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Basic and Applied Research on Integrated Nutriomics Encompassing Various Aspects of Lifestyle

Research Project

Project/Area Number 21380076
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

KATO Hisanori  東京大学, 総括プロジェクト機構, 特任教授 (40211164)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywordsニュートリゲノミクス / 遺伝子発現 / 栄養 / 生活習慣 / 運動 / 日内リズム / トランスクリプトミクス / プロテオミクス / メタボロミクス / データベース / ポリフェノール / タンパク質栄養 / 統合オミクス / 胎児期栄養 / バイオインフォマティクス / DNAマイクロアレイ / カロリー制限 / タウリン / プロヒビチン / 生体リズム / 生活習慣病
Research Abstract

Methods for analyzing huge kinds of biological molecules, which are so called "omics" methods, were employed to exhaustively examine the response of animals to consumption of specific foods. Multiple exhaustive analyses including those for the levels of mRNA, proteins, and metabolites were combined. Efforts were made to improve a database and an analytical tool for the promotion of these types of researches, and their effectiveness was proved. The effects of factors relating to dietary habits, which include exercise and circadian rhythm were also examined.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (50 results)

All 2012 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 14 results) Presentation (20 results) Book (6 results) Remarks (6 results)

  • [Journal Article] Role of the renin-angiotensin-aldosterone system in the enhancement of salt sensitivity caused by prenatal protein restriction in stroke-prone spontaneously hypertensive rats2012

    • Author(s)
      Otani, L., Sugimoto, N., Kaji, M., Murai, M., Chang, S.-J., Kato, H. and Murakami, T
    • Journal Title

      J. Nutr. Biochem

      Volume: (印刷中) Issue: 8 Pages: 892-899

    • DOI

      10.1016/j.jnutbio.2011.04.014

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Omics and integrated omics for the promotion of food and nutrition science2011

    • Author(s)
      Kato, H., Takahashi, S. and Saito, K
    • Journal Title

      J. Trad. Comp. Med

      Volume: 1 Pages: 25-30

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Mild caloric restriction up-regulates the expression of prohibitin2011

    • Author(s)
      Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K. and Kato, H
    • Journal Title

      A proteome study. Biochem. Biophys. Res. Commun

      Volume: 405 Issue: 3 Pages: 462-467

    • DOI

      10.1016/j.bbrc.2011.01.054

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant dissociation of expression patterns of the basic helix-loop-helix transcription factors Dec1 and Dec2 in rat kidney2011

    • Author(s)
      Wu, T., Ni, Y., Zhue, F., Sun, L., Xu, B., Kato, H., Fu, Z.
    • Journal Title

      J.Exp.Biol.

      Volume: 214(Pt.8) Issue: 8 Pages: 1257-1263

    • DOI

      10.1242/jeb.052100

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo2011

    • Author(s)
      Ha, B.G., Nagaoka, M., Yonezawa, T., Tanabe, R., Woo, J.T., Kato, H., Chung, U.I., Yagasaki, K.
    • Journal Title

      J.Nutr.Biochem.

      Volume: (印刷中) Issue: 5 Pages: 501-509

    • DOI

      10.1016/j.jnutbio.2011.02.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分子栄養学-遺伝子の働きから探る食品機能2011

    • Author(s)
      加藤久典
    • Journal Title

      バイオテクニシャン

      Volume: 19 Pages: 6-14

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Mild caloric restriction up-regulates the expression of prohibitin : A proteome study.2011

    • Author(s)
      Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K., Kato, H.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 405 Pages: 462-467

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats2010

    • Author(s)
      Wu, T., Ni, Y., Kato, H. and Fu, Z
    • Journal Title

      Chronobiol. Int

      Volume: 27 Issue: 1 Pages: 1-18

    • DOI

      10.3109/07420520903398625

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary iron deficiency induces a variety of metabolic changes and even apoptosis in rat liver : a DNA microarray study.2010

    • Author(s)
      Kamei, A., Watanabe, Y., Ishijima, T., Uehara, M., Arai, S., Kato, H., Nakai, Y. and Abe, K
    • Journal Title

      Physiol. Genomics

      Volume: 42 Issue: 2 Pages: 149-156

    • DOI

      10.1152/physiolgenomics.00150.2009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of circadian gene expression in the kidney by light and food cues in rats2010

    • Author(s)
      Wu, T., Ni, Y., Dong, Y., Kato, H. and Fu, Z. W
    • Journal Title

      Am. J. Physiol. Regul. Integr. Comp. Physiol

      Volume: 298 Issue: 3 Pages: 635-641

    • DOI

      10.1152/ajpregu.00578.2009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of mild restriction of food intake on gene expression profile in the liver of young rats : reference data for in vivo nutrigenomics study.2010

    • Author(s)
      Saito, K., Ohta, Y., Sami, M., Kanda, T. and Kato, H
    • Journal Title

      Brit. J. Nutr

      Volume: 104 Issue: 7 Pages: 941-950

    • DOI

      10.1017/s0007114510001625

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary iron deficiency induces a variety of metabolic changes and even apoptosis in rat liver : a DNA microarray study.2010

    • Author(s)
      Kamei, A., Watanabe, Y., Ishijima, T., Uehara, M., Arai, S., Kato, H., Nakai, Y., Abe, K.
    • Journal Title

      Physiol.Genomics

      Volume: 42 Pages: 149-156

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats.2010

    • Author(s)
      Wu, T., Ni, Y., Kato, H., Fu, Z.
    • Journal Title

      Chronobiol.Int.

      Volume: 27 Pages: 1-18

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary protein deprivation up-regulates insulin signaling and inhibits gluconeogenesis in rat liver.2010

    • Author(s)
      Toyoshima, Y, Tokita, R., Ohne, Y., Hakuno, F., Noguchi, T., Minami, S., Kato, H., Takahashi, S.I.
    • Journal Title

      J.Mol.Endocrinol.

      Volume: 45 Pages: 329-340

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of mild restriction of food intake on gene expression profile in the liver of young rats : reference data for in vivo nutrigenomics study.2010

    • Author(s)
      Saito, K., Ohta, Y., Sami, M., Kanda, T., Kato, H
    • Journal Title

      Brit.J.Nutr. 103(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of circadian gene expression in the kidney by light and food cues in rats.2010

    • Author(s)
      Wu, T., Ni, Y., Dong, Y., Kato, H., Fu, Z.W.
    • Journal Title

      Am.J.Physiol.Regul.Integr.Comp.Physiol. 298

      Pages: 635-641

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      Abe, K., Kato, H., Yasuoka, A., Nakai, Y.
    • Journal Title

      Genomics, proteomics, and metabolomics in nutraceuticals and functional foods.(Wiley-Blackwell)

      Pages: 127-154

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      加藤久典
    • Journal Title

      食の安全科学の展開-食のリスク予測と制御に向けて(シーエムシー出版)

      Pages: 98-102

    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合オミクス解析によるアミノ酸過剰摂取マーカーの探索2012

    • Author(s)
      加藤久典、今村渉
    • Organizer
      日本農芸化学会2012年大会
    • Place of Presentation
      京都女子大学(招待講演)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] セリン欠乏反応に関わるエピジェネティクス制御機構の解明2011

    • Author(s)
      仁木麻衣、佐矢野智子、加藤久典、古屋茂樹
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胎児期低タンパク質暴露と高血圧2011

    • Author(s)
      加藤久典
    • Organizer
      第9回高付加価値食品開発のためのフォーラム
    • Place of Presentation
      三島市(招待講演)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合オミクス技術と食品機能性解析第6回核酸2011

    • Author(s)
      加藤久典
    • Organizer
      核タンパク機能性研究会学術大会
    • Place of Presentation
      北海道恵庭市
    • Year and Date
      2011-08-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合オミクス技術と食品機能性解析2011

    • Author(s)
      加藤久典
    • Organizer
      第6回核酸・核タンパク機能性研究会学術大会
    • Place of Presentation
      恵庭市(招待講演)
    • Year and Date
      2011-08-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mild caloric restriction up-regulates the expression of prohibitin : A proteome study2011

    • Author(s)
      Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K., Kato, H
    • Organizer
      11th Asian Congress of Nutrition
    • Place of Presentation
      シンガポール
    • Year and Date
      2011-07-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Keggle : Web-based visualization tool of omics data for the promotion of nutri-omics study2011

    • Author(s)
      Saito, K. and Kato, H
    • Organizer
      11th Asian Congress of Nutrition
    • Place of Presentation
      シンガポール
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Mild caloric restriction up-regulates the expression of prohibitin : A prot eome study2011

    • Author(s)
      Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K., Kato, H.
    • Organizer
      11th Asian Congress of Nutrition
    • Place of Presentation
      シンガポール
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 網羅的解析技術による食品の機能性研究の現状2011

    • Author(s)
      加藤久典
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2011-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 網羅的解析技術による食品の機能性研究の現状2011

    • Author(s)
      加藤久典
    • Organizer
      第65回 日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学(招待講演)
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] コーヒー摂取による高脂肪食誘導性2型糖尿病の抑制2011

    • Author(s)
      江頭健二, 高橋祥子, 福島洋一, 阿部啓子, 加藤久典
    • Organizer
      第65回 日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 網羅的手法を用いたロイシン過剰摂取時における毒性評価2011

    • Author(s)
      今村渉、高井まりえ、金本龍平、加藤久典
    • Organizer
      第65回 日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胎児期タンパク質制限モデルにおける血圧調節関連遺伝子のメチル化解析2011

    • Author(s)
      今門泰久, 大谷りら, 大鐘潤, 村上哲男, 加藤久典
    • Organizer
      第65回 日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 穏やかなカロリー制限によるProhibitinの発現上昇2011

    • Author(s)
      高橋祥子、桝田旬子、島上洋、太田豊、神田智正、斉藤憲司、加藤久典
    • Organizer
      2011年日本農芸化学会大会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2011-03-26
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ニュートリオミクスがもたらす栄養学の新展開2010

    • Author(s)
      加藤久典
    • Organizer
      日本農芸化学会関東支部大会
    • Place of Presentation
      近畿大学(奈良県)
    • Year and Date
      2010-10-02
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 食品因子・運動負荷・薬剤がラット肝脂質代謝に与える影響のトランスクリプトーム解析2010

    • Author(s)
      斉藤憲司、小笠原由貴、加藤久典
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アスティ徳島(徳島県)
    • Year and Date
      2010-05-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] SHRSPラットにおける胎児期の低タンパク質栄養に起因する食塩感受性亢進機構のトランスクリプトーム解析2010

    • Author(s)
      大谷りら、斉藤憲司、末安俊明、村上哲男、加藤久典
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アスティ徳島(徳島県)
    • Year and Date
      2010-05-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Functional study of an amino acid response element of the phosphoenolpyruvate carboxykinase 2(PEPCK2)gene.2009

    • Author(s)
      石井駿介、小野絢香、斉藤憲司、加藤久典
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transgenerational Effects of Maternal Protein Restriction During Pregnancy on Salt Sensitivity and Life Span in Stroke-Prone Spontaneously Hypertensive Rats(SHRSP)2009

    • Author(s)
      Otani, L., Murakami, T. and Kato, H
    • Organizer
      19th International Congress of Nutrition
    • Place of Presentation
      BITEK(バンコク)
    • Year and Date
      2009-10-09
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Data Storage and Comparative Analysis of Gene Expression Profiles for Promotion of Nutrigenomics Study2009

    • Author(s)
      Saito, K., Ohta, Y., Sami, M., Kanda, T. and Kato, H
    • Organizer
      19th International Congress of Nutrition
    • Place of Presentation
      BITEK(バンコク)
    • Year and Date
      2009-10-06
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] 基礎栄養学2012

    • Author(s)
      佐藤隆一郎、加藤久典
    • Total Pages
      160
    • Publisher
      学文社
    • Related Report
      2011 Final Research Report
  • [Book] 食べ物と健康2012

    • Author(s)
      佐藤隆一郎、加藤久典(編)
    • Total Pages
      245
    • Publisher
      学文社
    • Related Report
      2011 Annual Research Report
  • [Book] 基礎栄養学2012

    • Author(s)
      佐藤隆一郎、加藤久典(編)
    • Total Pages
      160
    • Publisher
      学文社
    • Related Report
      2011 Annual Research Report
  • [Book] バイオチップ実用化ハンドブック2010

    • Author(s)
      加藤久典、斉藤憲司
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] Genomics, proteomics, and metabolomics in nutraceuticals and functional foods2010

    • Author(s)
      Abe, K., Kato, H., Yasuoka, A. and Nakai, Y.
    • Publisher
      Wiley-Blackwell
    • Related Report
      2011 Final Research Report
  • [Book] 食の安全科学の展開-食のリスク予測と制御に向けて2010

    • Author(s)
      加藤久典
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.nutrigenomics.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.keggle.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.nutrigenomics.jp

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.a.u-tokyo.ac.jp/topics/topics110303.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nutrigenomics.jp

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.keggle.jp

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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