| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
|
|---|
| Research Abstract |
We find out that several Lactobacillus strains can invade Caco-2 cell monolayer. Among those, the most invasive strain Lactobacillus crispatus JCM 5810 was used further studies on an invasive site and mechanism. It was shown that the bacterium enters the cells via apical side, and protein synthesis in the bacteria and rearrangement of microfilaments inside Caco-2 cells are essential for the invasion.
|
