• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The development of innovative asy mmetric synthetic methods by the enzyme-metal combo catalysis

Research Project

Project/Area Number 21390005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

AKAI Shuji  静岡県立大学, 薬学部, 教授 (60192457)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywords不斉合成 / 動的光学分割 / 加水分解酵素 / オキソバナジウム / アリルアルコール / メソポーラスシリカ / 転位反応 / 固定化触媒 / ベンジルアルコール / 複合触媒 / バナジウム化合物 / リパーゼ
Research Abstract

A new methodology for the conversion of racemic allyl alcohols into optically pure compounds was devised by the combined use of hydrolases and vanadium compounds. The results of this project present an innovative concept for the asymmetric synthesis of optically active compounds which is essential for the drug discovery research. It is noteworthy that in order to fulfill the original functions of the two highly reactive catalysts ; viz., enzymes and the oxovanadium compound, without mutual deactivation in a single reaction vessel, mesoporous silica was effectively employed to divide their work space.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (16 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] One-Pot Synthesis of Optically Active Allyl Esters via Lipase. Vanadium Combo Catalysis2010

    • Author(s)
      Akai, S.; Hanada, R.; Fujiwara, N.; Kita, Y.; Egi, M.
    • Journal Title

      Org. Lett

      Volume: 12 Issue: 21 Pages: 4900-4903

    • DOI

      10.1021/ol102053a

    • Related Report
      2011 Final Research Report
  • [Journal Article] One-Pot Synthesis of Optically Active Allyl Esters via Lipase-Vanadium Combo Catalysis2010

    • Author(s)
      赤井周司, 他
    • Journal Title

      Org.Lett.

      Volume: 12 Pages: 4900-4903

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 酵素と金属の協同作業:多触媒連続反応を志して2012

    • Author(s)
      赤井周司
    • Organizer
      日本薬学会東海支部特別講演会
    • Place of Presentation
      岐阜薬科大学
    • Year and Date
      2012-01-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 酵素と金属の協同作業:多触媒連続反応を志して2012

    • Author(s)
      赤井周司
    • Organizer
      日本薬学会東海支部特別講演会
    • Place of Presentation
      岐阜薬科大学(招待講演)
    • Year and Date
      2012-01-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規固定化触媒MPS-V/リパーゼ複合触媒を用いた動的光学分割2011

    • Author(s)
      杉山公二
    • Organizer
      第15回生体触媒化学シンポジウム
    • Place of Presentation
      慶応大学
    • Year and Date
      2011-12-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] バナジウム/リパーゼ複合触媒によるアリルアルコールの動的光学分割2011

    • Author(s)
      江木正浩, 杉山公二, 實藤盛朗, 花田良輔, 加藤勝也, 赤井周司
    • Organizer
      日本プロセス化学会2011ウィンターシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] バナジウム/リパーゼ複合触媒によるアリルアルコールの動的光学分割2011

    • Author(s)
      杉山公二
    • Organizer
      日本プロセス化学会2011ウィンターシンポジウム受賞講演
    • Place of Presentation
      東京大学(招待講演)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光学活性なビニルオキシランを鍵中間体とするimperaneneの全合成研究2011

    • Author(s)
      杉山公二, 江木正浩, 赤井周司
    • Organizer
      第41回複素環化学討論会
    • Place of Presentation
      熊本
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Asymmetric Synthesis of Allyl Esters via Vanadium. Lipase Combo Catalyzed Dynamic Kinetic Resolution2011

    • Author(s)
      江木正浩, 杉山公二, 實藤盛朗, 花田良輔, 加藤且也, 赤井周司
    • Organizer
      The 2nd International Symposium on Process Chemistry
    • Place of Presentation
      京都
    • Year and Date
      2011-08-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Asymmetric Synthesis of Allyl Esters via Vanadium-Lipase Combo Catalyzed Dynamic Kinetic Resolution2011

    • Author(s)
      杉山公二
    • Organizer
      The 2nd International Symposium on Process Chemistry
    • Place of Presentation
      京都市
    • Year and Date
      2011-08-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酵素とオキソメタルの協同作業:光学活性アリルエステルの新しい不斉合成法2011

    • Author(s)
      赤井周司
    • Organizer
      分離技術会年会2011「プロセス化学と分離技術」
    • Place of Presentation
      明治大学生田キャンパス
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 酵素とオキソメタルの協同作業:光学活性アリルエステルの新しい不斉合成法2011

    • Author(s)
      赤井周司
    • Organizer
      分離技術会年会2011「プロセス化学と分離技術」基調講演
    • Place of Presentation
      明治大学生田キャンパス(招待講演)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dynamic kinetic resolution of allyl alcohols by the combined use of lipase and vanadium catalysts : Application to various substrates2010

    • Author(s)
      花田良輔, 藤原登, 江木正浩, 赤井周司
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynamic kinetic resolution of allyl alcohols by the combined use of lipase and vanadium catalysts : Application to various substrates2010

    • Author(s)
      赤井周司, 他
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      米国ホノルル市
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] リパーゼ/バナジウム複合触媒を用いたアルケニルクロロヒドリンの動的光学分割2010

    • Author(s)
      赤井周司, 他
    • Organizer
      第14回生体触媒化学シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lipase-Vanadium Combo Catalysis : Dynamic Kinetic Resolution of Racemic Allyl Alcohols2010

    • Author(s)
      赤井周司
    • Organizer
      BIT's Inaugural Symposium on Enzymes & Biocatalysis
    • Place of Presentation
      中華人民共和国上海市
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 酵素-金属複合触媒反応系の創製:多段階ワンポット合成2010

    • Author(s)
      赤井周司
    • Organizer
      日本薬学会第130年会一般シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 酵素-金属複合触媒反応系の創製:多段階ワンポット合成2010

    • Author(s)
      赤井周司
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山市、岡山大学
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://w3pharm.u-shizuoka-ken.ac.jp/lsocus/

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] オキソバナジウム触媒とその製造方法ならびに光学活性エステルの製造方法2011

    • Inventor(s)
      赤井周司,江木正浩,加藤且也
    • Industrial Property Rights Holder
      静岡県立大学法人,独立行政法人産業技術総合研究所
    • Industrial Property Number
      2011-175401
    • Filing Date
      2011-08-10
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] オキソバナジウム触媒とその製造方法ならびに光学活性エステルの製造方法2011

    • Inventor(s)
      赤井周司, 江木正浩, 加藤且也
    • Industrial Property Rights Holder
      静岡県立大学法人,独立行政法人産業技術総合研究所
    • Industrial Property Number
      2011-175401
    • Filing Date
      2011-08-10
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] オキソバナジウム触媒とその製造方法ならびに光学活性アリルエステルの製造方法2010

    • Inventor(s)
      赤井周司,江木正浩,加藤且也
    • Industrial Property Rights Holder
      静岡県立大学法人,独立行政法人産業技術総合研究所
    • Industrial Property Number
      2010-233965
    • Filing Date
      2010-10-18
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi