| Project/Area Number |
21380195
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
ARAI Toshiro 日本獣医生命科学大学, 獣医学部, 教授 (70184257)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIOKA Katsumi 日本獣医生命科学大学, 獣医学部, 准教授 (60409258)
YAMAMOTO Ichiro 日本獣医生命科学大学, 獣医学部, 講師 (00424763)
HASHIMOTO Haruo 実験動物中央研究所, 研究部, 研究員 (30353478)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 動物 / 肥満 / 糖尿病 / 遺伝子 / インスリン / 早期診断 |
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| Research Abstract |
Early diagnostic method for obesity and diabetes mellitus using insulin signaling gene was investigated in dogs and cats. Expression of insulin signaling genes, insulin receptor substrate(IRS)-1,-2 and phosphatidylinositol kinase(PI3K), decreased significantly at the early stage of obesity in dogs and cats. Changes in plasma cholesterol profiles and adiponectin concentrations and peripheral leukocytes adiponectin receptor(ADIPOR) gene expression were also significant in obese and diabetic animals. IRS-2, PI3K and ADIPOR mRNA expression and plasma cholesterol profiles and adiponectin concentrations appeared to be potential diagnostic markers for obesity and diabetes in dogs and cats.
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