Natural Language Processing-Based Comprehensive Data Analysis for Interaction Between Chemicals and Drug Metabolism Network
| Project/Area Number |
21390008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Takayuki お茶の水女子大学, 大学院・人間文化創成科学研究科, 准教授 (80401595)
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| Co-Investigator(Renkei-kenkyūsha) |
FENG Chunlai 京都大学, 大学院・薬学研究科, 教務補佐員 (40456835)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 薬物代謝 / 薬物間相互作用 / 自然言語処理 / テキストマイニング / 構造活性相関 / 自然言語解析 / インシリコ予測 / ネットワーク解析 / 薬物相互作用 |
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| Research Abstract |
Drug metabolism is closely related to efficacy and safety of drugs, of which inhibition or induction is involved in drug-drug interaction following administration of multiple drugs. In order to predict drug-drug interactions, it is required to comprehensively understand not only interaction of chemicals with individual drug-metabolizing enzymes but that with a network system regulating expression and activity of the enzymes. In the present study, we developed a natural language processing-based text-mining technique for systematically collecting information on interaction between chemicals and a drug metabolism-related network. In addition, based on the information collected, we systematically performed structure-activity relationship analyses. These results will present a clue to drug design and discovery intended for development of safer drugs.
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Report
(4 results)
Research Products
(20 results)
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[Presentation] Techniques for ADME Screening2011
Author(s)
Fumiyoshi Yamashita, Data Mining and Visualization
Organizer
Spring International Convention of The Pharmaceutical Society of Korea
Place of Presentation
Busan Exhibition and Convention Center(Busan)
Year and Date
2011-04-22
Related Report
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[Presentation] Techniques for ADME Screening2010
Author(s)
Fumiyoshi Yamashita, Data Mining and Visualization
Organizer
FIP Pharmaceutical Sciences World Congress
Place of Presentation
The Ernest N. Morial Convention Center(New Orleans)
Year and Date
2010-11-17
Related Report
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