| Project/Area Number |
21380178
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HORI Masatoshi 東京大学, 大学院・農学生命科学研究科, 准教授 (70211547)
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| Co-Investigator(Renkei-kenkyūsha) |
MURATA Takahisa 東京大学, 大学院・農学生命科学研究科, 助教 (40422365)
URADE Yoshihiro (財)大阪バイオサイエンス研究所, 研究員 (10201360)
IINO Satoshi 福井大学, 医学部, 教授 (40242854)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | 消化管 / マクロファージ / 漿膜中皮細胞 / 炎症 / 免疫 / LPS / nACh受容体 / 蠕動運動 / 奨膜中皮細胞 / プロスタグランジン / 平滑筋細胞 |
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| Research Abstract |
In the present study, we tried to clarify immunoreactive and inflammatory reaction of muscle layer of small intestine independent with mucosal immunity. The immunoreactivity of muscle layer of small intestine could be the first defense in case of peritonitis and postoperative ileus. We found for the first time that serosal mesothelial cells and resident macrophages play a crucial role to induce inflammation. These cells have a sensor for PAMPs(Pathogen-Associated Molecular Patterns) such as LPS, which in turn express many inflammatory mediators. In addition, the inflammatory reaction directly affects on intestinal motility disorder. On the other hand, the immunoreactive and inflammatory signaling in the intestinal muscle wall can be regulated by an anti-inflammatory signaling pathway through nicotinic ACh receptors.
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