| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Research Abstract |
Tyrosine kinases are involved in cell proliferation, differentiation and cell motility, and their aberrations lead to neoplastic transformation. In this study, we showed that a kinase activity-independent and transient protein-protein interaction takes place between the Lyn kinase domain and long-chain acyl-CoA synthetase 3 (ACSL3) and the resulting protein-protein interaction triggers Lyn export from the Golgi membrane to the cell-surface membrane. Furthermore, we found that Lyn and c-Abl are involved in the regulation of gene expression through chromatin structure changes in a kinase activity-dependent manner.
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