): Yohei Okada, Asaki Nishimoto, Ryoich Akaba, Kazuhiro Chiba
  • Journal Title: J.Org.Chem. Volume: 印刷中
• [Journal Article] A practical solution-phase synthesis of an antagonistic peptide of TNF-・based on hydrophobic tag strategy (2010)
  • Author(s): Gegen Tana, Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba
  • Journal Title: Chemical Communications Volume: 46 Issue: 43 Pages: 8219-8221
  • DOI: 10.1039/c0cc03090b
• [Journal Article] Continuous Electrochemical Synthetic System Using a Multiphase Electrolyte Solution (2010)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Journal Title: Electrochimica Acta Volume: 55 Issue: 13 Pages: 4112-4119
  • DOI: 10.1016/j.electacta.2010.02.085
• [Journal Article] Continuous Electrochemical Synthetic System Using a Multiphase Electrolvte Solution (2010)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Journal Title: Electrochimica Acta Volume: 55 Pages: 4112-4119
  • Peer Reviewed
• [Journal Article] A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy (2010)
  • Author(s): Gegen Tana, Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba
  • Journal Title: Chemical Communications Volume: 46 Pages: 8219-8221
  • Peer Reviewed
• [Journal Article] Continuous Electrochemical Synthetic System Using a Multiphase Electrolyte Solution (2010)
  • Author(s): Yohei Okada, 千葉一裕
  • Journal Title: Electrochimica Acta 55 Pages: 4112-4119
  • Peer Reviewed
• [Journal Article] Synthesis of Hydrophobic Phase-Tagged Prolyl Peptides Featuring Rapid Reaction/Separation (2009)
  • Author(s): Kazuhiro Chiba, Mari Sugihara, Kazumi Yoshida, Yuzuru Mikami, Shokaku Kim
  • Journal Title: Tetrahedron Volume: 65 Issue: 38 Pages: 8014-8020
  • DOI: 10.1016/j.tet.2009.07.045
• [Journal Article] Anodic Carbon-Carbon Bond Formation in Lithium Perchlorate/Nitromethane Electrolyte Solution (2009)
  • Author(s): Kazuhiro Chiba, Shokaku Kim
  • Journal Title: Electrochemistry Volume: 77(1) Pages: 21-29
  • NAID: 130002150707
  • URL: http://www.electrochem.jp/journal/2009_01a.html#p021
• [Journal Article] Electrocatalytic Formal[ 2+2] Cycloaddition Reactions between Anodically Activated Aliphatic Enol Ethers and Unactivated Olefins Possessing an Alkoxyphenyl Group (2009)
  • Author(s): Yohei Okada ; Ryoichi Akaba ; Kazuhiro Chiba
  • Journal Title: Org. Lett. Volume: 11(4) Issue: 4 Pages: 1033-1035
  • DOI: 10.1021/ol802984n
• [Journal Article] Construction of Cold-triggered/Heat-destroyed Emulsions for Use as a Practical Cold-Storage Thermal History Indicator (2009)
  • Author(s): Tatsuya Mizoguchi, Kohdai Nagata, Makoto Kitsunai, Kumi Hirose, Akira Hirasawa, and Kazuhiro Chiba
  • Journal Title: J. Sci. Food Agric. Volume: 89(9) Issue: 9 Pages: 1453-1461
  • DOI: 10.1002/jsfa.3609
• [Journal Article] Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions (2009)
  • Author(s): Motoyuki Iijima, Yuzuru Mikami, Tomohiko Yoshioka, Shokaku Kim, Hidehiro Kamiya, Chiba, Kazuhiro
  • Journal Title: Langmuir Volume: 25(18) Issue: 18 Pages: 11043-11047
  • DOI: 10.1021/la901351s
• [Journal Article] Solution-Phase Chemical Processes Featuring Facile Multi-Step Reactions (2009)
  • Author(s): Shokaku Kim, Kazuhiro Chiba
  • Journal Title: Journal of Synthetic Organic Chemistry, Japan Volume: 67 Issue: 8 Pages: 809-819
  • DOI: 10.5059/yukigoseikyokaishi.67.809
  • NAID: 10025399805
  • ISSN: 0037-9980, 1883-6526
• [Journal Article] EC-backward-E Electrochemistry Supported by an Alkoxyphenyl Group (2009)
  • Author(s): Yohei Okada, Ryoichi Akaba, Kazuhiro Chiba
  • Journal Title: Tetrahedron Letters Volume: 50 Pages: 5413-5416
• [Journal Article] Electrocatalytic Formal [2+2] Cycloaddition Reactions between Anodic ally Activated Aliphatic Enol Ethers and Unactivated Olefins Possessing an Alkoxyphenyl Group (2009)
  • Author(s): Yohei Okada, Ryoichi Akaba, 千葉一裕
  • Journal Title: Org.Lett. 11(4) Pages: 1033-1035
  • Peer Reviewed
• [Journal Article] Construction of Cold-triggered/Heat-destroyed Emulsions for Use as a Practical Cold-Storage Thermal History Indicator (2009)
  • Author(s): Tatsuya Mizoguchi, Kohdai Nagata, Makoto Kitsunai, Kumi Hirose, Akira Hirasawa, 千葉一裕
  • Journal Title: J.Sci.Food Agric. 89(9) Pages: 1453-1461
  • Peer Reviewed
• [Journal Article] Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions (2009)
  • Author(s): Iijima, Motoyuki, Mikami, Yuzuru, Yoshioka, Tomohiko, Kim, Shokaku, Kamiya, Hidehiro, Chiba, Kazuhiro
  • Journal Title: Langmuir 25(18) Pages: 11043-11047
  • Peer Reviewed
• [Journal Article] Solution-Phase Chemical Processes Featuring Facile Multi-Step Reactions (2009)
  • Author(s): Kim Shokaku, Chiba Kazuhiro
  • Journal Title: Journal of Synthetic Organic Chemistry, Japan 67 Pages: 1453-1461
  • NAID: 10025399805
  • Peer Reviewed
• [Journal Article] EC-backward-E Electrochemistry Supported by an Alkoxyphenyl Group (2009)
  • Author(s): Yohei Okada, Ryoichi Akaba, 千葉一裕
  • Journal Title: Tetrahedron Letters 50 Pages: 5413-5416
  • Peer Reviewed
• [Journal Article] Synthesis of Hydrophobic Phase-Tagged Prolyl Peptides Featuring Rapid Reaction/Separation (2009)
  • Author(s): 千葉一裕, Mari Sugihara, Kazumi Yoshida, Yuzuru Mikami, Shokaku Kim
  • Journal Title: Tetrahedron 65 Pages: 8014-8020
  • Peer Reviewed
• [Presentation] 液相二相法を用いた有機電解フロー合成 (2012)
  • Author(s): 岡田洋平,小池幹男,千葉一裕
  • Organizer: 電気化学会第79回大会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2012-03-30
• [Presentation] 多相電解溶液を用いた効率的分子間炭素- (2012)
  • Author(s): 山口勇将,岡田洋平,千葉一裕
  • Organizer: 炭素結合形成反応電気化学会第79回大会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2012-03-29
• [Presentation] 多相電解溶液を用いた効率的分子間炭素-炭素結合形成反応 (2012)
  • Author(s): 山口勇将, 岡田洋平, 千葉一裕
  • Organizer: 電気化学会第79回大会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2012-03-29
• [Presentation] シクロアルカン熱応答性多相電解溶液における連続的コルベカップリング (2012)
  • Author(s): 上村和也,岡田洋平,千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-24
• [Presentation] 陽極酸化を用いた置換ピロリジンの一段階合成 (2012)
  • Author(s): 小路貴生,岡田洋平,金承鶴,千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 女子大学
  • Year and Date: 2012-03-24
• [Presentation] アルコール及びアルケンからのアミド化合物との反応によるN-置換アミドの合成 (2012)
  • Author(s): 岡田郁,千葉一裕,北野克和
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-24
• [Presentation] 陽極酸化を用いた置換ピロリジンの一段階合成 (2012)
  • Author(s): 小路貴生、岡田洋平、金承鶴、千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-24
• [Presentation] 液相二相合成法を用いた迅速な一容器ペプチド合成システムの構築 (2012)
  • Author(s): 小池幹男,岡田洋平,千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-23
• [Presentation] 疎水性タグを用いたジスルフィド架橋ペプチドの合成 (2012)
  • Author(s): 北田慎吾,藤田秀司^1,岡田洋平,金承鶴,千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-23
• [Presentation] 疎水性タグを用いた液相ペプチド合成会 (2012)
  • Author(s): 藤田裕子,格根塔娜,藤田秀司^1,岡田洋平,金承鶴,千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-23
• [Presentation] 液相二相合成法を用いた迅速な-容器ペプチド合成システムの構築 (2012)
  • Author(s): 小池幹男、岡田洋平、千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-23
• [Presentation] 疎水性タグを用いた液相ペプチド合成 (2012)
  • Author(s): 藤田裕子、格根塔郷、藤田秀司、岡田洋平、金承鶴、千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-23
• [Presentation] Hydrophobic Tag-assisted Multi-step Solution Phase Peptide Synthesis for Advanced Modifications and Large Scale (2012)
  • Author(s): Kazuhiro Chiba
  • Organizer: Production Asia TIDES
  • Place of Presentation: シェラトン東京
  • Year and Date: 2012-03-01
• [Presentation] Hydrophobic Tag-assisted Multi-step Solution Phase Peptide Synthesis for Advanced Modifications and Large Scale Production (2012)
  • Author(s): Kazuhiro Chiba
  • Organizer: Asia TIDES
  • Place of Presentation: シェラトン東京(招待講演)
  • Year and Date: 2012-03-01
• [Presentation] 疎水性タグを用いた効率的分子内ジスルフィド結合形成 (2011)
  • Author(s): 北田慎吾,藤田秀司,岡田洋平,金承鶴,千葉一裕
  • Organizer: 第48会ペプチド討論会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2011-09-27
• [Presentation] 新規ペプチド液相合成 "Molecular Hiving Technology" (2011)
  • Author(s): 阿部準,鈴木秀明,藤田秀司,長野和夫,鈴木俊英,江幡順良,千葉一裕
  • Organizer: 第48会ペプチド討論会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2011-09-27
• [Presentation] 新規ペプチド液相合成"Molecular Hiving Technology" (2011)
  • Author(s): 阿部準、鈴木秀明、藤田秀司、長野和夫、鈴木俊英、江幡順良、千葉一裕
  • Organizer: 第48会ペプチド討論会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2011-09-27
• [Presentation] Rate acceleration of Diels-Alder reactions utilizing a fluorous micellar system in water (2011)
  • Author(s): 西本浩介,岡田洋平,金承鶴,千葉一裕
  • Organizer: 電気化学秋季大会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2011-09-10
• [Presentation] Efficient Intermolecular Carbon-Carbon Bond Formation Reactions Assisted by Surface-condensed Electrodes (2011)
  • Author(s): 山口勇将,岡田洋平,千葉一裕
  • Organizer: 電気化学秋季大会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2011-09-10
• [Presentation] Electron Transfer-induced Intermolecular[ 2+2] Cycloaddition Reactions Based on the Aromatic "Redox Tag" Strategy (2011)
  • Author(s): 岡田洋平,西本朝希,千葉一裕
  • Organizer: 電気化学秋季大会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2011-09-10
• [Presentation] EIectron Transfer-induced Intermolecular [2+2] Cycloaddition Reactions Based on the Aromatic "Redox Tag" Strategy (2011)
  • Author(s): 岡田洋平, 西本朝希, 千葉一裕
  • Organizer: 電気化学秋季大会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2011-09-10
• [Presentation] Electron Transfer-Induced Reversible Intermolecular Olefin Cross-Coupling Reactions Based on "Redox Tag" (2011)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Organizer: Strategy 219th ECS Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-02
• [Presentation] Electron Transfer-Induced Reversible Intermolecular Olefin Cross-Coupling Reactions Based on "Redox Tag" Strategy (2011)
  • Author(s): Y.Okada, K.Chiba
  • Organizer: 219th ECS Meeting
  • Place of Presentation: Montreal, QC, Canada(招待講演)
  • Year and Date: 2011-05-02
• [Presentation] Synthesis of Electrochemically Modified Prolyl Peptides Based on Hydrophobically Tagged Strategy (2011)
  • Author(s): Shingo Kitada, Keisuke Yamamoto, Mari Sugihara, Tomomitsu Kawai, Shokaku Kim, and Kazuhiro Chiba
  • Organizer: 219th ECS Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-01
• [Presentation] Synthesis of Electrochemically Modified Prolyl Peptides Based on Hydrophobically Tagged Strategy (2011)
  • Author(s): S.Kitada, K.Yamamoto, M.Sugihara, T.Kawai, S.Kim, K.Chiba
  • Organizer: 219th ECS Meeting
  • Place of Presentation: Montreal, QC, Canada(招待講演)
  • Year and Date: 2011-05-01
• [Presentation] 不活性オレフィンを基軸とした新規分子間[ 2+2]付加環化反応 (2011)
  • Author(s): 西本朝希,岡田洋平,千葉一裕
  • Organizer: 電気化学会78回大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-31
• [Presentation] 効率的分子間反応を指向した局所的反応場の構築 (2011)
  • Author(s): 山口勇将,岡田洋平,千葉一裕
  • Organizer: 電気化学会78回大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-31
• [Presentation] 液相二相合成法を用いた新規有機電解フロー合成系の構築 (2011)
  • Author(s): 小池幹男,岡田洋平,千葉一裕
  • Organizer: 電気化学会78回大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-31
• [Presentation] 不活性オレフィンを基軸とした新規分子間[2+2]付加環化反応 (2011)
  • Author(s): 西本朝希, 岡田洋平, 千葉一裕
  • Organizer: 電気化学会78回大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-31
• [Presentation] 不活性オレフィンを基軸とした新規分子間[ 2+2]付加環化反応 (2011)
  • Author(s): 西本朝希,岡田洋平,千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 効率的分子間反応を指向した局所的反応場の構築 (2011)
  • Author(s): 山口勇将,岡田洋平,千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 相二相合成法を用いた新規有機電解フロー合成系の構築 (2011)
  • Author(s): 小池幹男,岡田洋平,千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 日登脱アミド化グリアジンの消化性向上に伴うアレルゲン性の変化 (2011)
  • Author(s): 阿部竜典,中島美弥,奥田久美子,菅井正枝,格根塔娜,千葉一裕,赤尾真,熊谷
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 疎水性タグを用いた環化ペプチド合成法の開発 (2011)
  • Author(s): 北田慎吾,千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 疎水性担体を用いた抗エイズ活性ペプチドT-20の液相合成研究 (2011)
  • Author(s): 津覇みあき,格根塔娜,千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 不活性オレフィンを基軸とした新規分子間[2+2]付加環化反応 (2011)
  • Author(s): 西本朝希,岡田洋平,千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 効率的秀子間友応を指向した局所的反応場の構築 (2011)
  • Author(s): 山口勇将, 岡田洋平, 千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 液相二相合成法を用いた新規有機電解フロー合成系の構築 (2011)
  • Author(s): 小池幹男, 岡田洋平, 千葉一裕
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] 脱アミド化グリアジンの消化性向上に伴うアレルゲン性の変化 (2011)
  • Author(s): 阿部竜典、中島美弥、奥田久美子、菅井正枝、格根塔娜、千葉一裕、赤尾真、熊谷日登
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] Solution phase synthesis of a cyclic peptide based on hydrophobic tag strategy (2010)
  • Author(s): Shingo Kitada, Shuji Fujita, Shokaku Kim, Kazuhiro Chiba
  • Organizer: 第47回ペプチド討論会
  • Place of Presentation: 京都
  • Year and Date: 2010-12-08
• [Presentation] Solution-phase peptide synthesis based on hydrophobic tag strategy : facile preparation for an antagonistic peptide of TNF-α (2010)
  • Author(s): Yohei Okada, Gegen Tana, Shingo Kitada, Shuji Fujita, Shokaku Kim, Kazuhiro Chiba
  • Organizer: 第47回ペプチド討論会
  • Place of Presentation: 京都
  • Year and Date: 2010-12-08
• [Presentation] Solution-phase peptide synthesis based on hydrophobic tag strategy : facile preparation for an antagonistic peptide of TN F-α (2010)
  • Author(s): Yohei Okada, Gegen Tana, Shingo Kitada, Shuji Fujita, Shokaku Kim, Kazuhiro Chiba
  • Organizer: 第47回ペプチド討論会
  • Place of Presentation: 京都
  • Year and Date: 2010-12-08
• [Presentation] Electron Transfer-induced Intermolecular Olefin Cross-coupling Reactions (2010)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Organizer: 1st German-Japanese Symposium on Electrosynthesis
  • Place of Presentation: Bonn
  • Year and Date: 2010-10-01
• [Presentation] Anodic Carbon-Carbon Bond Formation in Lithium Perchlorate/Nitromethane Electrolyte Solution (2010)
  • Author(s): Kazuhiro Chiba, Yohei Okada Shokaku Kim
  • Organizer: 1st German-Japanese Symposium on Electrosynthesis
  • Place of Presentation: Bonn
  • Year and Date: 2010-10-01
• [Presentation] Electron Transfer-induced Intermolecular Olefin Cross-coupling Reactions (2010)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Organizer: 1st German-Japanese Symposium on Electrosynthesis
  • Place of Presentation: Bon
  • Year and Date: 2010-10-01
• [Presentation] Anodic Carbon-Carbon Bond Formation in Lithium Perchlorate/N itromethane Electrolyte Solution (2010)
  • Author(s): Kazuhiro Chiba, Yohei Okada , Shokaku Kim
  • Organizer: 1st German-Japanese Symposium on Electrosynthesis
  • Place of Presentation: Bon
  • Year and Date: 2010-10-01
• [Presentation] Electron Transfer Induced Olefin Cross Metathesis Reactions (2010)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Organizer: 61st Annual Meeting of the International Society of Electrochemistry
  • Place of Presentation: Nice
  • Year and Date: 2010-09-30
• [Presentation] Electron transfer induced[ 2+2] cycloaddition reactions and cycloreversion reactions of cyclobutane ring (2010)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Organizer: 240th ACS National Meeting
  • Place of Presentation: Boston
  • Year and Date: 2010-08-24
• [Presentation] Electron transfer induced [2+2] cycloaddition reactions and cycloreversion reactions of cyclobutane ring (2010)
  • Author(s): Yohei Okada, Kazuhiro Chiba
  • Organizer: 240th ACS National Meeting
  • Place of Presentation: Boston
  • Year and Date: 2010-08-24
• [Presentation] 電極電子移動による分子間オレフィンクロスカップリング (2010)
  • Author(s): 岡田洋平,千葉一裕
  • Organizer: 有機電子移動化学討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2010-06-26
• [Presentation] 電解修飾プロリンのペプチド合成への応用 (2010)
  • Author(s): 木山正啓,河合朋充,山本圭介,杉原万里,千葉一裕
  • Organizer: 有機電子移動化学討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2010-06-25
• [Presentation] 疎水性タグを用いたペプチド誘導体の多段階液相合成法の開発とその応用 (2010)
  • Author(s): 菅井正枝・格根塔娜・熊谷日登美・千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京大学
  • Year and Date: 2010-03-28
• [Presentation] LCSTを有するアミド化合物を用いた残留農薬分析迅速簡易前処理法の研究 (2010)
  • Author(s): 橘内誠・小野哲・平澤朗・千葉一裕
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京大学
  • Year and Date: 2010-03-28
• [Presentation] 担体を導入したプロリン誘導体電解反応系の構築 (2010)
  • Author(s): 河合朋充・千葉一裕
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 近畿大学
  • Year and Date: 2010-03-28
• [Presentation] A liquid-phase synthesis of peptide derivatives using hydrophobic tags (2009)
  • Author(s): Gegen Tana, Shokaku Kim, Shuji Fujita, Kazuhiro Chiba
  • Organizer: 第46回ペプチド討論会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2009-11-05
• [Presentation] A practical solution phase synthesis of oligo-peptide using hydrophobic carriers (2009)
  • Author(s): Sanae Ariyoshi, Shokaku Kim, Shuji Fujita, Kazuhiro Chiba
  • Organizer: 第46回ペプチド討論会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2009-11-04
• [Presentation] Continuous Intermolecular Carbon-Carbon Bond Formation System using Multiphase Electrolyte Solution (2009)
  • Author(s): 岡田洋平,赤羽良一,千葉一裕
  • Organizer: 有機電子移動化学討論会
  • Place of Presentation: 慶応義塾大学
  • Year and Date: 2009-06-26
• [Presentation] 多相電解溶液を用いた分子間連続的炭素-炭素結合形成反応 (2009)
  • Author(s): 岡田洋平,赤羽良一,千葉一裕
  • Organizer: 電気化学秋季大会
• [Presentation] フェノール誘導体の電解反応による蛍光物質の合成 (2009)
  • Author(s): 植松順平,広瀬久美,千葉一裕
  • Organizer: 電気化学秋季大会
• [Presentation] 非天然型プロリン誘導体の合成 (2009)
  • Author(s): 河合朋充,山本圭介,千葉一裕
  • Organizer: 電気化学秋季大会
• [Book] Practical Intramolecular Disulfide Formation Based on Hydrophobic Tag Strategy (2012)
  • Author(s): Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba
  • Publisher: Peptide Science
• [Book] Electron-Transfer-Induced Intermolecular[ 2+2] Cycloaddition Reactions Assisted by Aromatic (2012)
  • Author(s): Kazuhiro Chiba, Yohei Okada
  • Publisher: Redox Tag
• [Book] 疎水性タグを用いた液相ペプチド合成 (2012)
  • Author(s): 千葉一裕
  • Publisher: 株式会社メディカルドゥ
• [Book] 最新ペプチド合成技術と創薬研究への応用 (2012)
  • Author(s): 千葉一裕
  • Publisher: 株式会社メディカルドゥ
• [Book] 簡易操作による多段階合成反応を実現する液相化学プロセス (2009)
  • Author(s): 金承鶴,千葉一裕
  • Publisher: 有機合成化学協会誌
• [Book] 相溶溶液反応 (2009)
  • Author(s): 千葉一裕
  • Total Pages: 848
  • Publisher: 有機合成化学協会誌
• [Remarks]
  • URL: http://www.tuat.ac.jp/research/20091116191531/20100422135501/20100428191755_20100202140447_20100412141248/index.html
• [Remarks]
  • URL: http://www.tuat.ac.jp/research/20091116191531/20100422135501/20100428191755_20100202140447_20100412141248/index.html