| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
The importance of interactions between neurons and glia in the pathogenesis of CNS disorders is becoming revealed and understood; however the pathophysiological roles of TRP channels in neuron-glia signaling remain to be elucidated. This study focused on TRPC3 expressed in astrocyte and TRPV4 and TRPM2 expressed in microglia. In vitro and in vivo experiments demonstrate that 1) TRPC3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice, 2) the opening of TRPV4 channel attenuates the driving force for extracellular Ca2+ and suppresses microglial activation, 3) TRPM2 could mediate the cerebral ischemic injury through NO release from macrophage/microglia. These results suggest that the above-mentioned TRP channelsmay constitute a new therapeutic target for CNS disorders.
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