Development of techniques for diagnosis and prevention of fish disease by the analysis of T cell function in fish immune response

• Project/Area Number: 21380126
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General fisheries
• Research Institution: Nihon University
• Principal Investigator: NAKANISHI Teruyuki 日本大学, 生物資源科学部, 教授 (00322496)
• Co-Investigator(Kenkyū-buntansha): SOMAMOTO Tomonori 九州大学, 農学研究科, 准教授 (40403993) ; ARAKI Kyousuke 鹿児島大学, 水産学部, 助教 (30409073) ; NAKAYASU Tihaya 水産総合研究センター, 養殖研究所, 研究員 (00311225)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 魚類 / T細胞 / 細胞性免疫 / ギンブナ / CD4 / CD8 / IFNγ / パーフォリン / グランザイム / モノクローナル抗体

Research Abstract

In this project, we showed a) tissue distribution of T cell subset, and the characteristics of CD4^+helper T cells using monoclonal antibodies in ginbuna, b) killing mechanisms and differentiation and activation of CD8^+ cytotoxic T lymphocyte, c) primary importance of cell-mediated immunity in the defense against cell-associate bacteria, d) establishment of basic tools for the induction of Th1 response in fish, e) identification of immune genes and analysis of immune mechanisms in rainbow trout, flounder and yellowtail which enable the studies on cell-mediated immunity in important fishes in aquaculture.

Research Products

• [Journal Article] Diversity of CD2 subfamily receptors in cyprinid fishes (2012)
  • Author(s): Sameshima S, Nakao M, Somamoto T
  • Journal Title: Results in Immunology Volume: 2 Pages: 25-34
  • Peer Reviewed
• [Journal Article] Adverse and beneficial effects of a long-term supplement of high-concentration ascorbic acid in rainbow trout Oncorhynchus mykiss (2012)
  • Author(s): Ishikawa, T., N.Mano, T.Nakanishi, H.Hirose
  • Journal Title: Fish.Sci. Volume: (In press) Issue: 6 Pages: 1009-1014
  • DOI: 10.1007/s12562-011-0411-2
  • Peer Reviewed
• [Journal Article] Localization analysis of fluorescent-labeled Aeromonas veronii in the intestinal tract of carp using an in vivo imaging system (2012)
  • Author(s): Namba, A., N.Mano, H.Hirose, T.Nakanishi
  • Journal Title: Fish Pathology Volume: 47 Pages: 7-11
  • NAID: 130004510233
  • Peer Reviewed
• [Journal Article] Ontogeny of anti-viral hemorrhagic septicemia virus (VHSV) immunity in developing Japanese flounder (2012)
  • Author(s): Matsuyama, T., C.Nakayasu, A.Fujiwara, Kurita, J., T.Takano, T.Ito, M.Sano
  • Journal Title: Dev.Comp.Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Antiviral protection mechanisms mediated by ginbuna crucian carp interferon gamma isoforms 1 and 2 through two distinct interferon gamma receptors (2011)
  • Author(s): Yabu, T., H. Toda, Y. Shibasaki, K. Araki, T. Nakanishi, 他7名
  • Journal Title: J. Biochem Volume: 150(6) Pages: 635-48
  • NAID: 10030589144
  • Peer Reviewed
• [Journal Article] Cytotoxic T cells in teleost fish (2011)
  • Author(s): Nakanishi T, H. Toda, Y. Shibasaki, T. Somamoto
  • Journal Title: Dev Comp Immunol Volume: 35 Pages: 1317-1323
  • Peer Reviewed
• [Journal Article] Molecular characterization of MHC class I and beta-2 microglobulin in a clonal strain of ginbuna crucian carp, Carassius auratus langsdorfii (2011)
  • Author(s): Urabe S, Somamoto T, Sameshima S, Unoki-Kato Y, T. Nakanishi, Nakao M
  • Journal Title: Fish Shellfish Immunol Volume: 31(3) Pages: 469-74
  • Peer Reviewed
• [Journal Article] Suppression subtractive hybridization coupled with microarray analysis to examine differential expression of genes in Japanese flounder Paralichthys olivaceus leukocytes during Edwardsiella tarda and viral hemorrhagic septicemia virus infection (2011)
  • Author(s): Matsuyama T, Fujiwara A, Takano T, Nakayasu C
  • Journal Title: Fish and shellfish immunology Volume: 31(4) Pages: 524-32
  • Peer Reviewed
• [Journal Article] The expression of CD8alpha discriminates distinct T cell subsets in teleost fish (2011)
  • Author(s): Takizawa, F., Dijkstra, J. M., T. Nakanishi., Fischer, U., 他5名
  • Journal Title: Dev Comp Immunol Volume: 35(7) Pages: 752-763
  • Peer Reviewed
• [Journal Article] Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish (2011)
  • Author(s): Toda H., Y. Saito, K. Araki, T. Yabu, T. Somamoto, T. Nakanishi, 他6名
  • Journal Title: Dev Comp Immunol Volume: 35(6) Pages: 650-660
  • Peer Reviewed
• [Journal Article] Evaluating antigenspecific cytotoxicity of CD8+T cells in fish by Granzyme B-like activity (2011)
  • Author(s): Toda H., T. Yabu, H. Shiba, T. Moritomo and T. Nakanishi
  • Journal Title: Vet Immunol Immunopathol Volume: 141 Pages: 168-172
  • Peer Reviewed
• [Journal Article] Clonal growth of carp(Cyprinus carpio) T cells in vitro (2011)
  • Author(s): Yamaguchi T, Katakura F, T. Yabu, T. Nakanishi, 他6名
  • Journal Title: Dev Comp Immunol Volume: 35(2) Pages: 193-202
  • Peer Reviewed
• [Journal Article] Perforin-dependent cytotoxic mechanism in killing by CD8 positive T cells in Ginbuna crucian carp, Carassius auratus langsdorfii (2011)
  • Author(s): Toda H, Araki K, Moritomo T, T. Nakanishi
  • Journal Title: Dev Comp Immunol Volume: 35(1) Pages: 88-93
  • Peer Reviewed
• [Journal Article] Constitutive high expression of interleukin 4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments (2011)
  • Author(s): Takizawa, F., E. O. Koppang, M. Ohtani, T. Nakanishi, K. Hashimoto, U. Fischer J. M. Dijkstra.
  • Journal Title: Mol. Immunol Volume: 48(12-13) Pages: 1360-8
  • Peer Reviewed
• [Journal Article] The expression of CD8alpha discriminates distinct T cell subsets in teleost fish (2011)
  • Author(s): Takizawa, F., Dijkstra, J.M., Kotterba, P., Korytar, T., Kock, H., Kollner, B., Jaureguiberry, B., Nakanishi, T., Fischer, U.
  • Journal Title: Dev.Comp.Immunol. Volume: 35 Issue: 7 Pages: 752-763
  • DOI: 10.1016/j.dci.2011.02.008
  • Peer Reviewed
• [Journal Article] Constitutive high expression of interleukin 4/13 A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments (2011)
  • Author(s): Takizawa, F., E.O.Koppang,; M.Ohtani, T.Nakanishi; K.Hashimoto, U.Fischer; J.M.Dijkstra
  • Journal Title: Mol.Immunol. Volume: 48 Issue: 12-13 Pages: 1360-1368
  • DOI: 10.1016/j.molimm.2011.02.014
  • Peer Reviewed
• [Journal Article] The complement system in teleost fish : Progress of post-homolog-hunting researches (2011)
  • Author(s): Nakao M, Tsujikura M, Ichiki S, Tam K.Vo, Somamoto T.
  • Journal Title: Dev.Comp.Immunol. Volume: 35 Issue: 12 Pages: 1296-1308
  • DOI: 10.1016/j.dci.2011.03.003
  • Peer Reviewed
• [Journal Article] Cytotoxic T cells in teleost fish (2011)
  • Author(s): Nakanishi, T., H.Toda, Y.Shibasaki, T.Somamoto
  • Journal Title: Dev.Comp.Immunol. Volume: 35 Issue: 12 Pages: 1317-1323
  • DOI: 10.1016/j.dci.2011.03.033
  • Peer Reviewed
• [Journal Article] Hematopoietic cell populations in dolphin bone marrow : Analysis of colony formation and differentiation (2011)
  • Author(s): Segawa T., T.Itou, M.Suzuki, T.Moritomo, T.Nakanishi, T.Sakai
  • Journal Title: Results in Immunology Volume: 1 Issue: 1 Pages: 1-5
  • DOI: 10.1016/j.rinim.2011.05.004
  • Peer Reviewed
• [Journal Article] Molecular characterization of MHC class I and beta-2 microglobulin in a clonal strain of ginbuna crucian carp, Carassius auratus langsdorfii (2011)
  • Author(s): Urabe S, Somamoto T, Sameshima S, Unoki-Kato Y, Nakanishi T, Nakao M
  • Journal Title: Fish Shellfish Immunol. Volume: 31 Issue: 3 Pages: 469-474
  • DOI: 10.1016/j.fsi.2011.06.004
  • Peer Reviewed
• [Journal Article] Suppression subtractive hybridization coupled with microarray analysis to examine differential expression of genes in Japanese flounder Paralichthys olivaceus leucocytes during Edwardsiella tarda and viral hemorrhagic septicemia virus infection (2011)
  • Author(s): Matsuyatna, T., A.Fujiwara, T.Takano, C.Nakayasu
  • Journal Title: Fish & Shellfish Immunol. Volume: 31 Issue: 4 Pages: 524-532
  • DOI: 10.1016/j.fsi.2011.06.015
  • Peer Reviewed
• [Journal Article] Microsporidian Infection in Rryukyu Ayu Plecoglossus altivelis ryukyuensis on Amami Oshima Island (2011)
  • Author(s): Niwa, N., A.Yamamoto, K.Araki, T.Kamaishi, A.Shinomiya
  • Journal Title: Fish Pathology Volume: 46 Issue: 3 Pages: 80-86
  • DOI: 10.3147/jsfp.46.80
  • NAID: 10029692326
  • ISSN: 0388-788X, 1881-7335
  • Peer Reviewed
• [Journal Article] A unique epidermal mucus lectin identified from catfish (Silurusasotus) : First evidence of intelectin in fish skin slime (2011)
  • Author(s): Tsutsui, S., Y.Komatsu, T.Sugiura, K.Araki, O.Nakamura
  • Journal Title: J.Biochem. Volume: 150 Issue: 5 Pages: 501-514
  • DOI: 10.1093/jb/mvr085
  • Peer Reviewed
• [Journal Article] Antiviral protection mechanisms mediated by ginbuna crucian carp interferon gamma isoforms 1 and 2 through two distinct interferon gamma receptors (2011)
  • Author(s): Yabu, T., H.Toda, Y.Shibasaki, K.Araki, M.Yamashita, H.Anzai, N.Mano, Y.Masuhiro, S.Hanazawa, H.Shiba, T.Moritomo, T.Nakanishi
  • Journal Title: J.Biochem. Volume: 150 Issue: 6 Pages: 635-648
  • DOI: 10.1093/jb/mvr108
  • NAID: 10030589144
  • Peer Reviewed
• [Journal Article] Perforin-dependent cytotoxic mechanism in killing by CD8 positive T cells in Ginbuna crucian carp, Carassius auratus langsdorfii. (2011)
  • Author(s): Toda H, Araki K, Moritomo T, Nakanishi T.
  • Journal Title: Dev.Comp.Immunol. Volume: 35 Pages: 88-93
  • Peer Reviewed
• [Journal Article] Clonal growth of carp (Cyprinus carpio) T cells in vitro. (2011)
  • Author(s): Yamaguchi T, Katakura F, Shitanda S, Niida Y, Toda H, Ohtani M, Yabu T, Suetake H, Moritomo T Nakanishi T.
  • Journal Title: Dev.Comp.Immunol. Volume: 35 Pages: 193-202
  • Peer Reviewed
• [Journal Article] Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish. (2011)
  • Author(s): Toda H., Y.Saito, T.Koike, F.Takizawa, K.Araki, T.Yabu, T.Somamoto, H.Suetake, Y.Suzuki, M.Ototake, T.Moritomo, T.Nakanishi
  • Journal Title: Dev.Comp.Immunol. Volume: 35 Pages: 650-660
  • Peer Reviewed
• [Journal Article] Evaluating antigen-specific cytotoxicity of CD8^+ T cells in fish by Granzyme B-like activity. (2011)
  • Author(s): Toda H., T.Yabu, H.Shiba, T.Moritomo, T.Nakanishi
  • Journal Title: Vet Immunol Immunopathol. Volume: 141 Pages: 168-172
  • Peer Reviewed
• [Journal Article] Detection of Japanese flounder antibody against fimbrial major protein of Edwardsiella tarda (2011)
  • Author(s): Sakai T., Miyoshi Y., Matsuyama T., Nakayasu C., Kamaishi T., Fukuda Y., Iida T.
  • Journal Title: Fish Pathology Volume: 46 Pages: 23-26
  • NAID: 10027836518
  • Peer Reviewed
• [Journal Article] Dijkstra A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes (2010)
  • Author(s): Ohashi K., F. Takizawa, N. Tokumaru, C. Nakayasu, H. Toda, U. Fischer, T. Moritomo1, K. Hashimoto, T. Nakanishi, J. M.
  • Journal Title: Immunogenetics Volume: 62(8) Pages: 543-59
  • Peer Reviewed
• [Journal Article] Kinetics of CD4+ and CD8α+ T-cell subsets in Graft-Versus-Host Reaction(GVHR) in ginbuna crucian carp Carassius auratus langsdorfii (2010)
  • Author(s): Shibasaki Y., H. Toda, I. Kobayashi, T. Moritomo and T. Nakanishi
  • Journal Title: Dev Comp Immunol Volume: 34 Pages: 1075-1081
  • Peer Reviewed
• [Journal Article] Zin-cdependent binding between peptides derived from rainbow trout CD8alpha and LCK (2010)
  • Author(s): Hayashi N, Takeuchi M, T. Nakanishi, Hashimoto K, Dijkstra JM
  • Journal Title: Fish Shellfish Immunol Volume: 26(1) Pages: 72-76
  • Peer Reviewed
• [Journal Article] Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells (2010)
  • Author(s): Kobayashi I, Ono H, Moritomo T, Kano K, T. Nakanishi, Suda T
  • Journal Title: Blood Volume: 115(2)
  • Peer Reviewed
• [Journal Article] Lymphocytes with T-cell-like properties express the Fas ligand in the Japanese flounder Paralichthys olivaceus (2010)
  • Author(s): Kurata O, Iwasaki T, Matsuyama T, Nakayasu C, Wada S, Hatai K
  • Journal Title: Fish Shellfish Immunol Volume: 30(2) Pages: 509-14
  • Peer Reviewed
• [Journal Article] The efficacy of five avirulent Edwardsiella tarda strains in a live vaccine against Edwardsiellosis in Japanese flounder, Paralichthys olivaceus (2010)
  • Author(s): Takano T, Matsuyama T, Oseko N, Sakai T, Kamaishi T, Nakayasu C, Sano M, Iida T
  • Journal Title: Fish Shellfish Immunol Volume: 29 Pages: 687-693
  • Peer Reviewed
• [Journal Article] Immunocytochemical studies of the ontogeny of peripheral blood leucocyte subpopulations in Japanese flounder(Paralichthys olivaceus) (2010)
  • Author(s): Matsuyama T, Nakayasu C, Sano M
  • Journal Title: Fish and shellfish immunology Volume: 29(2) Pages: 362-365
  • Peer Reviewed
• [Journal Article] Detection of Japanese flounder antibody against fimbrial major protein of Edwardsiella tarda (2010)
  • Author(s): Sakai T, Matsuyama T, Nakayasu C
  • Journal Title: Fish Pathology Volume: 46(1) Pages: 23-25
  • NAID: 10027836518
  • Peer Reviewed
• [Journal Article] Demonstration of T cell and macrophage progenitors in carp (Cyprinus carpio) kidney hematopoietic tissues. Development of clonal assay system for carp hematopoietic cells. (2010)
  • Author(s): Katakura, F., T.Yamaguchi, M.Yoshida, T.Moritomo, T.Nakanishi
  • Journal Title: Dev.Comp.Immunol. Volume: 34 Pages: 685-689
  • Peer Reviewed
• [Journal Article] Kinetics of CD4^+ and CD8α^+ T-cell subsets in Graft-Versus-Host Reaction (GVHR) in ginbuna crucian carp Carassius auratus langsdorfii (2010)
  • Author(s): Shibasaki Y., H.Toda, I.Kobayashi, T.Moritomo, T.Nakanishi
  • Journal Title: Dev Comp Immunol. Volume: 34 Pages: 1075-1081
  • Peer Reviewed
• [Journal Article] Use of flow cytometry to separate Leucocytozoon caulleryi gametocytes avian blood. (2010)
  • Author(s): Omori S, Sato Y, Toda H, Sasaki K, Isobe T, Nakanishi T, Murata K, Yukawa M.
  • Journal Title: Parasitology Volume: 12 Pages: 1-5
  • Peer Reviewed
• [Journal Article] A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes. (2010)
  • Author(s): Ohashi K., F.Takizawa, N.Tokumaru, C.Nakayasu, H.Toda, U.Fischer, T.Moritomol, K.Hashimoto, T.Nakanishi, J.M.Dijkstra
  • Journal Title: Immunogenetics Volume: 62 Pages: 543-559
  • Peer Reviewed
• [Journal Article] Activity of granulocytes and chemokines in the leukocyte-encapsulation response of Japanese flounder Paralichthys olivaceus. (2010)
  • Author(s): Kurata O., Nilubo K., Fujiwara A., Nakayasu C., Wada S., Hatai K.
  • Journal Title: Fish Pathology Volume: 45 Pages: 121-129
  • NAID: 10026600679
  • Peer Reviewed
• [Journal Article] Immunocytochemical studies of the ontogeny of peripheral blood leucocyte subpopulations in Japanese flounder (Paralichthys olivaceus) (2010)
  • Author(s): Matsuyama T, Nakayasu C, Sano M
  • Journal Title: Fish and shellfish immunology Volume: 29 Pages: 362-365
  • Peer Reviewed
• [Journal Article] The efficacy of five avirulent Edwardsiella tarda strains in a live vaccine against Edwardsiellosis in Japanese flounder, Paralichthys olivaceus (2010)
  • Author(s): Takano T., Matsuyama T., Oseko N., Sakai T., Kamaishi T., Nakayasu C., Sano M., Iida T.
  • Journal Title: Fish and shellfish immunology Volume: 29 Pages: 687-693
  • Peer Reviewed
• [Journal Article] 魚類における膜型補体制御因子の同定と機能解析:次世代魚病ワクチンアジュバントへの展開に向けて (2010)
  • Author(s): 辻倉正和・杣本智軌・鵜木陽子・中尾実樹
  • Journal Title: 生物機能研究 Volume: 14 Pages: 38-44
• [Journal Article] Immunocytochemical studies of the ontogeny of peripheral blood leucocyte subpopulations in Japanese flounder(Paralichthys Olivaceus) (2010)
  • Author(s): Matsuyama T, Nakayasu C, Sano M.
  • Journal Title: Fish Shellfish Immunol. (印刷中)
  • Peer Reviewed
• [Journal Article] In vitro generation of viral-antigen dependent cytotoxic T-cells from ginbuna crucian carp, Carassius auratus langsdorfii (2009)
  • Author(s): Somamoto, T., N. Okamoto, T. Nakanishi, M. Ototake, and M. i Nakao.
  • Journal Title: Virology Volume: 389(1-2) Pages: 26-33
  • Peer Reviewed
• [Journal Article] Allo-antigen specific killing is mediated by CD8 positive T cells in fish (2009)
  • Author(s): Toda H., Y. Shibasaki, T. Koike, M. Ohtani, F. Takizawa, M. Ototake, T. Moritomo and T. Nakanishi
  • Journal Title: Dev. Comp. Immunol Volume: 33 Pages: 646-652
  • Peer Reviewed
• [Journal Article] Cytokine-expression profiles of intestinal epithelial cells(IEC) in rainbow trout, Oncorhynchus mykiss, against bacterial and viral infection (2009)
  • Author(s): Komatsu K, Tsutsui S, Araki K, Nakamura O, Watanabe T.
  • Journal Title: Dev Comp Immunol Volume: 33 Pages: 499-506
  • Peer Reviewed
• [Journal Article] Identification of major antigenic proteins of Edwardsiella tarda recognized by Japanese flounder antibody (2009)
  • Author(s): Sakai T, Matsuyama T, Nishioka T, Nakayasu C, Kamaishi T, Yamaguchi K, Iida T
  • Journal Title: J. Vet. Diagn. Invest Volume: 21 Pages: 504-509
  • Peer Reviewed
• [Journal Article] Molecular cloning and expression analysis of interferon gamma gene in Japanese flounder(Paralichthys olivaceus) (2009)
  • Author(s): Matsuyama T, Fujiwara A, Sakai T and Nakayasu C
  • Journal Title: Fisheries Science Volume: 75 Pages: 751-756
  • NAID: 10024733927
  • Peer Reviewed
• [Journal Article] Allo-antigen specific killing is mediated by CD8 positive T cells in fish (2009)
  • Author(s): Toda H., Y.Shibasaki, T.Koike, M Ohtani, F.Takizawa, M.Ototake, T.Moritomo, T.Nakanishi
  • Journal Title: Dev.Comp.Immunol. 33 Pages: 646-652
  • Peer Reviewed
• [Journal Article] In vitro generation of viral-antigen dependent cytotoxic T-cells from ginbuna crucian carp, Carassius auratus langsdorfii (2009)
  • Author(s): Somamoto, T., N.Okamoto, T.Nakanishi, M.Ototake, M.Nakao
  • Journal Title: Virology 20 Pages: 26-33
  • Peer Reviewed
• [Journal Article] Co-culture of carp(Cyprinus carpio)kidney haematopoietic cells with feeder cells resulting in long-term proliferation of T-cell lineages (2009)
  • Author(s): Katakura F, Takizawa F, Yoshida M, Yamaguchi T, Araki K, Tomana M, Nakao M, Moritomo T, Nakanishi T.
  • Journal Title: Vet Immunol Immunopathol. 131 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Zinc-dependent binding between peptides derived from rainbow trout CD8alpha and LCK (2009)
  • Author(s): Hayashi N, Takeuchi M, Nakanishi T, Hashimoto K, Dijkstra J M.
  • Journal Title: Fish Shellfish Immunol. 26(1) Pages: 72-76
  • Peer Reviewed
• [Journal Article] Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells (2009)
  • Author(s): Kobayashi I, Ono H, Moritomo T, Kano K, Nakanishi T, Suda T.
  • Journal Title: Blood 14
  • Peer Reviewed
• [Journal Article] A novel C1q family member with fucose-binding activity from surffish, Neoditrema ransonnetii(Perciformes, Embiotocidae) (2009)
  • Author(s): Nakamura O, Wada Y, Namai F, Saito E, Araki K, Yamamoto A, Tsutsui S.
  • Journal Title: Fish Shellfish Immunol 27 Pages: 714-720
  • Peer Reviewed
• [Journal Article] Expression profiles of cytokines released in intestinal epithelial cells of the rainbow trout, Oncorhynchus mykiss, in response to bacterial infection (2009)
  • Author(s): Komatsu K, Tsutsui S, Hino K, Araki K, Yoshiura Y, Yamamoto A, Nakamura O, Watanabe T.
  • Journal Title: Dev Comp Immunol 33 Pages: 499-506
  • Peer Reviewed
• [Journal Article] Production and characterization of monoclonal antibodies to leukocytes and serum immunoglobulin in Japanese flounder Paralichthys olivaceus (2009)
  • Author(s): Matsuyama T, Nakayasu C, Sakai T, Oseko N.
  • Journal Title: Fisheries Science 75 Pages: 335-341
  • NAID: 10024970001
  • Peer Reviewed
• [Presentation] コイTh2様細胞のクローン性増殖 (2012)
  • Author(s): 山口卓哉、片倉文彦、森友忠昭、中西照幸
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2012-03-29
• [Presentation] コイIL-4/13BのB細胞培養に対する効果 (2012)
  • Author(s): 宮田俊輔・山口卓哉・片倉文彦・柴崎康宏・藪健史・森友忠昭・中西照幸
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2012-03-29
• [Presentation] コイの栓球造血におけるTPOとkitlaの作用 (2012)
  • Author(s): 杉江勇二・片倉文彦・藪健史・加藤尚志・森友忠昭・中西照幸
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2012-03-29
• [Presentation] ギンブナのEdwardsiella tarda強毒株および弱毒株により誘導される細胞性免疫応答の比較 (2012)
  • Author(s): 山崎雅俊・荒木亨介・多治見誠亮・中西照幸・中易千早・飯田貴次・山本淳
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2012-03-29
• [Presentation] ブリCD4遺伝子のクローニングおよび発現解析 (2012)
  • Author(s): 荒木亨介・下野友未・山崎雅俊・松山知正・柳宗悦・村瀬拓也・山本淳
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2012-03-29
• [Presentation] ブリCD8α鎖遺伝子のcDNAクローニングおよび発現解析 (2012)
  • Author(s): 下野友未・荒木亨介・山崎雅俊・松山知正・柳宗悦・村瀬拓也・山本淳
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2012-03-29
• [Presentation] Streptococcus parauberisに対するヒラメ白血球の活性化 (2012)
  • Author(s): 塚本春香・杣本智軌・中尾実樹
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2012-03-28
• [Presentation] 魚類の細胞性免疫機構について (2012)
  • Author(s): 中西照幸・柴崎康宏・藪健史・杣本智軌
  • Organizer: 第153回獣医学会微生物分科会シンポジウム
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2012-03-27
• [Presentation] 魚類の細胞性免疫機構について (2012)
  • Author(s): 中西照幸・柴崎康宏・藪健史・杣本智軌
  • Organizer: 第153回獣医学会微生物分科会シンポジウム
  • Place of Presentation: 宇都宮
  • Year and Date: 2012-03-27
• [Presentation] 不活化ウイルス経腸管感作後のギンブナT細胞の免疫応答 (2012)
  • Author(s): 多治見誠亮・杣本智軌・中西照幸・中尾実樹
  • Organizer: 日本水産学会九州支部大会
  • Place of Presentation: 鹿児島大学
  • Year and Date: 2012-01-19
• [Presentation] ギンブナのEdwardsiella tardaに対する感染防御における感作CTL移入効果の検討 (2011)
  • Author(s): 山崎雅俊・荒木亨介・中西照幸・中易千早・山本淳
  • Organizer: 日本魚病学会秋季大会
  • Place of Presentation: 長崎大学
  • Year and Date: 2011-10-02
• [Presentation] ギンブナアロ鱗移植部位におけるTリンパ球サブセットの活性化と動態 (2011)
  • Author(s): 西野達之・戸田秀明・柴崎康宏・藪健史・森友忠昭、中西照幸
  • Organizer: 日本水産学会秋季大会
  • Place of Presentation: 長崎大学
  • Year and Date: 2011-10-01
• [Presentation] Rag-1遺伝子欠損によるゼブラフィッシュの獲得免疫不全の検証と遺伝子の発現変動 (2011)
  • Author(s): 徳永弓枝・白水正道・安住薫・吉浦康寿、乙竹充・田代康介・杣本智軌・中尾実樹
  • Organizer: 日本水産学会秋季大会
  • Place of Presentation: 長崎大学
  • Year and Date: 2011-10-01
• [Presentation] ニジマスにおけるアスコルビン酸,アスタキサンチン,βグルカン,および三剤混合の短期高濃度投与効果1.人為感染実験における有効性の検証 (2011)
  • Author(s): 石川孝典・横塚哲也・難波亜紀・藪健史・間野伸宏・澤田守伸・中西照幸
  • Organizer: 日本水産学会秋季大会
  • Place of Presentation: 長崎大学
  • Year and Date: 2011-10-01
• [Presentation] ニジマスにおけるアスコルビン酸、アスタキサンチン、β-グルカン、および三剤混合の短期高濃度投与効果2.生体防御関連遺伝子の発現解析 (2011)
  • Author(s): 難波亜紀・石川孝典・横塚哲也・藪健史・間野伸宏・澤田守伸・中西照幸
  • Organizer: 日本水産学会秋季大会
  • Place of Presentation: 長崎大学
  • Year and Date: 2011-10-01
• [Presentation] 魚類特有のインターフェロン、IFNγrel 1, IFNγrel 2の同定 (2011)
  • Author(s): 柴崎康宏, 藪健史, 間野伸宏, 司馬肇, 森友忠昭, 中西照幸
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] 魚類特有の新規インターフェロン、IFNγrel 1およびIFNγrel 2の同定 (2011)
  • Author(s): 柴崎康宏, 藪健史, 間野伸宏, 司馬肇, 森友忠昭, 中西照幸
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] Immune-related gene expression in leukocyte subpopulations of Japanese flounder (2011)
  • Author(s): Takano, T., T.Matsuyama, A.Fujiwara, T.Sakai, C.Nakayasu
  • Organizer: European Association of Fish Pathologists
  • Place of Presentation: クロアチアスプリット
  • Year and Date: 2011-09-15
• [Presentation] ギンブナCD3ε分子の特性解明 (2011)
  • Author(s): 村田憲史、大橋健、柴崎康宏, 藪健史, 森友忠昭、中西照幸
  • Organizer: 日本比較免疫学会第23回学術集会、海洋研究開発機構
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-21
• [Presentation] ギンブナの移植片対宿主反応におけるCD8陽性T細胞の動態日本比較免疫学会 (2011)
  • Author(s): 田中洋枝、柴崎康宏、藪健史、森友忠昭、中西照幸
  • Organizer: 第23回学術集会、海洋研究開発機構
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-21
• [Presentation] ギンブナCB3ε分子の特性解明 (2011)
  • Author(s): 村田憲史、大橋健、柴崎康宏, 藪健史, 森友忠昭、中西照幸
  • Organizer: 日本比較免疫学会第23回学術集会
  • Place of Presentation: 海洋研究開発機構(横浜研究所)
  • Year and Date: 2011-08-21
• [Presentation] ギンブナの移植片対宿主反応におけるCD8陽性T細胞の動態 (2011)
  • Author(s): 田中洋枝、柴崎康宏、藪健史、森友忠昭、中西照幸
  • Organizer: 日本比較免疫学会 第23回学術集会
  • Place of Presentation: 海洋研究開発機構(横浜研究所)
  • Year and Date: 2011-08-21
• [Presentation] コイTPO遺伝子のクローニングおよび性状解析 (2011)
  • Author(s): 林潔高、片倉文彦、藪健史、森友忠昭、中西照幸
  • Organizer: 日本比較免疫学会第23回学術集会
  • Place of Presentation: 海洋研究開発機構(横浜研究所)
  • Year and Date: 2011-08-21
• [Presentation] 魚類の造血機構解明を目的としたコイkit ligand Aの機能解析 (2011)
  • Author(s): 尻無浜由希、片倉文彦、藪健史、森友忠昭、中西照幸
  • Organizer: 日本比較免疫学会第23回学術集会
  • Place of Presentation: 海洋研究開発機構(横浜研究所)
  • Year and Date: 2011-08-21
• [Presentation] Rag1欠損ゼブラフィッシュにおける獲得免疫不全の検証 (2011)
  • Author(s): 白水正道・徳永弓枝・吉浦康寿、乙竹充・杣本智軌・中尾実樹
  • Organizer: 第23回日本比較免疫学会
  • Place of Presentation: 独立行政法人海洋研究開発機構(横浜市)
  • Year and Date: 2011-08-21
• [Presentation] In vitroにおけるコイCD4+T細胞のクローン性増殖生体防御学会 (2011)
  • Author(s): 山口卓哉、片倉文彦、森友忠昭、中西照幸
  • Organizer: 第22回学術集会
  • Place of Presentation: 琉球大学沖縄
  • Year and Date: 2011-06-29
• [Presentation] In vitroにおけるコイCD4+T細胞のクローン性増殖 (2011)
  • Author(s): 山口卓哉、片倉文彦、森友忠昭、中西照幸
  • Organizer: 生体防御学会第22回学術集会
  • Place of Presentation: 琉球大学
  • Year and Date: 2011-06-29
• [Presentation] Yabu Diversified isotypes of immune-related genes in teleost 8th Int (2011)
  • Author(s): Nakanishi, T., Y. Shibasaki, T.
  • Organizer: Congress of Comp. Physiol. Biochem., Symposium on Evolution and diversity of innate and adaptive immune systems
  • Place of Presentation: Nagoya
  • Year and Date: 2011-06-03
• [Presentation] Diversified isotypes of immune-related genes in teleost (2011)
  • Author(s): Nakanishi, T., Y.Shibasaki, T.Yab
  • Organizer: 8^<th> Int.Congress of Comp.Physiol.Biochem.
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-06-03
• [Presentation] Characterization of interferon gamma structurally related (IFNγrel) isoform ginbuna crucian carp, Carassius auratus langsdorfii (2011)
  • Author(s): Shibasaki, Y., T.Yabu, T.Moritomo, T.Nakanishi
  • Organizer: The Second Comparative Immunology & Pathology Workshop
  • Place of Presentation: Edmonton, Canada
  • Year and Date: 2011-05-24
• [Presentation] Role of fish IFNγ-related gene (2011)
  • Author(s): Shibasaki, Y., T. Yabu, T. Moritomo, T. Nakanishi
  • Organizer: Immune system 2011 ASBMB Annual meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-04-11
• [Presentation] Role of fish IFNγ-related gene in immune system (2011)
  • Author(s): Shibasaki, Y., T.Yabu, T.Moritomo, T.Nakanishi
  • Organizer: 2011 American Society for Biochemistry and Molecular Biology (ASBMB) Annual meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-04-11
• [Presentation] 魚類の細胞性免疫機構について (2011)
  • Author(s): 中西照幸、杣本智軌、戸田秀明、柴崎康宏、藪健史
  • Organizer: 第151回日本獣医学会 微生物シンポジウム2
  • Place of Presentation: 東京農工大
  • Year and Date: 2011-03-31
• [Presentation] 魚類Delta遺伝子の同定および発現解析 (2011)
  • Author(s): 浦野孝太郎、山口卓哉、森友忠昭、中西照幸
  • Organizer: 第151回日本獣医学会
  • Place of Presentation: 東京農工大
  • Year and Date: 2011-03-30
• [Presentation] コイTPOの性状解析 (2011)
  • Author(s): 林潔高、片倉文彦、山口卓哉、藪健史、柴崎康宏、森友忠昭、中西照幸
  • Organizer: 第151回日本獣医学会
  • Place of Presentation: 東京農工大
  • Year and Date: 2011-03-30
• [Presentation] ギンブナのEdwardsiella tarda人為感染に対するIFNγの投与効果 (2011)
  • Author(s): 難波亜紀・藪健史・戸田秀明・柴崎康宏・間野伸宏・森友忠昭・中西照幸
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大
  • Year and Date: 2011-03-30
• [Presentation] 魚類栓球の異物貪食作用 (2011)
  • Author(s): 長沢貴宏、松山知正、中易千早、杣本智軌、中尾実樹
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 東京海洋大
  • Year and Date: 2011-03-30
• [Presentation] 冷水病感染時に高発現するアユ免疫関連遺伝子の解析 (2011)
  • Author(s): 鈴木究真・小西浩司・田中英樹・泉庄太郎・中易千早・釜石隆・松山知正・高野倫一
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2011-03-28
• [Presentation] 免疫沈降法による病原体感染に応答するヒラメ血漿タンパクの探索 (2011)
  • Author(s): 坂井貴光・松山知正・高野倫一・中易千早・乙竹充・飯田貴次
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2011-03-28
• [Presentation] ギンブナのEdwardsiella tardaに対する感染防御における抗体及び細胞障害性T細胞の有効性について (2011)
  • Author(s): 山崎雅俊・下野友未・鳥居加奈・荒木亨介・中易千早・中西照幸・山本淳
  • Organizer: 平成23年度日本魚病学会春季大会
  • Place of Presentation: 東京大学農学部
  • Year and Date: 2011-03-27
• [Presentation] Edwardsiella tardaホルマリン不活化菌体が宿主に十分な感染防御能を付与しない要因 (2011)
  • Author(s): 鳥居加奈・山崎雅俊・荒木亨介・中易千早・山本淳
  • Organizer: 平成22年度 日本水産学会九州支部大会
  • Place of Presentation: 鹿児島大学水産学部
  • Year and Date: 2011-01-22
• [Presentation] イルカ骨髄細胞の分化能および増殖能の解析 (2011)
  • Author(s): 瀬川太雄、伊藤琢也、森友忠昭、中西照幸、酒井健夫
  • Organizer: 日本大学幹細胞研究会
  • Place of Presentation: 日本大学医学部
  • Year and Date: 2011-01-20
• [Presentation] Characterization of interferon gamma structurally related(IFNγrel) isoform 1 and 2 in ginbuna crucian carp, Carassius auratus langsdorfii (2011)
  • Author(s): Shibasaki, Y., T. Yabu, T. Moritomo, and T. Nakanishi
  • Organizer: The Second Comparative Immunology & Pathology Workshop(CIPW)
  • Place of Presentation: Edmonton, Canada
• [Presentation] Immune response against Edwardsiella tarda in ginbuna crucian carp. (2010)
  • Author(s): Yamasaki, M., K.Araki, C.Nakayasu, A.Yamarnoto
  • Organizer: UJNR Aquaculture Panel The 39^<th> Scientific Symposium
  • Place of Presentation: 鹿児島大学稲盛会館
  • Year and Date: 2010-10-26
• [Presentation] ヒラメ抗体に認識される各種病原体抗原蛋白質の探索 (2010)
  • Author(s): 釜石隆・松山知正・坂井貴光・高野倫一・中易千早・三吉泰之・福田穣
  • Organizer: 平成22年度 日本魚病学会大会
  • Place of Presentation: 三重大学
  • Year and Date: 2010-09-22
• [Presentation] 異なるヒラメ白血球亜集団から構築したcDNAライブラリーを用いたEST解析 (2010)
  • Author(s): 高野倫一・藤原篤志・松山知正・中易千早
  • Organizer: 平成22年度 日本魚病学会大会
  • Place of Presentation: 三重大学
  • Year and Date: 2010-09-22
• [Presentation] 発現ライブラリーの抗体スクリーニングによるヒラメ食細胞膜タンパク遺伝子の選択的クローニング (2010)
  • Author(s): 松山知正・高野倫一・中易千早
  • Organizer: 平成22年度 日本魚病学会大会
  • Place of Presentation: 三重大学
  • Year and Date: 2010-09-22
• [Presentation] ギンブナに対するEdwardsiella tardaの生菌およびホルマリン不活化菌体接種後の免疫応答の比較 (2010)
  • Author(s): 山崎雅俊・荒木亨介・中易千早・山本淳
  • Organizer: 平成22年度 日本魚病学会大会
  • Place of Presentation: 三重大学
  • Year and Date: 2010-09-21
• [Presentation] コイ補体レクチン経路に関連するコレクチンの異物認識多様性 (2010)
  • Author(s): 一木昭土、塚本春香、杣本智軌、中尾実樹
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: 福島市三河南町
  • Year and Date: 2010-09-10
• [Presentation] Conserved Perforin/granzyme. mediated cytolytic mechanism in killing by CD8 positive T cells in teleost (2010)
  • Author(s): Toda H., K. Araki, T. Moritomo, T. Nakanishi
  • Organizer: 9th International Veterinary Immunology Symposium(9th IVIS)
  • Place of Presentation: Funabori Tower hall
  • Year and Date: 2010-08-17
• [Presentation] Conserved Perforin/granzyme-mediated cytolytic mechanism in killing by CD8 positive T cells in teleost (2010)
  • Author(s): Toda H, Araki K, Moritomo T, Nakanishi T
  • Organizer: 9^<th> Int. Veterinary Immunology Symposium
  • Place of Presentation: 船堀タワーホール
  • Year and Date: 2010-08-17
• [Presentation] MHC in salmonid fish and its linkage associations with disease resistance and social behavior (2010)
  • Author(s): J.M., Dijkstra, K.Hashimoto, T.Nakanishi, M.Ototake
  • Organizer: MHC workshop at 9^<th> Int.Veterinary Immunology Symposium
  • Place of Presentation: 船堀タワーホール
  • Year and Date: 2010-08-17
• [Presentation] ギンブナにおけるCD4, CD8陽性T細胞サブセットの組織分布 (2010)
  • Author(s): 小川詩乃、戸田秀明、柴崎康宏、森友忠昭、中西照幸
  • Organizer: 日本比較免疫学会第22回学術集会
  • Place of Presentation: 九州大学
  • Year and Date: 2010-08-03
• [Presentation] コイ末梢血白血球の培養におけるBリンパ球の増殖 (2010)
  • Author(s): 仁井田祥光, 片倉文彦, 山口卓哉, 森友忠昭, 中西照幸
  • Organizer: 日本比較免疫学会第22回学術集会
  • Place of Presentation: 九州大学
  • Year and Date: 2010-08-03
• [Presentation] ウイルス感染で誘導されたギンブナ細胞傷害T細胞と単球の細胞傷害活性 (2010)
  • Author(s): 杣本智軌、中西照幸、中尾実樹
  • Organizer: 日本比較免疫学会第22回学術集会
  • Place of Presentation: 九州大学
  • Year and Date: 2010-08-03
• [Presentation] Characterization of zymosan-binding proteins in Nile Tilapia serum (2010)
  • Author(s): Soha Gomma, T.Somamoto, M.Nakao
  • Organizer: 日本比較免疫学会 第22回学術集会
  • Place of Presentation: 九州大学
  • Year and Date: 2010-08-02
• [Presentation] Role of interferon gamma signaling in teleosts (2010)
  • Author(s): Yabu T. and T. Nakanishi
  • Organizer: 9th International Congress on the Biology of Fish
  • Place of Presentation: Barcelona
  • Year and Date: 2010-07-06
• [Presentation] Phenotypic differences between non-mucosal and mucosal CD8+T-cells in rainbow trout(Oncorhynchus mykiss) (2010)
  • Author(s): Takizawa F., Dijkstra J. M., Kotterba P., Kollner B., Nakanishi T., Fischer U.
  • Organizer: European Organisation of Fish Immunology
  • Place of Presentation: Viterbo, Italy
  • Year and Date: 2010-05-23
• [Presentation] Phenotypic differences between non-mucosal and mucosal CD8α+ T-cells in rainbow trout (Oncorhynchus mykiss) (2010)
  • Author(s): Takizawa F., Dijkstra J.M., Kotterba P., Kollner B., Nakanishi T., Fischer U.
  • Organizer: First Symposium of the European Organisation of Fish Immunology
  • Place of Presentation: Viterbo, Italy
  • Year and Date: 2010-04-02
• [Presentation] コイ成熟T細胞のin vitroにおける増殖 (2010)
  • Author(s): 山口卓哉・四反田聡・片倉文彦・大谷真紀・末武弘章・森友忠昭・中西照幸
  • Organizer: 平成22年度日本水産学会春季大会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2010-03-28
• [Presentation] コルチゾール添加培養系によるコイ腎臓造血前駆細胞の同定 (2010)
  • Author(s): 片倉文彦・江口沙穂・山口卓哉・森友忠昭・中西照幸
  • Organizer: 平成22年度 日本水産学会春季大会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2010-03-28
• [Presentation] コイ成熟T細胞の in vitro における増殖 (2010)
  • Author(s): 山口卓哉・四反田聡・片倉文彦・大谷真紀・末武弘章・森友忠昭・中西照幸
  • Organizer: 平成22年度 日本水産学会春季大会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2010-03-28
• [Presentation] ギンブナの Edwardsiella tarda 感染防御機構に関する研究 (2010)
  • Author(s): 山崎雅俊・荒木亨介・乙竹充・山本淳
  • Organizer: 平成22年度 日本水産学会春季大会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2010-03-28
• [Presentation] Cells and molecules involved in specific cell-mediated immunity in fish (2010)
  • Author(s): Nakanishi, T., H.Toda, Y.Shibasaki, T.Yabu
  • Organizer: Second International Symposium on "Aquatic Animal Defense Mechanisms against Invading Pathogens"
  • Place of Presentation: Gyeongsang National University, Korea(招待講演)
• [Presentation] Role of Interferon Gamma Signaling in Teleosts (2010)
  • Author(s): Yabu t., T.Nakanishi
  • Organizer: 9th International Congress on the Biology of Fish
  • Place of Presentation: Barcelona, Spain(招待講演)
• [Presentation] Function of diversity of the complement component isotypes in bony fish innate immunity : A model study using the common carp (2010)
  • Author(s): Nakao M, Ichiki S, Mutsuro J, Tsujikura M, Somamoto T.
  • Organizer: The ninth International Congress on the Biology of Fish
  • Place of Presentation: Barcelona, Spain(招待講演)
• [Presentation] ギンブナにおけるCD4,CD8陽性T細胞サブセットの組織分布 (2010)
  • Author(s): 小川詩乃、戸田秀明、柴崎康宏、森友忠昭、中西照幸
  • Organizer: 日本比較免疫学会 第22回学術集会
  • Place of Presentation: 九州大学
• [Presentation] コイ末梢血白血球の培養におけるBリンパ球の増殖 (2010)
  • Author(s): 仁井田祥光, 片倉文彦, 山口卓哉, 森友忠昭, 中西照幸
  • Organizer: 日本比較免疫学会 第22回学術集会
  • Place of Presentation: 九州大学
• [Presentation] ウイルス感染で誘導されたギンブナ細胞傷害T細胞と単球の細胞傷害活性 (2010)
  • Author(s): 杣本智軌、中西照幸、中尾実樹
  • Organizer: 日本比較免疫学会 第22回学術集会
  • Place of Presentation: 九州大学
• [Presentation] 魚類好中球における活性酸素産生と NADPH oxidase 遺伝子の発現 (2009)
  • Author(s): 川口祐紀・村田学博・森友忠昭・中西照幸
  • Organizer: 平成21年度 日本水産学会秋季大会
  • Place of Presentation: 東北大学
  • Year and Date: 2009-09-28
• [Presentation] ヒラメ感染症診断のための抗体アレイの開発 (2009)
  • Author(s): 中易千早, 松山知正, 坂井貴光, 釜石隆, 伊東尚史, 乙竹充, 倉田修, 三吉泰之, 福田穣
  • Organizer: 平成21年度 日本魚病学会
  • Place of Presentation: 東北大学
  • Year and Date: 2009-09-28
• [Presentation] コイ造血細胞の培養-増殖したT細胞のクローン性と分化段階の解析- (2009)
  • Author(s): 山口卓哉、片倉文彦、四反田聡、吉田美幸、森友忠昭、中西照幸
  • Organizer: 第21回日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-04
• [Presentation] コイ腎臓中の造血前駆細胞の同定 (2009)
  • Author(s): 片倉文彦, 吉田美幸, 山口卓哉, 森友忠昭, 中西照幸
  • Organizer: 第21回 日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-04
• [Presentation] コイ造血細胞の培養-増殖したT細胞のクローン性と分化段階の解析- (2009)
  • Author(s): 山口卓哉, 片倉文彦, 四反田聡, 吉田美幸, 森友忠昭, 中西照幸
  • Organizer: 第21回 日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-04
• [Presentation] 混合リンパ球培養におけるTリンパ球サブセットの動態および免疫関連遺伝子発現の解析 (2009)
  • Author(s): 戸田秀明、乙竹充、森友忠昭、中西照幸
  • Organizer: 第21回日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-03
• [Presentation] 魚類赤血球及び栓球におけるITAMを有するCD4様分子の存在 (2009)
  • Author(s): 大橋健、J. M. Dijkstra、瀧沢文雄、中易千早、森友忠昭、中西照幸
  • Organizer: 第21回日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-03
• [Presentation] ギンブナのアロ鱗移植部位におけるTリンパ球サブセットの動態 (2009)
  • Author(s): 今林望、戸田秀明、乙竹充、森友忠昭、中西照幸
  • Organizer: 第21回日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-03
• [Presentation] 混合リンパ球培養におけるTリンパ球サブセットの動態および免疫関連遺伝子発現の解析 (2009)
  • Author(s): 戸田秀明, 乙竹充, 森友忠昭, 中西照幸
  • Organizer: 第21回 日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-03
• [Presentation] 魚類赤血球及び栓球におけるITAMを有するCD4様分子の存在 (2009)
  • Author(s): 大橋健, J.M.Dijkstra, 瀧沢文雄, 中易千早, 森友忠昭, 中西照幸
  • Organizer: 第21回 日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-03
• [Presentation] ギンブナのアロ鱗移植部位におけるTリンパ球サブセットの動態 (2009)
  • Author(s): 今林望, 戸田秀明, 乙竹充, 森友忠昭, 中西照幸
  • Organizer: 第21回 日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-03
• [Presentation] ギンブナ Fas ligand のcDNAクローニングと発現解析 (2009)
  • Author(s): 中村一規・杣本智軌・中西照幸・中尾実樹
  • Organizer: 第21回 日本比較免疫学会
  • Place of Presentation: 日本大学生物資源科学部
  • Year and Date: 2009-08-03
• [Presentation] Kinetics of CD4+and CD8+T-cell subsets in graft-versus-host reaction(GVHR) in ginbuna crucian carp Carassius auratus langsdorfii (2009)
  • Author(s): Nakanishi T., Y. Shibazaki, I. Kobayashi, H. Toda, T. Moritomo
  • Organizer: 11th Congress of Int. Soc. of Dev. and Comp. Immunol.
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2009-06-30
• [Presentation] Expression analysis of immune genes in ginbuna, Carassius auratus langsdorfii upon vaccination with Aeromonas hydrophila (2009)
  • Author(s): Ohtani M., H. Toda, T. Moritomo and T. Nakanishi
  • Organizer: 11th Congress of Int. Soc. of Dev. and Comp. Immunol
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2009-06-30
• [Presentation] Perforin-dependent cytotoxic mechanisms of CD8 positive t cells in ginbuna crucian carp (2009)
  • Author(s): Toda H., M. Ototake, T. Moritomo and T. Nakanishi
  • Organizer: 11th Congress of Int. Soc. of Dev. and Comp. Immunol
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2009-06-30
• [Presentation] Development of the single-cell colonyforming assay system : characterization of carp(Cyprinus carpio) kidney hematopoietic progenitor cells (2009)
  • Author(s): Katakura F., M. Yoshida, T. Yamaguchi, T. Moritomo, and T. Nakanishi
  • Organizer: 11th Congress of Int. Soc. of Dev. and Comp. Immunol.
  • Place of Presentation: プラハ(共和国)
  • Year and Date: 2009-06-30
• [Presentation] Long-term proliferation of common carp(Cyprinus carpio) CD4+αβT-cells in culture (2009)
  • Author(s): Yamaguchi T., F. Katakura, M. Yoshida, M. Otani, T. Moritomo and T. Nakanishi
  • Organizer: 11th Congress of Int. Soc. of Dev. and Comp. Immunol.
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2009-06-30
• [Presentation] Characterization of MHC class I genes in clonal ginbuna crucian carp, Carassius auratus langsdorfii (2009)
  • Author(s): Urabe S., T. Somamoto, S. Sameshima, T. Nakanishi, M. Ototake and M. Nakao
  • Organizer: 11th Congress of Int. Soc. of Dev. and Comp. Immunol
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2009-06-30
• [Presentation] Role of interferon-gamma and perforin on the cell-mediated immunity in fish (2009)
  • Author(s): Araki K., F. Takizawa, M. Yamasaki, M. Esumi, M. Konishi, A. Yamamoto, T. Moritomo, M. Ototake, T. Nakanishi
  • Organizer: 11th Congress of Int. Soc. of Dev. and Comp. Immunol.
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2009-06-30
• [Presentation] Kinetics of CD4+ and CD8+ T-cell subsets in graft-versus-host reaction(GVHR)in ginbuna crucian carp Carassius auratus langsdorfii (2009)
  • Author(s): Nakanishi T., Y.Shibazaki, I.Kobayashi, H.Toda, T.Moritomo
  • Organizer: 11th Congress of Int.Soc.of Dev.and Comp.Immunol.
  • Place of Presentation: プラハ(チェコ共和国)
  • Year and Date: 2009-06-30
• [Presentation] Expression analysis of immune genes in ginbuna, Carassius auratus langsdorfii upon vaccination with Aeromonas hydrophila (2009)
  • Author(s): 大谷真紀, 戸田秀明, 森友忠昭, 中西照幸
  • Organizer: 11th Congress of Int.Soc.of Dev.and Comp.Immunol.
  • Place of Presentation: プラハ(チェコ共和国)
  • Year and Date: 2009-06-30
• [Presentation] Perforin-dependent cytotoxic mechanisms of CD8 positive T cells in ginbuna crucian carp (2009)
  • Author(s): 戸田秀明, 乙竹充, 森友忠昭, 中西照幸
  • Organizer: 11th Congress of Int.Soc.of Dev.and Comp.Immunol.
  • Place of Presentation: プラハ(チェコ共和国)
  • Year and Date: 2009-06-30
• [Presentation] Development of the single-cell colony-forming assay system : characterization of carp(Cyprinus carpio)kidney hematopoietic progenitor cells (2009)
  • Author(s): 片倉文彦, 吉田美幸, 山口卓哉, 森友忠昭, 中西照幸
  • Organizer: 11th Congress of Int.Soc.of Dev.and Comp.Immunol.
  • Place of Presentation: プラハ(チェコ共和国)
  • Year and Date: 2009-06-30
• [Presentation] Long-term proliferation of common carp(Cyprinus carpio)CD4+αβT-cells in culture (2009)
  • Author(s): 山口卓哉, 片倉文彦, 吉田美幸, 大谷真紀, 森友忠昭, 中西照幸
  • Organizer: 11th Congress of Int.Soc.of Dev.and Comp.Immunol.
  • Place of Presentation: プラハ(チェコ共和国)
  • Year and Date: 2009-06-30
• [Presentation] Characterization of MHC class I genes in clonal ginbuna crucian carp, Carassius auratus langsdorfii (2009)
  • Author(s): Urabe S., T.Somamoto, S.Sameshima, T.Nakanishi, M.Ototake, M.Nakao
  • Organizer: 11th Congress of Int.Soc.of Dev.and Comp.Immunol.
  • Place of Presentation: プラハ(チェコ共和国)
  • Year and Date: 2009-06-30
• [Presentation] Role of interferon-gamma and perforin on the cell-mediated immunity in fish (2009)
  • Author(s): Araki K, Takizawa F, Yamasaki M, Esumi M, Konishi M, Yamamoto A, Moritomo T, Ototake M, Nakanishi T.
  • Organizer: 11th Congress of Int.Soc.of Dev.and Comp.Immunol.
  • Place of Presentation: プラハ(チェコ共和国)
  • Year and Date: 2009-06-30
• [Presentation] 魚類における細胞傷害性Tリンパ球(CTL)の同定及び機能について (2009)
  • Author(s): 中西照幸
  • Organizer: 第12回マリンバイオテクノロジー学会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2009-05-31
• [Presentation] 魚類における細胞傷害性Tリンパ球(CTL)の同定及び機能について (2009)
  • Author(s): 中西照幸
  • Organizer: 第12回 マリンバイオテクノロジー学会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2009-05-31
• [Presentation] Protective immunity against Edwardsiella tarda in ginbuna crucian carp(Carassius auratus langsdorfii) (2009)
  • Author(s): 山崎雅俊・荒木亨介・乙竹充・山本淳
  • Organizer: 38^<th> Annual Convention and Scientific meeting of the Philippine Society for Microbiology
  • Place of Presentation: マニラ(フィリピン共和国)
  • Year and Date: 2009-05-15
• [Presentation] Characterization of CD8+ T cells and Thl-cytokines in fish (2009)
  • Author(s): 荒木亨介
  • Organizer: 38^<th> Annual Convention and Scientific meeting of the Philippine Society for Microbiology
  • Place of Presentation: マニラ(フィリピン共和国)
  • Year and Date: 2009-05-15
• [Book] 補体への招待「2.5.2.補体系の進化:脊椎動物」(大井洋之、木下タロウ、松下操編) (2011)
  • Author(s): 中尾実樹, 杣本智軌
  • Total Pages: 6
  • Publisher: メジカルビュー社
• [Book] 水産用ワクチンハンドブック (2009)
  • Author(s): 中西照幸・乙竹充
  • Total Pages: 130
  • Publisher: 恒星社厚生閣