Novel roles of lysolipid receptors : proton sensing and its biological function

• Project/Area Number: 21390016
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Gunma University
• Principal Investigator: OKAJIMA Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: プロトン感知性受容体 / TDAG8 / OGR1 / 細胞外pH / 炎症性サイトカイン / マクロファージ / 血管平滑筋細胞 / 骨代謝 / プロトン / 糖質コルチコイド / MCP-1 / 骨密度 / COX-2 / リポポリサッカライド / cAMP

Research Abstract

The roles of proton-sensing GPCRs in inflammation, vascular biology, and bone remodeling in response to extracellular pH change were investigated. Our results suggested that TDAG8/Gs/cAMP is involved in the inhibition of inflammatory cytokine production and superoxide anion production in macrophages and neutrophils and OGR1 is in the stimulation of COX-2 expression in smooth muscle cells and osteoblast cells.

Research Products

• [Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo (2012)
  • Author(s): Komachi M, Sato K, Tobo M, Mogi C, Yamada T, Ohta H, Tomura H, Kimura T, Im DS, Yanagida K, Ishii S, Takeyoshi I, Okajima F.
  • Journal Title: Cancer Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates panereatic cancer invasion and metastasis in vivo (2012)
  • Author(s): Komachi M
  • Journal Title: Cancer Science Volume: (印刷中) Issue: 6 Pages: 1099-1104
  • DOI: 10.1111/j.1349-7006.2012.02246.x
  • Peer Reviewed
• [Journal Article] Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages (2011)
  • Author(s): He XD, Tobo M, Mogi C, Nakakura T, Komachi M, Murata N, Takano M, Tomura H, Sato K, Okajima F.
  • Journal Title: Biochem Biophys Res Commun Volume: 415 Pages: 627-631
  • Peer Reviewed
• [Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells (2011)
  • Author(s): Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi M, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, and Okajima F.
  • Journal Title: Biophys Res Commun Volume: 413 Pages: 499-503
  • Peer Reviewed
• [Journal Article] Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion (2011)
  • Author(s): Uchiyama T, Tomono S, Utsugi T, Ohyama Y, Nakamura T, Tomura H, Kawazu S, Okajima F, Kurabayashi M.
  • Journal Title: Metabolism Volume: 60 Pages: 789-798
  • Peer Reviewed
• [Journal Article] Unmasking of LPA(1) receptor-mediated migration response to lysophosphatidic acid by interleukin-1 β-induced attenuation of Rho signaling pathways in rat astrocytes (2011)
  • Author(s): Sato K, Horiuchi Y, Jin Y, Malchinkhuu E, Komachi M, Kondo T, Okajima F.
  • Journal Title: J Neurochem Volume: 117 Pages: 164-174
  • Peer Reviewed
• [Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth musele cells (2011)
  • Author(s): Matsuzaki S
  • Journal Title: Biochem Biophys Res Commun Volume: 413 Issue: 4 Pages: 499-503
  • DOI: 10.1016/j.bbrc.2011.08.087
  • Peer Reviewed
• [Journal Article] Unmasking of LPA(1)receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytes (2011)
  • Author(s): Sato K
  • Journal Title: J Neurochem Volume: 117 Issue: 1 Pages: 164-174
  • DOI: 10.1111/j.1471-4159.2011.07188.x
  • Peer Reviewed
• [Journal Article] Unmasking of LPA(1) receptor-mediated migration response to lysophosphatidic acid by interleukin-1 β-induced attenuation of Rho signaling pathways in rat astrocytes. (2011)
  • Author(s): Sato K
  • Journal Title: J Neurochem Volume: 61(印刷中)
  • Peer Reviewed
• [Journal Article] Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein (2010)
  • Author(s): Sato K, Okajima F.
  • Journal Title: World J Biol Chem Volume: 1 Pages: 327-337
  • Peer Reviewed
• [Journal Article] Protective effect of resolvin E1 on the development of asthmatic airway inflammation (2010)
  • Author(s): Aoki H, Hisada T, Ishizuka T, Utsugi M, Ono A, Koga Y, Sunaga N, Nakakura T, Okajima F, Dobashi K, Mori M.
  • Journal Title: Biochem Biophys Res Commun Volume: 400 Pages: 128-133
  • Peer Reviewed
• [Journal Article] Lysophosphatidic acid inhibits CCL5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells. (2010)
  • Author(s): Matsuzaki S, Ishizuka T, Hisada T, Aoki H, Komachi M, Ichimonji I, Utsugi M, Ono A, Koga Y, Dobashi K, Kurose H, Tomura H, Mori M, Okajima F.
  • Journal Title: J Immunol Volume: 185 Pages: 4863-4872
  • Peer Reviewed
• [Journal Article] Extracellular acidification stimulates IL-6 production and Ca^<2+> mobilization through proton-Sensing OGR1 receptors In human airway smooth muscle cells (2010)
  • Author(s): Ichimonji I, Tomura H, Mogi C, Sato K, Aoki H, Hisada H, Dobashi K, Ishizuka T, Mori M, Okajima F.
  • Journal Title: Am J Physiol-Lung Cell Mol Physiol Volume: 299
  • Peer Reviewed
• [Journal Article] Ovarian cancer G-protein-coupled receptor 1-dependent and-independent vascular actions to acidic pH in human aortic smooth muscle cells (2010)
  • Author(s): Liu JP, Komachi M, Tomura H, Mogi C, Damirin A, Tobo M, Takano M, Nochi H, Tamoto K, Sato K, Okajima F.
  • Journal Title: Am J Physiol-Heart Circ Physiol Volume: 299 Pages: 731-742
  • Peer Reviewed
• [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways (2010)
  • Author(s): Liu JP, Nakakura T, Tomura H, Tobo M, Mogi C, Wang JQ, He XD, Takano M, Damirin A, Komachi M, Sato K, Okajima F.
  • Journal Title: Pharmacol Res Volume: 61 Pages: 499-505
  • Peer Reviewed
• [Journal Article] Cross-talk Between Exogenous Statins and Endogenous High-density Lipoprotein in Anti-inflammatory and Anti-atherogenic Actions (2010)
  • Author(s): Kimura T, Sato K, Tomura H, Okajima F
  • Journal Title: Endocrine, Metabolic and Immune Disorder-Drug Targets (EMID-DT) Volume: 10 Pages: 8-15
  • Peer Reviewed
• [Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells (2010)
  • Author(s): Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
  • Journal Title: J Biol Chem Volume: 285 Pages: 4387-4397
  • Peer Reviewed
• [Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AM P-activated protein kinase in endothelial cells (2010)
  • Author(s): Kimura T
  • Journal Title: J Biol Chem Volume: 285 Pages: 4387-4397
  • Peer Reviewed
• [Journal Article] Cross-talk Between Exogenous Statins and Endogenous High-density Lipo protein in Anti-inflammatory and Anti-atherozenic Actions (2010)
  • Author(s): Kimura T
  • Journal Title: Endocrine, Metabolic and Immune Disorder-Drug Targets Volume: 10 Pages: 8-15
  • Peer Reviewed
• [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR 4 is critical for extracellular proton-induced stimulation of multipleG-protein-signaling pathways (2010)
  • Author(s): Liu JP
  • Journal Title: Pharmacol Res Volume: 61 Pages: 499-505
  • Peer Reviewed
• [Journal Article] Ovarian cancer G-protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cell. (2010)
  • Author(s): Liu JP
  • Journal Title: Am J Physiol-Heart Circ Physiol. Volume: 299 Pages: 731-742
  • Peer Reviewed
• [Journal Article] Extracellular acidification stimulates IL-6 production and Ca^<2+> mobiliz ation through proton-Sensing OGRI receptors In human airway smooth muscle cells. (2010)
  • Author(s): Ichimonji I
  • Journal Title: Am J Physiol-Lung Cell Mol Physiol Volume: 299 Pages: 567-577
  • Peer Reviewed
• [Journal Article] Protective effect oferesolvin E1 on the development ofasthmatic airway inflammation. (2010)
  • Author(s): Aoki H
  • Journal Title: Biochem Biophys Res Commun. Volume: 400 Pages: 128-133
  • Peer Reviewed
• [Journal Article] Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density ? lipoprotein (2010)
  • Author(s): Sato K
  • Journal Title: World J Biol Chem Volume: 1 Pages: 327-337
  • Peer Reviewed
• [Journal Article] 細胞外pH環境を感知するプロトン感知性GPCRの機能と作用機構 (2010)
  • Author(s): 戸村秀明
  • Journal Title: 日本薬理学雑誌 Volume: 135 Pages: 240-244
• [Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells. (2010)
  • Author(s): Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
  • Journal Title: J Biol Chem 285 Pages: 4387-4397
  • Peer Reviewed
• [Journal Article] Cross-talk Between Exogenous Statins and Endogenous High-density Lipoprotein in Anti-inflammatory and Anti-atherogenic Actions. (2010)
  • Author(s): Kimura T, Sato K, Tomura H, Okajima F
  • Journal Title: Endocrine, Metabolic and Immune Disorder-Drug Targets (In press)
  • Peer Reviewed
• [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways (2010)
  • Author(s): Liu JP, Nakakura T, Tomura H, Tobo M, Mogi C, Wang JQ, He XD, Takano M, Damirin A, Komachi M, Sato K, Okajima F.
  • Journal Title: Pharmacol Res (In press)
  • Peer Reviewed
• [Journal Article] Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells (2009)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
  • Journal Title: Mol Biol Cell Volume: 20 Pages: 5156-5165
  • Peer Reviewed
• [Journal Article] MInhibition of superoxide anion production by extracellular acidification in neutrophils (2009)
  • Author(s): Murata N, Mogi C, Tobo M, Nakakura T, Sato K, Tomura H, Okajima F.
  • Journal Title: Cell Immunol Volume: 259 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Increase in sphingolipid catabolic enzyme activity during aging (2009)
  • Author(s): Sacket SJ, Chung HY, Okajima F, Im DS.
  • Journal Title: Acta Pharmacol Sin Volume: 30 Pages: 1454-1461
  • Peer Reviewed
• [Journal Article] Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages (2009)
  • Author(s): Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F
  • Journal Title: J Immunol Volume: 182 Pages: 3243-3251
  • Peer Reviewed
• [Journal Article] LPA_1 receptors mediate stimulation, whereas LPA_2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites (2009)
  • Author(s): Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, Okajima F
  • Journal Title: Carcinogenesis Volume: 30 Pages: 457-465
  • Peer Reviewed
• [Journal Article] Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells (2009)
  • Author(s): Komachi M, Damirin A, Malchinkhuu E, Mogi C, Tobo M, Ohta H, Sato K, Tomura H, Okajima F.
  • Journal Title: Vasc Pharmacol Volume: 50 Pages: 178-184
  • Peer Reviewed
• [Journal Article] Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I (2009)
  • Author(s): Okajima F, Sato K, Kimura T
  • Journal Title: Endocrine J Volume: 56 Pages: 315-332
  • NAID: 10026913244
  • Peer Reviewed
• [Journal Article] Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I. (2009)
  • Author(s): Okajima F, Sato K, Kimura T
  • Journal Title: Endocrine J 56 Pages: 315-332
  • NAID: 10026913244
  • Peer Reviewed
• [Journal Article] Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells. (2009)
  • Author(s): Komachi M, Damirin A, Malchinkhuu E, Mogi C, Tobo M, Obta H, Sato K, Tomura H, Okajima F.
  • Journal Title: Vasc Pharmacol 50 Pages: 178-184
  • Peer Reviewed
• [Journal Article] LPA_1_receptors mediate stimulation, whereas LPA_2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites. (2009)
  • Author(s): Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, Okajima F
  • Journal Title: Carcinogenesis 30 Pages: 457-465
  • Peer Reviewed
• [Journal Article] Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Pro-Inflammatory Cytokine Production In Peritoneal Macrophages. (2009)
  • Author(s): Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F
  • Journal Title: J Immunol 182 Pages: 3243-3251
  • Peer Reviewed
• [Journal Article] Increase in sphingolipid catabolic enzyme activity during aging (2009)
  • Author(s): Sacket SJ, Chung HY, Okajima F, Im DS.
  • Journal Title: Acta Pharmacol Sin. 30 Pages: 1454-1461
  • Peer Reviewed
• [Journal Article] Inhibition of superoxide anion production by extracellular acidification in neutrophils. (2009)
  • Author(s): Murata N, Mogi C, Tobo M, Nakakura T, Sato K, Tomura H, Okajima F.
  • Journal Title: Cell Immunol 259 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells. (2009)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
  • Journal Title: Mol Biol Cell 20 Pages: 5156-5165
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 岡島史和
  • Journal Title: 標準医療薬学-薬理学(第11章)内分泌・代謝(編集 辻本豪三、小池勝夫)(医学書院) Pages: 316-350
• [Presentation] プロトン受容体OGR1の喘息における役割 (2012)
  • Author(s): 茂木千尋
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(札幌)
• [Presentation] リゾホスファチジン酸ならびに低pHによるMCP-1産生制御 (2012)
  • Author(s): 当房雅之
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(札幌)
• [Presentation] プロトン感知性Gタンパク質共役型受容体OGR1の気管支喘息における関与について、 (2011)
  • Author(s): 青木悠, 茂木千尋, 久田剛志, 岩崎靖樹, 鶴巻寛朗, 山田秀典, 石塚全, 土橋邦生, 岡島史和, 森昌朋
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京)
• [Presentation] OGR1ファミリ.GPCRによるプロトン感知機構とその機能 (2011)
  • Author(s): 岡島史和
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] 血漿ならびにリポ蛋白質HDL中スフィンゴシン1-リン酸濃度調節におけるABCA1トランスポーターの役割 (2011)
  • Author(s): 佐藤幸市, 茂木千尋, 岡島史和
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] ク質共役型受容体細胞外pHを感知するGタンパ (2011)
  • Author(s): 岡島史和
  • Organizer: シンポジウムGタンパク質共役型受容体の日本薬学会第131年会シカッティングエッジ(紙上発表)
  • Place of Presentation: 静岡
• [Presentation] LPAのヒト気道上皮細胞におけるRANTES産生に対する抑制効果 (2011)
  • Author(s): 松崎晋一
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京)
• [Presentation] プロトン感知性Gタンパク質共役型受容体OGR1の気管支喘息における関与について (2011)
  • Author(s): 青木悠
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京)
• [Presentation] 細胞外pH低下はヒト気道平滑筋細胞からIL-8及び可溶性腫瘍壊死因子レセプター-1(sTNFa-1)を産生させる (2011)
  • Author(s): 山田秀典
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京)
• [Presentation] 肥満細胞からのLTC4産生は細胞内グルタチオン濃度に依存する (2011)
  • Author(s): 関香織
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京)
• [Presentation] OGR1ファミリーGPCRによるプロトン感知機構とその機能 (2011)
  • Author(s): 岡島史和
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 細胞外環境の酸性化が関節リウマチ滑膜細胞のCOX-2発現に及ぼす影響 (2011)
  • Author(s): 野地裕美
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 血漿ならびにリポ蛋白質HDL中スフィンゴシン1-リン酸濃度調節におけるABCA1トランスポーターの役割 (2011)
  • Author(s): 佐藤幸市
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] プロトン感知性OGR1を介したインスリン分泌調節メカニズム (2011)
  • Author(s): 中倉敬
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Induction of eNOS and SR-BI by cilostazol enhanced HDL-induced antiatherogenic actions in HUVECs (2011)
  • Author(s): Kimura T
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: ロイトン札幌
• [Presentation] ヒト膵臓がん細胞株のインビボ浸潤・転移に対するリゾホスファチジン酸受容体アンタゴニストKi16198の経口投与による抑制作用 (2011)
  • Author(s): 小町麻由美
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: ホテル東京ガーデンパレス(東京)
• [Presentation] ヒト膵臓癌細胞株のインビボ転移・浸潤に対するリゾホスファチジン酸受容体アンタゴニストKi16198の抑制作用 (2010)
  • Author(s): 小町麻由美, 佐藤幸市, 茂木千尋, 当房雅之, 山田敬之, 戸村秀明, 岡島史和
  • Organizer: BMB2010第33回日本分子生物学会、第83回日本生化学会合同学会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] 細胞外プロトンをセンスするGタンパク共役型受容体の情報交換機構と生体機能(シンポジウム) (2010)
  • Author(s): 戸村秀明, 茂木千尋, 当房雅之, 佐藤幸市, 岡島史和
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 森秋旅館(伊香保)
• [Presentation] 抗動脈硬化性・抗炎症性作用におけるスタチンと高密度リポ蛋白質のクロストーク (2010)
  • Author(s): 岡島史和
  • Organizer: 日本薬学会第130年会シンポジウム血管病発症のシグナル伝達と新たな治療戦略
  • Place of Presentation: 岡山コンベンションセンター(岡山)
• [Presentation] 細胞外プロトンをセンスするGタンパク共役型受容体の情報交換機構と生体機能(シンポジウム) (2010)
  • Author(s): 戸村秀明
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保(群馬)
• [Presentation] リゾホスファチジン酸による血管内皮細胞のVEカドヘリンのトランスロケーション制御機構 (2010)
  • Author(s): 木村孝穂
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保(群馬)
• [Presentation] 低密度リポタンパク質によるヒト冠状動脈平滑筋細胞の遊走と増殖におけるリゾホスファチジン酸の役割とそのシグナル伝達機構の解析 (2010)
  • Author(s): 小町麻由美
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保(群馬)
• [Presentation] 気管支喘息におけるプロトン感知性Gタンパク質共役型受容OGR1の役割 (2010)
  • Author(s): 青木悠
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 肥満細胞からのLTC4産生は細胞内グルタチオン濃度によって規定される (2010)
  • Author(s): 関香織
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] ヒト気道上皮細胞におけるリゾホスファチジン酸のRANTES産生抑制効果 (2010)
  • Author(s): 松崎晋一
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] インスリン分泌における細胞外pHの影響とOGR1の役割 (2010)
  • Author(s): 中倉敬
  • Organizer: BMB2010第33回日本分子生物学会、第83回日本生化学会合同学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Each one of specified histidine residues in GPR4 is important for acidic pH-induced stimulation of multiple sinaling pathways (2010)
  • Author(s): Tomura H
  • Organizer: BhB2010第33回日本分子生物学会、第83回日本生化学会合同学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 糖質コルチコイドの抗炎症作用におけるTDAG8の役割 (2010)
  • Author(s): He XD
  • Organizer: BMB2010第33回日本分子生物学会、第83回日本生化学会合同学会
  • Place of Presentation: 神戸ポーアイランド
• [Presentation] ヒト膵臓癌細胞株のインビボ転移・浸潤に対するリゾボスファチジン酸受容体アンタゴニストKi16198の抑制作用 (2010)
  • Author(s): 小町麻由美
  • Organizer: BMB2010第33回日本分子生物学会、第83回日本生化学会合同学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 抗動脈硬化性・抗炎症性作用におけるスタチンと高密度リポ蛋白質のクロストーク (2010)
  • Author(s): 岡島史和
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] 細胞外プロトンをリガンドとするGタンパク質共役受容体の骨リモデリングにおける役割 (2009)
  • Author(s): 茂木千尋, 岡島史和
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館(前橋)
• [Presentation] HDLによる血管内皮機能調節機構(シンポジウム"血管新生と心血管系内分泌の新展開") (2009)
  • Author(s): 木村孝穂、岡島史和、村上正己
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館(前橋)
• [Presentation] ヒト大動脈血管平滑筋細胞のCOX-2発現/プロスタサイクリン産生応答におけるプロトン感知性GPCRとLPA受容体のクロストーク (2009)
  • Author(s): 劉進朋、戸村秀明、茂木千尋、小町麻由美、当房雅之、佐藤幸市、岡島史和
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: ウィルあいち(愛知県女性総合センター:名古屋)
• [Presentation] LPA1 receptors and LPA2 receptors mediate stimulation and inhibition of migration of pancreatic cancer cells, respectively. (2009)
  • Author(s): Mayumi Komachi, Alatangaole Damirin, Hideaki Tomura, Fumikazu Okajima
  • Organizer: 21st IUBMB & 12th FAOBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: Shanghai China,
• [Presentation] ヒト大動脈平滑筋細胞における細胞外プロトン/OGR1受容体を介したシクロゲナーゼー2の発現のリゾホスファチジン酸による増加 (2009)
  • Author(s): 戸村秀明、劉進朋、茂木千尋、小町麻由美、当房雅之、中倉敬、佐藤幸市、岡島史和
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] ラットアストロサイトにおけるインターロイキン-1βによるリゾホスファチジン酸受容体/遊走応答系の特異的な増強作用とRhoシグナリング (2009)
  • Author(s): 佐藤幸市、堀内雄太、小町麻由美、岡島史和
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] ヒト膵臓癌細胞の遊走・浸潤におけるリゾホスファチジン酸受容体LPA2の役割について (2009)
  • Author(s): 小町麻由美、佐藤幸市、戸村秀明、岡島史和
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 気道上皮細胞においてLPAはIRF-1活性化を抑制しRANTES産生を抑制する (2009)
  • Author(s): 松崎晋一、石塚全、宇津木光克、久田剛志、土橋邦生、岡島史和、森昌朋
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田キャッスルホテル
• [Presentation] 細胞外プロトンをリガンドとするGタンパク質共役型受容体の気管支喘息における役割 (2009)
  • Author(s): 青木悠、久田剛志、石塚全、宇津木光克、小野昭浩、古賀康彦、松崎晋一、上出庸介、矢富正清、土橋邦生、森昌朋、岡島史和
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田キャッスルホテル
• [Presentation] 細胞外pH低下はOGR1を介してMAP kinaseの活性化を伴ってヒト気管支平滑筋細胞からIL-6を産生させる (2009)
  • Author(s): 一文字功、石塚全、久田剛志、青木悠、森昌朋、岡島史和
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田キャッスルホテル
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html
• [Remarks]
  • URL: http://imcr.showa.gmma-u.acjp/lab/signal/index.html
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html