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Development of Bioseparation Systems utilizing Environmentally Responsive Nano-interface Controlled Technology

Research Project

Project/Area Number 21390012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionKeio University

Principal Investigator

KANAZAWA Hideko  慶應義塾大学, 薬学部, 教授 (10240996)

Co-Investigator(Kenkyū-buntansha) NISHIO Tadashi  慶應義塾大学, 薬学部, 助教 (80401892)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords高分子合成 / ナノ材料 / 環境対応 / 生体分子
Research Abstract

We have been developed a novel bioseparation systems, based on environmentally responsive nano-interface controlled technology. We designed environmentally responsive copolymer with N-isopropylacrylamide and various monomers. These polymers responded to external stimuli. Our system is possible to separate the analytes by using only an aqueous solution. These separation systems could provide highly useful for bioactive molecules such as steroids, amino acids and peptides separation. We achieved the bed-side monitoring of pharmaceutical anesthetic agent in operation room. Analysis without organic solvent is advantageous from the point of view of patient safety and environmental reason.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (101 results)

All 2012 2011 2010 2009

All Journal Article (40 results) (of which Peer Reviewed: 40 results) Presentation (57 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques(Macaca fuscata fuscata)2012

    • Author(s)
      Takako Miyabe-Nishiwaki, Tadashi Nishio, Hideko Kanazawa, et al.
    • Journal Title

      Journal of Veterinary Pharmacology and Therapeutics

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High Stability of Thermoresponsive Polymer-Brush-Grafted Silica Beads as Chromatography Matrices2012

    • Author(s)
      Kenichi Nagase, Hideko Kanazawa, Teruo Okano, et al.
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 4(4) Issue: 4 Pages: 1998-2008

    • DOI

      10.1021/am201832b

    • NAID

      120005262993

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of polymer containing a naphthyl-alanine derivative on the separation selectivity for aromatic compounds in temperature-responsive chromatography2012

    • Author(s)
      Tadashi Nishio, Akari Nojima, Hideko Kanazawa, et al.
    • Journal Title

      J. Chromatogr. A

      Volume: 1228 Pages: 148

    • DOI

      10.1016/j.chroma.2011.07.047

    • URL

      https://pure.teikyo.jp/en/publications/06803ff1-2c01-4868-9443-a55ae019ddeb

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temperature-responsive Chromatography for the Separation of Biomolecules2011

    • Author(s)
      Hideko Kanazawa, Teruo Okano
    • Journal Title

      J. Chromatogr. A

      Volume: 1218 Issue: 49 Pages: 8738-8747

    • DOI

      10.1016/j.chroma.2011.04.015

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of reaction solvent on the preparation of thermoresponsive stationary phase through a surface initiated atom transfer radical polymerization2011

    • Author(s)
      Kenichi Nagase, Aya Mizutani Akimoto, Hideko Kanazawa, et al.
    • Journal Title

      J Chromatography A

      Volume: 1218 Issue: 48 Pages: 8617-8628

    • DOI

      10.1016/j.chroma.2011.09.082

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Poly(N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake2011

    • Author(s)
      Eri ayano, Miyuki Karaki, Tsutomu Ishihara, Hideko Kanazawa, Teruo Okano
    • Journal Title

      Colloids and Surfaces B : Biointerfaces

      Volume: (in press) Pages: 67-73

    • DOI

      10.1016/j.colsurfb.2011.10.003

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermoresponsive Polymer Brush on Monolithic-Silica-Rod for the High-Speed Separation of Bioactive Compounds2011

    • Author(s)
      Kenichi Nagase, Jun Kobayashi, Hideko Kanazawa, et al.
    • Journal Title

      Langmuir

      Volume: 27(17) Issue: 17 Pages: 10830-9

    • DOI

      10.1021/la201360p

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of the postmortem duration of mouse tissue by electron spin resonance spectroscopy2011

    • Author(s)
      Shinobu Ito, Tomohisa Mori, Hideko Kanazawa, Toshiko Sawaguchi
    • Journal Title

      Journal of Toxicology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reaction monitoring of tocopherols with active nitrogen oxides by ultra high-speed liquid chromatography2011

    • Author(s)
      Yoshiko Nagata, Tadashi Nishio, Hideko Kanazawa
    • Journal Title

      Journal of Pharmaceutical and Biomedical Analysis

      Volume: 55 Issue: 2 Pages: 241

    • DOI

      10.1016/j.jpba.2010.12.036

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface2011

    • Author(s)
      K.Nagase, S.F.Yuk, J.Kobayashi, A.Kikuchi, Y.Akiyama, H.Kanazawa, T.Okano
    • Journal Title

      JOURNAL OF MATERIALS CHEMISTRY

      Volume: 21 Issue: 8 Pages: 2590-2593

    • DOI

      10.1039/c0jm03453c

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermally-modulated on/off-adsorption materials for pharmaceutical protein purification2011

    • Author(s)
      Kenichi Nagase, Hideko Kanazawa, Teruo Okano, et al.
    • Journal Title

      Biomaterials

      Volume: 32 Issue: 2 Pages: 619-627

    • DOI

      10.1016/j.biomaterials.2010.09.012

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Separation of phosphorylated peptides utilizing dual pH- and temperature-responsive chromatography2011

    • Author(s)
      Tadashi Nishio, Eri Ayano, Yusuke Suzuki, Hideko Kanazawa, Teruo Okano
    • Journal Title

      J. Chromatogr. A

      Volume: 1218 Issue: 15 Pages: 2079

    • DOI

      10.1016/j.chroma.2010.10.076

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] LC-MS/MSによる畜水産物中のメトリブジンおよび代謝物の分析2011

    • Author(s)
      Shigemi Kai, Takeshi Akaboshi, Masumi Waki, Teruhisa Fuzimaki, Hideko Kanazawa
    • Journal Title

      食品衛生学雑誌

      Volume: 52(1) Pages: 28-33

    • NAID

      130000671808

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of the postmortem duration of mouse tissue by electron spin resonance spectroscopy2011

    • Author(s)
      S.Ito, T.Mori, H.Kanazawa, T.Sawaguchi
    • Journal Title

      Journal of Toxicology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Separation of phosphorylated peptides utilizing dual pH-and temperature-responsive chromatography.2011

    • Author(s)
      Tadashi Nishio
    • Journal Title

      J.Chromatogr.A

      Volume: 1218 Pages: 2079-2084

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermally-modulated on/off-adsorption materials for pharmaceutical protein purification.2011

    • Author(s)
      Kenichi Nagase
    • Journal Title

      Biomaterials

      Volume: 32 Pages: 619-627

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of thermo-responsive polymer brushes on hydrophilic polymeric beads by surface-initiated atom transfer radical polymerization for a highly resolutive separation of peptides2010

    • Author(s)
      A. Mizutani, K. Nagase, A. Kikuchi, H. Kanazawa, Y. Akiyama, J. Kobayashi, M. Annaka, T. Okano
    • Journal Title

      J. Chromatogr. A

      Volume: 1217(38) Issue: 38 Pages: 5978-5985

    • DOI

      10.1016/j.chroma.2010.07.067

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermoresponsive polymer brush surfaces with hydrophobic groups for all-aqueous chromatography2010

    • Author(s)
      Kenichi Nagase, Mio Kumazaki, Hideko Kanazawa, et al.
    • Journal Title

      ACS Appl Mater Interfaces.

      Volume: 2(4) Issue: 4 Pages: 1247-53

    • DOI

      10.1021/am100122h

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydration of Poly(Nisopropylacrylamide) Brushes on Micro-silica Beads Measured by a Fluorescent Probe2010

    • Author(s)
      Yusuke Hattori, Hideko Kanazawa, Teruo Okano, et al.
    • Journal Title

      Chemical Physics Letters

      Volume: 491 Issue: 4-6 Pages: 193-198

    • DOI

      10.1016/j.cplett.2010.03.082

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effective separation of peptides using highly dense thermo-responsive polymer brush-grafted porous polystyrene beads2010

    • Author(s)
      A. Mizutani, K. Nagase, A. Kikuchi, H. Kanazawa, Y. Akiyama, J. Kobayashi, M. Annaka, T. Okano
    • Journal Title

      J. Chromatogr. B. Anal. Technol. In Biomed. Life Sci

      Volume: 878(24) Issue: 24 Pages: 2191-2198

    • DOI

      10.1016/j.jchromb.2010.06.026

    • NAID

      10028040122

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermo-responsive polymer brush-grafted porous polystyrene beads for all-aqueous chromatography2010

    • Author(s)
      A. Mizutani, K. Nagase, A. Kikuchi, H. Kanazawa, Y. Akiyama, J. Kobayashi, M. Annaka, T. Okano
    • Journal Title

      J. Chromatogr. A

      Volume: 1217 Issue: 4 Pages: 522-529

    • DOI

      10.1016/j.chroma.2009.11.073

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Thermoresponsive Anionic Copolymer Brush Surfaces for Separating Basic Biomolecules2010

    • Author(s)
      Kenichi Nagase, Hideko Kanazawa, Teruo Okano, et al.
    • Journal Title

      Biomacromolecules

      Volume: 11(1) Issue: 1 Pages: 215-223

    • DOI

      10.1021/bm9010744

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anesthetic effects and pharmacokinetics of a single slow bolus dose of propofol in Japanese macaques(Macaca fsucata fsucata)2010

    • Author(s)
      Takako Miyabe-Nishiwaki, Hideko Kanazawa, et al.
    • Journal Title

      Veterinary Anaesthesia and Analgesia

      Volume: 37 Issue: 6 Pages: 501-510

    • DOI

      10.1111/j.1467-2995.2010.00564.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多機能性ポリマーを用いる環境低負荷型クロマトグラフィーシステムの開発2010

    • Author(s)
      西尾忠, 金澤秀子
    • Journal Title

      分析化学(BUNSEKI KAGAKU)

      Volume: 59(3) Pages: 163-173

    • NAID

      10025981132

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermo-responsive polymer brush-grafted porous polystyrene beads for all-aqueous chromatography.2010

    • Author(s)
      Aya Mizutani
    • Journal Title

      J.Chromatogr.A

      Volume: 1217 Pages: 522-529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective separation of peptides using highly dense thermo-responsive polymer brush-grafted porous polystyrene beads.2010

    • Author(s)
      Aya Mizutani
    • Journal Title

      J.Chromatogr.B

      Volume: 878 Pages: 2191-2198

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydration of Poly(N-isopropylacrylamide) Brushes on Micro-silica Beads Measured by a Fluorescent Probe.2010

    • Author(s)
      Yusuke Hattori
    • Journal Title

      Chemical Physics Letters

      Volume: 491 Pages: 193-198

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermoresponsive polymer brush surfaces with hydrophobic groups for all-aqueous chromatography.2010

    • Author(s)
      Kenichi Nagase
    • Journal Title

      ACS Appl Mater Interfaces

      Volume: 2 Pages: 1247-53

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of thermo-responsive polymer brushes on hydrophilic polymeric beads by surface-initiated atom transfer radical polymerization for a highly resolutive separation of peptides.2010

    • Author(s)
      Aya Mizutani
    • Journal Title

      J.Chromatogr.A

      Volume: 1217 Pages: 5978-5985

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多機能性ポリマーを用いる環境低負荷型クロマトグラフィーシステムの開発2010

    • Author(s)
      西尾忠
    • Journal Title

      分析化学 59(3)

      Pages: 163-173

    • NAID

      10025981132

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermo-responsive polymer brush-grafted porous polystyrene beads for all-aqueous chromatography.2010

    • Author(s)
      Aya Mizutani
    • Journal Title

      Journal of Chromatography A 1217

      Pages: 522-529

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual Temperature- and pH-Responsive Fluorescence Molecular Probe for Cellular Imaging Utilizing a PNIPAAm-Fluorescein Copolymer2009

    • Author(s)
      Hiroki Kobayashi, Mayumi Nishikawa, Chikako Sakamoto, Tadashi Nishio, Hideko Kanazawa, Teruo Okano
    • Journal Title

      Analytical Sciences

      Volume: 25 Issue: 8 Pages: 1043-1047

    • DOI

      10.2116/analsci.25.1043

    • NAID

      10025214255

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aqueous chromatographic system for the quantification of propofol in biological fluids using a temperature-responsive polymer modified stationary phase2009

    • Author(s)
      Tadashi Nishio, Rie Suzuki, Yuko Tsukada, Hideko Kanazawa, Teruo Okano, Takako Miyabe-Nishiwaki
    • Journal Title

      J. Chromatogr. A

      Volume: 1216 Issue: 44 Pages: 7427

    • DOI

      10.1016/j.chroma.2009.04.047

    • URL

      https://pure.teikyo.jp/en/publications/d89cc90d-bab6-42e2-a6c2-ffe62c00a3f6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness2009

    • Author(s)
      Tsutomu Ishihara, Hideko Kanazawa, et al.
    • Journal Title

      Int J Pharm.

      Volume: 375(1-2) Issue: 1-2 Pages: 148-154

    • DOI

      10.1016/j.ijpharm.2009.04.001

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides2009

    • Author(s)
      Tsutomu Ishihara, Hideko Kanazawa, et al.
    • Journal Title

      Drug Delivery

      Volume: 16(3) Issue: 3 Pages: 153-159

    • DOI

      10.1080/10717540902722774

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles2009

    • Author(s)
      Tsutomu Ishihara, Maoko Goto, Hideko Kanazawa, Megumu Higaki, Yutaka Mizushima
    • Journal Title

      J. Pharm. Sci

      Volume: 98(7) Issue: 7 Pages: 2357-2363

    • DOI

      10.1002/jps.21605

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Novel Thermally Responsible Separation Systems using Functional Polymers2009

    • Author(s)
      Hideko Kanazawa
    • Journal Title

      Chromatography

      Volume: 30(1) Pages: 1-9

    • NAID

      10029230781

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aqueous chromatographic system for the quantification of propofol in biological fluids using a temperature-responsive polymer modified stationary phase.2009

    • Author(s)
      西尾忠
    • Journal Title

      Journal of Chromatography A 1216

      Pages: 7427-7432

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual Temperature- and pH-Responsive Fluorescence Molecular Probe for Cellular Imaging utilizing a PNIPAAm-Fluorescein Copolymer.2009

    • Author(s)
      Hiroki Kobayashi
    • Journal Title

      Analytical Sciences 25

      Pages: 1043-1047

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Thermoresponsive Anionic Copolymer Brush Surfaces for Separating Basic Biomolecules.2009

    • Author(s)
      Kenichi Nagase
    • Journal Title

      Biomacromolecules 11

      Pages: 215-223

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] カチオン型高分子を用いた温度応答性クロマトグラフィーによる生体関連物質の分析2012

    • Author(s)
      小坂佳裕, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水系移動相で行う新規固相抽出カラムの開発2012

    • Author(s)
      山本忠平, 近藤賢治, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 誘導体化LC-MSによる温度応答性クロマトグラフィー分析の高感度化2012

    • Author(s)
      西尾忠, 松浦みなみ, 金澤秀子, 岡野光夫
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] Green Chromatography-An Environmentally Friendly HPLC system utilizing Temperature-responsive Polymer modified Stationary Phase-2011

    • Author(s)
      H. Kanazawa
    • Organizer
      The 37th International Symposium on High-Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Dalian, China
    • Year and Date
      2011-10-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Green Chromatography-An Environmentally Friendly HPLC system utilizing Temperature-responsive Polymer modified Stationary Phase-2011

    • Author(s)
      H.Kanazawa
    • Organizer
      36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Dalian, China(Invited lecture)
    • Year and Date
      2011-10-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] ソフト界面の動的特性を活かした分析化学2011

    • Author(s)
      金澤秀子
    • Organizer
      日本分析化学会第60年会特別シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature-Responsive Chromatography utilizing Amino-Acid Based Functional Copolymer2011

    • Author(s)
      T. Nishio, H. Kanazawa, et al.
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Aqueous Chromatographic System Utilizing Dual Temperature and pH-Responsive Polymer2011

    • Author(s)
      H. Kanazawa, T. Nishio, et al.
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Preparation of Novel Solid-Phase Extraction Cartridge utilizing Temperature-Responsive Polymer2011

    • Author(s)
      T. Nishio, H. Kanazawa, et al.
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Thermoresponsive Polymer Brush Modified Monolithic Silica for Separating Bioactive Compounds2011

    • Author(s)
      K. Nagase, H. Kanazawa, et al.
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of Novel Temperature-Responsive Chromatographic Stationary Phase with Tunable the Aromatic Selectivity2011

    • Author(s)
      A. Nojima, T. Nishio, H. Kanazawa, et al.
    • Organizer
      36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] The Synthesis and Design of Temperature-responsive Polymer for Aqueous and Green Chromatography2011

    • Author(s)
      M. Shimamura, T. Nishio, H. Kanazawa, et al.
    • Organizer
      36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 芳香族アミノ酸を導入した機能性ポリマーによる温度応答性クロマトグラフィー2011

    • Author(s)
      西尾忠, 金澤秀子, 他4名
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature-Responsive Chromatography utilizing Amino-Acid Based Functional Copolymer2011

    • Author(s)
      T.Nishio, R.Kanazashi, H.Kanazawa, T.Okano
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Aqueous Chromatographic System Utilizing Dual Temperatvire and pH-Responsive Polymer2011

    • Author(s)
      H.Kanazawa, E.Ayano, T.Nishio, T.Okano
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Preparation of Novel Solid-Phase Extraction Cartridge utilizing Temperature-Responsive Polymer2011

    • Author(s)
      C.Yamamoto, K.Kondo, T.Nishio, H.Kanazawa, T.Okano
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thermoresponsive Polymer Brush Modified Monolithic Silica for Separating Bioactive Compounds2011

    • Author(s)
      K.Nagase, J.Kobayashi, A.Kikuchi, Y.Akiyama, H.Kanazawa, T.Okano
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 芳香族アミノ酸含有ポリマーを用いる温度応答性クロマトグラフィー2011

    • Author(s)
      西尾忠, 金刺良祐, 金澤秀子, 岡野光夫
    • Organizer
      第18回クロマトグラフィーシンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 機能性高分子を用いる温度制御型固相抽出カラムの開発2011

    • Author(s)
      山本忠平, 近藤賢治, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      第18回クロマトグラフィーシンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 機能性高分子修飾充填剤を用いた温度?pH応答性クロマトグラフィーシステム2011

    • Author(s)
      小坂佳裕, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      第18回クロマトグラフィーシンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel Chromatographic System Utilizing Temperature-Responsive Polymer Containing Aromatic Amino Acids2011

    • Author(s)
      T.Nishio, R.Kanazashi, H.Kanazawa, K.Nagase, T.Okano
    • Organizer
      36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stability and Quality Evaluation of Pharmaceuticals using Ultra High-speed Liquid Chromatography2011

    • Author(s)
      H.Kanazawa, Y.Nagata
    • Organizer
      36th International Symposium on High-Performance liquid Phase Separations and Related Techniques
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2011 Annual Research Report
  • [Presentation] ソフト界面の動的特性を活かした分析化学2011

    • Author(s)
      金澤秀子
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温度応答性高分子を用いた水系移動相による新規固相抽出法の開発2011

    • Author(s)
      山本忠平, 近藤賢治, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 荷電性置換基を導入した温度応答性ポリマーによる高速液体クロマトグラフィーシステム2011

    • Author(s)
      小坂佳裕, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] アミノ酸誘導体ポリマーの分子間相互作用を利用する温度応答性クロマトグラフィー2011

    • Author(s)
      西尾忠, 金剌良祐, 金澤秀子, 岡野光夫
    • Organizer
      第22回クロマトグラフィー科学会議
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水系移動相のみで行う新規固相抽出カラムの開発2011

    • Author(s)
      山本忠平, 近藤賢治, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      第22回クロマトグラフィー科学会議
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温度-pH応答性クロマトグラフィーシステムを用いたリン酸化合物の分離2011

    • Author(s)
      小坂佳裕, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      第22回クロマトグラフィー科学会議
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] アミノ酸誘導体ポリマーを用いた温度応答性クロマトグラフィーシステムの開発2010

    • Author(s)
      金刺良祐
    • Organizer
      第21回クロマトグラフィー科学会議
    • Place of Presentation
      西宮
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 環境応答性高分子を用いる新規前処理カラムの開発2010

    • Author(s)
      近藤賢治
    • Organizer
      第21回クロマトグラフィー科学会議
    • Place of Presentation
      西宮
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 環境負荷を低減するグリーンクロマトグラフィーシステムの開発2010

    • Author(s)
      金澤秀子
    • Organizer
      新潟大学理学部化学科講演会
    • Place of Presentation
      新潟
    • Year and Date
      2010-07-28
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 環境負荷を低減するグリーンクロマトグラフィーシステムの開発2010

    • Author(s)
      金澤秀子
    • Organizer
      慶應義塾「地球環境に優しい科学技術」シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-07-08
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Development of a Novel Pretreatment Column Utilizing Temperature-Responsive Polymer for Maintaining Bioactivity of the Analytes.2010

    • Author(s)
      Kenji Kondo
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC2010)
    • Place of Presentation
      Boston, USA
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temperature-Responsive Chromatography Utilizing Amino-Acid Based Polymers.2010

    • Author(s)
      Ryosuke Kanazashi
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC2010)
    • Place of Presentation
      Boston, USA
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dual Temperature and pH-Responsive Chromatography Utilizing Functional Polymer.2010

    • Author(s)
      Hideko Kanazawa
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC2010)
    • Place of Presentation
      Boston, USA
    • Year and Date
      2010-06-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] アミノ酸誘導体高分子修飾による機能性表面を用いた分離システムとDDSの開発2010

    • Author(s)
      石川真
    • Organizer
      第19回ライフサポート学会フロンティア講演会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dual Temperature and pH-Responsive Chromatography Utilizing Functional Polymer2010

    • Author(s)
      H. Kanazawa, T. Nishio, E. Ayano
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques(HPLC2010)
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of a Novel Pretreatment Column Utilizing Temperature-Responsive Polymer for Maintaining Bioactivity of the Analytes2010

    • Author(s)
      K. Kondo, T. Nishio, H. Kanazawa
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques(HPLC2010)
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature-Responsive Chromatography Utilizing Amino-Acid Based Polymers2010

    • Author(s)
      R. Kanazashi, T. Nishio, H. Kanazawa, et al.
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques(HPLC2010)
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel Aqueous Chromatographic System for Quantification of Pharmaceutical Compounds using Temperature-Responsive Polymers as the Stationary Phase2010

    • Author(s)
      T. Nishio, Y. Ueda, H. Kanazawa
    • Organizer
      35th International Symposium on High Performance Liquid Phase Separations and Related Techniques(HPLC2010)
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 芳香族アミノ酸誘導体修飾カラムを用いた温度応答性クロマトグラフィー2010

    • Author(s)
      金刺良祐, 西尾忠, 金澤秀子, 他7名
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 機能性ポリマーを用いた環境応答型蛍光プローブの開発2010

    • Author(s)
      西尾忠, 小林浩規, 金澤秀子, 岡野光夫
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] アミノ酸誘導体高分子を用いた分子認識型温度応答性クロマトグラフィーシステムの開発2010

    • Author(s)
      金刺良祐, 西尾忠, 金澤秀子, 他5名
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      仙台
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 温度制御を用いた試料吸脱着法による新規固相抽出法の確立2010

    • Author(s)
      近藤賢治, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      仙台
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 温度応答性ポリマーを用いた水系クロマトグラフィーによる麻酔薬プロポフォールの血中濃度測定2010

    • Author(s)
      西尾忠
    • Organizer
      第20回生物試料分析科学会年次学術集会
    • Place of Presentation
      北里大(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 温度で薬物の放出を制御できるナノ粒子DDS2009

    • Author(s)
      金澤秀子
    • Organizer
      社団法人高分子学会高分子同友会勉強会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 環境応答型ナノ界面制御技術を応用したクロマトグラフィーシステム2009

    • Author(s)
      金澤秀子
    • Organizer
      第220回液体クロマトグラフィー研究懇談会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-14
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] アミノ酸誘導体を用いた機能性高分子による温度制御型クロマトグラフィーシステム2009

    • Author(s)
      石川真, 西尾忠, 金澤秀子, 他7名
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 機能性高分子を用いた環境応答型新規蛍光プローブの基礎研究2009

    • Author(s)
      小林浩規, 西尾忠, 金澤秀子, 岡野光夫
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature-dependent drug release utilizing functional polymer introduced liposome2009

    • Author(s)
      C. Sakamoto, H. Kanazawa, et al.
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Fukuoka
    • Related Report
      2011 Final Research Report
  • [Presentation] Thermoresponsive Anionic Copolymer Brush Surfaces for Adsorption Chromatography2009

    • Author(s)
      Kenichi Nagase
    • Organizer
      8th International Symposium on Frontiers in Biomedical Polymers
    • Place of Presentation
      Mishima, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thermoresponsive chromatography using polymer brush grafted porous polystyrene beads2009

    • Author(s)
      Aya Mizutani
    • Organizer
      International Symposium on Frontiers in Biomedical Polymers
    • Place of Presentation
      Mishima, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロリン誘導体修飾カラムを用いた温度応答性クロマトグラフィー2009

    • Author(s)
      近藤賢治
    • Organizer
      第22回バイオメディカル分析化学シンポジウム
    • Place of Presentation
      岐阜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 官能基化proline誘導体を用いる温度応答性分離システムの開発2009

    • Author(s)
      嶋村美来
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] 芳香族アミノ酸誘導体高分子を用いる温度応答性クロマトグラフィー2009

    • Author(s)
      金刺良祐
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロリン誘導体カラムを用いた温度応答性クロマトグラフィー2009

    • Author(s)
      石川真
    • Organizer
      第20回クロマト科学会議
    • Place of Presentation
      新橋(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 芳香族アミノ酸誘導体を用いる環境応答性クロマトグラフィーの開発2009

    • Author(s)
      坂本千賀子
    • Organizer
      第20回クロマト科学会議
    • Place of Presentation
      新橋(東京)
    • Related Report
      2009 Annual Research Report
  • [Book] Handbook of Green Analytical Chemistry2012

    • Author(s)
      Hideko Kanazawa, et al.
    • Related Report
      2011 Final Research Report
  • [Book] Handbook of Green Analytical Chemistry2012

    • Author(s)
      Tadashi Nishio, Hideko Kanazawa
    • Total Pages
      546
    • Publisher
      Willey & Sons
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 物質分離用前処理カートリッジ及びそれを利用した前処理方法2009

    • Inventor(s)
      金澤秀子、岡野光夫
    • Industrial Property Rights Holder
      セルシード(株)、金澤秀子
    • Industrial Property Number
      2009-221536
    • Filing Date
      2009-09-01
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 物質分離用前処理カートリッジ及びそれを利用した前処理方法2009

    • Inventor(s)
      金澤秀子, 岡野光夫
    • Industrial Property Rights Holder
      セルシード(株)金澤秀子
    • Industrial Property Number
      2009-221536
    • Filing Date
      2009-09-01
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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