| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
In eukaryotic cells, the genome forms chromatin together with histones, and chromatin is packed into the nucleus in a highly organized manner. These chromatin and nuclear organizations are fundamentals of epigenetic regulation. The maintenance of genome stability is a subject of epigenetic regulation; however, molecular mechanisms involved in the genome stability are largely unknown yet. In this project, we showed that INO80chromatin remodeling complex and histone acetylation complexes play important and evolutionarily conserved roles in the maintenance of the genome stability.
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