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Development of techniques for diagnosis and prevention of fish disease by the analysis of T cell function in fish immune response

Research Project

Project/Area Number 21380126
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionNihon University

Principal Investigator

NAKANISHI Teruyuki  日本大学, 生物資源科学部, 教授 (00322496)

Co-Investigator(Kenkyū-buntansha) SOMAMOTO Tomonori  九州大学, 農学研究科, 准教授 (40403993)
ARAKI Kyousuke  鹿児島大学, 水産学部, 助教 (30409073)
NAKAYASU Tihaya  水産総合研究センター, 養殖研究所, 研究員 (00311225)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords魚類 / T細胞 / 細胞性免疫 / ギンブナ / CD4 / CD8 / IFNγ / パーフォリン / グランザイム / モノクローナル抗体
Research Abstract

In this project, we showed a) tissue distribution of T cell subset, and the characteristics of CD4^+helper T cells using monoclonal antibodies in ginbuna, b) killing mechanisms and differentiation and activation of CD8^+ cytotoxic T lymphocyte, c) primary importance of cell-mediated immunity in the defense against cell-associate bacteria, d) establishment of basic tools for the induction of Th1 response in fish, e) identification of immune genes and analysis of immune mechanisms in rainbow trout, flounder and yellowtail which enable the studies on cell-mediated immunity in important fishes in aquaculture.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (160 results)

All 2012 2011 2010 2009

All Journal Article (59 results) (of which Peer Reviewed: 58 results) Presentation (99 results) Book (2 results)

  • [Journal Article] Diversity of CD2 subfamily receptors in cyprinid fishes2012

    • Author(s)
      Sameshima S, Nakao M, Somamoto T
    • Journal Title

      Results in Immunology

      Volume: 2 Pages: 25-34

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adverse and beneficial effects of a long-term supplement of high-concentration ascorbic acid in rainbow trout Oncorhynchus mykiss2012

    • Author(s)
      Ishikawa, T., N.Mano, T.Nakanishi, H.Hirose
    • Journal Title

      Fish.Sci.

      Volume: (In press) Issue: 6 Pages: 1009-1014

    • DOI

      10.1007/s12562-011-0411-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization analysis of fluorescent-labeled Aeromonas veronii in the intestinal tract of carp using an in vivo imaging system2012

    • Author(s)
      Namba, A., N.Mano, H.Hirose, T.Nakanishi
    • Journal Title

      Fish Pathology

      Volume: 47 Pages: 7-11

    • NAID

      130004510233

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ontogeny of anti-viral hemorrhagic septicemia virus (VHSV) immunity in developing Japanese flounder2012

    • Author(s)
      Matsuyama, T., C.Nakayasu, A.Fujiwara, Kurita, J., T.Takano, T.Ito, M.Sano
    • Journal Title

      Dev.Comp.Immunol.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral protection mechanisms mediated by ginbuna crucian carp interferon gamma isoforms 1 and 2 through two distinct interferon gamma receptors2011

    • Author(s)
      Yabu, T., H. Toda, Y. Shibasaki, K. Araki, T. Nakanishi, 他7名
    • Journal Title

      J. Biochem

      Volume: 150(6) Pages: 635-48

    • NAID

      10030589144

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic T cells in teleost fish2011

    • Author(s)
      Nakanishi T, H. Toda, Y. Shibasaki, T. Somamoto
    • Journal Title

      Dev Comp Immunol

      Volume: 35 Pages: 1317-1323

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of MHC class I and beta-2 microglobulin in a clonal strain of ginbuna crucian carp, Carassius auratus langsdorfii2011

    • Author(s)
      Urabe S, Somamoto T, Sameshima S, Unoki-Kato Y, T. Nakanishi, Nakao M
    • Journal Title

      Fish Shellfish Immunol

      Volume: 31(3) Pages: 469-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression subtractive hybridization coupled with microarray analysis to examine differential expression of genes in Japanese flounder Paralichthys olivaceus leukocytes during Edwardsiella tarda and viral hemorrhagic septicemia virus infection2011

    • Author(s)
      Matsuyama T, Fujiwara A, Takano T, Nakayasu C
    • Journal Title

      Fish and shellfish immunology

      Volume: 31(4) Pages: 524-32

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of CD8alpha discriminates distinct T cell subsets in teleost fish2011

    • Author(s)
      Takizawa, F., Dijkstra, J. M., T. Nakanishi., Fischer, U., 他5名
    • Journal Title

      Dev Comp Immunol

      Volume: 35(7) Pages: 752-763

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish2011

    • Author(s)
      Toda H., Y. Saito, K. Araki, T. Yabu, T. Somamoto, T. Nakanishi, 他6名
    • Journal Title

      Dev Comp Immunol

      Volume: 35(6) Pages: 650-660

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating antigenspecific cytotoxicity of CD8+T cells in fish by Granzyme B-like activity2011

    • Author(s)
      Toda H., T. Yabu, H. Shiba, T. Moritomo and T. Nakanishi
    • Journal Title

      Vet Immunol Immunopathol

      Volume: 141 Pages: 168-172

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clonal growth of carp(Cyprinus carpio) T cells in vitro2011

    • Author(s)
      Yamaguchi T, Katakura F, T. Yabu, T. Nakanishi, 他6名
    • Journal Title

      Dev Comp Immunol

      Volume: 35(2) Pages: 193-202

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perforin-dependent cytotoxic mechanism in killing by CD8 positive T cells in Ginbuna crucian carp, Carassius auratus langsdorfii2011

    • Author(s)
      Toda H, Araki K, Moritomo T, T. Nakanishi
    • Journal Title

      Dev Comp Immunol

      Volume: 35(1) Pages: 88-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive high expression of interleukin 4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments2011

    • Author(s)
      Takizawa, F., E. O. Koppang, M. Ohtani, T. Nakanishi, K. Hashimoto, U. Fischer J. M. Dijkstra.
    • Journal Title

      Mol. Immunol

      Volume: 48(12-13) Pages: 1360-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of CD8alpha discriminates distinct T cell subsets in teleost fish2011

    • Author(s)
      Takizawa, F., Dijkstra, J.M., Kotterba, P., Korytar, T., Kock, H., Kollner, B., Jaureguiberry, B., Nakanishi, T., Fischer, U.
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 35 Issue: 7 Pages: 752-763

    • DOI

      10.1016/j.dci.2011.02.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive high expression of interleukin 4/13 A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments2011

    • Author(s)
      Takizawa, F., E.O.Koppang,; M.Ohtani, T.Nakanishi; K.Hashimoto, U.Fischer; J.M.Dijkstra
    • Journal Title

      Mol.Immunol.

      Volume: 48 Issue: 12-13 Pages: 1360-1368

    • DOI

      10.1016/j.molimm.2011.02.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The complement system in teleost fish : Progress of post-homolog-hunting researches2011

    • Author(s)
      Nakao M, Tsujikura M, Ichiki S, Tam K.Vo, Somamoto T.
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 35 Issue: 12 Pages: 1296-1308

    • DOI

      10.1016/j.dci.2011.03.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic T cells in teleost fish2011

    • Author(s)
      Nakanishi, T., H.Toda, Y.Shibasaki, T.Somamoto
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 35 Issue: 12 Pages: 1317-1323

    • DOI

      10.1016/j.dci.2011.03.033

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic cell populations in dolphin bone marrow : Analysis of colony formation and differentiation2011

    • Author(s)
      Segawa T., T.Itou, M.Suzuki, T.Moritomo, T.Nakanishi, T.Sakai
    • Journal Title

      Results in Immunology

      Volume: 1 Issue: 1 Pages: 1-5

    • DOI

      10.1016/j.rinim.2011.05.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of MHC class I and beta-2 microglobulin in a clonal strain of ginbuna crucian carp, Carassius auratus langsdorfii2011

    • Author(s)
      Urabe S, Somamoto T, Sameshima S, Unoki-Kato Y, Nakanishi T, Nakao M
    • Journal Title

      Fish Shellfish Immunol.

      Volume: 31 Issue: 3 Pages: 469-474

    • DOI

      10.1016/j.fsi.2011.06.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression subtractive hybridization coupled with microarray analysis to examine differential expression of genes in Japanese flounder Paralichthys olivaceus leucocytes during Edwardsiella tarda and viral hemorrhagic septicemia virus infection2011

    • Author(s)
      Matsuyatna, T., A.Fujiwara, T.Takano, C.Nakayasu
    • Journal Title

      Fish & Shellfish Immunol.

      Volume: 31 Issue: 4 Pages: 524-532

    • DOI

      10.1016/j.fsi.2011.06.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microsporidian Infection in Rryukyu Ayu Plecoglossus altivelis ryukyuensis on Amami Oshima Island2011

    • Author(s)
      Niwa, N., A.Yamamoto, K.Araki, T.Kamaishi, A.Shinomiya
    • Journal Title

      Fish Pathology

      Volume: 46 Issue: 3 Pages: 80-86

    • DOI

      10.3147/jsfp.46.80

    • NAID

      10029692326

    • ISSN
      0388-788X, 1881-7335
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A unique epidermal mucus lectin identified from catfish (Silurusasotus) : First evidence of intelectin in fish skin slime2011

    • Author(s)
      Tsutsui, S., Y.Komatsu, T.Sugiura, K.Araki, O.Nakamura
    • Journal Title

      J.Biochem.

      Volume: 150 Issue: 5 Pages: 501-514

    • DOI

      10.1093/jb/mvr085

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral protection mechanisms mediated by ginbuna crucian carp interferon gamma isoforms 1 and 2 through two distinct interferon gamma receptors2011

    • Author(s)
      Yabu, T., H.Toda, Y.Shibasaki, K.Araki, M.Yamashita, H.Anzai, N.Mano, Y.Masuhiro, S.Hanazawa, H.Shiba, T.Moritomo, T.Nakanishi
    • Journal Title

      J.Biochem.

      Volume: 150 Issue: 6 Pages: 635-648

    • DOI

      10.1093/jb/mvr108

    • NAID

      10030589144

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perforin-dependent cytotoxic mechanism in killing by CD8 positive T cells in Ginbuna crucian carp, Carassius auratus langsdorfii.2011

    • Author(s)
      Toda H, Araki K, Moritomo T, Nakanishi T.
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 35 Pages: 88-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonal growth of carp (Cyprinus carpio) T cells in vitro.2011

    • Author(s)
      Yamaguchi T, Katakura F, Shitanda S, Niida Y, Toda H, Ohtani M, Yabu T, Suetake H, Moritomo T Nakanishi T.
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 35 Pages: 193-202

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish.2011

    • Author(s)
      Toda H., Y.Saito, T.Koike, F.Takizawa, K.Araki, T.Yabu, T.Somamoto, H.Suetake, Y.Suzuki, M.Ototake, T.Moritomo, T.Nakanishi
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 35 Pages: 650-660

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating antigen-specific cytotoxicity of CD8^+ T cells in fish by Granzyme B-like activity.2011

    • Author(s)
      Toda H., T.Yabu, H.Shiba, T.Moritomo, T.Nakanishi
    • Journal Title

      Vet Immunol Immunopathol.

      Volume: 141 Pages: 168-172

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Japanese flounder antibody against fimbrial major protein of Edwardsiella tarda2011

    • Author(s)
      Sakai T., Miyoshi Y., Matsuyama T., Nakayasu C., Kamaishi T., Fukuda Y., Iida T.
    • Journal Title

      Fish Pathology

      Volume: 46 Pages: 23-26

    • NAID

      10027836518

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dijkstra A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes2010

    • Author(s)
      Ohashi K., F. Takizawa, N. Tokumaru, C. Nakayasu, H. Toda, U. Fischer, T. Moritomo1, K. Hashimoto, T. Nakanishi, J. M.
    • Journal Title

      Immunogenetics

      Volume: 62(8) Pages: 543-59

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of CD4+ and CD8α+ T-cell subsets in Graft-Versus-Host Reaction(GVHR) in ginbuna crucian carp Carassius auratus langsdorfii2010

    • Author(s)
      Shibasaki Y., H. Toda, I. Kobayashi, T. Moritomo and T. Nakanishi
    • Journal Title

      Dev Comp Immunol

      Volume: 34 Pages: 1075-1081

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zin-cdependent binding between peptides derived from rainbow trout CD8alpha and LCK2010

    • Author(s)
      Hayashi N, Takeuchi M, T. Nakanishi, Hashimoto K, Dijkstra JM
    • Journal Title

      Fish Shellfish Immunol

      Volume: 26(1) Pages: 72-76

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells2010

    • Author(s)
      Kobayashi I, Ono H, Moritomo T, Kano K, T. Nakanishi, Suda T
    • Journal Title

      Blood

      Volume: 115(2)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphocytes with T-cell-like properties express the Fas ligand in the Japanese flounder Paralichthys olivaceus2010

    • Author(s)
      Kurata O, Iwasaki T, Matsuyama T, Nakayasu C, Wada S, Hatai K
    • Journal Title

      Fish Shellfish Immunol

      Volume: 30(2) Pages: 509-14

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The efficacy of five avirulent Edwardsiella tarda strains in a live vaccine against Edwardsiellosis in Japanese flounder, Paralichthys olivaceus2010

    • Author(s)
      Takano T, Matsuyama T, Oseko N, Sakai T, Kamaishi T, Nakayasu C, Sano M, Iida T
    • Journal Title

      Fish Shellfish Immunol

      Volume: 29 Pages: 687-693

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunocytochemical studies of the ontogeny of peripheral blood leucocyte subpopulations in Japanese flounder(Paralichthys olivaceus)2010

    • Author(s)
      Matsuyama T, Nakayasu C, Sano M
    • Journal Title

      Fish and shellfish immunology

      Volume: 29(2) Pages: 362-365

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Japanese flounder antibody against fimbrial major protein of Edwardsiella tarda2010

    • Author(s)
      Sakai T, Matsuyama T, Nakayasu C
    • Journal Title

      Fish Pathology

      Volume: 46(1) Pages: 23-25

    • NAID

      10027836518

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Demonstration of T cell and macrophage progenitors in carp (Cyprinus carpio) kidney hematopoietic tissues. Development of clonal assay system for carp hematopoietic cells.2010

    • Author(s)
      Katakura, F., T.Yamaguchi, M.Yoshida, T.Moritomo, T.Nakanishi
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 34 Pages: 685-689

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of CD4^+ and CD8α^+ T-cell subsets in Graft-Versus-Host Reaction (GVHR) in ginbuna crucian carp Carassius auratus langsdorfii2010

    • Author(s)
      Shibasaki Y., H.Toda, I.Kobayashi, T.Moritomo, T.Nakanishi
    • Journal Title

      Dev Comp Immunol.

      Volume: 34 Pages: 1075-1081

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of flow cytometry to separate Leucocytozoon caulleryi gametocytes avian blood.2010

    • Author(s)
      Omori S, Sato Y, Toda H, Sasaki K, Isobe T, Nakanishi T, Murata K, Yukawa M.
    • Journal Title

      Parasitology

      Volume: 12 Pages: 1-5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes.2010

    • Author(s)
      Ohashi K., F.Takizawa, N.Tokumaru, C.Nakayasu, H.Toda, U.Fischer, T.Moritomol, K.Hashimoto, T.Nakanishi, J.M.Dijkstra
    • Journal Title

      Immunogenetics

      Volume: 62 Pages: 543-559

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activity of granulocytes and chemokines in the leukocyte-encapsulation response of Japanese flounder Paralichthys olivaceus.2010

    • Author(s)
      Kurata O., Nilubo K., Fujiwara A., Nakayasu C., Wada S., Hatai K.
    • Journal Title

      Fish Pathology

      Volume: 45 Pages: 121-129

    • NAID

      10026600679

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunocytochemical studies of the ontogeny of peripheral blood leucocyte subpopulations in Japanese flounder (Paralichthys olivaceus)2010

    • Author(s)
      Matsuyama T, Nakayasu C, Sano M
    • Journal Title

      Fish and shellfish immunology

      Volume: 29 Pages: 362-365

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The efficacy of five avirulent Edwardsiella tarda strains in a live vaccine against Edwardsiellosis in Japanese flounder, Paralichthys olivaceus2010

    • Author(s)
      Takano T., Matsuyama T., Oseko N., Sakai T., Kamaishi T., Nakayasu C., Sano M., Iida T.
    • Journal Title

      Fish and shellfish immunology

      Volume: 29 Pages: 687-693

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 魚類における膜型補体制御因子の同定と機能解析:次世代魚病ワクチンアジュバントへの展開に向けて2010

    • Author(s)
      辻倉正和・杣本智軌・鵜木陽子・中尾実樹
    • Journal Title

      生物機能研究

      Volume: 14 Pages: 38-44

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Immunocytochemical studies of the ontogeny of peripheral blood leucocyte subpopulations in Japanese flounder(Paralichthys Olivaceus)2010

    • Author(s)
      Matsuyama T, Nakayasu C, Sano M.
    • Journal Title

      Fish Shellfish Immunol. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro generation of viral-antigen dependent cytotoxic T-cells from ginbuna crucian carp, Carassius auratus langsdorfii2009

    • Author(s)
      Somamoto, T., N. Okamoto, T. Nakanishi, M. Ototake, and M. i Nakao.
    • Journal Title

      Virology

      Volume: 389(1-2) Pages: 26-33

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allo-antigen specific killing is mediated by CD8 positive T cells in fish2009

    • Author(s)
      Toda H., Y. Shibasaki, T. Koike, M. Ohtani, F. Takizawa, M. Ototake, T. Moritomo and T. Nakanishi
    • Journal Title

      Dev. Comp. Immunol

      Volume: 33 Pages: 646-652

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine-expression profiles of intestinal epithelial cells(IEC) in rainbow trout, Oncorhynchus mykiss, against bacterial and viral infection2009

    • Author(s)
      Komatsu K, Tsutsui S, Araki K, Nakamura O, Watanabe T.
    • Journal Title

      Dev Comp Immunol

      Volume: 33 Pages: 499-506

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of major antigenic proteins of Edwardsiella tarda recognized by Japanese flounder antibody2009

    • Author(s)
      Sakai T, Matsuyama T, Nishioka T, Nakayasu C, Kamaishi T, Yamaguchi K, Iida T
    • Journal Title

      J. Vet. Diagn. Invest

      Volume: 21 Pages: 504-509

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and expression analysis of interferon gamma gene in Japanese flounder(Paralichthys olivaceus)2009

    • Author(s)
      Matsuyama T, Fujiwara A, Sakai T and Nakayasu C
    • Journal Title

      Fisheries Science

      Volume: 75 Pages: 751-756

    • NAID

      10024733927

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allo-antigen specific killing is mediated by CD8 positive T cells in fish2009

    • Author(s)
      Toda H., Y.Shibasaki, T.Koike, M Ohtani, F.Takizawa, M.Ototake, T.Moritomo, T.Nakanishi
    • Journal Title

      Dev.Comp.Immunol. 33

      Pages: 646-652

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro generation of viral-antigen dependent cytotoxic T-cells from ginbuna crucian carp, Carassius auratus langsdorfii2009

    • Author(s)
      Somamoto, T., N.Okamoto, T.Nakanishi, M.Ototake, M.Nakao
    • Journal Title

      Virology 20

      Pages: 26-33

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-culture of carp(Cyprinus carpio)kidney haematopoietic cells with feeder cells resulting in long-term proliferation of T-cell lineages2009

    • Author(s)
      Katakura F, Takizawa F, Yoshida M, Yamaguchi T, Araki K, Tomana M, Nakao M, Moritomo T, Nakanishi T.
    • Journal Title

      Vet Immunol Immunopathol. 131

      Pages: 127-136

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc-dependent binding between peptides derived from rainbow trout CD8alpha and LCK2009

    • Author(s)
      Hayashi N, Takeuchi M, Nakanishi T, Hashimoto K, Dijkstra J M.
    • Journal Title

      Fish Shellfish Immunol. 26(1)

      Pages: 72-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells2009

    • Author(s)
      Kobayashi I, Ono H, Moritomo T, Kano K, Nakanishi T, Suda T.
    • Journal Title

      Blood 14

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel C1q family member with fucose-binding activity from surffish, Neoditrema ransonnetii(Perciformes, Embiotocidae)2009

    • Author(s)
      Nakamura O, Wada Y, Namai F, Saito E, Araki K, Yamamoto A, Tsutsui S.
    • Journal Title

      Fish Shellfish Immunol 27

      Pages: 714-720

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiles of cytokines released in intestinal epithelial cells of the rainbow trout, Oncorhynchus mykiss, in response to bacterial infection2009

    • Author(s)
      Komatsu K, Tsutsui S, Hino K, Araki K, Yoshiura Y, Yamamoto A, Nakamura O, Watanabe T.
    • Journal Title

      Dev Comp Immunol 33

      Pages: 499-506

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production and characterization of monoclonal antibodies to leukocytes and serum immunoglobulin in Japanese flounder Paralichthys olivaceus2009

    • Author(s)
      Matsuyama T, Nakayasu C, Sakai T, Oseko N.
    • Journal Title

      Fisheries Science 75

      Pages: 335-341

    • NAID

      10024970001

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] コイTh2様細胞のクローン性増殖2012

    • Author(s)
      山口卓哉、片倉文彦、森友忠昭、中西照幸
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] コイIL-4/13BのB細胞培養に対する効果2012

    • Author(s)
      宮田俊輔・山口卓哉・片倉文彦・柴崎康宏・藪健史・森友忠昭・中西照幸
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] コイの栓球造血におけるTPOとkitlaの作用2012

    • Author(s)
      杉江勇二・片倉文彦・藪健史・加藤尚志・森友忠昭・中西照幸
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ギンブナのEdwardsiella tarda強毒株および弱毒株により誘導される細胞性免疫応答の比較2012

    • Author(s)
      山崎雅俊・荒木亨介・多治見誠亮・中西照幸・中易千早・飯田貴次・山本淳
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ブリCD4遺伝子のクローニングおよび発現解析2012

    • Author(s)
      荒木亨介・下野友未・山崎雅俊・松山知正・柳宗悦・村瀬拓也・山本淳
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ブリCD8α鎖遺伝子のcDNAクローニングおよび発現解析2012

    • Author(s)
      下野友未・荒木亨介・山崎雅俊・松山知正・柳宗悦・村瀬拓也・山本淳
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Streptococcus parauberisに対するヒラメ白血球の活性化2012

    • Author(s)
      塚本春香・杣本智軌・中尾実樹
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 魚類の細胞性免疫機構について2012

    • Author(s)
      中西照幸・柴崎康宏・藪健史・杣本智軌
    • Organizer
      第153回獣医学会微生物分科会シンポジウム
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 魚類の細胞性免疫機構について2012

    • Author(s)
      中西照幸・柴崎康宏・藪健史・杣本智軌
    • Organizer
      第153回獣医学会微生物分科会シンポジウム
    • Place of Presentation
      宇都宮
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 不活化ウイルス経腸管感作後のギンブナT細胞の免疫応答2012

    • Author(s)
      多治見誠亮・杣本智軌・中西照幸・中尾実樹
    • Organizer
      日本水産学会九州支部大会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2012-01-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] ギンブナのEdwardsiella tardaに対する感染防御における感作CTL移入効果の検討2011

    • Author(s)
      山崎雅俊・荒木亨介・中西照幸・中易千早・山本淳
    • Organizer
      日本魚病学会秋季大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ギンブナアロ鱗移植部位におけるTリンパ球サブセットの活性化と動態2011

    • Author(s)
      西野達之・戸田秀明・柴崎康宏・藪健史・森友忠昭、中西照幸
    • Organizer
      日本水産学会秋季大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Rag-1遺伝子欠損によるゼブラフィッシュの獲得免疫不全の検証と遺伝子の発現変動2011

    • Author(s)
      徳永弓枝・白水正道・安住薫・吉浦康寿、乙竹充・田代康介・杣本智軌・中尾実樹
    • Organizer
      日本水産学会秋季大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニジマスにおけるアスコルビン酸,アスタキサンチン,βグルカン,および三剤混合の短期高濃度投与効果1.人為感染実験における有効性の検証2011

    • Author(s)
      石川孝典・横塚哲也・難波亜紀・藪健史・間野伸宏・澤田守伸・中西照幸
    • Organizer
      日本水産学会秋季大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニジマスにおけるアスコルビン酸、アスタキサンチン、β-グルカン、および三剤混合の短期高濃度投与効果2.生体防御関連遺伝子の発現解析2011

    • Author(s)
      難波亜紀・石川孝典・横塚哲也・藪健史・間野伸宏・澤田守伸・中西照幸
    • Organizer
      日本水産学会秋季大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 魚類特有のインターフェロン、IFNγrel 1, IFNγrel 2の同定2011

    • Author(s)
      柴崎康宏, 藪健史, 間野伸宏, 司馬肇, 森友忠昭, 中西照幸
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 魚類特有の新規インターフェロン、IFNγrel 1およびIFNγrel 2の同定2011

    • Author(s)
      柴崎康宏, 藪健史, 間野伸宏, 司馬肇, 森友忠昭, 中西照幸
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immune-related gene expression in leukocyte subpopulations of Japanese flounder2011

    • Author(s)
      Takano, T., T.Matsuyama, A.Fujiwara, T.Sakai, C.Nakayasu
    • Organizer
      European Association of Fish Pathologists
    • Place of Presentation
      クロアチアスプリット
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ギンブナCD3ε分子の特性解明2011

    • Author(s)
      村田憲史、大橋健、柴崎康宏, 藪健史, 森友忠昭、中西照幸
    • Organizer
      日本比較免疫学会第23回学術集会、海洋研究開発機構
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ギンブナの移植片対宿主反応におけるCD8陽性T細胞の動態日本比較免疫学会2011

    • Author(s)
      田中洋枝、柴崎康宏、藪健史、森友忠昭、中西照幸
    • Organizer
      第23回学術集会、海洋研究開発機構
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ギンブナCB3ε分子の特性解明2011

    • Author(s)
      村田憲史、大橋健、柴崎康宏, 藪健史, 森友忠昭、中西照幸
    • Organizer
      日本比較免疫学会第23回学術集会
    • Place of Presentation
      海洋研究開発機構(横浜研究所)
    • Year and Date
      2011-08-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ギンブナの移植片対宿主反応におけるCD8陽性T細胞の動態2011

    • Author(s)
      田中洋枝、柴崎康宏、藪健史、森友忠昭、中西照幸
    • Organizer
      日本比較免疫学会 第23回学術集会
    • Place of Presentation
      海洋研究開発機構(横浜研究所)
    • Year and Date
      2011-08-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] コイTPO遺伝子のクローニングおよび性状解析2011

    • Author(s)
      林潔高、片倉文彦、藪健史、森友忠昭、中西照幸
    • Organizer
      日本比較免疫学会第23回学術集会
    • Place of Presentation
      海洋研究開発機構(横浜研究所)
    • Year and Date
      2011-08-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 魚類の造血機構解明を目的としたコイkit ligand Aの機能解析2011

    • Author(s)
      尻無浜由希、片倉文彦、藪健史、森友忠昭、中西照幸
    • Organizer
      日本比較免疫学会第23回学術集会
    • Place of Presentation
      海洋研究開発機構(横浜研究所)
    • Year and Date
      2011-08-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rag1欠損ゼブラフィッシュにおける獲得免疫不全の検証2011

    • Author(s)
      白水正道・徳永弓枝・吉浦康寿、乙竹充・杣本智軌・中尾実樹
    • Organizer
      第23回日本比較免疫学会
    • Place of Presentation
      独立行政法人海洋研究開発機構(横浜市)
    • Year and Date
      2011-08-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vitroにおけるコイCD4+T細胞のクローン性増殖生体防御学会2011

    • Author(s)
      山口卓哉、片倉文彦、森友忠昭、中西照幸
    • Organizer
      第22回学術集会
    • Place of Presentation
      琉球大学沖縄
    • Year and Date
      2011-06-29
    • Related Report
      2011 Final Research Report
  • [Presentation] In vitroにおけるコイCD4+T細胞のクローン性増殖2011

    • Author(s)
      山口卓哉、片倉文彦、森友忠昭、中西照幸
    • Organizer
      生体防御学会第22回学術集会
    • Place of Presentation
      琉球大学
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Yabu Diversified isotypes of immune-related genes in teleost 8th Int2011

    • Author(s)
      Nakanishi, T., Y. Shibasaki, T.
    • Organizer
      Congress of Comp. Physiol. Biochem., Symposium on Evolution and diversity of innate and adaptive immune systems
    • Place of Presentation
      Nagoya
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Diversified isotypes of immune-related genes in teleost2011

    • Author(s)
      Nakanishi, T., Y.Shibasaki, T.Yab
    • Organizer
      8^<th> Int.Congress of Comp.Physiol.Biochem.
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of interferon gamma structurally related (IFNγrel) isoform ginbuna crucian carp, Carassius auratus langsdorfii2011

    • Author(s)
      Shibasaki, Y., T.Yabu, T.Moritomo, T.Nakanishi
    • Organizer
      The Second Comparative Immunology & Pathology Workshop
    • Place of Presentation
      Edmonton, Canada
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of fish IFNγ-related gene2011

    • Author(s)
      Shibasaki, Y., T. Yabu, T. Moritomo, T. Nakanishi
    • Organizer
      Immune system 2011 ASBMB Annual meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-04-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of fish IFNγ-related gene in immune system2011

    • Author(s)
      Shibasaki, Y., T.Yabu, T.Moritomo, T.Nakanishi
    • Organizer
      2011 American Society for Biochemistry and Molecular Biology (ASBMB) Annual meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-04-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 魚類の細胞性免疫機構について2011

    • Author(s)
      中西照幸、杣本智軌、戸田秀明、柴崎康宏、藪健史
    • Organizer
      第151回日本獣医学会 微生物シンポジウム2
    • Place of Presentation
      東京農工大
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 魚類Delta遺伝子の同定および発現解析2011

    • Author(s)
      浦野孝太郎、山口卓哉、森友忠昭、中西照幸
    • Organizer
      第151回日本獣医学会
    • Place of Presentation
      東京農工大
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] コイTPOの性状解析2011

    • Author(s)
      林潔高、片倉文彦、山口卓哉、藪健史、柴崎康宏、森友忠昭、中西照幸
    • Organizer
      第151回日本獣医学会
    • Place of Presentation
      東京農工大
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] ギンブナのEdwardsiella tarda人為感染に対するIFNγの投与効果2011

    • Author(s)
      難波亜紀・藪健史・戸田秀明・柴崎康宏・間野伸宏・森友忠昭・中西照幸
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 魚類栓球の異物貪食作用2011

    • Author(s)
      長沢貴宏、松山知正、中易千早、杣本智軌、中尾実樹
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京海洋大
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 冷水病感染時に高発現するアユ免疫関連遺伝子の解析2011

    • Author(s)
      鈴木究真・小西浩司・田中英樹・泉庄太郎・中易千早・釜石隆・松山知正・高野倫一
    • Organizer
      平成23年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫沈降法による病原体感染に応答するヒラメ血漿タンパクの探索2011

    • Author(s)
      坂井貴光・松山知正・高野倫一・中易千早・乙竹充・飯田貴次
    • Organizer
      平成23年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ギンブナのEdwardsiella tardaに対する感染防御における抗体及び細胞障害性T細胞の有効性について2011

    • Author(s)
      山崎雅俊・下野友未・鳥居加奈・荒木亨介・中易千早・中西照幸・山本淳
    • Organizer
      平成23年度日本魚病学会春季大会
    • Place of Presentation
      東京大学農学部
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Edwardsiella tardaホルマリン不活化菌体が宿主に十分な感染防御能を付与しない要因2011

    • Author(s)
      鳥居加奈・山崎雅俊・荒木亨介・中易千早・山本淳
    • Organizer
      平成22年度 日本水産学会九州支部大会
    • Place of Presentation
      鹿児島大学水産学部
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] イルカ骨髄細胞の分化能および増殖能の解析2011

    • Author(s)
      瀬川太雄、伊藤琢也、森友忠昭、中西照幸、酒井健夫
    • Organizer
      日本大学幹細胞研究会
    • Place of Presentation
      日本大学医学部
    • Year and Date
      2011-01-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of interferon gamma structurally related(IFNγrel) isoform 1 and 2 in ginbuna crucian carp, Carassius auratus langsdorfii2011

    • Author(s)
      Shibasaki, Y., T. Yabu, T. Moritomo, and T. Nakanishi
    • Organizer
      The Second Comparative Immunology & Pathology Workshop(CIPW)
    • Place of Presentation
      Edmonton, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Immune response against Edwardsiella tarda in ginbuna crucian carp.2010

    • Author(s)
      Yamasaki, M., K.Araki, C.Nakayasu, A.Yamarnoto
    • Organizer
      UJNR Aquaculture Panel The 39^<th> Scientific Symposium
    • Place of Presentation
      鹿児島大学稲盛会館
    • Year and Date
      2010-10-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒラメ抗体に認識される各種病原体抗原蛋白質の探索2010

    • Author(s)
      釜石隆・松山知正・坂井貴光・高野倫一・中易千早・三吉泰之・福田穣
    • Organizer
      平成22年度 日本魚病学会大会
    • Place of Presentation
      三重大学
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 異なるヒラメ白血球亜集団から構築したcDNAライブラリーを用いたEST解析2010

    • Author(s)
      高野倫一・藤原篤志・松山知正・中易千早
    • Organizer
      平成22年度 日本魚病学会大会
    • Place of Presentation
      三重大学
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発現ライブラリーの抗体スクリーニングによるヒラメ食細胞膜タンパク遺伝子の選択的クローニング2010

    • Author(s)
      松山知正・高野倫一・中易千早
    • Organizer
      平成22年度 日本魚病学会大会
    • Place of Presentation
      三重大学
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ギンブナに対するEdwardsiella tardaの生菌およびホルマリン不活化菌体接種後の免疫応答の比較2010

    • Author(s)
      山崎雅俊・荒木亨介・中易千早・山本淳
    • Organizer
      平成22年度 日本魚病学会大会
    • Place of Presentation
      三重大学
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] コイ補体レクチン経路に関連するコレクチンの異物認識多様性2010

    • Author(s)
      一木昭土、塚本春香、杣本智軌、中尾実樹
    • Organizer
      第47回補体シンポジウム
    • Place of Presentation
      福島市三河南町
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Conserved Perforin/granzyme. mediated cytolytic mechanism in killing by CD8 positive T cells in teleost2010

    • Author(s)
      Toda H., K. Araki, T. Moritomo, T. Nakanishi
    • Organizer
      9th International Veterinary Immunology Symposium(9th IVIS)
    • Place of Presentation
      Funabori Tower hall
    • Year and Date
      2010-08-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Conserved Perforin/granzyme-mediated cytolytic mechanism in killing by CD8 positive T cells in teleost2010

    • Author(s)
      Toda H, Araki K, Moritomo T, Nakanishi T
    • Organizer
      9^<th> Int. Veterinary Immunology Symposium
    • Place of Presentation
      船堀タワーホール
    • Year and Date
      2010-08-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] MHC in salmonid fish and its linkage associations with disease resistance and social behavior2010

    • Author(s)
      J.M., Dijkstra, K.Hashimoto, T.Nakanishi, M.Ototake
    • Organizer
      MHC workshop at 9^<th> Int.Veterinary Immunology Symposium
    • Place of Presentation
      船堀タワーホール
    • Year and Date
      2010-08-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ギンブナにおけるCD4, CD8陽性T細胞サブセットの組織分布2010

    • Author(s)
      小川詩乃、戸田秀明、柴崎康宏、森友忠昭、中西照幸
    • Organizer
      日本比較免疫学会第22回学術集会
    • Place of Presentation
      九州大学
    • Year and Date
      2010-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] コイ末梢血白血球の培養におけるBリンパ球の増殖2010

    • Author(s)
      仁井田祥光, 片倉文彦, 山口卓哉, 森友忠昭, 中西照幸
    • Organizer
      日本比較免疫学会第22回学術集会
    • Place of Presentation
      九州大学
    • Year and Date
      2010-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] ウイルス感染で誘導されたギンブナ細胞傷害T細胞と単球の細胞傷害活性2010

    • Author(s)
      杣本智軌、中西照幸、中尾実樹
    • Organizer
      日本比較免疫学会第22回学術集会
    • Place of Presentation
      九州大学
    • Year and Date
      2010-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of zymosan-binding proteins in Nile Tilapia serum2010

    • Author(s)
      Soha Gomma, T.Somamoto, M.Nakao
    • Organizer
      日本比較免疫学会 第22回学術集会
    • Place of Presentation
      九州大学
    • Year and Date
      2010-08-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of interferon gamma signaling in teleosts2010

    • Author(s)
      Yabu T. and T. Nakanishi
    • Organizer
      9th International Congress on the Biology of Fish
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-07-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Phenotypic differences between non-mucosal and mucosal CD8+T-cells in rainbow trout(Oncorhynchus mykiss)2010

    • Author(s)
      Takizawa F., Dijkstra J. M., Kotterba P., Kollner B., Nakanishi T., Fischer U.
    • Organizer
      European Organisation of Fish Immunology
    • Place of Presentation
      Viterbo, Italy
    • Year and Date
      2010-05-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Phenotypic differences between non-mucosal and mucosal CD8α+ T-cells in rainbow trout (Oncorhynchus mykiss)2010

    • Author(s)
      Takizawa F., Dijkstra J.M., Kotterba P., Kollner B., Nakanishi T., Fischer U.
    • Organizer
      First Symposium of the European Organisation of Fish Immunology
    • Place of Presentation
      Viterbo, Italy
    • Year and Date
      2010-04-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] コイ成熟T細胞のin vitroにおける増殖2010

    • Author(s)
      山口卓哉・四反田聡・片倉文彦・大谷真紀・末武弘章・森友忠昭・中西照幸
    • Organizer
      平成22年度日本水産学会春季大会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] コルチゾール添加培養系によるコイ腎臓造血前駆細胞の同定2010

    • Author(s)
      片倉文彦・江口沙穂・山口卓哉・森友忠昭・中西照幸
    • Organizer
      平成22年度 日本水産学会春季大会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] コイ成熟T細胞の in vitro における増殖2010

    • Author(s)
      山口卓哉・四反田聡・片倉文彦・大谷真紀・末武弘章・森友忠昭・中西照幸
    • Organizer
      平成22年度 日本水産学会春季大会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ギンブナの Edwardsiella tarda 感染防御機構に関する研究2010

    • Author(s)
      山崎雅俊・荒木亨介・乙竹充・山本淳
    • Organizer
      平成22年度 日本水産学会春季大会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cells and molecules involved in specific cell-mediated immunity in fish2010

    • Author(s)
      Nakanishi, T., H.Toda, Y.Shibasaki, T.Yabu
    • Organizer
      Second International Symposium on "Aquatic Animal Defense Mechanisms against Invading Pathogens"
    • Place of Presentation
      Gyeongsang National University, Korea(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Interferon Gamma Signaling in Teleosts2010

    • Author(s)
      Yabu t., T.Nakanishi
    • Organizer
      9th International Congress on the Biology of Fish
    • Place of Presentation
      Barcelona, Spain(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Function of diversity of the complement component isotypes in bony fish innate immunity : A model study using the common carp2010

    • Author(s)
      Nakao M, Ichiki S, Mutsuro J, Tsujikura M, Somamoto T.
    • Organizer
      The ninth International Congress on the Biology of Fish
    • Place of Presentation
      Barcelona, Spain(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ギンブナにおけるCD4,CD8陽性T細胞サブセットの組織分布2010

    • Author(s)
      小川詩乃、戸田秀明、柴崎康宏、森友忠昭、中西照幸
    • Organizer
      日本比較免疫学会 第22回学術集会
    • Place of Presentation
      九州大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] コイ末梢血白血球の培養におけるBリンパ球の増殖2010

    • Author(s)
      仁井田祥光, 片倉文彦, 山口卓哉, 森友忠昭, 中西照幸
    • Organizer
      日本比較免疫学会 第22回学術集会
    • Place of Presentation
      九州大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウイルス感染で誘導されたギンブナ細胞傷害T細胞と単球の細胞傷害活性2010

    • Author(s)
      杣本智軌、中西照幸、中尾実樹
    • Organizer
      日本比較免疫学会 第22回学術集会
    • Place of Presentation
      九州大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 魚類好中球における活性酸素産生と NADPH oxidase 遺伝子の発現2009

    • Author(s)
      川口祐紀・村田学博・森友忠昭・中西照幸
    • Organizer
      平成21年度 日本水産学会秋季大会
    • Place of Presentation
      東北大学
    • Year and Date
      2009-09-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒラメ感染症診断のための抗体アレイの開発2009

    • Author(s)
      中易千早, 松山知正, 坂井貴光, 釜石隆, 伊東尚史, 乙竹充, 倉田修, 三吉泰之, 福田穣
    • Organizer
      平成21年度 日本魚病学会
    • Place of Presentation
      東北大学
    • Year and Date
      2009-09-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] コイ造血細胞の培養-増殖したT細胞のクローン性と分化段階の解析-2009

    • Author(s)
      山口卓哉、片倉文彦、四反田聡、吉田美幸、森友忠昭、中西照幸
    • Organizer
      第21回日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-04
    • Related Report
      2011 Final Research Report
  • [Presentation] コイ腎臓中の造血前駆細胞の同定2009

    • Author(s)
      片倉文彦, 吉田美幸, 山口卓哉, 森友忠昭, 中西照幸
    • Organizer
      第21回 日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] コイ造血細胞の培養-増殖したT細胞のクローン性と分化段階の解析-2009

    • Author(s)
      山口卓哉, 片倉文彦, 四反田聡, 吉田美幸, 森友忠昭, 中西照幸
    • Organizer
      第21回 日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 混合リンパ球培養におけるTリンパ球サブセットの動態および免疫関連遺伝子発現の解析2009

    • Author(s)
      戸田秀明、乙竹充、森友忠昭、中西照幸
    • Organizer
      第21回日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 魚類赤血球及び栓球におけるITAMを有するCD4様分子の存在2009

    • Author(s)
      大橋健、J. M. Dijkstra、瀧沢文雄、中易千早、森友忠昭、中西照幸
    • Organizer
      第21回日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] ギンブナのアロ鱗移植部位におけるTリンパ球サブセットの動態2009

    • Author(s)
      今林望、戸田秀明、乙竹充、森友忠昭、中西照幸
    • Organizer
      第21回日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 混合リンパ球培養におけるTリンパ球サブセットの動態および免疫関連遺伝子発現の解析2009

    • Author(s)
      戸田秀明, 乙竹充, 森友忠昭, 中西照幸
    • Organizer
      第21回 日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 魚類赤血球及び栓球におけるITAMを有するCD4様分子の存在2009

    • Author(s)
      大橋健, J.M.Dijkstra, 瀧沢文雄, 中易千早, 森友忠昭, 中西照幸
    • Organizer
      第21回 日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ギンブナのアロ鱗移植部位におけるTリンパ球サブセットの動態2009

    • Author(s)
      今林望, 戸田秀明, 乙竹充, 森友忠昭, 中西照幸
    • Organizer
      第21回 日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ギンブナ Fas ligand のcDNAクローニングと発現解析2009

    • Author(s)
      中村一規・杣本智軌・中西照幸・中尾実樹
    • Organizer
      第21回 日本比較免疫学会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Kinetics of CD4+and CD8+T-cell subsets in graft-versus-host reaction(GVHR) in ginbuna crucian carp Carassius auratus langsdorfii2009

    • Author(s)
      Nakanishi T., Y. Shibazaki, I. Kobayashi, H. Toda, T. Moritomo
    • Organizer
      11th Congress of Int. Soc. of Dev. and Comp. Immunol.
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2009-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression analysis of immune genes in ginbuna, Carassius auratus langsdorfii upon vaccination with Aeromonas hydrophila2009

    • Author(s)
      Ohtani M., H. Toda, T. Moritomo and T. Nakanishi
    • Organizer
      11th Congress of Int. Soc. of Dev. and Comp. Immunol
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2009-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Perforin-dependent cytotoxic mechanisms of CD8 positive t cells in ginbuna crucian carp2009

    • Author(s)
      Toda H., M. Ototake, T. Moritomo and T. Nakanishi
    • Organizer
      11th Congress of Int. Soc. of Dev. and Comp. Immunol
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2009-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the single-cell colonyforming assay system : characterization of carp(Cyprinus carpio) kidney hematopoietic progenitor cells2009

    • Author(s)
      Katakura F., M. Yoshida, T. Yamaguchi, T. Moritomo, and T. Nakanishi
    • Organizer
      11th Congress of Int. Soc. of Dev. and Comp. Immunol.
    • Place of Presentation
      プラハ(共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Long-term proliferation of common carp(Cyprinus carpio) CD4+αβT-cells in culture2009

    • Author(s)
      Yamaguchi T., F. Katakura, M. Yoshida, M. Otani, T. Moritomo and T. Nakanishi
    • Organizer
      11th Congress of Int. Soc. of Dev. and Comp. Immunol.
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2009-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of MHC class I genes in clonal ginbuna crucian carp, Carassius auratus langsdorfii2009

    • Author(s)
      Urabe S., T. Somamoto, S. Sameshima, T. Nakanishi, M. Ototake and M. Nakao
    • Organizer
      11th Congress of Int. Soc. of Dev. and Comp. Immunol
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2009-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of interferon-gamma and perforin on the cell-mediated immunity in fish2009

    • Author(s)
      Araki K., F. Takizawa, M. Yamasaki, M. Esumi, M. Konishi, A. Yamamoto, T. Moritomo, M. Ototake, T. Nakanishi
    • Organizer
      11th Congress of Int. Soc. of Dev. and Comp. Immunol.
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2009-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Kinetics of CD4+ and CD8+ T-cell subsets in graft-versus-host reaction(GVHR)in ginbuna crucian carp Carassius auratus langsdorfii2009

    • Author(s)
      Nakanishi T., Y.Shibazaki, I.Kobayashi, H.Toda, T.Moritomo
    • Organizer
      11th Congress of Int.Soc.of Dev.and Comp.Immunol.
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression analysis of immune genes in ginbuna, Carassius auratus langsdorfii upon vaccination with Aeromonas hydrophila2009

    • Author(s)
      大谷真紀, 戸田秀明, 森友忠昭, 中西照幸
    • Organizer
      11th Congress of Int.Soc.of Dev.and Comp.Immunol.
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Perforin-dependent cytotoxic mechanisms of CD8 positive T cells in ginbuna crucian carp2009

    • Author(s)
      戸田秀明, 乙竹充, 森友忠昭, 中西照幸
    • Organizer
      11th Congress of Int.Soc.of Dev.and Comp.Immunol.
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of the single-cell colony-forming assay system : characterization of carp(Cyprinus carpio)kidney hematopoietic progenitor cells2009

    • Author(s)
      片倉文彦, 吉田美幸, 山口卓哉, 森友忠昭, 中西照幸
    • Organizer
      11th Congress of Int.Soc.of Dev.and Comp.Immunol.
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Long-term proliferation of common carp(Cyprinus carpio)CD4+αβT-cells in culture2009

    • Author(s)
      山口卓哉, 片倉文彦, 吉田美幸, 大谷真紀, 森友忠昭, 中西照幸
    • Organizer
      11th Congress of Int.Soc.of Dev.and Comp.Immunol.
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of MHC class I genes in clonal ginbuna crucian carp, Carassius auratus langsdorfii2009

    • Author(s)
      Urabe S., T.Somamoto, S.Sameshima, T.Nakanishi, M.Ototake, M.Nakao
    • Organizer
      11th Congress of Int.Soc.of Dev.and Comp.Immunol.
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of interferon-gamma and perforin on the cell-mediated immunity in fish2009

    • Author(s)
      Araki K, Takizawa F, Yamasaki M, Esumi M, Konishi M, Yamamoto A, Moritomo T, Ototake M, Nakanishi T.
    • Organizer
      11th Congress of Int.Soc.of Dev.and Comp.Immunol.
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 魚類における細胞傷害性Tリンパ球(CTL)の同定及び機能について2009

    • Author(s)
      中西照幸
    • Organizer
      第12回マリンバイオテクノロジー学会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2009-05-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 魚類における細胞傷害性Tリンパ球(CTL)の同定及び機能について2009

    • Author(s)
      中西照幸
    • Organizer
      第12回 マリンバイオテクノロジー学会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protective immunity against Edwardsiella tarda in ginbuna crucian carp(Carassius auratus langsdorfii)2009

    • Author(s)
      山崎雅俊・荒木亨介・乙竹充・山本淳
    • Organizer
      38^<th> Annual Convention and Scientific meeting of the Philippine Society for Microbiology
    • Place of Presentation
      マニラ(フィリピン共和国)
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of CD8+ T cells and Thl-cytokines in fish2009

    • Author(s)
      荒木亨介
    • Organizer
      38^<th> Annual Convention and Scientific meeting of the Philippine Society for Microbiology
    • Place of Presentation
      マニラ(フィリピン共和国)
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Book] 補体への招待「2.5.2.補体系の進化:脊椎動物」(大井洋之、木下タロウ、松下操編)2011

    • Author(s)
      中尾実樹, 杣本智軌
    • Total Pages
      6
    • Publisher
      メジカルビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] 水産用ワクチンハンドブック2009

    • Author(s)
      中西照幸・乙竹充
    • Total Pages
      130
    • Publisher
      恒星社厚生閣
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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