| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
Syntheses of several polycyclic and bioactive natural products have been studied. Unnatural (E)-ircinal B has been synthesized. A study will continue to synthesize natural (Z)-ircinal B, one of manzamine alkaloids. Total syntheses of lundurin A and B have been accomplished by two new synthetic routs. Evaluation anti-melanoma acitivity will be started using the synthesized lundrins. Reported structure of shizocommunin has been synthesized. However, spectral data of the product were not identical to ones reported. A quinazolon derivative has been synthesized and the structure was identical to natural syzocommunin.
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