Physiological functions of secreted phospholipase A_2 enzymes

• Project/Area Number: 21390027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: 財団法人東京都医学総合研究所 (2011); Tokyo Metropolitan Organization for Medical Research (2009-2010)
• Principal Investigator: MURAKAMI Makoto 財団法人東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員 (60276607)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Kei 財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (30304504) ; TAKETOMI Yoshitaka 財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員 (40365804)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 脂質 / ホスホリパーゼ / ノックアウトマウス / ホスホリパーゼA_2 / トランスジェニックマウス / 生体膜 / 脂質メタボロミクス / リン脂質 / 脂質メディエーター / 不飽和脂肪酸 / 皮膚 / 脂肪酸 / 炎症 / 精子

Research Abstract

To explore the in vivo functions of secreted phospholipase A_2s(sPLA_2s), we analyzed knockout and transgenic mice for individual sPLA_2 isoforms. We found that(1) the two sPLA_2s, III and X, respectively regulates sperm maturation and activation in male genital tracts ;(2) sPLA_<2-> X regulates hair homeostasis, gastrointestinal lipid digestion, and neuronal functions ;(3) sPLA_<2-> IID, a dendritic cell-specific isoform, participates in resolution of contact hypersensitivity ; and(4) sPLA_<2-> V, a diet-inducible adipocyte-derived sPLA_2, plays a role in amelioration of metabolic syndrome.

Research Products

• [Journal Article] PGD_2 induces eotaxin-3 via PPARγ from sebocytes : a possible pathogenesis of eosinophilic pustular folliculitis (2012)
  • Author(s): Nakahigashi, K., et al
  • Journal Title: J.Allergy Clin.Immunol. Volume: 129 Issue: 2 Pages: 536-543
  • DOI: 10.1016/j.jaci.2011.11.034
  • Peer Reviewed
• [Journal Article] Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2alpha, not iPLA2beta, to lipid mobilization in proximal mast cells and distal fibroblasts. (2011)
  • Author(s): Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M.
  • Journal Title: J. Biol. Chem. Volume: 186 Issue: 43 Pages: 37249-37263
  • DOI: 10.1074/jbc.m111.290312
  • Peer Reviewed
• [Journal Article] m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice (2011)
  • Author(s): Miyazaki, T., Taketomi, Y., Takimoto, M., Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
  • Journal Title: Circulation Volume: 124 Issue: 23 Pages: 2522-2532
  • DOI: 10.1161/circulationaha.111.021675
  • Peer Reviewed
• [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin (2011)
  • Author(s): Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
  • Journal Title: J. Biol. Chem Volume: 286 Issue: 13 Pages: 11616-11631
  • DOI: 10.1074/jbc.m110.206714
  • Peer Reviewed
• [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function (2011)
  • Author(s): Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
  • Journal Title: J. Biol. Chem Volume: 286 Issue: 13 Pages: 11632-11648
  • DOI: 10.1074/jbc.m110.206755
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A_2 revisited (2011)
  • Author(s): Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
  • Journal Title: J. Biochem. Volume: 150 Issue: 3 Pages: 233-255
  • DOI: 10.1093/jb/mvr088
  • NAID: 10030587186
  • Peer Reviewed
• [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans (2011)
  • Author(s): Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., and Yamamoto, K.
  • Journal Title: Prog. Lipid Res Volume: 50 Issue: 2 Pages: 152-192
  • DOI: 10.1016/j.plipres.2010.12.001
  • Peer Reviewed
• [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology (2011)
  • Author(s): Murakami, M., et al
  • Journal Title: Int.J.Mol.Sci. Volume: 12 Issue: 3 Pages: 1474-1495
  • DOI: 10.3390/ijms12031474
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis : integration with lipidomics (2011)
  • Author(s): Yamamoto, K., et al
  • Journal Title: Anal.Bioanal.Chem. Volume: 400 Issue: 7 Pages: 1829-1842
  • DOI: 10.1007/s00216-011-4864-z
  • Peer Reviewed
• [Journal Article] Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation (2011)
  • Author(s): Lu, Y., et al
  • Journal Title: Biochem.Pharmacol. Volume: 82 Pages: 1700-1708
  • Peer Reviewed
• [Journal Article] Lipid mediators in life science. (2011)
  • Author(s): Murakami, M.
  • Journal Title: Exp.Anim Volume: 60 Pages: 7-20
  • NAID: 10029549738
  • Peer Reviewed
• [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology. (2011)
  • Author(s): Murakami, M., Taketomi, Y., Sato, H., Yamamoto, K.
  • Journal Title: Int.J.Mol.Sci. Volume: 12 Pages: 1474-1495
  • Peer Reviewed
• [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans. (2011)
  • Author(s): Murakami, M., 他4名, Yamamoto, K.
  • Journal Title: Prog.Lipid Res. Volume: 50 Pages: 152-192
  • Peer Reviewed
• [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin. (2011)
  • Author(s): Yamamoto, K., 他18名, Murakami, M.
  • Journal Title: J.Biol.Chem Volume: 286 Pages: 11616-11631
  • Peer Reviewed
• [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. (2011)
  • Author(s): Sato, H., 他18名, Murakami, M.
  • Journal Title: J.Biol.Chem Volume: 286 Pages: 11632-11648
  • Peer Reviewed
• [Journal Article] マスト細胞生物学における脂質代謝ネットワーク (2011)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: YAKUGAKU ZASSHI Volume: 131 Pages: 73-84
  • NAID: 130000451529
• [Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca^<2+>-indpendent phospholipase A_2(iPLA_<2γ>) deficient mice (2010)
  • Author(s): Yoda, E., Hachisu, K., Taketomi, Y., Yoshida, K., Nakamura, M., Ikeda, K., Taguchi, R., Nakatani, Y., Kuwata, H., Murakami, M., Kudo, I., and Hara, S.
  • Journal Title: J. Lipid Res Volume: 51 Issue: 10 Pages: 3003-3015
  • DOI: 10.1194/jlr.m008060
  • Peer Reviewed
• [Journal Article] Group III secreted phospholipase A_2 regulates epididymal sperm maturation and fertility in mice (2010)
  • Author(s): Sato, H., Taketomi, Y., Isogai, Y., Miki, Y., Yamamoto, K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R., Hara, S., Kudo, I., and Murakami, M.
  • Journal Title: J. Clin. Invest Volume: 120 Issue: 5 Pages: 1400-1414
  • DOI: 10.1172/jci40494
  • Peer Reviewed
• [Journal Article] Group X phospholipase A_2 is released during sperm acrosome reaction and controls fertility outcome in mice (2010)
  • Author(s): Escoffier, J., Jemel, I., Tanemoto, A., Taketomi, Y., Payre, C., Coatrieux, C., Sato, H., Yamamoto, K., Masuda, S., Pernet-Gallay, K., Pierre, V., Hara, S., Murakami, M., De Waard, M., Lambeau, G., and Arnoult, C.
  • Journal Title: J. Clin. Invest Volume: 120 Issue: 5 Pages: 1415-1428
  • DOI: 10.1172/jci40493
  • Peer Reviewed
• [Journal Article] Emerging roles of secreted phospholipase A_2 enzymes : lessons from transgenic and knockout mice (2010)
  • Author(s): Murakami, M., Taketomi, Y., Girard, G., Yamamoto, K., and Lambeau, G.
  • Journal Title: Biochimie Volume: 92 Issue: 6 Pages: 561-582
  • DOI: 10.1016/j.biochi.2010.03.015
  • Peer Reviewed
• [Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca^<2+> indpendent phospholipase A_2(iPLA_2γ)deficient mice. (2010)
  • Author(s): Yoda, E., 他8名, Murakami, M., Kudo, I., Hara, S.
  • Journal Title: J.Lipid Res. Volume: 51 Pages: 3003-3015
  • Peer Reviewed
• [Journal Article] Emerging roles of secreted phospholipase A_2 enzymes : lessons from transgenic and knockout mice. (2010)
  • Author(s): Murakami, M., 他3名, Lambeau, G.
  • Journal Title: Biochimie Volume: 92 Pages: 561-582
  • Peer Reviewed
• [Journal Article] Prostaglandin E synthases : understanding their pathophysiological roles through mouse genetic models. (2010)
  • Author(s): Ham, S., 他4名, Murakami, M.
  • Journal Title: Biochimie Volume: 92 Pages: 651-659
  • Peer Reviewed
• [Journal Article] 分泌性ホスホリパーゼA_2 (2010)
  • Author(s): 村上誠
  • Journal Title: 日薬理誌 Volume: 135 Pages: 217-218
  • NAID: 10026439447
• [Journal Article] 分泌性ボスホリパーゼA_2遺伝子改変マウス (2010)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: The Lipid Volume: 121 Pages: 4-12
• [Journal Article] ホスホリパーゼA_2の生理的・病理的役割 (2010)
  • Author(s): 村上誠、佐藤弘泰、平林哲也、山本圭、武富芳隆
  • Journal Title: 実験医学 Volume: 28 Pages: 114-125
• [Journal Article] Group III secreted phospholipase A_2 regulates epididymal sperm maturation and fertility in mice (2010)
  • Author(s): Sato H, Taketomi T, 他14名, Murakami M.
  • Journal Title: J.Clin.Invest. 120 Pages: 1400-1414
  • Peer Reviewed
• [Journal Article] Group X phospholipase A_2 is released during sperm acrosome reaction and controls fertility outcome in mice (2010)
  • Author(s): Escoffier J, 他12名, Murakami M, Lambeau G, Arnoult C.
  • Journal Title: J.Clin.Invest. 120 Pages: 1415-1428
  • Peer Reviewed
• [Journal Article] Group III secreted phospholipase A_2 transgenic mice spontaneously develop inflammation (2009)
  • Author(s): Sato, H., Taketomi, Y., Isogai, Y., Masuda, S., Kobayashi, T., Yamamoto, K., and Murakami, M.
  • Journal Title: Biochem. J. Volume: 421 Issue: 1 Pages: 17-27
  • DOI: 10.1042/bj20082429
  • Peer Reviewed
• [Journal Article] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria (2009)
  • Author(s): Nakamura Y, Kambe N, 他3名, Murakami M, Nunez G, Matsue H.
  • Journal Title: J.Exp.Med. 206 Pages: 1037-1046
  • Peer Reviewed
• [Journal Article] Group III secreted phospholipase A_2 transgenic mice spontaneously develop inflammation (2009)
  • Author(s): Sato H, Taketomi Y, 他4名, Murakami, M.
  • Journal Title: Biochem.J. 425 Pages: 361-371
  • Peer Reviewed
• [Journal Article] Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumor growth, invasion and metastasis (2009)
  • Author(s): Kamei D, Murakami M, 名8他, Kudo I.
  • Journal Title: Biochem.J. 425 Pages: 361-371
  • Peer Reviewed
• [Journal Article] Distribution of smooth muscle cells and macrophages expressing scavenger receptor Bi/II in atherosclerosis (2009)
  • Author(s): Ishikawa Y, Murakami M, 他3名, Ishii T.
  • Journal Title: J.Ather.Thromb. 16 Pages: 829-839
  • NAID: 130004444353
  • Peer Reviewed
• [Journal Article] アレルギー性疾患における脂質メディエーターの役割 (2009)
  • Author(s): 武富芳隆、佐藤弘泰、村上誠
  • Journal Title: 実験医学 27 Pages: 2074-2079
• [Journal Article] 脂質メディエーターの機能:医療への応用を目指す基礎研究 (2009)
  • Author(s): 横溝岳彦、村上誠
  • Journal Title: 実験医学 27 Pages: 2040-2046
• [Journal Article] ホスホリパーゼA_2と炎症 (2009)
  • Author(s): 山本圭、村上誠
  • Journal Title: 炎症と免疫 17 Pages: 359-365
  • NAID: 10005879972
• [Presentation] Searching the secrets of secreted phospholipase A_<2s> (2011)
  • Author(s): Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier Symposium : New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in reproduction (2011)
  • Author(s): Ushida, A., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in skin homeostasis (2011)
  • Author(s): Yamamoto, K., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in anaphylaxis (2011)
  • Author(s): Taketomi, Y., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in metabolic syndrome (2011)
  • Author(s): Sato, H., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in atopic dermatitis (2011)
  • Author(s): Shimo, K., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Searching the secrets of secreted phospholipase A_2s (2011)
  • Author(s): Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-11-15
• [Presentation] アレルギー応答を制御する新しい脂質ネットワーク (2011)
  • Author(s): 村上誠、武富芳隆
  • Organizer: 第61回日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] アレルギー応答を制御する新しい脂質ネットワーク (2011)
  • Author(s): 村上誠、武富芳隆
  • Organizer: 第61回日本アレルギー学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-12
• [Presentation] sPLA_2 in epidermal differentiation, acidification, and barrier function (2011)
  • Author(s): Murakami, M., Lambeau, G., Gelb, M. H., and Yamamoto, K.
  • Organizer: The 8^<th> GERLI Lipidomics Meeting
  • Place of Presentation: Lyon, France
  • Year and Date: 2011-10-28
• [Presentation] Secreted Phospholipase A_2 in epidermal differentiation, acidification, and barrier function (2011)
  • Author(s): Murakami, M., Yamamoto, K.
  • Organizer: The 8^<th> GERLI Lipidomics meeting
  • Place of Presentation: Lyon, France(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] Hair follicular expression and fianction of group X secreted phospholipase A_2 in mouse skin (2011)
  • Author(s): Yamamoto, K., Murakami, M.
  • Organizer: The 8^<th> GERLI Lipidomics meeting
  • Place of Presentation: Lyon, France
  • Year and Date: 2011-10-27
• [Presentation] sPLA_2-IIDは抗炎症性脂質の産生を制御して炎症応答の寛解に関与する (2011)
  • Author(s): 三木寿美、村上誠
  • Organizer: ファーマ・バイオフォーラム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-09
• [Presentation] 細胞内II型PAFアセチルハイドロラーゼマスト細胞における機能解析 (2011)
  • Author(s): 嶋中雄太、村上誠、新井洋由
  • Organizer: ファーマ・バイオフォーラム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-08
• [Presentation] 皮脂腺に特異的に発現する新規脂質代謝酵素の機能解析 (2011)
  • Author(s): 平林哲也、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] 皮膚病態生理における分泌性ホスホリパーゼA_2の機能 (2011)
  • Author(s): 山本圭、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] PGE_2-EP3受容体シグナルはマスト細胞の活性化を介して炎症を惹起する (2011)
  • Author(s): 森本和志、村上誠、杉本幸彦
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] 好酸球性膿疱性毛包炎におけるPGD_2の役割の解明 (2011)
  • Author(s): 中東恭子、村上誠、椛島健次
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] 皮膚病態生理における分泌性ホスホリパーゼA_2の機能 (2011)
  • Author(s): 山本圭、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-09-23
• [Presentation] アトピー性皮膚炎モデルにおける分泌性ホスホリパーゼA_2分子群の機能解析 (2011)
  • Author(s): 下華奈子、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] X型分泌性ホスホリパーゼA_2の消化、神経機能、体毛形成における新規機能 (2011)
  • Author(s): 佐藤弘泰、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] X型分泌性ホスホリパーゼA_2の生殖における新規機能 (2011)
  • Author(s): 牛田絢子、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] ホスファチジルエタノールアミンは破骨細胞融合に関与する (2011)
  • Author(s): 入江敦、山本圭、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] 細胞内II型PAFアセチルヒドラーゼのマスト細胞における機能解析 (2011)
  • Author(s): 嶋中雄太、村上誠、新井洋由
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2011)
  • Author(s): 武富芳隆、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] Getting new insights into the functions of sPLA_2s (2011)
  • Author(s): Murakami, M., Sato, H., Taketomi, Y., and Yamamoto, K.
  • Organizer: The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: Seattle, WA, USA
  • Year and Date: 2011-09-21
• [Presentation] Getting new insights into the functions of sPLA_2s (2011)
  • Author(s): Murakami, M.
  • Organizer: The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-21
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2011)
  • Author(s): 武富芳隆、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] An adipokine-like phospholipase A_2 from hypertrophied adipocytes controls lipid metabolism and obesity (2011)
  • Author(s): Sato, H., Murakami, M.
  • Organizer: The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-19
• [Presentation] Group IIF phospholipase A_2 maintains epidermal homeostasis (2011)
  • Author(s): Yamamoto, K., Murakami, M.
  • Organizer: The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-19
• [Presentation] Phospholipase A_2s in adiposity and metabolic syndrome (2011)
  • Author(s): Murakami, M.
  • Organizer: The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2011-06-30
• [Presentation] Phospholipase A_2s in adiposity and metabolic syndrome (2011)
  • Author(s): Murakami, M.
  • Organizer: The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] Roles of multiple sPLA_2 enzymes in obesity, hepatic steatosis, insulin tolerance, lipoprotein metabolism and adipose inflammation (2011)
  • Author(s): Sato, H., Murakami, M.
  • Organizer: The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-30
• [Presentation] Metabolic pathways regulating formation and composition of lipid droplets in sebocytes (2011)
  • Author(s): Hirabayashi, T., Murakami, M.
  • Organizer: The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-30
• [Presentation] 外根鞘に局在するsPLA_2-Xは体毛の恒常性維持に関与する (2011)
  • Author(s): 山本圭、村上誠
  • Organizer: 第53回脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] 樹状細胞のsPLA_2-IIDは炎症応答の寛解を制御する (2011)
  • Author(s): 三木寿美、村上誠
  • Organizer: 第53回脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] 脂肪過栄養により誘導されるsPLA_2-Vは全身的な脂質代謝異常を制御する (2011)
  • Author(s): 佐藤弘泰、村上誠
  • Organizer: 第53回脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] 分泌性ボスホリパーゼA_2と循環器疾患 (2011)
  • Author(s): 村上誠
  • Organizer: 日本薬学会
  • Place of Presentation: 静岡(招待講演)
  • Year and Date: 2011-03-30
• [Presentation] ホスホリパーゼA_2による精子成熟と活性化の制御 (2011)
  • Author(s): 佐藤弘泰、原俊太郎、村上誠
  • Organizer: 日本薬学会
  • Place of Presentation: 静岡(招待講演)
  • Year and Date: 2011-03-29
• [Presentation] New insights into the functions of secreted phospholipase A_2s (2010)
  • Author(s): 村上誠
  • Organizer: BMB2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] New insights into the functions of secreted phospholipase A_2S. (2010)
  • Author(s): 村上誠
  • Organizer: BMB2010
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2010-12-10
• [Presentation] ホスホリパーゼA_2研究における脂質メタボロームの応用展開 (2010)
  • Author(s): 村上誠
  • Organizer: ホスファチジルセリン研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-12-03
• [Presentation] 分泌性ホスホリパーゼA_2による生命応答の制御 (2010)
  • Author(s): 村上誠
  • Organizer: 東大脂質談話会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-10-27
• [Presentation] 脂質メタボロミクスの応用展開:ホスホリパーゼA_2と生活習慣病 (2010)
  • Author(s): 村上誠
  • Organizer: 日本医用マススペクトル学会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2010-09-09
• [Presentation] sPLA_2の新展開:アレルギー、メタボリックシンドロームにおける新しい機能 (2010)
  • Author(s): 村上誠
  • Organizer: 武田薬品特別シンポジウム
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-08-31
• [Presentation] Secreted phospholipase A_2, lipid mediators, and immunity (2010)
  • Author(s): Murakami, M., Taketomi, Y., and Yamamoto, K.
  • Organizer: 14^<th> International Congress of Inflammation
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-27
• [Presentation] Secreted phospholipase A_2, lipid mediators, and immunity. (2010)
  • Author(s): Murakami, M., Taketomi, Y., Yamamoto, K.
  • Organizer: 14^<th> International Congress of Inflammation
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-27
• [Presentation] Emerging roles of secreted phospholipase A_2 in atherosclerosis and metabolic disorders (2010)
  • Author(s): 村上誠
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] Emerging roles of secreted phospholipase A_2 in atherosclerosis and metabolic disorders. (2010)
  • Author(s): 村上誠
  • Organizer: 日本動脈硬化学会
  • Place of Presentation: 岐阜(招待講演)
  • Year and Date: 2010-07-16
• [Presentation] Solving the secrets of secreted phospholipase A_2s (2010)
  • Author(s): Murakami, M.
  • Organizer: FASEB Summer Research Conferences on Phospholipid Metabolism
  • Place of Presentation: Steamboat Springs, USA
  • Year and Date: 2010-06-30
• [Presentation] Solving the secrets of secreted phospholipase A_2S. (2010)
  • Author(s): Murakami, M
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Steamboat Springs, USA(招待講演)
  • Year and Date: 2010-06-30
• [Presentation] Biological functions of sPLA_2s (2010)
  • Author(s): Murakami, M.
  • Organizer: Keystone Symposia
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-07
• [Presentation] Biological functions of sPLA_2S. (2010)
  • Author(s): Murakami, M
  • Organizer: Keystone Symposia
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2010-06-07
• [Presentation] マスト細胞生物学における脂質ネットワーク (2010)
  • Author(s): 武富芳隆、村上誠
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] マスト細胞の成熟とエフェクター機能を制御する新しい分子マシナリー (2010)
  • Author(s): 村上誠
  • Organizer: 第18回関東アレルギークラブ
  • Place of Presentation: 東京
  • Year and Date: 2010-02-20
• [Presentation] 油はなぜ体に必要か? 脂質代謝酵素のノックアウトからわかる脂質の重要性 (2009)
  • Author(s): 村上誠
  • Organizer: The 4^<th> JOCS-ILSI Japan Joint Symposium
  • Place of Presentation: 東京
  • Year and Date: 2009-11-06
• [Presentation] sPLA_2ネットワーク (2009)
  • Author(s): 村上誠
  • Organizer: 日本生化学会第82年会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] Group III secreted phospholipase A_2, an endogenous bee venom phospholipase A_2 homolog, is a critical regulator of mast cell maturation and functions (2009)
  • Author(s): Taketomi, Y., Sato, H., 他7名, Murakami, M.
  • Organizer: The 9^h World Congress on Inflammation
  • Place of Presentation: 東京
  • Year and Date: 2009-07-07
• [Presentation] ヘビ毒ホスホリパーゼA_2の哺乳動物における内因性ホモログの生理的機能 (2009)
  • Author(s): 村上誠
  • Organizer: アルカロイド研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-06-27
• [Presentation] Group III phospholipase A_2 in reproduction and allergy (2009)
  • Author(s): Murakami, M.
  • Organizer: The 4^<th> International Conference on Phospholipase A_2s and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2009-05-27
• [Presentation] Group III phospholipase A_2 in reproduction and allergy (2009)
  • Author(s): 村上誠
  • Organizer: The 4^<th> International Conference on Phospholipase A_2s and Lipid Mediators
  • Place of Presentation: 東京
  • Year and Date: 2009-05-27
• [Presentation] Group IIF phospholipase A_2 ; an epidermal secreted phospholipase A_2 (2009)
  • Author(s): Yamamoto, K., Taketomi, Y., 他6名, Murakami, M.
  • Organizer: The 4^<th> International Conference on Phospholipase A_2s and Lipid Mediators
  • Place of Presentation: 東京
  • Year and Date: 2009-05-27
• [Book] Phospholipase A_2 and lipid mediators. Biochimie special issue (2010)
  • Author(s): Lambeau, G. and Murakami, M.
• [Book] Phospholipase A_2 and lipid mediators (2010)
  • Author(s): Lambeau, G.Murakami, M
  • Total Pages: 728
  • Publisher: Biochimie Special Issue(Elsevier)
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