| Project/Area Number |
21390013
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Takashi 大阪薬科大学, 薬学部, 准教授 (20278592)
NISHIMURA Mitsuhiro 大阪薬科大学, 薬学部, 博士研究員 (40510285)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Keywords | 創薬 / 糖尿病 / 最終糖化産物 / AGE / RAGE / SBDD / バーチャルスクリーニング / NMR / 合理的薬物設計 / AGE受容体 / AGE-RAGE相互作用 / PPARγ / 等温滴定型熱量計 / 水和 / 終末糖化産物 / 糖尿病合併症 / 分子間相互作用 / 超遠心分析用蛍光測定装置 / 超遠心分析 / 合理的創薬 / 糖尿病血管合併症 / リガンド / レセプター |
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| Research Abstract |
The worst three complications of diabetes ; retinopathy, nephritis and neurosis, are due to phenomena in vascular endothelial cells induced by the binding of AGE to its receptor.(AGE ; Advanced Glycation End products, the reaction products between protein and sugar in blood) The aim of this project is to develop therapeutic agents for diabetic vascular complications by rational design and chemical synthesis of candidates to inhibit this interaction with considering the structural information obtained by NMR, X-ray crystallography, conformation energy calculation and thermodynamic information by ultracentrifugation analysis and isothermal titration calorimetry and so on.
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