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Structural analysis of zoonosis-related high-molecular protein aggregation by double electron-electron resonance (DEER) technique

Research Project

Project/Area Number 21380185
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionHokkaido University

Principal Investigator

INANAMI Osamu  北海道大学, 大学院・獣医学研究科, 教授 (10193559)

Co-Investigator(Kenkyū-buntansha) INABA Mustumi  北海道大学, 大学院・獣医学研究科, 教授 (00183179)
HORIUCHI Motohiro  北海道大学, 大学院・獣医学研究科, 教授 (30219216)
KUWABARA Mikinori  北海道大学, 大学院・獣医学研究科, 名誉教授 (10002081)
YAMAMORI Tohru  北海道大学, 大学院・獣医学研究科, 准教授 (00512675)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsプリオン / 構造生物学 / ESR分光法 / ニトロオキシドプローブ / 距離情報 / 部位特異的スピンラベル法 / 人獣共通感染症 / インフルエンサ / インフルエンザ
Research Abstract

In this study, to obtain the structural information for this pathological fibrous form of PrPs', we measured the intermolecular distance in the pathological fibrous form with D178N mutation by the site-directed spin labeling (SDSL) with continuous wave (CW) ESR (X-band) and pulsed ESR (Q-band). After the formation of the fibrous structure by exposure to 1M of guanidine hydrochloride in pH4.0, the ESR spectra were measured by CW-ESR. The interspin-distances in pathological fibrous form were measured by continuous wave ESR (CW-ESR) and the four-pulse double electron-electron resonance (DEER) technique. The information of intermolecular distances will be useful to estimate the pathogenic fibrous structure of the familial prion disease, since it is difficult to analyze the macromolecules such as the fibrous protein by NMR or X-ray crystallography.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (85 results)

All 2012 2011 2010 2009 Other

All Journal Article (27 results) (of which Peer Reviewed: 23 results) Presentation (54 results) Remarks (4 results)

  • [Journal Article] A nucleoside anticancer drug, 1-(3-C-ethynyl-Q-D-ribo-pentofuranosyl ) cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression2011

    • Author(s)
      Meike S., Yamamori T., Yasui H., Eitaki M., Matsuda A., Morimatsu M., Fukushima M., Yamasaki Y., and Inanami O.
    • Journal Title

      Molecular Cancer

      Volume: 10 Issue: 1 Pages: 92-92

    • DOI

      10.1186/1476-4598-10-92

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 8-Aminoadenosine Enhances Radiation-induced Cell Death in Human Lung Carcinoma A549 Cells2011

    • Author(s)
      Meike S., Yamamori T., Yasui H., Eitaki M., Matsuda A., and Inanami O
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Issue: 4 Pages: 456-463

    • DOI

      10.1269/jrr.10188

    • NAID

      10029122169

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial 2-integrin-related neutrophil dysfunction.2011

    • Author(s)
      Kobayashi S, Abe Y, Inanami 0, Oda S, Yamauchi K, Hankanga C, Yasuda J, Sato R.
    • Journal Title

      Veterinary Immunology and Immunopathology

      Volume: 143 Issue: 1-2 Pages: 155-161

    • DOI

      10.1016/j.vetimm.2011.05.027

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity2011

    • Author(s)
      Yamamori, T., Mizobata, A., Saito, Y., Urano, Y., Inanami, O., Irani, K. and Noguchi, N.
    • Journal Title

      Free Radical Research

      Volume: 45 Issue: 3 Pages: 342-350

    • DOI

      10.3109/10715762.2010.532496

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis.2011

    • Author(s)
      Yamanaka, K., Saito, Y., Yamamori, T., Urano, Y., Noguchi, N.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Issue: 28 Pages: 24666-24673

    • DOI

      10.1074/jbc.m111.236273

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of DNA repair enzyme AP endonuclease 1 by lifespan regulation-related protein Sirt1.2011

    • Author(s)
      Yamamori, T. and Irani, K.
    • Journal Title

      The Journal of the Hokkaido Veterinary Medical Association

      Volume: 55 Pages: 45-49

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulation of DNA repair enzyme AP endonuclease 1 by lifespanregulation-related protein Sirt12011

    • Author(s)
      Yamamori, T. and Irani, K.
    • Journal Title

      The Journal of the Hokkaido Veterinary Medical Association

      Volume: 55 Pages: 45-49

    • Related Report
      2011 Final Research Report
  • [Journal Article] 8-Amino-adenosine Enhances Radiation-induced Cell Deathin Human Lung Carcinoma A549 Cells2011

    • Author(s)
      Meike S
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicitY.2011

    • Author(s)
      Yamamori T
    • Journal Title

      Free Radical Research

      Volume: 45 Pages: 342-350

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SIRT1 deacetylates APE1 and regulates cellular base excision repair.2010

    • Author(s)
      Yamamori, T., DeRicco, J., Naqvi A, Hoffman TA., Mattagajasingh, I., Kasuno, K., Jung SB, Kim CS., and Irani, K.
    • Journal Title

      Nucleic Acids Research

      Volume: 38 Pages: 832-845

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease.2010

    • Author(s)
      Asanuma, T., Ono, M., kubota, K., Hirose, A., Hayashi, Y., Saibara, T., Inanami, O., Enzan, H., Onishi, S., Kuwabara, M., and Oben, JA.
    • Journal Title

      Gut

      Volume: 59 Pages: 258-266

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells.2010

    • Author(s)
      Yasui, H., Ito, N., Yamamori, T., Nakamura, H., Okano, J., Asanuma, T., Nakajima, T., Kuwabara, M. , and Inanami, O.
    • Journal Title

      Free Radical Research

      Volume: 44 Pages: 645-654

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein.2010

    • Author(s)
      Watanabe, Y., Hiraoka, W., Igarashi, M., Ito, K., Shimoyama, Y., Horiuchi, M., Yamamori, T., Yasui, H., Kuwabara, M., Inagaki, F., and Inanami, O.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 394 Pages: 522-528

    • NAID

      120002148672

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] New insight into hypoxia-targeting cancer therapy.2010

    • Author(s)
      Yasui, H., Yamamori. T., Meike, S., Eitaki, M., Iizuka, D., Kuwabara, M., and Inanami, O.
    • Journal Title

      Radiation Biology Research Communications

      Volume: 45 Pages: 45-57

    • Related Report
      2011 Final Research Report
  • [Journal Article] Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease.2010

    • Author(s)
      Asanuma T
    • Journal Title

      Gut.

      Volume: 59 Pages: 258-266

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathwav in PC12 cells.2010

    • Author(s)
      Yasui H
    • Journal Title

      Free Radical Research

      Volume: 44 Pages: 645-654

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein.2010

    • Author(s)
      Watanabe Y
    • Journal Title

      Biochemical and Biophysical Research Communications.

      Volume: 394 Pages: 522-528

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New insight into Hypoxia-targeting cancer therapy.2010

    • Author(s)
      Yasui H
    • Journal Title

      Radiation Biology Research communications (in japanese)

      Volume: 45 Pages: 45-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低酸素環境を標的とした癌治療の新たな展開2010

    • Author(s)
      安井博宣、山盛徹、女池俊介、永瀧正人、飯塚大輔、桑原幹典、稲波修
    • Journal Title

      Free Radic Res. 45

      Pages: 58-70

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation.2009

    • Author(s)
      Kobayashi S., Sato R., Abe Y., Inanami O., Yasui H., Omoe K., Yasuda J., Hankanga C., Oda S., and Sasaki J.
    • Journal Title

      Veterinary Immunology and Immunopathology.

      Volume: 130 Pages: 187-196

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Redox regulation in radiation-nduced cytochrome c release from mitochondria of human lung carcinoma A549 cells.2009

    • Author(s)
      Ogura A., Oowada S., Kon Y., Hirayama A., Yasui H., Meike S., Kobayashi S., Kuwabara M., and Inanami O.
    • Journal Title

      Cancer Letter

      Volume: 277(1) Pages: 64-71

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation.2009

    • Author(s)
      Kobayashi S, Sato R, Abe Y, Inanami 0, Yasui H, Omoe K, Yasuda J, Hankanga C, Oda S, Sasaki J.
    • Journal Title

      Veterinary Immunology and Imunopathology

      Volume: 130(3-4) Pages: 187-96

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.2009

    • Author(s)
      Ogura A, Oowada S, Kon Y, Hirayama A, Yasui H, Meike S, Kobayashi S, Kuwabara M, Inanami O.
    • Journal Title

      Cancer Lett. 277

      Pages: 64-71

    • NAID

      120001253404

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation.2009

    • Author(s)
      Kobayashi S, Sato R, Abe Y, Inanami O, Yasui H, Omoe K, Yasuda J, Hankanga C, Oda S, Sasaki J.
    • Journal Title

      Vet Immunol Immunopathol. 130

      Pages: 187-196

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease.2009

    • Author(s)
      Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T, Inanami O, Ogawa Y, Enzan H, Onishi S, Kuwabara M, Oben JA.
    • Journal Title

      Gut. 59

      Pages: 258-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein.2009

    • Author(s)
      Watanabe Y, Hiraoka W, Igarashi M, Ito K, Shimoyama Y, Horiuchi M, Yamamori T, Yasui H, Kuwabara M, Inagaki F, Inanami O.
    • Journal Title

      Biochem Biophys Res Commun. 394

      Pages: 522-528

    • NAID

      120002148672

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells.

    • Author(s)
      Yasui H, Ito N, Yamamori T, Nakamura H, Okano J, Asanuma T, Nakajima T, Kuwabara M, Inanami O.
    • Journal Title

      Free Radic Res. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Structual characterization in the mouse prion protein by site-directed spin-labeling and ESR technique2012

    • Author(s)
      稲波修
    • Organizer
      Advanced ESR Studies for New Frontiers in Biofunctional Spin Science and Technology
    • Place of Presentation
      神戸,神戸大瀧川メモリアルホール
    • Year and Date
      2012-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線誘導性再酸素化の動態と一酸化窒素の関与2012

    • Author(s)
      稲波修
    • Organizer
      アイソトープ放射線薬学研究会
    • Place of Presentation
      KKRホテル札幌(札幌)(招待講演)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射線誘導性再酸素化の動態と一酸化窒素の関与2012

    • Author(s)
      永根大幹、安井博宣、山盛徹、趙松吉、久下祐司、中村秀夫、稲波修
    • Organizer
      第14回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘(奈良)
    • Year and Date
      2012-02-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nitric oxide production associated with radiation-induced tumor reoxygenation2012

    • Author(s)
      Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Nakamura H, Inanami O
    • Organizer
      20^<th> Core-to-Core Seminar International Redox Core Symposium on In Vivo Magnetic Resonance Imaging
    • Place of Presentation
      西鉄グランドホテル(福岡)
    • Year and Date
      2012-02-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] DISTANCE MEASUREMENTS OF FIBROUS PRION PROTEINS BY SITE-DIRECTED SPIN LABELING(SDSL) AND ESR SPECTROSCOPY2012

    • Author(s)
      Inanami O, Furukawa K, Nakamura T, Yamamori T, Hiraoka W
    • Organizer
      20^<th> Core-to-Core Seminar International Redox Core Symposium on In Vivo Magnetic Resonance Imaging
    • Place of Presentation
      西鉄グランドホテル(福岡)(招待講演)
    • Year and Date
      2012-02-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Histological visualization of intermittent hypoxia and its influence on resistance in rat glioma2012

    • Author(s)
      Yasui H, Yamamori T, Matsumoto S, Krishna M, Inanami O
    • Organizer
      19^<th> JSPS Core-to-Core Seminar Winter School in Fukuoka
    • Place of Presentation
      九州大学Innovation Centrer for Medical Redox Navigation(福岡)
    • Year and Date
      2012-02-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Distance measurements of fibrous prion proteins by site-directed spin labeling(SDSL) and ESR spectrouscopy2012

    • Author(s)
      稲波修
    • Organizer
      20^<th> JSPS Coe-to-core Seminar Internatiional Redox Core Symposium on In Vivo Magnetic Resonance Imaging
    • Place of Presentation
      福岡,西鉄グランドホテル
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳室内移植グリオーマにおける間欠的低酸素の存在と放射線抵抗性への寄与2011

    • Author(s)
      安井博宣、新坊弦也、山盛徹、稲波修
    • Organizer
      第9回がんとハイポキシア研究会
    • Place of Presentation
      学習院大学目白キャンパス(東京)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 免疫組織化学と電子スピン共鳴法を用いた腫瘍における放射線照射後の再酸素化機構に関する研究2011

    • Author(s)
      永根大幹、安井博宣、山盛徹、中村秀夫、稲波修
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍組織に特徴的な間欠的低酸素のイメージングと放射線抵抗性への関与2011

    • Author(s)
      安井博宣、松元慎吾、新坊弦也、Krishna Murali、山盛徹、Mitchell James、稲波修
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射線誘導バイスタンター効果が細胞の浸潤能に与える影響2011

    • Author(s)
      永瀧正人、山盛徹、安井博宣、稲波修
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Methyl-pyruvateによるミトコンドリア機能の修飾と放射線増感効果2011

    • Author(s)
      西田直哉、安井博宣、山盛徹、稲波修
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小胞体ストレスがDNA損傷修復機構に及ぼす影響とそれを利用した放射線増感の可能性の検討2011

    • Author(s)
      女池俊介、山盛徹、安井博宣、稲波修
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射線により引き起こされるミトコンドリア由来ROS産生のメカニズム2011

    • Author(s)
      山盛徹、安井博宣、稲波修
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] X線照射によるアポトーシスはミトコンドリアが主体となりおこる2011

    • Author(s)
      馬嶋秀行、犬童寛子、稲波修、幸村知子、中川靖一、松本謙一郎、小澤俊彦
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structual characterization in the mouse prion protein by site-directed spin-labeling and ESR technique2011

    • Author(s)
      Inanami O, Yamamori T, Yasui H, Kuwabara M, Hiraoka W
    • Organizer
      Advanced ESR Studies for New Frontiers in Biofunctional Spin Science and Technology
    • Place of Presentation
      神戸大瀧川メモリアルホール(神戸)(招待講演)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] p66shcはHSP72との相互作用を介して細胞の放射線感受性を調節する2011

    • Author(s)
      山盛徹、松下明子、女池俊介、永瀧正人、安井博宣、稲波修
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビンクリスチンはGEF-H1/RhoA/ROCK/Myosin light chainシグナルを介してMKN45細胞のアメーバ様運動を促進する2011

    • Author(s)
      永瀧正人、山盛徹、女池俊介、安井博宣、稲波修
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核酸代謝拮抗剤TAS106による相同組換え修復阻害作用を介した放射線増感効果2011

    • Author(s)
      女池俊介、山盛徹、安井博宣、松田彰、森松正美、福島正和、山崎靖人、稲波修
    • Organizer
      第152回日本獣医学会学術集会学会
    • Place of Presentation
      大阪府大中百舌鳥キャンパス(大阪)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット脳腫瘍における間欠的低酸素の可視化と放射線感受性に与える影響2011

    • Author(s)
      安井博宣、新坊弦也、山盛徹、趙松吉、久下祐司、稲波修
    • Organizer
      第152回日本獣医学会学術集会学会
    • Place of Presentation
      大阪府大中百舌鳥キャンパス(大阪)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] p66shc CH2ドメインを介したタンパク質相互作用が細胞の放射線感受性に与える影響2011

    • Author(s)
      山盛徹、松下明子、女池俊介、永瀧正人、安井博宣、稲波修
    • Organizer
      第152回日本獣医学会学術集会学会
    • Place of Presentation
      大阪府大中百舌鳥キャンパス(大阪)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス扁平上皮癌SCCV II細胞におけるmethyl-pyruvateを用いた放射線増感効果とそのメカニズムの解析2011

    • Author(s)
      西田直哉、安井博宣、山盛徹、稲波修
    • Organizer
      第152回日本獣医学会学術集会学会
    • Place of Presentation
      大阪府大中百舌鳥キャンパス(大阪)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] インビボ電子スピン共鳴法を用いた放射線照射後の再酸素化機構に関する研究2011

    • Author(s)
      永根大幹、安井博宣、山盛徹、中村秀夫、稲波修
    • Organizer
      第152回日本獣医学会学術集会学会
    • Place of Presentation
      大阪府大中百舌鳥キャンパス(大阪)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Guanine nucleotide exchange factor-H1はMKN45細胞においてビンクリスチンによる浸潤能の促進を媒介する2011

    • Author(s)
      永瀧正人、山盛徹、女池俊介、安井博宣、稲波修
    • Organizer
      第152回日本獣医学会学術集会学会
    • Place of Presentation
      大阪府大中百舌鳥キャンパス(大阪)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Iozing radiation stimulates mitochondrial electron transport chainactivity and increases mitochondrial content2011

    • Author(s)
      Yamamori T, Yasui H, Yamazumi M, Nakamura Y, Nakamura H, Inanami O
    • Organizer
      5th Biennial Meeting of Society for Free Radical Research-Asia, 8th Conference of Asian Society for Mitochondrial Research and Medicine, 11th Conference of Japanese Society of Mitochondrial Research and Medicine
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel EPR imaging to visualize cycling hypoxia associated with a defect of vascular integrity in transplanted tumors2011

    • Author(s)
      Yasui H, Inanami O, Matsumoto S, J.B.Michell, M.C.Krishna
    • Organizer
      14th International Congress of Radiation Research Incorporating 57^<th> Annual Meeting of the Radiation Research Society
    • Place of Presentation
      Memorial to Maria Sklodowska-Curie(ワルシャワ)
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel EPR imaging to visualize cycling hypoxia associated with a defect of vascular integrity integrity in transplanted tumors.2011

    • Author(s)
      稲波修,安井博宣
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warsaw, Memorial to Maria Sklodowska-Curie
    • Year and Date
      2011-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] X線照射により引き起こされるミトコンドリア由来活性酸素種生成メカニズムの解析2011

    • Author(s)
      山盛徹、安井博宣、山住雅之、中村吉就、中村秀夫、桑原幹典、稲波修
    • Organizer
      第64回日本酸化ストレス学会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション(虻田郡留寿都村)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞周期との関連性からみたX線照射に起因する活性酸素種の遅発性産生機構2011

    • Author(s)
      安井博宣, 山盛徹, 和田悠佑, 山住雅之, 稲波修
    • Organizer
      第64回日本酸化ストレス学会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション(虻田郡留寿都村)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dichloroacetateを用いたがん細胞の代謝調節による放射線増感作用2011

    • Author(s)
      安井博宣, 西田直哉, 山盛徹, 稲波修
    • Organizer
      第17回国際癌治療増感研究会
    • Place of Presentation
      岩松旅館(仙台)
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 間欠的低酸素がラットグリオーマ細胞の放射線感受性に与える影響2011

    • Author(s)
      安井博宣、新坊弦也、山盛徹、趙松吉、久下祐司、稲波修
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘、京都
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ionizing radiation increased mitochondrial electrontrasnsport chain activity and mitochondrial content inhuman lung carcinoma A549 cells2011

    • Author(s)
      Tohoru Yamamori, Hironobu Yasui, Hideo Nakamura, Masayuki Yamazumi, Osamu Inanami
    • Organizer
      International Symposium on Free Radical Research
    • Place of Presentation
      Hyatt Regency Kyoto 京都
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線照射により誘導されるミトコンドリア由来活性酸素種生成上昇メカニズムの解析2010

    • Author(s)
      山盛徹、安井博宣、中村秀夫、山住雅之、稲波修
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線照射されたA549細胞における遅発性細胞内活性酸素種産生と細胞周期との関連性2010

    • Author(s)
      和田悠祐、山盛徹、安井博宣、山住雅之、稲波修
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 核酸代謝拮抗剤TAS106による相同組換え修復阻害作用を介した放射線増感効果2010

    • Author(s)
      女池俊介、山盛徹、安井博宣、松田彰、森松正美、福島正和、山崎靖人、稲波修
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 間欠的低酸素が腫瘍内の放射線抵抗性に与える影響2010

    • Author(s)
      新坊弦也、安井博宣、山盛徹、稲波修
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of a novel Cu (II) binding site in full-length murine prionprotein by using ESR/SDSL technique.2010

    • Author(s)
      O.Inanami, Y.Watanabe, M.Igarashi, K.Ito, T.Yamamori, Hyasui, W.Hiraoka
    • Organizer
      Asia-Pacific EPR/ESR Symposium2010
    • Place of Presentation
      International Convention Center、済州(韓国)
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高濃度VincristineはROCK経路活性化を介してアメーバ様浸潤を誘導する2010

    • Author(s)
      永瀧正人、山盛徹、稲波修
    • Organizer
      第150回日本獣医学会学術集会
    • Place of Presentation
      帯広畜産大学、帯広
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線照射後に遅れて起きる細胞内活性酸素種の増加反応2010

    • Author(s)
      稲波修、安井博宣、山住雅之、桑原幹典、山盛徹
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      神奈川県民ホール、横浜
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規抗癌剤と放射線併用によるG_2チェックポイントとアポトーシス誘導2010

    • Author(s)
      稲波修
    • Organizer
      第12回 癌治療増感研究シンポジウム 4つの"R"-現象論から分子メカニズムの解明へ-
    • Place of Presentation
      奈良
    • Year and Date
      2010-02-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Idenfication of a novel Cu (II) binding site in full-length murine prionprotein by using ESR/SDSL technique2010

    • Author(s)
      稲波修
    • Organizer
      Asia-Pacific EPR/ESR Symposium
    • Place of Presentation
      Jeju
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス扁平上皮がんSCC VII細胞におけるエネルギー代謝と放射線感受性2009

    • Author(s)
      西田直哉、山盛徹、安井博宣、稲波修
    • Organizer
      第52回 日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] X線照射はA549細胞においてミトコンドリア機能亢進と遅発性細胞内活性酸素種産生を誘導する2009

    • Author(s)
      山住雅之、山盛徹、稲波修
    • Organizer
      第52回 日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 金粒子含有ナノゲル存在下でのX線照射による細胞死の増強作用とその機序の解析2009

    • Author(s)
      武内亮、安井博宣、山盛徹、中村隆仁、大石基、長崎幸夫、稲波修
    • Organizer
      第52回 日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 8-Amino-adenosineによる放射線誘導細胞死の増感効果2009

    • Author(s)
      女池俊介、山盛徹、安井博信、松田彰、稲波修
    • Organizer
      第52回 日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト胃腺がん細胞MKN45における浸潤能と微小管重合状態の関連性2009

    • Author(s)
      永瀧正人、山盛徹、稲波修
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスプリオンタンパク質ヒスジン186周辺の銅イオン結合部位に関する構造解析2009

    • Author(s)
      稲波修、渡辺康子、五十嵐学、伊藤公人、堀内基広、桑原幹典、平岡和佳子
    • Organizer
      第148回 日本獣医学会学術集会
    • Place of Presentation
      鳥取
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] A549細胞における8-amino-adenosineと放射線の併用による抗腫瘍効果の検討2009

    • Author(s)
      女池俊介、山盛徹、安井博信、松田彰、稲波修
    • Organizer
      第148回 日本獣医学会学術集会
    • Place of Presentation
      鳥取
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腫瘍細胞における金粒子含有ナノゲルを用いた放射線増感作用2009

    • Author(s)
      武内亮、安井博宣、山盛徹、中村隆仁、大石基、長崎幸夫、稲波修
    • Organizer
      第48回 日本医学放射線学会生物部会学術大会
    • Place of Presentation
      富山
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヌクレオシド誘導体による放射線増感2009

    • Author(s)
      稲波修
    • Organizer
      第39回 放射線による制癌シンポジウム-基礎と臨床との対話-
    • Place of Presentation
      富山
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 制癌剤処理細胞における細胞内活性酸素種の増加と浸潤能力との関連性について2009

    • Author(s)
      永瀧正人、山盛徹、稲波修
    • Organizer
      第62回 日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放射線照射したA549細胞に見られる遅延性細胞内活性酸素種の上昇に関する研究2009

    • Author(s)
      山住雅之、山盛徹、稲波修
    • Organizer
      第62回 日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 経口吸着薬AST-120(クレメジン^<[○!R]>)は虚血性急性腎不全(ARF)ラット腎ミトコドリアからのフリーラジカル産生を抑制する2009

    • Author(s)
      大和田滋、平山暁、植田敦志、伊藤俊輔、後藤寿美恵、西島冬彦、稲波修
    • Organizer
      第62回 日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスプリオンタンパク質ヒスチジン186周辺の銅イオン結合部位に関する構造解析2009

    • Author(s)
      稲波修
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/radbiol/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/radbiol/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.ju/organization/radbiol/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/radbiol/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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