Studies on opportunistic infection mechanisms of lactobacilli and bifidobacteria
| Project/Area Number |
21380162
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Zootechnical science/Grassland science
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
TOBA Takahiro 弘前大学, 農学生命科学部, 教授 (10108483)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
|
|---|
| Keywords | 乳酸菌 / 乳酸桿菌 / 腸管上皮細胞 / 侵入性 / 上皮細胞 |
|---|
| Research Abstract |
We find out that several Lactobacillus strains can invade Caco-2 cell monolayer. Among those, the most invasive strain Lactobacillus crispatus JCM 5810 was used further studies on an invasive site and mechanism. It was shown that the bacterium enters the cells via apical side, and protein synthesis in the bacteria and rearrangement of microfilaments inside Caco-2 cells are essential for the invasion.
|
Report
(4 results)
Research Products
(6 results)
