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Study on the antitumor effect of vitamin B6

Research Project

Project/Area Number 21380083
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionHiroshima University

Principal Investigator

KATO Norihisa  広島大学, 大学院・生物圏科学研究科, 教授 (20144892)

Co-Investigator(Kenkyū-buntansha) YANAKA Noriyuki  広島大学, 大学院・生物圏科学研究科, 准教授 (70346526)
MATSUBARA Kiminori  広島大学, 教育学研究科, 准教授 (90254565)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
KeywordsビタミンB6 / 抗腫瘍作用 / 遺伝子発現 / オートファジー / 炎症 / 大腸 / 大腸がん / インフラマソーム / Cystatin A / NOX-1 / リンパ管新生 / HSP / DNA microarray / SPI-3
Research Abstract

This study was performed to examine why the anti-tumor effect of vitamin B6 is profound in the colon. This reason was explained by indicating the higher sensitivity of colon levels of B6-vitamers to dietary supplemental vitamin B6. Further study with animals and colon cancer cells was conducted to examine the gene expression in response to vitamin B6. The results indicated the vitamin B6 altered the expression of genes relating to mast cells and cytotoxicT-cell activity and cytoprotection, which may lead to the anti-tumor effect

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (21 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Regulation of colon geneexpression by vitamin B6 supplementation2012

    • Author(s)
      Toya Keigo, Hirata Atsuko, OhataTomomi, Sanada Yohei
    • Journal Title

      Mol. Nutr. Food Res

      Volume: 56 Issue: 4 Pages: 641-652

    • DOI

      10.1002/mnfr.201100707

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin B6 suppressesserine protease inhibitor 3 expression inthe colon of rats and in TNF-α-stimulated HT-29 cells2011

    • Author(s)
      Noriyuki Yanaka, Tomomi Ohata, KeigoToya, Mayumi Kanda, Atsuko Hirata, Norihisa Kato
    • Journal Title

      Mol. Nutr. Food Res.

      Volume: 55 Issue: 4 Pages: 635-645

    • DOI

      10.1002/mnfr.201000282

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Consumption of vitamin B6 reduces colonicdamage and protein expression of HSP70and HO-1 in rats exposed to1, 2-dimethylhydrazine2011

    • Author(s)
      Kayashima Tomoko, Tanaka Kenta, Okazaki Yukako, Matsubara Kiminori, Yanaka Noriyuki, Kato Norihisa
    • Journal Title

      Oncol. Lett

      Volume: 2 Issue: 6 Pages: 1243-1246

    • DOI

      10.3892/ol.2011.370

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin B6 regulates mRNA expression of peroxisome proliferator-activatedreceptor-γtarget genes2011

    • Author(s)
      Yanaka Noriyuki, Kanda Mayumi, Toya Keigo, Suehiro Haruna, Kato Norihisa
    • Journal Title

      Exp. Ther. Med

      Volume: 2 Issue: 3 Pages: 419-424

    • DOI

      10.3892/etm.2011.238

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells2011

    • Author(s)
      Noriyuki Yanaka, Tomomi Ohata, Keigo Toya, Mayumi Kanda, Atsuko Hirata, Norihisa Kato
    • Journal Title

      Molecular Nutrition and Food Research

      Volume: 55 Pages: 635-643

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ビタミンB6のがん予防研究の新展開2010

    • Author(s)
      加藤範久
    • Journal Title

      ビタミン

      Volume: 84 Pages: 17-19

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ビタミンB6のがん予防研究の新展開2010

    • Author(s)
      加藤範久
    • Journal Title

      ビタミン 84

      Pages: 17-20

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Inhibitory effect of vitamin B6, pyridoxal 5'-phosphate on lymphangiogenesis2012

    • Author(s)
      Matsubara Kiminori, Kato Norihisa
    • Organizer
      Advances and Controversies in B-Vitaminsand Choline
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2012-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Consumption of Vitamin B6 Modulates Colonic Luminal Environment in Rats2011

    • Author(s)
      Sofya Suidasari, Yukako Okazaki, Utama Zaki, Aimi Ohsaki, Noriyuki Yanaka, Hiroyuki Tomotake, Norihisa Kato
    • Organizer
      2011 International Conference on Food Factors
    • Place of Presentation
      台北、台湾
    • Year and Date
      2011-11-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of dietary vitamin B6 on colonic luminal environment in rats2011

    • Author(s)
      Sofya Suidasari, Okazaki Yukako, ZakiUtama, Zhang Peipei, Ohsaki Aimi, YanakaNoriyuki, Tomotake Hiroyuki, KatoNorihisa
    • Organizer
      2011International Conference on Food Factors
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular mechanisms of anti-tumor effect of vitamin B62011

    • Author(s)
      Kato Norihisa
    • Organizer
      2011International Conference on Food Factors
    • Place of Presentation
      Taipei, tqiwan
    • Year and Date
      2011-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular Mechanisms of Anti-tumor Effect of Vitamin B62011

    • Author(s)
      Norihisa Kato
    • Organizer
      2011 International Conference on Food Factors
    • Place of Presentation
      台北、台湾
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビタミンB6摂取に対する組織PLP,及びS1P濃度の応答2011

    • Author(s)
      ソフィアスイダサリ, カボマシシ, 矢中規之, 加藤範久
    • Organizer
      第43回日本栄養・食糧学会中四国支部大会
    • Place of Presentation
      高知
    • Year and Date
      2011-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] ビタミンB6による遺伝子発現変動の解析2011

    • Author(s)
      加藤範久
    • Organizer
      第426回ビタミンB研究協議会
    • Place of Presentation
      大津
    • Year and Date
      2011-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] ビタミンB6による遺伝子発現変動の解析2011

    • Author(s)
      加藤範久
    • Organizer
      ビタミンB研究委員会
    • Place of Presentation
      大津市
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Anti-tumor Effect of Dietary vitamin B6 and its me chanisms2011

    • Author(s)
      Kato Norihisa
    • Organizer
      International Conference on Cofactors 03
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2011-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Anti-tumor Effect of Dietary Vitamin B6 and Its Mechanisms2011

    • Author(s)
      Norihisa Kato
    • Organizer
      The Third International Conference on Cofactors 03
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Consumption of Vitamin B6 Modulates Colonic Luminal Environment in Rats Fed a High-fat Diet2011

    • Author(s)
      Yukako Okazaki, Noriyuki Yanaka, Norihisa Kato
    • Organizer
      The Third International Conference on Cofactors 03
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Consumption of vtamin B6 modulates colonic luminal environment in rats fed a high-fat diet2011

    • Author(s)
      Okazaki Yukako, Zaki Utama, SofyaSuidasari, Zhang Peipei, Ohsaki Aimi, Yanaka Noriyuki, Tomotake Hiroyuki, Sakaguchi Ei, Kato Norihisa
    • Organizer
      International Conference on Cofactors 03
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2011-07-13
    • Related Report
      2011 Final Research Report
  • [Presentation] ビタミンB6摂取に応答する大腸遺伝子発現のDNA microarray解析2011

    • Author(s)
      加藤範久
    • Organizer
      第424回ビタミンB研究協議会
    • Place of Presentation
      広島
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] ビタミンB6摂取が単球・マクロファージの白色脂肪組織への浸潤に与える影響2011

    • Author(s)
      久本高央、真田洋平、末廣春奈、加藤範久、矢中規之
    • Organizer
      日本農芸化学会中四国支部大会
    • Place of Presentation
      岡山市
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビタミンB6摂取のラット腸内環境への影響2011

    • Author(s)
      Sofya Suidasari、張培培、大崎愛美、矢中規之、岡崎由佳子、友竹浩之、坂口英、加藤範久
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビタミンB6摂取量に対するマウス各臓器B6代謝物の応答の比較2011

    • Author(s)
      Masisi Kabo, Sofya Suidasari, 矢中規之, 加藤範久
    • Organizer
      日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Viamin B6の摂取が脂肪組織の遺伝子発現に及ぼす影響2011

    • Author(s)
      真田洋平, 矢中規之, 末廣春奈, 久本高央, 平田敦子, 西村英紀, 加藤範久
    • Organizer
      2011年度日本農芸化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] azoxymethane誘発大腸腫瘍モデルマウスの初期病変に関わる新規標的因子の同定,および抗癌活性を有するvitamin B6の予防効果に関する解析2010

    • Author(s)
      平田敦子, 真田洋平, 末廣春奈, 大畑智美, 矢中規之, 加藤範久
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] ビタミンB6摂取に部する組織PLP、及びS1P濃度の応答2010

    • Author(s)
      ソフィアスイダサリ、カボマシシ、矢中規之、加藤範久
    • Organizer
      第43回 日本栄養・食糧学会 中四国支部大会
    • Place of Presentation
      高知女子大学
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビタミンB6摂取による大腸における遺伝子発現調節作用2010

    • Author(s)
      大畑智美, 矢中規之, 平田敦子, 真田洋平, 末廣春奈, 鳥家圭伍, 加藤範久
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒタミンB6摂取による大腸における遺伝子発現調節作用2010

    • Author(s)
      矢中規之
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場(東京都)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Book] Wageningen AcademicPublishers, Role of vitamin B6 in skin healthand diseases. Chapter 42012

    • Author(s)
      Kato Norihisa
    • Publisher
      Handbook of diet, nutrition and the skin. ed. by Victor R. Reedy
    • Related Report
      2011 Final Research Report
  • [Book] Role of vitamin B6 in skin health and diseases. Hand Book of diet, nutrition and the skin2012

    • Author(s)
      Norihisa Kato (edited by Victor R.Preedy)
    • Total Pages
      8
    • Publisher
      Wageningen Academic Publishers
    • Related Report
      2011 Annual Research Report
  • [Book] ビタミン総合事典2010

    • Author(s)
      加藤範久,朝倉書店
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/nutri/index.htm

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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