| Project/Area Number |
21380188
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied veterinary science
|
|---|
| Research Institution | Osaka Prefecture University |
|---|
Principal Investigator |
KOZAKI Syunji 大阪府立大学, 生命環境科学研究科, 教授 (10109895)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Tadayoshi 大阪府立大学, 生命環境科学研究科・獣医学専攻, 教授 (00171611)
MIYAKE Masami 大阪府立大学, 生命環境科学研究科・獣医学専攻, 教授 (10251175)
KATOH Keiko 京都産業大学, 総合生命科学部, 教授 (90252684)
NAKAJIMA Hidemitsu 大阪府立大学, 生命環境科学研究科・獣医学専攻, 准教授 (30405360)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
|---|
| Keywords | 疾病予防・制御 / 新規治療薬開発 / ボツリヌス菌 / C3酵素 / 脳神経疾患 / てんかん / パーキンソン病 / ボツリヌス毒素 / ポリグルタミン病 |
|---|
| Research Abstract |
To explore the possible clinical applications of botulinum neurotoxin to intractable brain disorders, we investigated whether or not the benefits of A2-botulinum neurotoxin(A2NTX) or cell-permeable C3 enzyme(Tat-C3) are exerted in several intractable brain disorders-model in rodents. Here we show the potent effectiveness of A2NTX against several types of seizer in mice or of 6-OHDA-elicited parkinsonian-like motor dysfunctions in rats. Additionally, preliminary study using brain ischemia indicates the neuroprotective effects in rats treated with Tat-C3.These results suggest that both A2NTX and Tat-C3 may indicate the beneficial possibility of medical treatments with intractable brain disorders such as epilepsy, Parkinson disease, and ischemic stroke.
|
