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Development of a collagen-derived food ingredient with palatability and physiological functions

Research Project

Project/Area Number 21380167
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Zootechnical science/Grassland science
Research InstitutionKitasato University

Principal Investigator

ARIHARA Keizo  北里大学, 獣医学部, 教授 (00175994)

Research Collaborator OHATA Motoko  北里大学, 獣医学部, 助教 (60453510)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Keywordsコラーゲン / ペプチド / メイラード反応 / 保健的機能性 / 嗜好性 / 抗酸化作用 / 畜産副産物 / 食品素材
Research Abstract

Collagen of animal by-products(e. g., chicken skin) was utilized for developing a novel food ingredient. Heat-denatured collagen was hydrolyzed by protease treatment. Hydrolyzed collagen was heat-treated after the addition of carbohydorate(e. g., Xylose). By these procedures, a Maillard reaction product from collagen was obtained. This product showed a strong antioxidative activity in vitro. Also, in vivo assay showed the decrease of oxidative stress marker value(serum hydoroxiperoxide value) and the antihypertensive effect. Palatability of this products was also preferable.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (46 results)

All 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (8 results) Book (13 results) Remarks (8 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Isolation, purification and characterisation of angiotensin I-converting enzyme inhibitory peptides derived from catfish muscle protein thermolysin hydrolysates2012

    • Author(s)
      Ghassem M, Arihara K, Babji A S, Said M, Ibrahim S.
    • Journal Title

      International Journal of Food Science and Technology

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meat-based bioactive compounds and functional meat products2012

    • Author(s)
      Arihara K.
    • Journal Title

      Food Science and Technology

      Volume: 26 Pages: 26-28

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antihypertensive effect and antioxidant activity of peptide fractions extracted from Spanish dry-cured ham2012

    • Author(s)
      Escudero E, Aristoy M-C, Nishimura H, Arihara K, Toldra F.
    • Journal Title

      Meat Science

      Volume: 91 Pages: 306-311

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat2012

    • Author(s)
      Escudero E, Toldra F, Sentandreu M A, Nishimura H, and Arihara K.
    • Journal Title

      Meat Science

      Volume: 91 Pages: 382-384

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antihypertensive effect and antioxidant activity of peptide tractions extracted from Spanish dry-cured ham2012

    • Author(s)
      Escudero E, et al
    • Journal Title

      Meat Science

      Volume: 91 Pages: 306-311

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antihypertensive activity of peptides identified in the in vitro gastorointestinal digest of pork meat2012

    • Author(s)
      Escudero E, et al
    • Journal Title

      Meat Science

      Volume: 91 Pages: 382-384

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meat-based bioactive compounds and functional meat products (Review)2012

    • Author(s)
      Arihara K
    • Journal Title

      Food Science and Technology Journal

      Volume: 26 Pages: 26-28

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification and identification of ACE inhibitory peptides from Haruan(Channa striatus) myofibrillar protein hydrolysate using HPLC-ESI-TOF MS/MS2011

    • Author(s)
      Ghassem M, Arihara K, Babji A S, Said M, Ibrahim S.
    • Journal Title

      Food Chemistry

      Volume: 129 Pages: 1770-1777

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 牛乳および食肉の機能性食品への展開2010

    • Author(s)
      有原圭三
    • Journal Title

      ブレインテクノニュース

      Volume: 141 Pages: 1-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Angiotensin I converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat2010

    • Author(s)
      Escudero E, Sentandreu M, Arihara K, Toldra F.
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 58 Pages: 2895-2901

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鶏肉あるいは鰹肉をパパインで分解して調製したペプチド性キャットフード素材の嗜好性に対する影響2010

    • Author(s)
      大畑素子, 有原圭三, 石川伸一, 伊藤良
    • Journal Title

      ペット栄養学会誌

      Volume: 13 Pages: 1-13

    • NAID

      130004951805

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 牛乳および食肉の機能性食品への展開(総説)2010

    • Author(s)
      有原圭三
    • Journal Title

      ブレインテクノニュース

      Volume: 141 Pages: 1-7

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 食肉・食肉製品の機能性研究:とくに食肉タンパク質由来のペプチドについて2009

    • Author(s)
      有原圭三, 大畑素子
    • Journal Title

      食肉の科学

      Volume: 50 Pages: 202-211

    • NAID

      10027222746

    • Related Report
      2011 Final Research Report
  • [Journal Article] 食肉・食肉製品の機能性研究-食肉タンパク質由来のペプチドについて-2009

    • Author(s)
      有原圭三, 大畑素子
    • Journal Title

      食肉の科学 50

      Pages: 202-211

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] キャットフードの調製におけるペプチドおよび糖の添加が香気成分生成量に及ぼす影響2012

    • Author(s)
      大畑素子, 池田真穂, 有原圭三
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      十和田
    • Year and Date
      2012-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 食肉タンパク質分解物から調製したメイラード反応生成物の保健的機能2011

    • Author(s)
      西村仁志, 大鷲智慧, 和地俊, 大畑素子, 有原圭三
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      十和田
    • Year and Date
      2011-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 食肉発酵調味料の生体内発生活性酸素に対する抗酸化能の評価2011

    • Author(s)
      内田冴子, 大畑素子, 柳内延也, 山本和貴, 有原圭三
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      十和田
    • Year and Date
      2011-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 味覚センサを用いたペットフードの評価方法の確立2011

    • Author(s)
      渡邉えり香, 大畑素子, 有原圭三
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      十和田
    • Year and Date
      2011-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 食肉タンパク質分解物から調製したメイラード反応生成物の保健的機能2011

    • Author(s)
      西村仁志, 他
    • Organizer
      日本畜産学会第114回大会
    • Place of Presentation
      北里大学獣医学部(十和田市)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 鶏肉パパイン分解物添加キャットフードの香気寄与成分の検索2010

    • Author(s)
      大畑素子, 有原圭三, 石川伸一, 伊藤良
    • Organizer
      第112回日本畜産学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 食肉タンパク質由来ペプチドの機能解明と利用開2010

    • Author(s)
      有原圭三
    • Organizer
      日本畜産学会主催シンポジウム「乳・肉の機能性因子の発見と実用の展望」
    • Place of Presentation
      東京
    • Year and Date
      2010-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 食肉タンパク質由来ペプチドの機能解明と利用開発2010

    • Author(s)
      有原圭三
    • Organizer
      日本畜産学会主催シンポジウム「ルミナントバイオロジーの新展開」
    • Place of Presentation
      東京(明治大学)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Book] 機能性ペプチド機能性アミノ酸・ペプチドの技術と市場2012

    • Author(s)
      有原圭三
    • Publisher
      シーエムシー出版(印刷中)
    • Related Report
      2011 Final Research Report
  • [Book] Functional Foods Encyclopedia of Meat Sciences(2nd Edition)2012

    • Author(s)
      Arihara K.
    • Publisher
      Oxford(印刷中)
    • Related Report
      2011 Final Research Report
  • [Book] Relevance of peptide bioactivity in foods Proteomics in Foods : Principles and Applications2012

    • Author(s)
      Arihara K.
    • Publisher
      Springer(New York)(印刷中)
    • Related Report
      2011 Final Research Report
  • [Book] 食肉と食肉製品の機能性と健康への寄与畜産物利用学2011

    • Author(s)
      有原圭三
    • Publisher
      文永堂出版
    • Related Report
      2011 Final Research Report
  • [Book] Functional meat products Functional Foods : Concept to Products(2nd Edition)2011

    • Author(s)
      Arihara K, & Ohata M.
    • Publisher
      Woodhead Publishing(Cambridge)
    • Related Report
      2011 Final Research Report
  • [Book] Functional Foods : Concept to Products (2nd Edition)2011

    • Author(s)
      Arihara K, Ohata M
    • Total Pages
      22
    • Publisher
      Woodhead Publishing (Cambridge)
    • Related Report
      2011 Annual Research Report
  • [Book] Technology, Stability and Benefits to Human Health(Probiotic and Prebiotic Foods)2011

    • Author(s)
      Arihara K, Ohata M
    • Total Pages
      13
    • Publisher
      Nova Science Publishers (New York)
    • Related Report
      2010 Annual Research Report
  • [Book] Functional meat products Handbook of Meat Processing2010

    • Author(s)
      Arihara K, & Ohata M.
    • Publisher
      Wiley-Blackwell(Ames)
    • Related Report
      2011 Final Research Report
  • [Book] Handbook of Meat Processing2010

    • Author(s)
      Arihara K, Ohata M(分担執筆)
    • Publisher
      Wiley-Blackwell(Ames)
    • Related Report
      2009 Annual Research Report
  • [Book] 機能性ペプチドの最新応用技術2010

    • Author(s)
      有原圭三(監修)
    • Total Pages
      334
    • Publisher
      シーエムシー出版(東京)
    • Related Report
      2009 Annual Research Report
  • [Book] 機能性ペプチドの最新応用技術2009

    • Author(s)
      有原圭三
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] Possibilities and limitations of functional foods Agriculture-Environment-Medicine2009

    • Author(s)
      Arihara K.
    • Publisher
      Yokendo
    • Related Report
      2011 Final Research Report
  • [Book] 食の安全と予防医学2009

    • Author(s)
      有原圭三(分担執筆)
    • Publisher
      養賢堂(東京)
    • Related Report
      2009 Annual Research Report
  • [Remarks] 株式会社フード・ペプタイドホームページ(トピックスページ)

    • URL

      http://topics.foodpeptide.com/

    • Related Report
      2011 Final Research Report
  • [Remarks] 北里大学獣医学部食品機能安全学研究室ホームページ

    • URL

      http://food-kitasato.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://topics.foodpeptide.com/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://food-kitasato.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://topics.foodpeptide.com/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://food-kitasato.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://topics.foodpeptide.com/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://food-kitasato.jp/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] ペットフード用の嗜好性向上・改善剤2012

    • Inventor(s)
      大畑素子,有原圭三
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Industrial Property Number
      2012-093079
    • Filing Date
      2012-04-16
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 食肉タンパク質由来の抗疲労ペプチド2011

    • Inventor(s)
      有原圭三,冨田耕平,石川伸一,伊藤良,秋元政信,鮫島隆
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Acquisition Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ビフィズス菌増殖促進ペプチド2011

    • Inventor(s)
      有原圭三,石川伸一,伊藤良
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Acquisition Date
      2011-04-22
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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