Development of oxoammonium-salt-type catalysts for highly enantioselective oxidation of alcohols
| Project/Area Number |
21390001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBUYA Masatoshi 東北大学, 大学院・薬学研究科, 助教 (40359534)
福田 隼 東北大学, 大学院・薬学研究科, 助手 (30434450)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 有機触媒 / 酸化反応 / オキソアンモニウム塩 / ニトロキシド / 不斉反応 / アザアダマンタン / 不斉酸化 / アルコール酸化 / 不斉触媒 / 分子認識 / ニトロキシルラジカル |
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| Research Abstract |
We have developed organocatalytic highly enatiolselecitve oxidation of alcohols based on chiral modifications of 2-azaadamantane N-oxy (AZADO)-derived oxoammonium salts. The chiral AZADOs enabled a highly enantioselecitive kinetic oxidation of racemic secondary alcohols with a broad substrate applicability.
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Report
(4 results)
Research Products
(21 results)
