Comprehensive analyses of bioactive lysophospholipids

• Project/Area Number: 21390015
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: AOKI Junken 東北大学, 大学院・薬学研究科, 教授 (20250219)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: リゾリン脂質 / リゾホスファチジン酸 / Gタンパク質共役型受容体 / GPCR / 産生酵素 / メディエーター / リゾホスファチジルセリン / 受容体 / ノックアウトマウス / 生理活性脂質

Research Abstract

Lysophosphatidic acid (LPA)is one of the most attractive lipid mediators. LPA is constitutively produced in blood stream. However, role of theplasma LPA remains elusive. In this study we focused on the physiological function of plasma LPA and found that it has a critical factor regulating theactivity of vagal nerve, possibly though the third LPA receptor, LPA_3.

Research Products

• [Journal Article] Synthetic biotinylated peptide compounds derived from Asp-hemolysin : Novel potent inhibitors of platelet-activating factor (2012)
  • Author(s): Sato A, Kumagai T, Aoki J, Ebina K
  • Journal Title: Eur J Pharmacol Volume: 685 Issue: 1-3 Pages: 205-212
  • DOI: 10.1016/j.ejphar.2012.04.025
  • Peer Reviewed
• [Journal Article] Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry (2012)
  • Author(s): Saigusa D, Shiba K, Inoue A, Hama K, Okutani M, Iida N, Saito M, Suzuki K, Kaneko T, Suzuki N, Yamaguchi H, Mano N, Goto J, Hishinuma T, Aoki J, Tomioka Y
  • Journal Title: Anal Bioanal Chem Volume: 403巻 Issue: 7 Pages: 1897-1905
  • DOI: 10.1007/s00216-012-6004-9
  • Peer Reviewed
• [Journal Article] The β9 Loop Domain of PA-PLA(1)α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis (2012)
  • Author(s): Shinkuma S, Inoue A, Aoki J, Nishie W, Natsuga K, Ujiie H, Nomura T, Abe R, Akiyama M, Shimizu H
  • Journal Title: The Journal of Investigative Dermatology Volume: (印刷中) Issue: 8 Pages: 2093-2095
  • DOI: 10.1038/jid.2012.96
  • Peer Reviewed
• [Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice (2012)
  • Author(s): Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N
  • Journal Title: J Clin Invest Volume: 122 Pages: 1416-1426
  • Peer Reviewed
• [Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position (2012)
  • Author(s): Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y, Nakamura S, Otani Y, Ohwada T, Aoki J
  • Journal Title: J Biochem Volume: 151 Issue: 5 Pages: 511-518
  • DOI: 10.1093/jb/mvs011
  • NAID: 10031166091
  • Peer Reviewed
• [Journal Article] A 3D view of autotaxin (2012)
  • Author(s): Nishimasu H, Ishitani R, Aoki J, Nureki O
  • Journal Title: Trends Pharmacol Sci Volume: 33 Issue: 3 Pages: 138-145
  • DOI: 10.1016/j.tips.2011.12.004
  • Peer Reviewed
• [Journal Article] Surface loops of extracellular phospholipase A(1)determine both substrate specificity and preference for lysophospholipids (2012)
  • Author(s): Arima N, Inoue A, Makide K, Nonaka T, Aoki J
  • Journal Title: J Lipid Res Volume: 53 Pages: 513-521
  • Peer Reviewed
• [Journal Article] Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107 (2012)
  • Author(s): Uyama T, Ichi I, Kono N, Inoue A, Tsuboi K, Jin XH, Araki N, Aoki J, Arai H, Ueda N
  • Journal Title: J Biol Chem Volume: 287 Issue: 4 Pages: 2706-2718
  • DOI: 10.1074/jbc.m111.267575
  • Peer Reviewed
• [Journal Article] Identification and biochemical characterization of a novel autotaxin isoform, ATXδ, with a four-amino acid deletion (2012)
  • Author(s): Hashimoto T, Okudaira S, Igarashi K, Hama K, Yatomi Y, Aoki J
  • Journal Title: J Biochem Volume: 151 Issue: 1 Pages: 89-97
  • DOI: 10.1093/jb/mvr126
  • NAID: 10031166046
  • Peer Reviewed
• [Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice (2012)
  • Author(s): Fukuhara S, et al
  • Journal Title: J Clin Invest Volume: (In press)(未定) Issue: 4 Pages: 1416-1426
  • DOI: 10.1172/jci60746
  • Peer Reviewed
• [Journal Article] Surface loops of extracellular phospholipase A(1) determine both substrate specificity and preference for lysophospholipids (2012)
  • Author(s): Arima N, Inoue A., et al
  • Journal Title: J Lipid Res Volume: 53 Issue: 3 Pages: 513-521
  • DOI: 10.1194/jlr.m022400
  • Peer Reviewed
• [Journal Article] Autotaxin regulates vascular development via multiple lysophosphatidic acid(LPA)receptors in zebrafish (2011)
  • Author(s): Yukiura H, Hama K, Nakanaga K, Tanaka M, Asaoka Y, Okudaira S, Arima N, Inoue A, Hashimoto T, Arai H, Kawahara A, Nishina H, Aoki J
  • Journal Title: J Biol Chem Volume: 286 Issue: 51 Pages: 43972-43983
  • DOI: 10.1074/jbc.m111.301093
  • Peer Reviewed
• [Journal Article] LPA-producing enzyme PA-PLA1a regulates hair follicle development by modulating EGFR signaling (2011)
  • Author(s): Inoue A., Arima N., et al
  • Journal Title: EMBO J Volume: vol.30 Issue: 20 Pages: 4248-4260
  • DOI: 10.1038/emboj.2011.296
  • Peer Reviewed
• [Journal Article] Serum autotaxin measurements in pregnant women : application for the differentiation of normal pregnancy and pregnancy-induced hypertension (2011)
  • Author(s): Masuda A, Fujii T, Iwasawa Y, Nakamura K, Ohkawa R, Igarashi K, Okudaira S, Ikeda H, Kozuma S, Aoki J, Yatomi Y
  • Journal Title: Clin Chim Acta Volume: 412 Issue: 21-22 Pages: 1944-1950
  • DOI: 10.1016/j.cca.2011.06.039
  • Peer Reviewed
• [Journal Article] Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor (2011)
  • Author(s): Mitsuyasu Kawaguchi, Takayoshi Okabe, Shinichi, Okudaira, Kenjiro Hanaoka, Yuuta Fujikawa, Takuya Terai, Toru Komatsu, Hirotatsu Kojima, Junken Aoki, Tetsuo Nagano
  • Journal Title: Journal of the American Chemical Society Volume: 133 Issue: 31 Pages: 12021-12030
  • DOI: 10.1021/ja201028t
  • Peer Reviewed
• [Journal Article] Specific increase in serum autotaxin activity in patients with pancreatic cancer (2011)
  • Author(s): Nakai Y, Ikeda H, Nakamura K, Kume Y, Fujishiro M, Sasahira N, Hirano K, Isayama H, Tada M, Kawabe T, Komatsu Y, Omata M, Aoki J, Koike K, Yatomi Y
  • Journal Title: Clin Biochem Volume: 44 Issue: 8-9 Pages: 576-581
  • DOI: 10.1016/j.clinbiochem.2011.03.128
  • Peer Reviewed
• [Journal Article] Autotaxin as a novel serum marker of liver fibrosis (2011)
  • Author(s): Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y
  • Journal Title: Clin Chim Acta Volume: 412 Issue: 13-14 Pages: 1201-1206
  • DOI: 10.1016/j.cca.2011.03.014
  • Peer Reviewed
• [Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators (2011)
  • Author(s): Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O
  • Journal Title: Nat Struct Mol Biol Volume: 18 Issue: 2 Pages: 205-212
  • DOI: 10.1038/nsmb.1998
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of autotaxin(ATX)/lysophospholipase D(lysoPLD)in submucosal invasive colorectal cancer (2011)
  • Author(s): Kazama S, Kitayama J, Aoki J, Mori K, Nagawa H.
  • Journal Title: J Gastrointest Cancer Volume: 42 Pages: 204-211
  • Peer Reviewed
• [Journal Article] Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine (2010)
  • Author(s): Nagai J, Uchida H, Matsushita Y, Yano R, Ueda M, Niwa M, Aoki J, Chun J, Ueda H
  • Journal Title: Mol Pain Volume: 6 Pages: 78-78
  • DOI: 10.1186/1744-8069-6-78
  • Peer Reviewed
• [Journal Article] Development of an activity-based probe for autotaxin (2010)
  • Author(s): Cavalli S, Houben AJ, Albers HM, van Tilburg EW, de Ru A, Aoki J, van Veelen P, Moolenaar WH, Ovaa H
  • Journal Title: Chembiochem Volume: 11 Issue: 16 Pages: 2311-2317
  • DOI: 10.1002/cbic.201000349
  • Peer Reviewed
• [Journal Article] Autotaxin controls caudal diencephalon-mesencephalon development in the chick (2010)
  • Author(s): Ohuchi H, Fukui H, Matsuyo A, Tomonari S, Tanaka M, Arai H, Noji S, Aoki J
  • Journal Title: Dev Dyn Volume: 239 Issue: 10 Pages: 2647-2658
  • DOI: 10.1002/dvdy.22403
  • Peer Reviewed
• [Journal Article] Expression of phosphatidylserine-specific phospholipase A(1)mRNA in human THP-1-derived macrophages (2010)
  • Author(s): Hosono H, Homma M, Ogasawara Y, Makide K, Aoki J, Niwata H, Watanabe M, Inoue K, Ohkohchi N, Kohda Y
  • Journal Title: Cell Transplant Volume: 19 Pages: 759-64
  • Peer Reviewed
• [Journal Article] Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver (2010)
  • Author(s): Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H
  • Journal Title: J Lipid Res Volume: 51 Issue: 9 Pages: 2571-80
  • DOI: 10.1194/jlr.m004648
  • Peer Reviewed
• [Journal Article] Autotaxin-an LPA producing enzyme with diverse functions (2010)
  • Author(s): Nakanaga K, Hama K, Aoki J
  • Journal Title: J Biochem Volume: 148 Issue: 1 Pages: 13-24
  • DOI: 10.1093/jb/mvq052
  • NAID: 10027876904
  • Peer Reviewed
• [Journal Article] Biological roles of lysophosphatidic acid signaling through its production by autotaxin (2010)
  • Author(s): Okudaira S, Yukiura H, Aoki J
  • Journal Title: Biochimie Volume: 92 Issue: 6 Pages: 698-706
  • DOI: 10.1016/j.biochi.2010.04.015
  • Peer Reviewed
• [Journal Article] A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1)in human serum samples (2010)
  • Author(s): Nakamura K, Igarashi K, Ohkawa R, Saiki N, Nagasaki M, Uno K, Hayashi N, Sawada T, Syukuya K, Yokota H, Arai H, Ikeda H, Aoki J, Yatomi Y
  • Journal Title: Clin Chim Acta Volume: 411 Issue: 15-16 Pages: 1090-1094
  • DOI: 10.1016/j.cca.2010.04.006
  • Peer Reviewed
• [Journal Article] Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts (2010)
  • Author(s): David M, Wannecq E, Descotes F, Jansen S, Deux B, Ribeiro J, Serre CM, Gres S, Bendriss-Vermare N, Bollen M, Saez S, Aoki J, Saulnier-Blache JS, Clezardin P, Peyruchaud O
  • Journal Title: PLoS One Volume: 17 Issue: 3 Pages: e9741-e9741
  • DOI: 10.1371/journal.pone.0009741
  • Peer Reviewed
• [Journal Article] LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid (2010)
  • Author(s): Hama K, Aoki J
  • Journal Title: Prog Lipid Res Volume: 49 Issue: 4 Pages: 335-342
  • DOI: 10.1016/j.plipres.2010.03.001
  • Peer Reviewed
• [Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis (2010)
  • Author(s): Shinkuma S, Akiyama M, Inoue A, Aoki J, Natsuga K, Nomura T, Arita K, Abe R, Ito K, Nakamura H, Ujiie H, Shibaki A, Suga H, Tsunemi Y, Nishie W, Shimizu H
  • Journal Title: Hum Mutat Volume: 31 Pages: 602-10
  • DOI: 10.1002/humu.21235
  • Peer Reviewed
• [Journal Article] Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain (2010)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H
  • Journal Title: J Pharmacol Exp Ther Volume: 333 Issue: 2 Pages: 540-546
  • DOI: 10.1124/jpet.109.164830
  • Peer Reviewed
• [Journal Article] Adiponectin suppresses tumorigenesis in Apc(Min)(/+)mice (2010)
  • Author(s): Otani K, Kitayama J, Yasuda K, Nio Y, Iwabu M, Okudaira S, Aoki J, Yamauchi T, Kadowaki T, Nagawa H
  • Journal Title: Cancer Lett Volume: 288 Issue: 2 Pages: 177-82
  • DOI: 10.1016/j.canlet.2009.06.037
  • Peer Reviewed
• [Journal Article] Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine (2010)
  • Author(s): Nagai J, et al
  • Journal Title: Mol Pain Volume: 9 Pages: 78-78
  • Peer Reviewed
• [Journal Article] Autotaxin controls caudal diencephalon-mesencephalon development in the chick (2010)
  • Author(s): Ohuchi H, et al
  • Journal Title: Dev.Dyn. Volume: 239 Pages: 2647-2658
  • Peer Reviewed
• [Journal Article] Immunohistochemical Detection of Autotaxin (ATX)/Lysophospholipase D (lysoPLD) in Submucosal Invasive Colorectal Cancer (2010)
  • Author(s): Kazama S, et al
  • Journal Title: J Gastrointest Cancer Volume: (Epub ahead)
  • Peer Reviewed
• [Journal Article] Expression of phosphatidylserine-specific phospholipase A(1) mRNA in human THP-1-derived macrophages (2010)
  • Author(s): Hosono H, et al
  • Journal Title: Cell Transplant Volume: 19 Pages: 759-764
  • Peer Reviewed
• [Journal Article] Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver (2010)
  • Author(s): Takahashi K, et al
  • Journal Title: J Lipid Res Volume: 51 Pages: 2571-2580
  • Peer Reviewed
• [Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis (2010)
  • Author(s): Shinkuma S., et al
  • Journal Title: Hum Mutat Volume: i31 Pages: 602-610
  • Peer Reviewed
• [Journal Article] A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples (2010)
  • Author(s): Nakamura K, et al
  • Journal Title: Clin Chim Acta Volume: 411 Pages: 1090-1094
  • Peer Reviewed
• [Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain (2010)
  • Author(s): Ma L, et al
  • Journal Title: J Pharmacol Exp Ther Volume: 333 Pages: 540-546
  • Peer Reviewed
• [Journal Article] Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts (2010)
  • Author(s): David M, et al
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts (2010)
  • Author(s): David M, et al., 14人中13番目
  • Journal Title: PLoS One 5(3)
  • Peer Reviewed
• [Journal Article] LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid (2010)
  • Author(s): Hama K, Aoki J
  • Journal Title: Prog Lipid Res (In press)
  • Peer Reviewed
• [Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis (2010)
  • Author(s): Shinkuma S, et al., 16人中4番目
  • Journal Title: Hum Mutat (In press)
  • Peer Reviewed
• [Journal Article] Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain (2010)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H
  • Journal Title: J Pharmacol Exp Ther 333(2) Pages: 540-546
  • Peer Reviewed
• [Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid : an initiator of nerve injury-induced neuropathic pain (2009)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H
  • Journal Title: Mol Pain 5 Pages: 64-64
  • NAID: 120006984666
  • Peer Reviewed
• [Journal Article] Synaptic PRG-1 modulates excitatory transmission via lipid phosphatemediated signaling (2009)
  • Author(s): Trimbuch T, et al., 30人中24番目
  • Journal Title: Cell 138(6) Pages: 1222-1235
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative (2009)
  • Author(s): Iwashita M, et al., 11人中9番目
  • Journal Title: J Med Chem 52(19) Pages: 5837-5863
  • Peer Reviewed
• [Journal Article] Adiponectin suppresses tumorigenesis in Apc(Min)(/+)mice (2009)
  • Author(s): Otani K, et al., 10人中7番目
  • Journal Title: Cancer Lett 288(2) Pages: 177-182
  • Peer Reviewed
• [Journal Article] Intracellular phospholipase Algamma(iPLA1gamma)is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex (2009)
  • Author(s): Morikawa RK, Aoki J, et al.
  • Journal Title: J Biol Chem 284(39) Pages: 26620-26630
  • Peer Reviewed
• [Journal Article] Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta (2009)
  • Author(s): Iwasawa Y, et al., 15人中13番目
  • Journal Title: Am J Reprod Immunol 62(2) Pages: 90-95
  • Peer Reviewed
• [Journal Article] Expression of autotaxin and acylglycerol kinase in prostate cancer : association with cancer development and progression (2009)
  • Author(s): Nouh MA, et al., 11人中10番目
  • Journal Title: Cancer Sci 100(9) Pages: 1631-1638
  • Peer Reviewed
• [Journal Article] Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol (2009)
  • Author(s): Makide K, Kitamura H, Sato Y, Okutani M, Aoki J
  • Journal Title: Prostaglandins Other Lipid Mediat 89(3-4) Pages: 135-139
  • Peer Reviewed
• [Journal Article] Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood (2009)
  • Author(s): Endo T, et al., 14人中14番目
  • Journal Title: J Biochem 146(2) Pages: 283-293
  • Peer Reviewed
• [Journal Article] Autotaxin enzyme immunoassay in human cerebrospinal fluid samples (2009)
  • Author(s): Nakamura K, et al., 16人中16番目
  • Journal Title: Clin Chim Acta 405(1-2) Pages: 160-162
  • Peer Reviewed
• [Presentation] アカデミック発創薬:東北大学の試み (2012)
  • Author(s): 青木淳賢
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2012-03-30
• [Presentation] リゾホスファチジン酸受容体LPA3の迷走神経を介した心・呼吸抑制作用の解析 (2012)
  • Author(s): 可野邦行
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] ゼブラフィッシュを用いたLPAシグナリングの骨形成シグナリングにおける機能解析 (2012)
  • Author(s): 有馬直明
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] 酸化リン脂質に応答する新規受容体の同定 (2012)
  • Author(s): 石黒純
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] 生体内におけるリゾホスファチジルセリンの検出 (2012)
  • Author(s): 奥谷倫世
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] 血管形成におけるLPAシグナル調節機構の解析 (2012)
  • Author(s): 雪浦弘志, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] リゾホスファチジン酸の血管透過性亢進作用メカニズムの解明 (2012)
  • Author(s): 近藤朋恵, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] リゾホスファチジルセリンは自己免疫性肝炎を緩解する (2012)
  • Author(s): 鈴木健介, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] Ectodomain shedding of TGFα as a versatile readout for GPCR activation (2012)
  • Author(s): Asuka Inoue, 他
  • Organizer: Keystone Symposia G Protein-Coupled Receptors : Molecular Mechanisms and Novel Functional Insights
  • Place of Presentation: Banff, Canada
  • Year and Date: 2012-02-17
• [Presentation] Development and characterization of TGFalpha shedding assay : a novel and powerful method to detect G12/13 signaling (2012)
  • Author(s): Jun Ishiguro, 他
  • Organizer: Keystone Symposia G Protein-Coupled Receptors : Molecular Mechanisms and Novel Functional Insights
  • Place of Presentation: Banff, Canada
  • Year and Date: 2012-02-17
• [Presentation] An improved method for the detection of phospholipids (2012)
  • Author(s): Keita Nakanaga, 他
  • Organizer: The 7th KOREA-JAPAN conference on cellular signaling for young scientists
  • Place of Presentation: Ulsan, Korea
  • Year and Date: 2012-02-17
• [Presentation] Mechanism of LPA-mediated vasculogenesis (2012)
  • Author(s): Hiroshi Yukiura, 他
  • Organizer: The 7th KOREA-JAPAN conference on cellular signaling for young scientists
  • Place of Presentation: Ulsan, Korea
  • Year and Date: 2012-02-17
• [Presentation] リゾホスファチジルセリンによる免疫抑制作用 (2012)
  • Author(s): 巻出久美子, 他
  • Organizer: 新学術領域若手ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2012-02-01
• [Presentation] 新規LysoPS受容体の同定 (2012)
  • Author(s): 奥谷倫世, 他
  • Organizer: 新学術領域若手ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2012-02-01
• [Presentation] ゼブラフィッシュにおけるLPAの機能 (2012)
  • Author(s): 雪浦弘志, 他
  • Organizer: 新学術領域若手ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2012-02-01
• [Presentation] Immunosuppressive roles of lysophosphatidylserine in mice (2011)
  • Author(s): Kumiko Makide, 他
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] Effects of lysophophatidylserine on lymphocytes (2011)
  • Author(s): Hajime Kitamura, 他
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] リゾホスファチジン酸受容体LPA3を介した迷走神経活性化の解明 (2011)
  • Author(s): 可野邦行, 他
  • Organizer: ファーマ・バイオフォーラム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-08
• [Presentation] 骨形成におけるLPAシグナリングの役割の解明 (2011)
  • Author(s): 板井恵理子, 他
  • Organizer: ファーマ・バイオフォーラム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-08
• [Presentation] 2-アシル型リゾリン脂質の検出とその受容体活性化機構の解析 (2011)
  • Author(s): 首藤啓明, 他
  • Organizer: ファーマ・バイオフォーラム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-08
• [Presentation] ゼブラフィッシュ体節間血管形成におけるリゾホスファチジン酸シグナルの作用機序 (2011)
  • Author(s): 濱弘太郎, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] 生理活性リゾリン脂質の定量系の開発と産生機構の解析 (2011)
  • Author(s): 井上飛鳥, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] ゼブラフィッシュを用いたLPAシグナリングの骨形成シグナリングにおける機能解析 (2011)
  • Author(s): 有馬直明, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] リゾホスファチジン酸受容体LPA3を介した求心性迷走神経活性化作用の解析 (2011)
  • Author(s): 可野邦行, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] リゾホスファチジルセリンの細胞接着抑制作用 (2011)
  • Author(s): 北村一, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] 新規GPCRシグナル検出法～TGFalpha切断アッセイ～の開発」 (2011)
  • Author(s): 石黒純, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] リゾホスファチジルセリンの免疫抑制作用 (2011)
  • Author(s): 奥谷倫世, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] 2-アシル型リゾリン脂質の検出とその受容体活性化機構の解析 (2011)
  • Author(s): 首藤啓明, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] 骨形成におけるLPAシグナリングの役割の解明 (2011)
  • Author(s): 板井恵理子, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] 血管形成におけるLPAシグナル調節機構の解析 (2011)
  • Author(s): 雪浦弘志, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] Autotaxin regulates vascular development via multiple LPA receptors in zebrafish (2011)
  • Author(s): Junken Aoki
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-15
• [Presentation] New aspects of autotaxin : structure and function (2011)
  • Author(s): Junken Aoki, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy(招待講演)
  • Year and Date: 2011-08-14
• [Presentation] The characterization of ATX and LPA receptors in zebrafish (2011)
  • Author(s): Kotaro Hama, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] TGF-alpha ectodomain shedding underlies LPA-induced hair formation (2011)
  • Author(s): Asuka Inoue, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] LPA signaling in bone development (2011)
  • Author(s): Naoaki Arima, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] Activation of vasal afferents via lysophosphatidic acid-3 receptor in mice (2011)
  • Author(s): Kuniyuki Kano, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] Autotaxin-lysophosphatidic acid signaling functionally modulate sphingosine-1-phosphate signaling (2011)
  • Author(s): Keita Nakanaga, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] Regulation of LPA signal in blood vessel formation (2011)
  • Author(s): Hiroshi Yukiura, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] リゾホスファチジン酸は体毛形成に関与する (2011)
  • Author(s): 井上飛鳥, 他
  • Organizer: 日本生化学会東北支部第77回例会・シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2011-07-23
• [Presentation] リゾホスファチジン酸産生酵素オートタキシンの結晶構造解析 (2011)
  • Author(s): 奥平真一, 他
  • Organizer: 日本生化学会東北支部第77回例会・シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2011-07-23
• [Presentation] LPAによる血管透過性先進作用メカニズムの解明 (2011)
  • Author(s): 近藤朋恵, 他
  • Organizer: 日本生化学会東北支部第77回例会・シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2011-07-23
• [Presentation] 新規AutotaxinスプライシングアイソフォームATXδの性状解析 (2011)
  • Author(s): 橋本崇史, 他
  • Organizer: 日本生化学会東北支部第77回例会・シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2011-07-23
• [Presentation] Lysophosphatidic acid signaling in zebrafish vascular formation (2011)
  • Author(s): Kotaro Hama, 他
  • Organizer: 第30回内藤コンファレンス
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-28
• [Presentation] Role of lysophosphatidylserine in inflamination-associated mast cell degranulation (2011)
  • Author(s): Kumiko Makide, 他
  • Organizer: 第30回内藤コンファレンス
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-28
• [Presentation] リゾホスファチジン酸産生酵素オートタキシンの結晶構造解析 (2011)
  • Author(s): 奥平真一, 他
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] リゾホスファチジン酸受容体LPA3を介した求心性迷走神経活性化作用の解析 (2011)
  • Author(s): 可野邦行, 他
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] 骨形成におけるLPAシグナリングの役割の解明 (2011)
  • Author(s): 板井恵理子, 他
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] ホスホリパーゼA1(PLA1)により産生される2-アシル型リゾリン脂質の分離とその性状解析 (2011)
  • Author(s): 首藤啓明, 他
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] Mechanism of extracellular production of bioactive lysophospholipids using a newly developed LC-MS/MS method (2011)
  • Author(s): Asuka Inoue, 他
  • Organizer: LIPID MAPS Annual Meeting 2011
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-05-02
• [Presentation] ゼブラフィッシュを用いたLPAシグナリングの骨形成における機能解析 (2010)
  • Author(s): 有馬直明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] LC-ESI-MS/MSを用いたリゾホスファチジルセリンおよびリゾホスファチジルスレオニンの検出 (2010)
  • Author(s): 奥谷倫世
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 胎生期骨形成におけるLPAシグナリングの役割の解明 (2010)
  • Author(s): 板井恵理子
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 広範なGPCRシグナルを検出する新規測定法-TGFα切断アッセイ-の開発 (2010)
  • Author(s): 石黒純
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] リゾホスファチジルセリンの活性化リンパ球に対する効果 (2010)
  • Author(s): 北村一
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] PLA1型リゾリン脂質産生酵素の受容体活性化機構の解析 (2010)
  • Author(s): 首藤啓明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] LPA_3を介した降圧・徐脈作用機構の解明 (2010)
  • Author(s): 可野邦行
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 肺・腎線維化における生理活性脂質リゾホスファチジン酸の役割 (2010)
  • Author(s): 奥平真一
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] モデル生物を用いたLPAシグナルの作用機序の解析 (2010)
  • Author(s): 濱弘太郎
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 炎症反応のマスト細胞活性化におけるリゾホスファチジルセリンの役割 (2010)
  • Author(s): 巻出久美子
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 血管形成におけるオートタキシン-LPAシグナルの解析 (2010)
  • Author(s): 雪浦弘志
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] ATX-LPAシグナルによるS1Pシグナルの抑制 (2010)
  • Author(s): 中永景太
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 新規AutotaxinスプライシングアイソフォームATXΦの性状解析 (2010)
  • Author(s): 橋本崇史
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] リゾホスファチジン酸受容体LPA_3特異的アゴニストによる気管収縮作用の解析 (2010)
  • Author(s): 近藤朋恵
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫、神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 肺・腎線維化における生理活性脂質リゾホスファチジン酸の役割 (2010)
  • Author(s): 奥平真一
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山、富山国際会議場
  • Year and Date: 2010-11-30
• [Presentation] NPP6の肝臓における発現解析 (2010)
  • Author(s): 山本泰生
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 福島、奥羽大学
  • Year and Date: 2010-10-24
• [Presentation] 肺・腎線維化における生理活性脂質リゾホスファチジン酸の役割 (2010)
  • Author(s): 奥平真一
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 福島、奥羽大学
  • Year and Date: 2010-10-24
• [Presentation] LC-ESI-MS/MSを用いたリゾホスファチジルセリンの検出 (2010)
  • Author(s): 奥谷倫世
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 福島、奥羽大学
  • Year and Date: 2010-10-24
• [Presentation] ホスファチジルセリン特異的ホスホリパーゼA1の病理的機能の解明 (2010)
  • Author(s): 佐藤侑介
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 福島、奥羽大学
  • Year and Date: 2010-10-24
• [Presentation] TGFα切断アッセイを用いたオーファンGPCRのリガンドスクリーニング (2010)
  • Author(s): 石黒純
  • Organizer: 第9回次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都、京都大学大学院薬学研究科
  • Year and Date: 2010-10-02
• [Presentation] LPS受容体P2Y10の同定と細胞接着における機能 (2010)
  • Author(s): 北村一
  • Organizer: 第9回次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都、京都大学大学院薬学研究科
  • Year and Date: 2010-10-02
• [Presentation] 血管形成におけるオートタキシン-LPAシグナルの解析 (2010)
  • Author(s): 雪浦弘志
  • Organizer: 第9回次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都、京都大学大学院薬学研究科
  • Year and Date: 2010-10-02
• [Presentation] ゼブラフィッシュを用いたLPAシグナリングの骨形成における機能解析 (2010)
  • Author(s): 有馬直明
  • Organizer: 第16回小型魚類研究会
  • Place of Presentation: 埼玉、プラザイースト
  • Year and Date: 2010-09-18
• [Presentation] ゼブラフィッシュを用いた生理活性脂質の機能解析 (2010)
  • Author(s): 中永景太
  • Organizer: 第16回小型魚類研究会
  • Place of Presentation: 埼玉、プラザイースト
  • Year and Date: 2010-09-18
• [Presentation] 血管形成におけるオートタキシン-LPAシグナルの解析 (2010)
  • Author(s): 雪浦弘志
  • Organizer: 第16回小型魚類研究会
  • Place of Presentation: 埼玉、プラザイースト
  • Year and Date: 2010-09-18
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2010)
  • Author(s): 奥平真一
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Kobe Port Island
  • Year and Date: 2010-08-22
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2010)
  • Author(s): 奥平真一
  • Organizer: The 27th Naito Conference on Menmbrane Dynamics and Lipid Biology [I]
  • Place of Presentation: Sapporo, CHATERAISE Gateaux Kingdom SAPPORO
  • Year and Date: 2010-06-29
• [Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGF-alpha release and EGFR transactivation (2010)
  • Author(s): 井上飛鳥
  • Organizer: The 27th Naito Conference on Menmbrane Dynamics and Lipid Biology [I]
  • Place of Presentation: Sapporo, CHATERAISE Gateaux Kingdom SAPPORO
  • Year and Date: 2010-06-29
• [Presentation] Autotaxin and LPA Signaling in Cardiovascular Development (2010)
  • Author(s): 青木淳賢
  • Organizer: International Vascular Biology Meeting 2010
  • Place of Presentation: Los Angels, CA, USA
  • Year and Date: 2010-06-20
• [Presentation] The functional interaction between lysophosphatidic acid and sphingosine-1-phosphate signaling in heart morphogenesis in zebrafish (2010)
  • Author(s): 濱弘太郎
  • Organizer: 9th international conference on zebrafish development and genetics
  • Place of Presentation: Madison, WI, USA
  • Year and Date: 2010-06-16
• [Presentation] LC-ESI-MS/MSを用いたリゾリン脂質定量系の開発 (2010)
  • Author(s): 井上飛鳥
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 群馬、秋森旅館
  • Year and Date: 2010-06-15
• [Presentation] 様々な線維症におけるオートタキシンの寄与の解析 (2010)
  • Author(s): 奥平真一
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 群馬、秋森旅館
  • Year and Date: 2010-06-15
• [Presentation] ATX-LPAシグナルによるS1Pシグナル抑制 (2010)
  • Author(s): 中永景太
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 群馬、秋森旅館
  • Year and Date: 2010-06-15
• [Presentation] オートタキシントランスジェニックマウスの解析 (2010)
  • Author(s): 雪浦弘志
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 群馬、秋森旅館
  • Year and Date: 2010-06-15
• [Presentation] TGFα切断アッセイによるGPCRシグナルの検出 (2010)
  • Author(s): 石黒純
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 群馬、秋森旅館
  • Year and Date: 2010-06-15
• [Presentation] Autotaxin and LPA Signaling in Cardiovascular Development (2010)
  • Author(s): Junken Aoki
  • Organizer: Keystone Symposia
  • Place of Presentation: Kyoto, Japa
  • Year and Date: 2010-06-08
• [Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGFa release and EGFR transactivation (2010)
  • Author(s): 井上飛鳥
  • Organizer: Keystone Symposia Bioactive Lipids : Biochemistry and Diseases (D2)
  • Place of Presentation: Kyoto, Westin Miyako Kyoto
  • Year and Date: 2010-06-07
• [Presentation] Autotaxin and LPA Signaling in Cardiovascular Development (2010)
  • Author(s): 青木淳賢
  • Organizer: Keystone Symposia Bioactive Lipids : Biochemistry and Diseases (D2)
  • Place of Presentation: Kyoto, Westin Miyako Kyoto
  • Year and Date: 2010-06-07
• [Presentation] 肺線維症におけるリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2010)
  • Author(s): 奥平真一
  • Organizer: 第76回日本生化学会東北支部例会
  • Place of Presentation: 福島、コラッセふくしま
  • Year and Date: 2010-05-08
• [Presentation] TGFα切断アッセイによるG12/13シグナルの検出 (2010)
  • Author(s): 石黒純
  • Organizer: 第7回GPCR研究会
  • Place of Presentation: 東京、日本科学未来館みらいCANホール
  • Year and Date: 2010-05-07
• [Presentation] 血管形成におけるオートタキシン-LPAシグナルの解析 (2010)
  • Author(s): 雪浦弘志
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡、静岡県コンベンションアーツセンター
  • Year and Date: 2010-03-28
• [Presentation] モデル生物を用いたLPAシグナルの作用機序の解析 (2010)
  • Author(s): 濱弘太郎
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡、静岡県コンベンションアーツセンター
  • Year and Date: 2010-03-28
• [Presentation] リゾホスファチジン酸受容体LPA_3を介した求心性迷走神経活性化作用の解析 (2010)
  • Author(s): 可野邦行
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡、静岡県コンベンションアーツセンター
  • Year and Date: 2010-03-28
• [Presentation] 炎症時におけるリゾホスファチジルセリン産生の変動解析 (2010)
  • Author(s): 奥谷倫世
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡、静岡県コンベンションアーツセンター
  • Year and Date: 2010-03-28
• [Presentation] 新規GPCRシグナル検出法-TGFα切断アッセイ-の開発 (2010)
  • Author(s): 石黒純
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡、静岡県コンベンションアーツセンター
  • Year and Date: 2010-03-28
• [Presentation] LC-ESI-MS/MSを用いた生理活性リゾリン脂質定量系の開発 (2010)
  • Author(s): 井上飛鳥
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡、静岡県コンベンションアーツセンター
  • Year and Date: 2010-03-28
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2009)
  • Author(s): 小野めぐみ
  • Organizer: 次世代を担う若手ファーマ・バイオフォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-23
• [Presentation] コンディショナルノックアウトマウスを用いたオートタキシンの機能解析 (2009)
  • Author(s): 有馬直明
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] ゼブラフィッシュを用いたオートタキシンの血管形成メカニズムの解析 (2009)
  • Author(s): 中永景太
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2009)
  • Author(s): 小野めぐみ
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] オートタキシントランスジェニックマウスの解析 (2009)
  • Author(s): 雪浦弘志
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Baculovirusを用いたオートタキシンの大量発現系の確立 (2009)
  • Author(s): 菅野究
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] リゾホスファチジン酸産生酵素オートタキシンの血管形成過程における役割 (2009)
  • Author(s): 中永景太
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-12
• [Presentation] Pthways for LPA production and their patho-physiological roles (2009)
  • Author(s): Junken Aoki
  • Organizer: 2009 FASEB Summer Research Conference
  • Place of Presentation: Arizona, USA
  • Year and Date: 2009-06-29
• [Presentation] Pathways for LPA production and their path-physiological roles (2009)
  • Author(s): 青木淳賢
  • Organizer: FASEB Summer Research Conference "Lysophospholipid Mediators in Health and Disease"
  • Place of Presentation: アメリカアリゾナ
  • Year and Date: 2009-06-28
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2009)
  • Author(s): 奥平真一
  • Organizer: FASEB Summer Research Conference "Lysophospholipid Mediators in Health and Disease"
  • Place of Presentation: アメリカアリゾナ
  • Year and Date: 2009-06-28
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2009)
  • Author(s): 小野めぐみ
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Remarks]
  • URL: http://www.pharm.tohoku.ac.jp/~seika/H21/index.html
• [Remarks]
  • URL: http://www.pharm.tohoku.ac.jp/%7Eseika/H21/index.html
• [Patent(Industrial Property Rights)] オートタキシンアイソフォーム特異的抗体および検出方法 (2011)
  • Inventor(s): 青木淳賢、五十嵐浩二
  • Industrial Property Rights Holder: 株式会社東ソー、東北大学
  • Industrial Property Number: 2011-150054
  • Filing Date: 2011-07-06
• [Patent(Industrial Property Rights)] 自己免疫疾患治療薬のスクリーニング方法 (2011)
  • Inventor(s): 青木淳賢、巻出久美子、井上飛鳥、大和田智彦、井久保仁也、尾谷優子
  • Industrial Property Rights Holder: 東北大学、東京大学
  • Industrial Property Number: 2011-112881
  • Filing Date: 2011-05-29
• [Patent(Industrial Property Rights)] 自己免疫疾患治療薬のスクリーニング方法 (2011)
  • Inventor(s): 青木淳賢、巻出久美子、井上飛鳥、大和田智彦
  • Industrial Property Rights Holder: 東北大学、東京大学
  • Industrial Property Number: 2011-112881
  • Filing Date: 2011-05-19
• [Patent(Industrial Property Rights)] ホスファチジルセリン特異的ホスホリパーゼA1測定による全身性エリテマトーデスの検査方法および検査薬 (2010)
  • Inventor(s): 沢田哲治、矢冨裕、中村和宏、青木淳賢、五十嵐浩二
  • Industrial Property Rights Holder: 株式会社東ソー、東京大学、東北大学
  • Industrial Property Number: 2010-172068
  • Filing Date: 2010-07-30