| Project/Area Number |
21390011
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Gifu Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
戸塚 裕一 岐阜薬科大学, 薬学部, 准教授 (50312963)
原 英彰 岐阜薬科大学, 薬学部, 教授 (20381717)
田原 耕平 岐阜薬科大学, 薬学部, 助教 (30454325)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WERLE Martin Syngenta Crop Protection, Strategy Manager, PhD
SRIAMORNSAK Pornsak Silpakorn University, Associate Professor
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
|---|
| Keywords | 製剤学 / リポソーム / 局所体内挙動 / 網膜 / 点眼剤 / 微粒子 / リモートローディング / 経肺投与 / 抗炎症薬 / ステロイド / ペプチド |
|---|
| Research Abstract |
The purpose of this research project is development of noninvasive drug delivery systems to promote drug delivery in several administration routes. Two administration routes are targeted in this study ; One is ophthalmic delivery system to treat the diseases in posterior part of the eye and another is pulmonary system for both topical and systemic drug delivery for poorly absorbable drug such as a peptide drug. We succeeded in design of optimum particulate design of ocular delivery liposomal system and demonstrated its positive pharmacological effects on damage in retina with the liposomal eye drops. The effects are much improved by surface modification of the liposomal particles with suitable polymers. In pulmonary drug delivery, surface modification with polymers could control the retention of the carrier particles after administration. By using this liposomal system, a prolonged pharmacological effect of the peptide drug was observed in animal experiments. These results can strongly support to develop non-invasive drug delivery systems as an alternative to the former invasive drug administration such as an injection.
|
