| Project/Area Number |
21380079
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
HORIO Fumihiko 名古屋大学, 生命農学研究科, 教授 (20165591)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OHNO Tamio 名古屋大学, 大学院・医学系研究科, 准教授 (90293620)
IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062)
MURAI Atsushi 名古屋大学, 大学院・生命農学研究科, 准教授 (10313975)
KOBAYASHI Misato 名古屋大学, 大学院・生命農学研究科, 助教 (20456586)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Keywords | 栄養生化学 / 糖尿病 / 糖尿病遺伝子 / 高脂肪食 / マウス |
|---|
| Research Abstract |
SMXA-5 mouse is a novel animal model for type 2 diabetes induced by high fat diet-feeding. We have mapped the diabetic QTL (quantitative trait locus:T2dm2sa) on chromosome 2 of SMXA-5 mouse. The aim of this study is to choose the candidate gene for this diabetogenic gene and identify it as a causative gene. Simultaneously, the controlled genes by the isolated gene, which contribute to the development of diabetes,were screened.The chromosomal region which this diabetogenic gene exists was narrowed to 5Mb region of chromosome 2 by the phenotipic analyses of several diabetic congenic strains. As a candidate gene, Rapgef 4 was chosen. In the exon of Rapgef4 of SMXA-5 mouse, we observed a mutation causing the amino acid substitution. Further study is needed to clarify that this mutation of rapgef4 caused the development of diabetes.
|
