Studies of the roles of pituitary transcription factors for pituitary development and progenitor cells
Project/Area Number |
21380184
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
|
Research Institution | Meiji University |
Principal Investigator |
KATO Yukio 明治大学, 農学部, 教授 (30114177)
|
Co-Investigator(Renkei-kenkyūsha) |
KATO Takako 明治大学, 研究知財, 研究員 (90445859)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | 転写調節因子 / ホメオティック因子 / 性腺刺激ホルモン / 転写因子ネットワーク / 相互作用 / クローニング / 遺伝子 / 発現制御 / 内分泌学 / 生殖 / 細胞・組織 |
Research Abstract |
This study aimed to understand how homeotic transcription factors develop anterior pituitary and provide abilities to produce several hormones and regenerate hormone-producing cells throughout the life. By several approaches of molecular biology, cell biology and immunohistochemistry, we demonstrated that a pituitary specific transcription factor PROP1 and novel pituitary factors PRX1/PRX2 are indispensable for the pituitary organogenesis. To clarify the molecular functions are remained to be resolved in near future.
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Report
(4 results)
Research Products
(91 results)
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[Journal Article] Gene expression of lymphocyte prolactin receptor was suppressed in lactating mothers.2010
Author(s)
Maeda H, Izumi S-I, Kato Y, Cai L-Y, Kato T, Suzuki T, Nakamura, E., Sugiyama T, Fuda T, Takahashi K.
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Journal Title
The Tokai Journal of Experimental and Clinical Medicine.
Volume: 32
Pages: 62-65
Related Report
Peer Reviewed
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[Journal Article] Highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of pituitary glycoprotein hormone common α subunit gene.2010
Author(s)
Susa T, Ishikawa A, Cai LY, Kato T, Matsumoto K, Kitahara K, Kurokawa R, Ono T, Kato Y.
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Journal Title
Biosci Rep.
Volume: 30
Pages: 51-58
Related Report
Peer Reviewed
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[Journal Article] Highly related LIM factors, LMOI,LMO3 and LM04, play different roles in the regulation of pituitary glycoprotein hormone common a subunit gene.2010
Author(s)
Susa T, Ishikawa A, Cai LY, Kato T, Matsumoto K, Kitahara K, Kurokawa R, Ono T, Kato Y
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Journal Title
Biosci Rep. 30
Pages: 51-58
Related Report
Peer Reviewed
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