• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on opportunistic infection mechanisms of lactobacilli and bifidobacteria

Research Project

Project/Area Number 21380162
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Zootechnical science/Grassland science
Research InstitutionHirosaki University

Principal Investigator

TOBA Takahiro  弘前大学, 農学生命科学部, 教授 (10108483)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords乳酸菌 / 乳酸桿菌 / 腸管上皮細胞 / 侵入性 / 上皮細胞
Research Abstract

We find out that several Lactobacillus strains can invade Caco-2 cell monolayer. Among those, the most invasive strain Lactobacillus crispatus JCM 5810 was used further studies on an invasive site and mechanism. It was shown that the bacterium enters the cells via apical side, and protein synthesis in the bacteria and rearrangement of microfilaments inside Caco-2 cells are essential for the invasion.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 Other

All Presentation (2 results) Book (4 results)

  • [Presentation] Arcobacter butzleriの細胞侵入性および炎症性サイトカインの産生に与える乳酸菌の影響2010

    • Author(s)
      藤村江里子
    • Organizer
      日本畜産学会第112回大会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Arcobacter butzleriの細胞侵入性および炎症性サイトカインの産生に与える乳酸菌の影響

    • Author(s)
      藤村江里子、梅澤沙織、戸羽隆宏
    • Organizer
      日本畜産学会第112回大会
    • Place of Presentation
      明治大学駿河台キャンパスにて口頭発表
    • Related Report
      2011 Final Research Report
  • [Book] 世紀を越えるビフィズス菌の研究2011

    • Author(s)
      戸羽隆宏, 他
    • Publisher
      日本ビフィズス菌センター
    • Related Report
      2011 Final Research Report
  • [Book] 世紀を越えるビフィズス菌の研究2011

    • Author(s)
      上野川修一
    • Publisher
      日本ビフィズス菌センター
    • Related Report
      2011 Annual Research Report
  • [Book] 乳酸菌とビフィズス菌のサイエンス2010

    • Author(s)
      戸羽隆宏, 他
    • Publisher
      京都大学学術出版会
    • Related Report
      2011 Final Research Report
  • [Book] 乳酸菌とビフィズス菌のサイエンス2010

    • Author(s)
      戸羽隆宏
    • Publisher
      京都大学学術出版会
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi