Identification and analysis of epigenetic mechanisms involved in the maintenance of genome stability
| Project/Area Number |
21380204
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tohoku University |
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Principal Investigator |
HARATA Masahiko 東北大学, 大学院・農学研究科, 准教授 (70218642)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Kunihiro 東京大学, 総合文化研究科, 教授 (90211789)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | クロマチン / ゲノム安定性 / エピジェネティック / アクチン関連タンパク質 / ゲノム安定性維持 / クロマチンリモデリング複合体 / ゲノム安全性 / DNA複製 / 染色体 / 細胞核 |
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| Research Abstract |
In eukaryotic cells, the genome forms chromatin together with histones, and chromatin is packed into the nucleus in a highly organized manner. These chromatin and nuclear organizations are fundamentals of epigenetic regulation. The maintenance of genome stability is a subject of epigenetic regulation; however, molecular mechanisms involved in the genome stability are largely unknown yet. In this project, we showed that INO80chromatin remodeling complex and histone acetylation complexes play important and evolutionarily conserved roles in the maintenance of the genome stability.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei2012
Author(s)
Maruyama, E.O., Hori, T., Tanabe, H., Kitamura, H., Matsuda. R., Tone, S., Hozak, P., Habermann, F.A., von Hase, J., Cremer, C., Fukagawa, T., Harata, M
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Journal Title
J Cell Sci
Volume: 125
Pages: 3739-3743
Related Report
Peer Reviewed
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[Journal Article] Identification and characterization of two isoforms of the vertebrate H2A2010
Author(s)
Matsuda, R., Hori, T., Kitamura, H., Takeuchi, K., Fukagawa, T., Harata, M
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Journal Title
Z histone variant. Nucleic Acids Res
Volume: 38
Pages: 4263-4673
Related Report
Peer Reviewed
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[Journal Article] Actin-related protein Arp6 influences H2AZ-dependent and -independent gene expression and links ribosomalprotein genes to nuclear pores2010
Author(s)
Yoshida, T, Shimada, K., Oma, Y., Kalck, V., Akimura, K., Taddei, A., Iwahashi, H., Kugou, K., Ohta, K., Gasser, S.M., Harata, M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair Exp Cell2009
Author(s)
Kitayama, K., Kamo, M., Oma, Y., Matsuda, R., Uchida, T., Ikura, T., Tashiro, S., Ohyama, T., Winsor, B., Harata, M
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Journal Title
Related Report
Peer Reviewed
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