Analysis on the control of oxidative stress derived from overproduction by inflammation reaction and suppression by Antioxidative Food Factors
| Project/Area Number |
21380080
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Aichi Gakuin University (2010-2011)
Nagoya University (2009) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UENO Yuki 愛知学院大学, 心身科学部, 講師 (20388060)
MOCHIDUKI Mika 愛知学院大学, 心身科学部, 助手 (60513091)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 酸化ストレス / 脳内老化 / 好中球 / 脂質ヒドロペルオキシド・アラキドン酸 / ドコサヘキサエン酸 / 未病診断 / モノクローナル抗体 / 脂質ヒドロペルオキシド / アラキドン酸 / 炎症反応 / ハロゲン化DNA / 酸化ストレスバイオマーカー / 抗酸化ポリフェノール / イソフラボノイド / ゴマリグナン / 酸化修飾リン脂質 |
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| Research Abstract |
Immunocyte is important for biophylaxis, however, overproductionof oxidative stress can be produced during the inflammation reaction, and interacts withmany biological components such as proteins, phospholipids and DNA. We have alsosucceeded in construction of novel biomarkers specific to overproduction of oxidativestress during inflammation process by chemical and immunological approach and developmentof “antibody chip” by application of these biomarkers. We also succeeded in functionalevaluation of antioxidative food factors such as soy isoflavonoids, curcuminoid andsesame rignans.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor2011
Author(s)
Xiang, L., Nakamura, Lim, Y-M., Yamasaki, Y., Kurokawa, Y., Young-Mi -Nose, Maruyama
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Journal Title
Aging
Volume: 3(11)
Pages: 1098-1107
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Peer Reviewed
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[Presentation] 長寿社会と食品2011
Author(s)
大澤俊彦
Organizer
包装食品技術協会基調講演
Place of Presentation
名古屋逓信会館(名古屋)
Year and Date
2011-05-23
Related Report
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[Presentation]2011
Author(s)
日坂真輔、林佳美、大澤俊彦
Organizer
第84回日本生化学会大会
Place of Presentation
国立京都国際会館(京都府)
Related Report
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[Presentation] Coprino extract, the extract from Coprinus comatus suppresses photo-damage in fibroblasts and mouse skin induced by ultraviolet-B2011
Author(s)
Ito, T., Shimoda, H., Harada, E., Wu, X., Osawa, T.
Organizer
International Conference on Food Factors（(ICoFF2011)
Place of Presentation
台北（中華民国）
Related Report
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[Presentation] Effect of Administration of Extract from Coprinus Comatus on Skin Inflammation induced by UV-B2011
Author(s)
Wu, X., Shimoda, H., Kato, Y., Hisaka, S., Harada, E., Ito, T., Osawa, T.
Organizer
International Conference on Food Factors（(ICoFF2011)
Place of Presentation
台北（中華民国）
Related Report
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[Presentation] New estimation method of food for health progress by simultaneously monitoring superoxide generation and intracelluler calcium ion concentration of neutrophils2011
Author(s)
Kazumura, K., Satozono, H., Okazaki, S., Tsuchiya, H., Koike, T., Sato, Y., Miyata, M., Harada, K., Osawa, T.
Organizer
International Conference on Food Factors（(ICoFF2011)
Place of Presentation
台北（中華民国）
Related Report
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