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Clarification of new regulatory mechanisms of prolactin secretion by salsolinol and its physiological actions in ruminants

Research Project

Project/Area Number 21380169
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionIwate University

Principal Investigator

HASHIZUME Tsutomu  岩手大学, 農学部, 教授 (60124533)

Co-Investigator(Renkei-kenkyūsha) KASUYA Etsuko  (独)農業生物資源研究所, 研究員 (90355743)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords生産機能制御 / サルソリノール / プロラクチン / ドーパミン / ヤギ / メラトニン / L-DOPA / ウシ
Research Abstract

The effects of salsolinol (SAL) on the secretion of prolactin (PRL) were examined in ruminants.SAL was able to stimulate the release of PRL not only in male and female calves, but also in adult cows. The seasonal effects on PRL-releasing response to SAL were observed in goats, and a long photo period enhanced the PRL-releasing response to SAL in goats. A dopamine agonist inhibited the SAL-induced PRL release in goats. These results show that SAL is a potent physiological PRL-releasing factor in ruminants.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (22 results) Remarks (3 results)

  • [Journal Article] Effects of photoperiod on the secretion of growth hormone in female goats2012

    • Author(s)
      Jin J., Yaegashi T., Sawai K., Hashizume T
    • Journal Title

      Animal Science Journal

      Volume: (in press) Issue: 8 Pages: 610-616

    • DOI

      10.1111/j.1740-0929.2011.00998.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of photoperiod on salsolinol-induced prolactin secretion in goats2012

    • Author(s)
      Yaegashi T., Jin J., Sawada T., Saito H., Ful.p F., Nagy G.M., Hashizume T
    • Journal Title

      Animal Science Journal

      Volume: 83 Pages: 63-67

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bromocriptine inhibits salsolinol-induced prolactin release in male goats2012

    • Author(s)
      Hashizume T., Sawada T., Nakajima Y., Yaegashi T., Saito H., Goto Y., Jin J., Ful. p F., Nagy G.M.
    • Journal Title

      Animal Science Journal

      Volume: 83 Pages: 63-67

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of photoperiod on salsolinol-induced prolactin secretion in goats2012

    • Author(s)
      Yaegashi T.…Hashizume T.
    • Journal Title

      Animal Science Journal

      Volume: 83 Issue: 5 Pages: 418-425

    • DOI

      10.1111/j.1740-0929.2011.00965.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ference FULOP, Gy.rgy Miklos Nagy,橋爪力雄ヤギにおけるサルソリノールによるプロラクチン放出反応2011

    • Author(s)
      澤田建, 中嶋侑佳, 八重樫朋祥, 斉藤隼人, 後藤由希, 金金, 澤井健
    • Journal Title

      東北畜産学会報

      Volume: 63 Pages: 116-122

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bromoceiptine inhibibits salsol-induced prolactin release in male goats2011

    • Author(s)
      Hashizume T., et al.
    • Journal Title

      Animal Science Journal

      Volume: 82(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 雄ヤギにおけるサルソリノールによるプロラクチン放出反応2011

    • Author(s)
      澤田建, 橋爪力
    • Journal Title

      東北畜産学会報

      Volume: 60 Pages: 116-122

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of prolactin-releasing response to salsolinol in vivo in cattle2010

    • Author(s)
      Hashizume T., Sawada T., Yaegashi T., Saito H., Ezzat Ahmed A., Goto Y., Nakajima Y., Jin J., Kasuya E., Nagy G.M
    • Journal Title

      Domestic Animal Endocrinology

      Volume: 39 Pages: 21-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of prolactin-releasing response to salsolinol in vlvo in cattle2010

    • Author(s)
      Hashizume T., et al.
    • Journal Title

      Domestic Animal Endocrinology

      Volume: 39 Pages: 21-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of prolactin-releasing response to salsolinol in vivo in cattle2010

    • Author(s)
      Hashizume T., et al.
    • Journal Title

      Domestic Animal Endocrinology doi : 10.1016/j.domaniend.2010.01.002

      Pages: 1-1

    • Related Report
      2009 Annual Research Report
  • [Presentation] Salsolinolにより誘起されるヤギのプロラクチン分泌に及ぼすL-dopaとCarbidopaの影響2012

    • Author(s)
      橋爪力, ら
    • Organizer
      第115回日本畜産学会大会
    • Place of Presentation
      名古屋大学(愛知県)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Salsolinolにより誘起されるヤギのプロラクチン分泌に及ぼすL-dopaとCarbidopaの影響2012

    • Author(s)
      橋爪力,齋藤祐奈,遊佐瞳,後藤由希,金金,大場梨絵,澤井健
    • Organizer
      日本畜産学会第115大会
    • Place of Presentation
      名古屋,名古屋大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 長日条件下でのメラトニン処理がSalsolinolによるヤギのプロラクチン放出反応に及ぼす影響2011

    • Author(s)
      橋爪力, ら
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      盛岡市アイーナ(岩手県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成熟雄ヤギと雄子ヤギにおけるSalsolinolによるプロラクチン分泌反応2011

    • Author(s)
      遊佐瞳…橋爪力
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学(青森県)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Salsolinolにより誘起されるヤギのプロラクチン分泌に及ぼすL-DOPAの影響2011

    • Author(s)
      澤田建…橋爪力
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学(青森県)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 長日条件下でのメラトニン処理がSalsolinolによるヤギのプロラクチン放出反応に及ぼす影響2011

    • Author(s)
      橋爪力,八重樫朋祥,金金,後藤由希,遊佐瞳,澤井健
    • Organizer
      第104回日本繁殖生物学会
    • Place of Presentation
      盛岡市,アイーナ
    • Related Report
      2011 Final Research Report
  • [Presentation] 成熟雄ヤギと雄子ヤギにおけるSalsolinolによるプロラクチン分泌反応2011

    • Author(s)
      遊佐瞳,後藤由希,金金,澤井健,橋爪力
    • Organizer
      日本畜産学会第115大会
    • Place of Presentation
      十和田市,北里大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Salsolinolにより誘起されるヤギのプロラクチン分泌に及ぼすL-DOPAの影響2011

    • Author(s)
      澤田建,八重樫朋祥,遊佐瞳,後藤由希,金金,澤井健,橋爪力
    • Organizer
      日本畜産学会第115大会
    • Place of Presentation
      十和田市,北里大学
    • Related Report
      2011 Final Research Report
  • [Presentation] ウシの生殖生理と関連した新しい下垂体ホルモン分泌因子2010

    • Author(s)
      橋爪力
    • Organizer
      FAMS生産科学セミナー(招待講演)
    • Place of Presentation
      盛岡市,岩手大学
    • Year and Date
      2010-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] ウシの生殖生理と関連した新しい下垂体ホルモン分泌因子2010

    • Author(s)
      橋爪力
    • Organizer
      FAMS生産科学セミナー
    • Place of Presentation
      岩手大学農学部 招待講演
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日長及び温度変化とSalinolによるヤギのプロラクチン分泌反応2010

    • Author(s)
      八重樫朋祥, 橋爪力
    • Organizer
      第103回日本繁殖生物学会大会
    • Place of Presentation
      北里大学獣医学部
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 雄ヤギとSalsolinolによるヤギのプロラクチン分泌反応2010

    • Author(s)
      澤田建, 橋爪力
    • Organizer
      第103回日本繁殖生物学会大会
    • Place of Presentation
      北里大学獣医学部
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Salsolinolによる反芻家畜の新しいプロラクチン分泌支配機構に関する研究2010

    • Author(s)
      澤田建, 橋爪力
    • Organizer
      第60回東北畜産学会大会
    • Place of Presentation
      盛岡市アイーナ
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo characteristics of salsolinol on the secretion of prolactin in ruminants2010

    • Author(s)
      Hashizume T., et al.
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 雄ヤギとSalsolinolによるプロラクチン分泌反応2010

    • Author(s)
      澤田建,中嶋侑佳,八重樫朋祥,斉藤隼人,後藤由希,金金,澤井健,橋爪力
    • Organizer
      第103回日本繁殖生物学会
    • Place of Presentation
      十和田市,北里大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 日長および温度変化とSalsolinolによるヤギのプロラクチン分泌反応2010

    • Author(s)
      八重樫朋祥,金金,澤田建,斉藤隼人,後藤由希,中嶋侑佳,澤井健,橋爪力
    • Organizer
      第103回日本繁殖生物学会
    • Place of Presentation
      十和田市,北里大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Salsolinolによる反芻家畜の新しいプロラクチン分泌支配機構に関する研究2010

    • Author(s)
      澤田建,中嶋侑佳,八重樫朋祥,斉藤隼人,後藤由希,金金,澤井健,橋爪力
    • Organizer
      第60回東北畜産学会
    • Place of Presentation
      盛岡市,アイーナ
    • Related Report
      2011 Final Research Report
  • [Presentation] In vivo characteristics of salsolinol on the secretion of prolactin in ruminants2010

    • Author(s)
      Hashizume T., Sawada T., Yaegashi T., Saito H., Nakajima Y., Goto Y., Ezzat Ahmed A., Jin J., Sawai K., Kasuya E., Nagy, G.M
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] 成熟雌ヤギ及び分娩後の雌ウシにおけるSalsolinolによるプロラクチン分泌2009

    • Author(s)
      澤田建, 橋爪力
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日長変化とSalsolinolによるプロラクチン分泌反応に関する研究2009

    • Author(s)
      八重樫朋祥, 橋爪力
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日長変化とSalsolinolによるヤギのプロラクチン分泌反応に関する研究2009

    • Author(s)
      Hashizume T., Sawada T., Yaegashi T., Saito H., Ezzat Ahmed A., Goto Y., Nakajima Y., Jin J., Kasuya E., Nagy G.M八重樫朋祥,澤田建,中嶋侑佳,金金,斉藤隼人,後藤由希,Ahmed Ezzat Ahmed,澤井健,橋爪力
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      奈良,近畿大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 成熟雄ヤギ及び分娩後の雌ウシにおけるSalsolinolによるプロラクチン分泌2009

    • Author(s)
      澤田建,中嶋侑佳,八重樫朋祥,斉藤隼人,後藤由希,金金,Ahmed Ezzat Ahmed,澤井健,橋爪力
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      奈良,近畿大学
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://sp2.cc.iwate-u.ac.jp/~hashi/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://sp2.cc.iwate-u.ac.jp/~hashi/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://sp2.cc.iwate-u.ac.jp/~hashi/

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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