Sorting of tyrosine kinases to organelles and signal transduction
| Project/Area Number |
21390017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
YAMAGUCHI Naoto 千葉大学, 大学院・薬学研究院, 教授 (00166620)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Uji 千葉大学, 大学院・薬学研究院, 准教授 (10280918)
FUKUMOTO Yasunori 千葉大学, 大学院・薬学研究院, 助教 (10447310)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | チロシンリン酸化 / シグナル伝達 / 細胞内トラフィック / 共焦点顕微鏡 / 癌 / ゴルジ体 / 細胞核 / クロマチンダイナミックス / Lyn / ACSL3 / 遺伝子 |
|---|
| Research Abstract |
Tyrosine kinases are involved in cell proliferation, differentiation and cell motility, and their aberrations lead to neoplastic transformation. In this study, we showed that a kinase activity-independent and transient protein-protein interaction takes place between the Lyn kinase domain and long-chain acyl-CoA synthetase 3 (ACSL3) and the resulting protein-protein interaction triggers Lyn export from the Golgi membrane to the cell-surface membrane. Furthermore, we found that Lyn and c-Abl are involved in the regulation of gene expression through chromatin structure changes in a kinase activity-dependent manner.
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Report
(4 results)
Research Products
(197 results)
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[Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis2011
Author(s)
Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A
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Journal Title
Blood
Volume: 118
Pages: 2443-2453
Related Report
Peer Reviewed
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[Journal Article] Direct activation of Stat5 by ETV6-Lyn fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis2011
Author(s)
Takeda Y, Nakaseko C, Tanaka H, Takeuchi M, Yui M, Saraya A, Miyagi S, Wang C, Tanaka S, Ohwada C, Sakaida E, Yamaguchi N, Yokote K, Hennighausen L, Iwama A
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Journal Title
Br. J. Haematol
Volume: 153
Pages: 589-598
Related Report
Peer Reviewed
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[Journal Article] Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification2011
Author(s)
Huang YC, Hasegawa H, Wang SW, Ku CC, Lin YC, Chiou SS, Hou MF, Wu DC, Tsai EM, Saito S, Yamaguchi N, Yokoyama KK
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Journal Title
J. Biomed. Biotechnol
Pages: 569034-569034
Related Report
Peer Reviewed
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[Journal Article] Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A22010
Author(s)
Pan J, Nakade K, Huang YC, Zhu ZW, Masuzaki S, Hasegawa H, Murata T, Yoshiki A, Yamaguchi N, Lee CH, Yang WC, Tsai EM, Obata Y, Yokoyama KK
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Journal Title
Oncogene
Volume: 29
Pages: 6245-6256
Related Report
Peer Reviewed
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[Journal Article] Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine2010
Author(s)
Fukumoto Y, Obata Y, Ishibashi K, Tamura N, Kikuchi I, Aoyama K, Hattori Y, Tsuda K, Nakayama Y, Yamaguchi N
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Journal Title
Cytotechnology
Volume: 67
Pages: 73-82
Related Report
Peer Reviewed
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[Journal Article] Role of histone chaperone JDP2 in replicative senescence2009
Author(s)
Nakade K, Pan J, Yamasaki T, Noguchi M, Masuzaki S, Kishikawa S, Murata T, Zhu ZW, Chen XY, Hasegawa H, Yamaguchi N, Tsai EM, Lee JN, Yokoyama KK
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Journal Title
Curr. Top. Biochem. Res
Volume: 11
Pages: 75-97
Related Report
Peer Reviewed
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[Journal Article] Differential trafficking of c-Src, Lyn, c-Yes and Fyn is specified by the state of palmitoylation in the SH4 domain2009
Author(s)
Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, Yokoyama KK, Saito T, Yamaguchi N
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Journal Title
J. Cell Sci
Volume: 122
Pages: 965-975
Related Report
Peer Reviewed
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