Development of techniques for diagnosis and prevention of fish disease by the analysis of T cell function in fish immune response
| Project/Area Number |
21380126
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SOMAMOTO Tomonori 九州大学, 農学研究科, 准教授 (40403993)
ARAKI Kyousuke 鹿児島大学, 水産学部, 助教 (30409073)
NAKAYASU Tihaya 水産総合研究センター, 養殖研究所, 研究員 (00311225)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 魚類 / T細胞 / 細胞性免疫 / ギンブナ / CD4 / CD8 / IFNγ / パーフォリン / グランザイム / モノクローナル抗体 |
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| Research Abstract |
In this project, we showed a) tissue distribution of T cell subset, and the characteristics of CD4^+helper T cells using monoclonal antibodies in ginbuna, b) killing mechanisms and differentiation and activation of CD8^+ cytotoxic T lymphocyte, c) primary importance of cell-mediated immunity in the defense against cell-associate bacteria, d) establishment of basic tools for the induction of Th1 response in fish, e) identification of immune genes and analysis of immune mechanisms in rainbow trout, flounder and yellowtail which enable the studies on cell-mediated immunity in important fishes in aquaculture.
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Report
(4 results)
Research Products
(155 results)
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[Journal Article] The expression of CD8α discriminates distinct T cell subsets in teleost fish.2012
Author(s)
Takizawa, F., Dijkstra, J.M., Kotterba, P., Korytar, T., Kock, H., Kollner, B., Jaureguiberry, B., Nakanishi, T., Fischer, U.
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Journal Title
Developmental & Comparative Immunology
Volume: 35
Pages: 752-763
DOI
Related Report
Peer Reviewed
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[Journal Article] Antiviral Protection Mechanisms Mediated by Ginbuna Crucian Carp Interferon Gamma (Ifn_Y) Isoforms 1 and 2 Through Two Distinct Ifn_Y-Receptors2011
Author(s)
Yabu, T., H.Toda, Y.Shibasaki, K.Araki, M.Yamashita, H.Anzai, N.Mano, Y.Masuhiro, S.Hanazawa, H.Shiba, T.Moritomo, T.Nakanishi
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Journal Title
Journal of Biochemistry
Volume: 150
Pages: 635-648
DOI
Related Report
Peer Reviewed
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[Journal Article] Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish.2011
Author(s)
Toda H., Y.Saito, T.Koike, F.Takizawa, K.Araki, T.Yabu, T.Somamoto, H.Suetake, Y.Suzuki, M.Ototake, T.Moritomo, T.Nakanishi
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Journal Title
Dev.Comp.Immunol.
Volume: 35
Pages: 650-660
Related Report
Peer Reviewed
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[Journal Article] Dijkstra A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes2010
Author(s)
Ohashi K., F. Takizawa, N. Tokumaru, C. Nakayasu, H. Toda, U. Fischer, T. Moritomo1, K. Hashimoto, T. Nakanishi, J. M.
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Journal Title
Immunogenetics
Volume: 62(8)
Pages: 543-59
Related Report
Peer Reviewed
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[Journal Article] A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes.2010
Author(s)
Ohashi K., F.Takizawa, N.Tokumaru, C.Nakayasu, H.Toda, U.Fischer, T.Moritomol, K.Hashimoto, T.Nakanishi, J.M.Dijkstra
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Journal Title
Immunogenetics
Volume: 62
Pages: 543-559
Related Report
Peer Reviewed
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[Presentation] ギンブナCD3ε分子の特性解明2011
Author(s)
村田憲史、大橋健、柴崎康宏, 藪健史, 森友忠昭、中西照幸
Organizer
日本比較免疫学会第23回学術集会、海洋研究開発機構
Place of Presentation
横浜
Year and Date
2011-08-21
Related Report
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[Presentation] 魚類栓球の異物貪食作用2011
Author(s)
長沢貴宏、松山知正、中易千早、杣本智軌、中尾実樹
Organizer
日本水産学会春季大会
Place of Presentation
東京海洋大
Year and Date
2011-03-30
Related Report
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