Fluorinated Medicines : Drug Development based on Functional Groups

• Project/Area Number: 21390030
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: SHIBATA Norio 名古屋工業大学, 大学院・工学研究科, 教授 (40293302)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
• Keywords: 医薬品化 / 有機化学 / フッ素 / 創薬 / 不斉合成 / 生理活性物質 / 不斉導入 / 有機触媒 / トリフルオロメチル / モノフルオロメチル / 医薬品 / α-トリフルオロメチルケトン / 脱炭酸反応 / アリル化 / パラジウム / 触媒反応 / カップリング / 銅 / 求核的 / 求電子的 / 触媒 / アルキルハライド

Research Abstract

We have developed the novel trifluoromethylation and monofluoromethylation reaction toward for drug development and the methods were applied to the synthesis of biologically attractive molecules.

Research Products

• [Journal Article] Influence of New Fullerene Derivatives with Fluorocarbon Substituent on Performance of Polymer Solar Cells (2011)
  • Author(s): Ichiko Yamada, Manoj Pandey, Yasuhiko Hayashi, Norio Shibata, Tesuo Saga, Takeshi Torub
  • Journal Title: Physics Procedia Volume: 14 Pages: 192-197
  • Peer Reviewed
• [Journal Article] A New Synthetic Approach to Efavirenz through Enantioselective Trifluorome thylation by Using the Ruppert Prakash Reagent (2011)
  • Author(s): Hiroyuki Kawai, Takashi Kitayama, Etsuko Tokunaga, Norio Shibata
  • Journal Title: Eur. J. Org. Chem Volume: 30 Pages: 5959-5961
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of Chiral Trifluoromethylated Heliotridane via Highly Catalytic Asymmetric Frieder-Crafts Alkylation with ls-Trifluorome thylated Acrylates and Pyrroles (2011)
  • Author(s): Yiyong Hwang, Satoru Suzuki, Guokai Lin, Etsuko Tokunaga, Mo too Shire and Norio Shibata
  • Journal Title: New. J. Chem Volume: 35 Pages: 2614-2621
  • Peer Reviewed
• [Journal Article] AsymmetricAllylic Monofluorome thylationand Methylation of Morita-Baylis-Hillman Carbonates with FBSM and BSM by Cooperative Cinchona Alkaloid/FeCl2 Catalysis (2011)
  • Author(s): Tatsuya Furukawa, Jumper Kawazoe, wet Zhang, Takayuki Nishimine, Etsuko Tokunaga, Takashi Matsumoto, Dr. Mo too Shire, Prof. Norio Shibata
  • Journal Title: Angew. Chem. Mt. Ed Volume: 50(41) Pages: 9684-9688
  • Peer Reviewed
• [Journal Article] Organocatalyzed Regia and Enantioselective Allylic Trifluoromethylation of Morita-Baylis Hillman Adducts Using Ruppert Prakash Reagent (2011)
  • Author(s): Tatsuya Furukawa, Takayuki Nishimine, Etsuko Tokunaga, Kimiko Hasegawa, Mo too Shire, and Norio Shibata
  • Journal Title: Org. Left Volume: 13(15) Pages: 3972-3975
  • Peer Reviewed
• [Journal Article] Construction of Trifluorome thyl Bearing Quaternary Carbon Centers by Intramolecular Decarboxylative Allylation of a Trifluoromethyl 6-Keto Esters (2011)
  • Author(s): Norio Shibata, Satoru Suzukil, Tatsuya Furukawa, Hiroyuki Kawai, Etsuko Tokunaga, Zhe Yuan, Dominique Canard
  • Journal Title: Adv. Synth. Catal Volume: 353(11-12) Pages: 2037-2041
  • Peer Reviewed
• [Journal Article] A Characterization of Maternal and Developmental Toxicity in Rabbits and Mice (2011)
  • Author(s): Crystal J. J. Lee, Norio Shibata, Michael J. Wiley and Peter G. wellst
  • Journal Title: Toxicol. Sci Volume: 122(1) Pages: 157-169
  • Peer Reviewed
• [Journal Article] Cu Mediated Chemo-selective Trifluoromethylation of Benzyl Bromides using Shelf-stable Electrophilic Trifluoromethylating Reagents (2011)
  • Author(s): Hiroyuki Kawai, Tatsuya Furukawa, Yoshinori Nomura, Etsuko Tokunaga, and Norio Shibata
  • Journal Title: Org. Left Volume: 13(14) Pages: 3596-3599
  • Peer Reviewed
• [Journal Article] Trifluoromethylation of Aromatic Isoxazoles : Regia and Di istereoselective Route to 5-Trifluoromethyl-2-isoxazolines (2011)
  • Author(s): Hiroyuki Kawai, Kentaro Tachi, Etsuko Tokunaga, Dr. Motoo Shire, Prof. Norio Shibata
  • Journal Title: Angew. Chem. Int. Ed Volume: 123(34) Pages: 7949-7952
  • Peer Reviewed
• [Journal Article] In vive Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice (2011)
  • Author(s): Hiroshi Yamazaki, Hiroshi Suemizu, She Igaya, Makiko Shimizu, Norio Shibata
  • Journal Title: Chem. Res. Toxicol Volume: 24(3) Pages: 287-289
  • Peer Reviewed
• [Journal Article] Robust Synthesis of Trifluoromethionine and Its Derivatives by Reductive Trifluoromethylation of Amino Acid Disulfides by CFsI/NaILiq. NH3 system (2011)
  • Author(s): Hiroyuki Yasui, Takeshi Yamamoto, Etsuko Tokunaga, Norio Shibata
  • Journal Title: J Fluorine Chem Volume: 132(3) Pages: 186-189
  • Peer Reviewed
• [Journal Article] A sterically Demanding Electrophilic Fluorinating Reagent for Enantioselective Fluorination (2011)
  • Author(s): Hiroyuki Yasui, Takeshi Yamamoto, Takehisa Ishimaru, Takeo Fukuzumi, Etsuko Tokunaga, Kakehi Akikazu, Mo too Shire, Norio Shibata
  • Journal Title: J. Fluorine Chem Volume: 132(3) Pages: 222-225
  • Peer Reviewed
• [Journal Article] Catalyst-Free and Catalytic Friedel Crafts Alkylations of Indoles in Solkane(R) 365mfc, an Environmentally Benign Alternative Solvent (2011)
  • Author(s): Xiu-Hua Xu, Akihiro Kusuda, Etsuko Tokunaga and Norio Shibata
  • Journal Title: Green Chem Volume: 13 Pages: 46-50
  • Peer Reviewed
• [Journal Article] Organic Reaction in Solkane(R) 365mfc : Homocoupling Reaction of Terminal Alkynes (2011)
  • Author(s): Akihiro Kusuda, Xiu-Hua Xu, Xin Wang, Etsuko Tokunaga and Norio Shibata
  • Journal Title: Green Chem Volume: 13 Pages: 843-846
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of Both Mirror Images of s' Fluorothalidomideby Enantiodivergent Fluorination Using a Single (2011)
  • Author(s): Takeshi Yamamoto, Yuka Suzuki, Emi Ita, Etsuko Tokunaga, and Norio Shibata
  • Journal Title: Org. Lef Volume: 13(3) Pages: 470-473
  • Peer Reviewed
• [Journal Article] Inherent Oxygen Preference in Enolate Monofluoromethylation and a Synthetic Entry to Monofluoromethyl Ethers (2011)
  • Author(s): Yoshinori Nomura, Etsuko Tokunaga, Prof. Norio Shibata
  • Journal Title: Angew. Chem. Int. Ed Volume: 50 Pages: 1885-1889
  • Peer Reviewed
• [Journal Article] A sterically Demanding Electrophilic Fluorinating Reagent for Enantioselective Fluorination (2011)
  • Author(s): Hiroyuki Yasui, Takeshi Yamamoto, Takehisa Ishimaru, Takeo Fukuzumi, Etsuko Tokunaga, Kakehi Akikazu, Mo too Shire, Norio Shibata
  • Journal Title: J. Fluorine Chem. Volume: 132(3) Pages: 222-225
  • Peer Reviewed
• [Journal Article] Robust Synthesis of Trifluoromethionine and Its Derivatives by Reductive Trifluoromethylation of Amino Acid Disulfides by CFsI/Na/Liq. NH3 system (2011)
  • Author(s): Hiroyuki Yasui, Takeshi Yamamoto, Etsuko Tokunaga, Norio Shibata
  • Journal Title: J. Fluorine Chem. Volume: 132(3) Pages: 186-189
  • Peer Reviewed
• [Journal Article] Catalyst-Free and Catalytic Frieder-Crafts Alkylations of Indoles in Solkane(R) 365mfc, an Environmentally Benign Alternative Solvent (2011)
  • Author(s): Xiu-Hua Xu, Akihiro Kusuda, Etsuko Tokunaga, Norio Shibata
  • Journal Title: Green Chem. Volume: 13 Pages: 46-50
  • Peer Reviewed
• [Journal Article] Inherent Oxygen Preference in Enolate Monofluorome thylation and a Synthetic Entry to Monofluoromethyl Ethers (2011)
  • Author(s): Yoshinori Nomura, Etsuko Tokunaga, Norio Shibata
  • Journal Title: Angew Chem. Int. Ed. Volume: 50 Pages: 1885-1889
  • Peer Reviewed
• [Journal Article] A New Synthetic Approach to Efavirenz based on the Enantioselective Trifluoromethylation using Ruppert-Prakash Reagent (2011)
  • Author(s): Hiroyuki Kawai
  • Journal Title: European Journal of Organic Chemistry Volume: 30 Issue: 30 Pages: 5959-5961
  • DOI: 10.1002/ejoc.201101038
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of Chiral Trifluoromethylated Heliotridane via Highly Catalytic Asymmetric Friedel-Crafts Alkylation with β-Trifluorom ethylated Acrylates and Pyrroles (2011)
  • Author(s): Suzuki Satoru
  • Journal Title: New.J.Chem. Volume: 35 Issue: 11 Pages: 2614-2621
  • DOI: 10.1039/c1nj20550a
  • Peer Reviewed
• [Journal Article] Asymmetric Allylic Monofluoromethylation and Methylation of Morita-Baylis Hillman Carbonates with FBSM and BSM by Cooperative Cinchona Alkaloid/FeCl_2 Catalysis (2011)
  • Author(s): Tatsuya Furukawa
  • Journal Title: Angew.Chem.Int.Ed. Volume: 50 Issue: 41 Pages: 9684-9688
  • DOI: 10.1002/anie.201103748
  • Peer Reviewed
• [Journal Article] Organocatalyzed Regio- and Enantioselective Trifluoromethylation of Morita-Baylis-Hillman Adducts Using Ruppert Reagent (2011)
  • Author(s): Tatsuya Furukawa
  • Journal Title: Org.Lett. Volume: 13 Issue: 15 Pages: 3972-3975
  • DOI: 10.1021/ol201490e
  • Peer Reviewed
• [Journal Article] Construction of Trifluoromethyl-Bearing Quaternary Carbon Centers by Intramolecular Decarboxylative Allylation of α-Trifluoromethyl β-Keto Esters (2011)
  • Author(s): Norio Shibata
  • Journal Title: Advanced Synthesis & Catalysis Volume: 353 Issue: 11-12 Pages: 2037-2041
  • DOI: 10.1002/adsc.201100359
  • Peer Reviewed
• [Journal Article] Synthesis of Indole and Biindolyl Triflones : Trifluoromethanesulfonylation of Indoles with Tf2O/TTBP (2,4,6-tri-tert-butylpyridine) System (2011)
  • Author(s): Xu, Xiu-Hua
  • Journal Title: Org.Lett. Volume: 13 Issue: 18 Pages: 4845-4857
  • DOI: 10.1021/ol201931x
  • Peer Reviewed
• [Journal Article] Fluorothalidomide : A Characterization of Maternal and Developmental Toxicity in Rabbits and Mice (2011)
  • Author(s): Shibata Norio
  • Journal Title: Toxicol.Sci. Volume: 122 Issue: 1 Pages: 157-169
  • DOI: 10.1093/toxsci/kfr086
  • Peer Reviewed
• [Journal Article] Cu-Mediated Chemo-selective Trifluoromethylation of Benzyl Bromides using Shelf-stable Electrophilic Trifluoromethylating Reagents (2011)
  • Author(s): Hiroyuki Kawai
  • Journal Title: Organic Lettres Volume: 13 Issue: 14 Pages: 3596-3599
  • DOI: 10.1021/ol201205t
  • Peer Reviewed
• [Journal Article] Trifluoromethylation of Aromatic Isoxazoles : Regio- and Diastereoselective Route to 5-Trifluoromethyl-2-isoxazolines (2011)
  • Author(s): Hiroyuki Kawai
  • Journal Title: Angewandte Chemie International Edition Volume: 50 Issue: 34 Pages: 7803-7806
  • DOI: 10.1002/anie.201102442
  • Peer Reviewed
• [Journal Article] In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG (2011)
  • Author(s): Yamazaki, H., Suemizu, H.(8名・2番目)
  • Journal Title: Mice Chem Res Toxicol Volume: 24 Issue: 3 Pages: 287-289
  • DOI: 10.1021/tx200005g
  • Peer Reviewed
• [Journal Article] Robust Synthesis of Trifluoromethionine and Its Derivatives by Reductive Trifluoromethylation of Amino Acid Disulfides by CF3I/Na/Liq.NH3 system (2011)
  • Author(s): Yasui, Hiroyuki
  • Journal Title: J.Fluorine Chem. Volume: 132 Issue: 3 Pages: 186-189
  • DOI: 10.1016/j.jfluchem.2011.01.001
  • Peer Reviewed
• [Journal Article] N-Fluoro-(3,5-di-tert-butyl-4-methyoxy)benzenesulfonimide (NFBSI) : A sterically Demanding Electrophilic Fluorinating Reagent for Enantioselective Fluorination (2011)
  • Author(s): Yasui, Hiroyuki
  • Journal Title: J.Fluorine Chem. Volume: 132 Issue: 3 Pages: 222-225
  • DOI: 10.1016/j.jfluchem.2011.01.005
  • Peer Reviewed
• [Journal Article] Catalyst-Free and Catalytic Friedel-Crafts Alkylations of Indoles in Solkane[○!R] 365mfc, an Environmentally Benign Alternative Solvent (2011)
  • Author(s): Xu, Xiu-Hua
  • Journal Title: Green Chem. Volume: 13 Issue: 1 Pages: 843-846
  • DOI: 10.1039/c0gc00619j
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of Both Mirror Images of 3'-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid (2011)
  • Author(s): Yamamoto Takeshi
  • Journal Title: Org.Lett. Volume: 13 Issue: 3 Pages: 470-473
  • DOI: 10.1021/ol102818g
  • Peer Reviewed
• [Journal Article] Inherent Oxygen Preference in Enolate Monofluoromethylation and a Synthetic Entry to Monofluoromethyl Ethers (2011)
  • Author(s): Nomura Yoshinori
  • Journal Title: Angew.Chem.Int.Ed. Volume: 20 Issue: 8 Pages: 1885-1889
  • DOI: 10.1002/anie.201006218
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of Both Mirror Images of s' Fluorothalidomide by Enantiodivergent Fluorination Using a Single (2010)
  • Author(s): Takeshi Yamamoto, Yuka Suzuki, Emi Ita, Etsuko Tokunaga, Norio Shibata
  • Journal Title: Org. Left. Volume: 12(22) Pages: 5104-5107
  • Peer Reviewed
• [Journal Article] Cinchona Alkaloid Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane (2010)
  • Author(s): Hiroyuki Kawai, Kentaro Tachi, Etsuko Tokunaga, Mo too Shire, Norio Shibata
  • Journal Title: Org. Left. Volume: 12(22) Pages: 5104-5107
  • Peer Reviewed
• [Journal Article] Expeditious Synthesis of Trifluoromethylated Heterocycles : Noncatalytic 1, sDipolar Cyclization of Azomethine Imines with(aTrifluoromethyl) acrylates (2010)
  • Author(s): Shinichi Ogawa, Takayuki Nishimine, Etsuko Tokunaga, Norio Shibata
  • Journal Title: Synthesis Volume: 19 Pages: 3274-3281
  • Peer Reviewed
• [Journal Article] Enantioselective Syntehsis of Trifluoromethyl Substituted 2 Isoxazolines : Asymmetric Hydroxylamine/Enone Cascade Reaction (2010)
  • Author(s): Kazutaka Matoba, Hiroyuki Kawai, Tatsuya Furukawa, Akihiro Kusuda, Etsuko Tokunaga, Shuichi Nakamura, Mo too Shire, Norio Shibata
  • Journal Title: Angew. Chem. Int. Ed Volume: 49(33) Pages: 5762-5766
  • Peer Reviewed
• [Journal Article] Trifluoroethoxy Coating Improves the Axal Ligand Substitution of Subphthalocyanine (2010)
  • Author(s): Norio Shibata, Banibrata Das, Etsuko Tokunaga, Mo too Shire, Nagao Kobayashi
  • Journal Title: Chem. Eur : J Volume: 16(25) Pages: 7554-7562
  • Peer Reviewed
• [Journal Article] Chinchona alkaloid/Ti' vCatalyzed Enantioselective Enamine Trifluoropyruvate Condensation Cyclization Reaction anc Its Application to Drug-like Heterocycles (2010)
  • Author(s): Shinichi Ogawa, Norihito Iida, Etsuko Tokunaga, Mo too Shire, Norio Shibata
  • Journal Title: Chem. Eur J Volume: 16(24) Pages: 7090-7095
  • Peer Reviewed
• [Journal Article] Perfluoroisopropyl Zinc Phthalocyaines Conjugated with Deoxyribonucleosides : Synthesis, Photophysical Properties and In Vitro PHotodynamic Activities (2010)
  • Author(s): Banibrata Das, Etsuko Tokunaga, Motohiro Tanaka, Takuma Sasaki, Norio Shibata
  • Journal Title: Eur J. Org. Chem Volume: 15 Pages: 2878-2884
  • Peer Reviewed
• [Journal Article] Solubility of Trifluoroethoxyphthalocyanines and Subphthalocyanines in Liquid and Supercritical Carbon Dioxide (2010)
  • Author(s): Banibrata Das, Etsuko Tokunaga, Norio Shibata, Nagao Kobayashi
  • Journal Title: J. Fluorine Chem Volume: 131(5) Pages: 652-654
  • Peer Reviewed
• [Journal Article] Enantioselective Frieder-Crafts Reaction of lsTrifluoromethylated Acrylates with Pyrroles and Its Application to the Synthesis of Trifluorinated Heliotridane (2010)
  • Author(s): Yiyong Hwang, Etsuko Tokunaga, Satoru Suzuki, Mo too Shire, Norio Shibata
  • Journal Title: Org. Left Volume: 12(5) Pages: 1136-1138
  • Peer Reviewed
• [Journal Article] Synthesis of Benzenecentered Trinuclear Phthalocyanines by Triple-click Chemistry (2010)
  • Author(s): Banibrata Das, Masashi Umeda, Etsuko Tokunaga, Takeshi Torn, Norio Shibata
  • Journal Title: Chem. Left Volume: 39(4) Pages: 337-338
  • Peer Reviewed
• [Journal Article] Self Disproportionation of Enantiomers of Heterocyclic Compounds Having a Tertiary Trifluoromethyl Alcohol Center on Chromatography with a Non Chiral System (2010)
  • Author(s): Shinichi Ogawa, Takayuki Nishimine, Etsuko Tokunaga, Shuichi Nakamura Norio Shibata
  • Journal Title: J Fluorine Chem Volume: 131(4) Pages: 521-524
  • Peer Reviewed
• [Journal Article] 2-Fluoro-1, 3-benzodithiole-1, 1, 3, 3-tetraoxide : A Reagent for Nucleophilic Monofluoromethylation of Aldehydes (2010)
  • Author(s): Tatsuya Furukawa, Yosuke Goto, Jumper Kawazoe, Etsuko Tokunaga, Shuichi Nakamura, Yudong Yang, Hongguang Du, Akikazu Kakehi, Mo too Shire, Norio Shibata
  • Journal Title: Angew. Chem. Mt. Ed Volume: 49(9) Pages: 1642-1647
  • Peer Reviewed
• [Journal Article] Efficient Access to Extended Yagupolskii Umemoto-Type Reagents : Triflic Acid Catalyzed Intramolecular Cyclization of or the Ethynylaryltrifluoromethylsulfanes (2010)
  • Author(s): Andrej Matsnev, Shun Noritake, Yoshinori Nomura, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata
  • Journal Title: Angew. Chem. Mt. Ed Volume: 49(3) Pages: 572-576
  • Peer Reviewed
• [Journal Article] Perfluoroisopropyl Zinc Phthalocyanines Conjugated with Deoxyribonucle osides : Synthesis, Photophysical Properties and In Vitro Photodynamic Activities (2010)
  • Author(s): Banibrata Das
  • Journal Title: Eur.J.Org.Chem. Pages: 2878-2884
  • Peer Reviewed
• [Journal Article] Cinchona Alkaloid/TiIV-Catalyzed Enantioselective Enamine-Trifluoropyruvate Condensation-Cyclization Reaction and Its Application to Drug-like Heterocycles (2010)
  • Author(s): Shinichi Ogawa
  • Journal Title: Chem.Eur.J. Volume: 16 Pages: 7090-7095
  • Peer Reviewed
• [Journal Article] Trifluoroethoxy-Coating Improves the Axial Ligand Substitution of Subp hthalocyanine (2010)
  • Author(s): Norio Shibata
  • Journal Title: Chem.Eur.J. Volume: 16 Pages: 7554-7562
  • Peer Reviewed
• [Journal Article] Enantioselective Synthesis of Trifluoromethyl-Substituted 2-Isoxazolines : Asymmetric Hydroxylamine/Enone Cascade Reaction (2010)
  • Author(s): Kazutaka Matoba
  • Journal Title: Angew.Chem.Int.Ed. Volume: 49 Pages: 5762-5766
  • Peer Reviewed
• [Journal Article] Expeditious Synthesis of Trifluoromethylated Heterocycles : Noncatalytic 1,3-Dipolar Cyclization of Azomethine Imines with (α-Trifluoromethyl) acrylates (2010)
  • Author(s): Shinichi Ogawa
  • Journal Title: Synthesis Pages: 3274-3281
  • Peer Reviewed
• [Journal Article] Cinchona Alkaloid-Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane (2010)
  • Author(s): Hiroyuki Kawai
  • Journal Title: Org.Lett. Volume: 12 Pages: 5104-5107
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of Both Mirror Images of 3-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid (2010)
  • Author(s): Takeshi Yamamoto
  • Journal Title: Org.Lett. Volume: 13 Pages: 470-473
  • Peer Reviewed
• [Journal Article] Catalyst-free and catalytic Friedel? Crafts alkylations of indoles in SolkaneR 365mfc, an environmentally benign alternative solvent (2010)
  • Author(s): Xiu-Hua Xu
  • Journal Title: Green Chem. Volume: 13 Pages: 46-50
  • Peer Reviewed
• [Journal Article] Inherent Oxygen Preference in Enolate Monofluoromethylation and a Synthetic Entry to Monofluoromethyl Ethers (2010)
  • Author(s): Yoshinori Nomura
  • Journal Title: Angew.Chem.Int.Ed. Volume: 50 Pages: 1885-1889
  • Peer Reviewed
• [Journal Article] Synthesis of Fluorinated Alienes via Palladium Catalyzed Monofluoromethylation Using FBSM (2009)
  • Author(s): Masamichi Ogasawara, HidetoshiMurakami, Tatsuya Furukawa, Tamotsu Takahashi, Norio Shibata
  • Journal Title: Chem. Commun Volume: 47 Pages: 7366-7368
  • Peer Reviewed
• [Journal Article] Construction of Nonadjacent Stereocenters Containing a Trifluoromethylated Carbon by Organocatalyzed Michael Addition of lsKetoesters to 2(Trifluoromethyl) acrylate (2009)
  • Author(s): Shinichi Ogawa, Hiroyuki Yasui, Shuichi Nakamura, Norio Shibata
  • Journal Title: Chem. Left Volume: 10 Pages: 1006-1007
  • Peer Reviewed
• [Journal Article] Design and Synthesis of Thalidomide Deoxyribonucleoside Chimeras (2009)
  • Author(s): Shigeru Suzuki, Takeshi Yamamoto, Etsuko Tokunata, Shuichi Nakamura, Motohiro Tanaka, Takuma Sasaki, Norio Shibata
  • Journal Title: Chem. Lef Volume: 11 Pages: 1046-1047
  • NAID: 10025547854
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of a Sulfenyl(sketoesters Using DBFOXPh/Ni(II) complex (2009)
  • Author(s): Takehisa Ishimaru, Shinichi Ogawa, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata
  • Journal Title: J. Fluorine Chem Volume: 130(11) Pages: 1049-1053
  • Peer Reviewed
• [Journal Article] Solkane(R) 365mfc is an Environmentally Benign Alternative Solvent for Trifluoromethylation Reaction (2009)
  • Author(s): Akihiro Kusuda, Hiroyuki Kawai, Shuichi Nakamura, Norio Shibata
  • Journal Title: Green Chem Volume: 11 Pages: 1733-1735
  • Peer Reviewed
• [Journal Article] Catalytic Enantioselective Trifluoro methylation of Azomethine Imines With Trimethyl(trifluoromethyl) (2009)
  • Author(s): Hiroyuki Kawai, Akihiro Kusuda, Shuichi Nakamura, Mo too Shire, Norio Shibata
  • Journal Title: Angew. Chem. Mt. Ed Volume: 48(34) Pages: 6324-6327
  • Peer Reviewed
• [Journal Article] Photophysical and Electrochemical Properties of Perfluoroisopropyl Substituted Binuclear Phthalocyanine Conjugated with a Butadiyne Linker (2009)
  • Author(s): Norio Shibata, Banibrata Das, Masamichi Hayashi, Shuichi Nakamura, Takeshi Torn
  • Journal Title: J. Fluorine Chem Volume: 130(12) Pages: 1164-1170
  • Peer Reviewed
• [Journal Article] A DBFOXPh-Based Combinatorial Catalyst for Enantioselective Fluorination of Aryl Acetyl and sButenoyl Thiazolidinones (2009)
  • Author(s): hande Sudhakar Reddy, Norio Shibata, Takao Horikawa, Satoru Suzuki, Shuichi Nakamura, Takeshi Torn, Mo too Shire
  • Journal Title: Chemistry An Asian Journal Volume: 4(9) Pages: 1411-1415
  • Peer Reviewed
• [Journal Article] Synthesis of Novel C2Symmetric Chiral Crown Ethers and Their Applications to Enantioselective Trifluoromethylation of Aldehydes and Ketones (2009)
  • Author(s): Hiroyuki Kawai, Akihiro Kusuda, ShuichiNakamura, Satoshi Mizuta, Yasuhiro Funahashi, Hideki Masuda, Norio Shibata
  • Journal Title: J. Fluorine Chem Volume: 130(8) Pages: 762-765
  • Peer Reviewed
• [Journal Article] Enantioselective Electrophilic Trifluoro methylation of ls-Keto Esters with Umemoto Reagents Induced by Chiral Nonracemic Guanidine (2009)
  • Author(s): Shun Noritake, Norio Shibata, Yoshinori Nomura, Yiyong Hwang, Andrej Matsnev, Shuichi Nakamura, Takeshi Toni, Dominique Canard
  • Journal Title: Org. Biomol. Chem Volume: 7 Pages: 3599-3604
  • Peer Reviewed
• [Journal Article] Ionic Liquids as Media for Nucleophilic Ring Opening Fluorination of Aziridines (2009)
  • Author(s): Shun Noritake, Norio Shibata, Hiroyuki Kawai, Pandy Manoj Kumar, Shuichi Nakamura, Takeshi Torn
  • Journal Title: Heterocycl. Commun Volume: 15(2) Pages: 105-113
  • Peer Reviewed
• [Journal Article] Synthesis of Trifluoroethoxy Coated Binuclear Phthalocyanines with Click Spacers and Investigation of Their Clamshell (2009)
  • Author(s): Behaviour, Yoshiyama, Norio Shibata, Takefumi Sate, Shuichi Nakamura, Takeshi Toru
  • Journal Title: Org. Biomol. Chem Volume: 7(11) Pages: 2265-2269
  • Peer Reviewed
• [Journal Article] Enantioselective electrophilic trifluoromethylation of beta-keto esters with Umemoto reagents induced by chiral nonracemic guanidines (2009)
  • Author(s): Shun Noritake
  • Journal Title: Org.Biomol.Chem. Volume: 7 Pages: 3599-3604
  • Peer Reviewed
• [Journal Article] A DBFOX-Ph-Based Combinatorial Catalyst for Enantioselective Fluorination of Aryl Acetyl and 3-Butenoyl Thiazolidinones (2009)
  • Author(s): Dhande Sudhakar Reddy
  • Journal Title: Chemistry-An Asian Journal Volume: 4 Pages: 1411-1415
  • Peer Reviewed
• [Journal Article] Synthesis of novel C2-symmetric chiral crown ethers and their application to enantioselective trifluoromethylation of aldehydes and ketones (2009)
  • Author(s): Hiroyuki Kawai
  • Journal Title: J.Fluorine Chem. Volume: 130 Pages: 762-765
  • Peer Reviewed
• [Journal Article] Catalytic Enantioselective Trifluoromethylation of Azomethine Imines with Trimethyl(trifluoromethyl)silane (2009)
  • Author(s): Hiroyuki Kawai
  • Journal Title: Angew.Chem.Int.Ed. Volume: 48 Pages: 6324-6327
  • Peer Reviewed
• [Journal Article] Asymmetric synthesis of a-fluoro-a-sulfenyl-b-ketoesters using DBFOX-Ph/Ni(II) complex (2009)
  • Author(s): Takehisa Ishimaru
  • Journal Title: J.Fluorine Chem. Volume: 130 Pages: 1049-1053
  • Peer Reviewed
• [Journal Article] Construction of Nonadjacent Stereocenters Containing a Trifluoromethylated Carbon by Organocatalyzed Michael Addition of b-Ketoesters to 2-(Trifluoromethyl)acrylate (2009)
  • Author(s): Shinichi Ogawa
  • Journal Title: Chem.Lett. Volume: 38 Pages: 1006-1007
  • Peer Reviewed
• [Presentation] サリドマイドの右手型および左手型の薬理作用の相違について (2011)
  • Author(s): 徳永恵津子
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2011
  • Place of Presentation: ウインクあいち
  • Year and Date: 2011-11-23
• [Presentation] 光学活性サリドマイドの水中での不斉不均一化現象 (2011)
  • Author(s): 伊藤絵美
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2011
  • Place of Presentation: ウインクあいち
  • Year and Date: 2011-11-23
• [Presentation] 光学活性サリドマイドのカラムクロマトグラフィー上での不斉不均一化現象 (2011)
  • Author(s): 前野万也香
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2011
  • Place of Presentation: ウインクあいち
  • Year and Date: 2011-11-23
• [Presentation] アリル位不斉フルオロアルキル化反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第31回有機合成若手セミナー
  • Place of Presentation: 京都大学
  • Year and Date: 2011-11-16
• [Presentation] Ruppert-Prakash試薬と金属酸化物を用いたトリフルオロメチル化反応の開発 (2011)
  • Author(s): 杉田豊
  • Organizer: 第1回CSJ化学フェスタ-2011世界化学年記念大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2011-11-14
• [Presentation] ソルカン365mfcを溶媒に用いたアゾメチンイミンに対する不斉トリフルオロメチル化反応の開発 (2011)
  • Author(s): 大楠賢
  • Organizer: 第1回CSJ化学フェスタ-2011世界化学年記念大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2011-11-14
• [Presentation] ソルカン中での鈴木宮浦クロスカップリング反応の開発 (2011)
  • Author(s): 東綾香
  • Organizer: 第1回CSJ化学フェスタ-2011世界化学年記念大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2011-11-14
• [Presentation] トリフルオロピルビン酸エチルを用いた不斉アルドール型環化反応 (2011)
  • Author(s): 飯田紀士
  • Organizer: 第1回CSJ化学フェスタ-2011世界化学年記念大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2011-11-14
• [Presentation] 有機触媒を用いた不斉フルオロアルキル化反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第1回CSJ化学フェスタ-2011世界化学年記念大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2011-11-14
• [Presentation] 環境に優しい溶媒ソルカンを用いた有機合成反応の開発 (2011)
  • Author(s): 柴田哲男
  • Organizer: フルオラス科学研究会第4回シンポジウム
  • Place of Presentation: 大阪府立大学(招待講演)
  • Year and Date: 2011-10-07
• [Presentation] アリル位の不斉フルオロメチル化反応の開発 (2011)
  • Author(s): 古川達也
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] 芳香族イソキサゾールへの直接的トリフルオロメチル化反応による5-トリフルオロメチルー2-イソキサゾリン化合物の合成 (2011)
  • Author(s): 河合洋幸
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] ソルカン365mfcを溶媒に用いたエナンチオ選択的トリフルオロメチル化反応の開発 (2011)
  • Author(s): 大楠賢
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] β-トリフルオロメチルピロリンの触媒的不斉合成 (2011)
  • Author(s): 北山卓
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] トリフルオロメチル-β-ケトエステルに対する辻アリル化反応 (2011)
  • Author(s): 鈴木悟
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] ソルカン中での鈴木宮浦クロスカップリング反応の開発 (2011)
  • Author(s): 東綾香
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] F3TBSIに対する立体選択的マンニッヒ型反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] フッ素と生理活性:サリドマイド誘導体の合成と評価 (2011)
  • Author(s): 徳永恵津子
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] Ruppert-Prakash試薬と酸化銀を用いたトリフルオロメチル化反応の開発 (2011)
  • Author(s): 杉田豊
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] サリドマイド及び3'-フルオロサリドマイドのカラムクロマトグラフィーによる自己不均一化現象 (2011)
  • Author(s): 前野万也香
  • Organizer: 第35回フッ素化学討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-27
• [Presentation] 有機触媒を用いたフッ素化合物の不斉合成 (2011)
  • Author(s): 柴田哲男
  • Organizer: 第4回有機触媒シンポジウム
  • Place of Presentation: 東京理科大学(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] 有機触媒を用いたマイケル付加タイプトリフルオロメチル化反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第4回有機触媒シンポジウム
  • Place of Presentation: 東京理科大学
  • Year and Date: 2011-09-17
• [Presentation] サリドマイド及びその誘導体のカラムクロマトグラフィーによる自己不均一化現象 (2011)
  • Author(s): 前野万也香
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 金城学院大学
  • Year and Date: 2011-07-09
• [Presentation] Ruppert試薬を用いたβ位選択的トリフルオロメチル化反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 金城学院大学
  • Year and Date: 2011-07-09
• [Presentation] エイズ治療薬Efavirenzの触媒的不斉合成法の開発 (2011)
  • Author(s): 北山卓
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 金城学院大学
  • Year and Date: 2011-07-09
• [Presentation] 脱炭酸反応を利用したα-トリフルオロメチルケトンの合成 (2011)
  • Author(s): 鈴木悟
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 金城学院大学
  • Year and Date: 2011-07-09
• [Presentation] 新規求電子的ブロモジフルオロメチル化試薬の設計と合成 (2011)
  • Author(s): 森悟
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 金城学院大学
  • Year and Date: 2011-07-09
• [Presentation] 含フッ素複素環の合成 (2011)
  • Author(s): 河合洋幸
  • Organizer: 反応集積化の合成化学-革新的手法の開拓と有機物質創製への展開
  • Place of Presentation: 三重大学
  • Year and Date: 2011-06-11
• [Presentation] アリル位フルオロメチル化反応 (2011)
  • Author(s): 古川達也
  • Organizer: 反応集積化の合成化学-革新的手法の開拓と有機物質創製への展開
  • Place of Presentation: 三重大学
  • Year and Date: 2011-06-11
• [Presentation] Asymmetric Allylic Fluoroalkylation of Morita BaylisHillman Adducts Catalyzed by Cinchona Alkaloid (2011)
  • Author(s): Takayuki Nishimine, Tatsuya Furukawa, Jumper Kawazoe, Wet Zhang, Etsuko Tokunaga, Norio Shibata
  • Organizer: International Symposium on Catalysis and Fine Chemicals
  • Place of Presentation: Nara, Japan
• [Presentation] Palladiumcatalyzed Decarboxylative Allylation of uTrifluoromethyl R-Keto Esters (2011)
  • Author(s): Satoru Suzuki, Etsuko Tokunaga, Norio Shibata
  • Organizer: International Symposium on Catalysis and Fine Chemicals
  • Place of Presentation: Nara, Japan
• [Presentation] 右手型と左手型:サリドマイド誘導体の光学異性体と生理活性 (2011)
  • Author(s): 徳永恵津子
  • Organizer: Symposium on Molecular Chirality
  • Place of Presentation: 東京工業大学
• [Presentation] 求核的モノフルオロメチル化反応の開発 (2011)
  • Author(s): 古川達也
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] 求電子的トリフルオロメチル化試薬を用いたベンジル位のトリフルオロメチル化反応 (2011)
  • Author(s): 河合洋幸
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] 含フッ素複素環化合物の迅速合成 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] 1,3-双極子環化反応を用いたトリフルオロメチルピラゾロピラゾロン誘導体の合成 (2011)
  • Author(s): 鈴木悟
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] トリフルオロピルビン酸エチルを用いたエナミンとの不斉アルドール型環化反応 (2011)
  • Author(s): 飯田紀土
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] ソルカン365mfcを溶媒に用いた不斉トリフルオロメチル化反応の開発 (2011)
  • Author(s): 大楠賢
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] トリフルオロメチルエノンに対するニトリアルカンの触媒的不斉マイケル付加反応 (2011)
  • Author(s): 北山卓
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] サリドマイドのカラムクロマトグラフィーによる自己不均一化現象 (2011)
  • Author(s): 前野万也香
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] ジアリールスルホニウム塩型求電子的ブロモジフルオロメチル化剤の開発 (2011)
  • Author(s): 森悟
  • Organizer: 第1回フッ素化学若手の会
  • Place of Presentation: ぎふ長良川温泉ホテルパーク
• [Presentation] Enantioselective Mono- and Trifluoromethylation Reactions (2011)
  • Author(s): Norio Shibata
  • Organizer: Third UK/Japanese Conference in Catalytic Asymmetric Synthesis
  • Place of Presentation: Oxford, England(招待演講)
• [Presentation] Enantioselective Fluoromethylation Reactions (2011)
  • Author(s): Norio Shibata
  • Organizer: BIT's 2nd Annual World Congress of Catalytic Asymmetric Synthesis
  • Place of Presentation: Beijing, China(招待講演)
• [Presentation] Trifluoromethylation of Alkenes Using Ruppert's reagent (2011)
  • Author(s): Takayuki Nishimine
  • Organizer: The 2nd International Symposium on Process Chemistry ISPC2011
  • Place of Presentation: 国立京都国際会館
• [Presentation] Catalytic Asymmetric Synthesis of Efavirenz, an HIV-1 Reverse Transcriptase Inhibitor (2011)
  • Author(s): Takashi Kitayama
  • Organizer: The 2nd International Symposium on Process Chemistry ISPC2011
  • Place of Presentation: 国立京都国際会館
• [Presentation] The Self-disproportionation of Enantiomers of Thalidomide on an Achiral System (2011)
  • Author(s): Mayaka Maeno
  • Organizer: The 2nd International Symposium on Process Chemistry ISPC2011
  • Place of Presentation: 国立京都国際会館
• [Presentation] A Novel Electrophilic Bromodifluoromethylating Reagents, S-(bromodifluoromethyl)diaryl-sulfonium salts (2011)
  • Author(s): Satoru Mori
  • Organizer: The 2nd International Symposium on Process Chemistry ISPC2011
  • Place of Presentation: 国立京都国際会館
• [Presentation] Decarboxylative Allylation of α-Trifluoromethyl ss-Keto Esters (2011)
  • Author(s): Satoru Suzuki
  • Organizer: The 2nd International Symposium on Process Chemistry ISPC2011
  • Place of Presentation: 国立京都国際会館
• [Presentation] Lewis Acid-catalyzed Carbocyclization of 1,3-Dicarbonyl Compounds (2011)
  • Author(s): Norio Shibata
  • Organizer: 14th Asian Chemical Congress 2011 (14 ACC)
  • Place of Presentation: Bangkok, Thailand(招待講演)
• [Presentation] Organocatalyzed Allylic Trifluoromethylation using Ruppert's reagent (2011)
  • Author(s): Takayuki Nishimine
  • Organizer: 14th Asian Chemical Congress 2011 (14 ACC)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Asymmetric Allylic Trifluoromethylation Using Ruppert's Reagent (2011)
  • Author(s): Takayuki Nishimine
  • Organizer: The 7th International Symposium on Integrated Synthesis (ISIS-7)
  • Place of Presentation: Seaside Hotel Maiko Vilia
• [Presentation] The development of trifluoromethylation reaction (2011)
  • Author(s): Hiroyuki Kawai
  • Organizer: 第2回大津会議
  • Place of Presentation: 大津プリンスホテル
• [Presentation] Environmentally Benign Synthesis using Fluorine Chemistry (2011)
  • Author(s): Norio Shibata
  • Organizer: International Workshop on Organofluorine Chemistry
  • Place of Presentation: Tianjin, China(招待講演)
• [Presentation] 脱炭酸反応によるα-フルオロメチルケトンの合成 (2011)
  • Author(s): 鈴木悟
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] サリドマイド誘導体の抗がん活性について (2011)
  • Author(s): 徳永恵津子
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] 触媒的不斉フルオロメチル化反応の開発 (2011)
  • Author(s): 古川達也
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] ソルカン365mfcを溶媒に用いる環境調和型不斉トリフルオロメチル化反応の開発 (2011)
  • Author(s): 大楠賢
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] 有機触媒を用いたβ-トリフルオロメチルピロリンの不斉合成 (2011)
  • Author(s): 北山卓
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] カラムクロマトグラフィーによるサリドマイド及びその誘導体の自己不均一化現象 (2011)
  • Author(s): 前野万也香
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] 1,3-ジカルボニル化合物のF3TBSIに対するジアステレオ選択的求核付加反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] 金属酸化物を用いたトリフルオロメチル化反応の開発 (2011)
  • Author(s): 杉田豊
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] FBSMを用いたモノフルオロメチルインドール類の合成研究 (2011)
  • Author(s): 松崎浩平
  • Organizer: 第42回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 信州大学工学部
• [Presentation] 脱炭酸アリル化反応による第4級α-トリフルオロメチルケトンの合成研究 (2011)
  • Author(s): 鈴木悟
  • Organizer: 第37回反応と合成の進歩シンポジウム
  • Place of Presentation: あわぎんホール徳島
• [Presentation] アリル位トリフルオロメチル化反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第37回反応と合成の進歩シンポジウム
  • Place of Presentation: あわぎんホール徳島
• [Presentation] 5-トリフルオロメチル-2-イソキサゾリン化合物の合成法の開発 (2011)
  • Author(s): 河合洋幸
  • Organizer: 第37回反応と合成の進歩シンポジウム
  • Place of Presentation: あわぎんホール徳島
• [Presentation] フルオロメチル化試薬を用いた含フッ素イソキサゾリン誘導体の合成 (2011)
  • Author(s): 古川達也
  • Organizer: 第26回農薬デザイン研究会
  • Place of Presentation: メルパルク京都
• [Presentation] FBSMを用いたインドール類に対するモノフルオロメチル化反応 (2011)
  • Author(s): 松崎浩平
  • Organizer: 第26回農薬デザイン研究会
  • Place of Presentation: メルパルク京都
• [Presentation] インドールトリフロンの合成と生理活性 (2011)
  • Author(s): 徳永恵津子
  • Organizer: 第26回農薬デザイン研究会
  • Place of Presentation: メルパルク京都
• [Presentation] アリル位選択的不斉フルオロアルキル化反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第100回有機合成シンポジウム
  • Place of Presentation: 早稲田大学国際会議場
• [Presentation] Organocatalyzed Asymmetric Allylic Fluoroalkylation of Morita-Baylis-Hillman Adducts (2011)
  • Author(s): Takayuki Nishimine
  • Organizer: 10th International Symposium on Organic Reactions (ISOR10)
  • Place of Presentation: Keio University
• [Presentation] Decarboxylative Allylation of α-Trifluoromethyl ss-Keto Esters ; Construction of Trifluoromethyl-bearing Quaternary Carbon Centers (2011)
  • Author(s): Satoru Suzuki
  • Organizer: 10th International Symposium on Organic Reactions (ISOR10)
  • Place of Presentation: Keio University
• [Presentation] Organocatalyzed Regio- and Enantioselective Allylic Fluoroally lation of Morita-Baylis-Hillman Adducts Catalyzed by Cinchona Alkaloid (2011)
  • Author(s): Takayuki Nishimine
  • Organizer: 7th and 8th Yoshimasa Hirata Memorial Lectures
  • Place of Presentation: Nagoya University
• [Presentation] Enantioselective Trifluoromethylation in Solkane[○!R]-365mfc (2011)
  • Author(s): Satoshi Okusu
  • Organizer: 7th and 8th Yoshimasa Hirata Memorial Lectures
  • Place of Presentation: Nagoya University
• [Presentation] Intramolecular Allylation of α-Trifluoromethyl ss-Keto Esters ; Construction of Trifluoromethyl-bearing Quaternary Carbon Centers (2011)
  • Author(s): Satoru Suzuki
  • Organizer: 7th and 8th Yoshimasa Hirata Memorial Lectures
  • Place of Presentation: Nagoya University
• [Presentation] Asymmetric Allylic Fluoroalkylation of Morita-Baylis-Hillman Adducts Catalyzed by Cinchona Alkaloid (2011)
  • Author(s): Takayuki Nishimine
  • Organizer: International Symposium on Catalysis and Fine Chemicals 2011 (C&FC2011)
  • Place of Presentation: Nara in Japan
• [Presentation] Palladium-catalyzed Decarboxylative Allylation of α-Trifluorom ethyl ss-Keto Esters (2011)
  • Author(s): Satoru Suzuki
  • Organizer: International Symposium on Catalysis and Fine Chemicals 2011 (C&FC2011)
  • Place of Presentation: Nara in Japan
• [Presentation] FBSMを用いたβ位のモノフルオロメチル化反応 (2011)
  • Author(s): 古川達也
  • Organizer: 第38回有機典型元素化学討論会
  • Place of Presentation: 石川県立音楽堂邦楽ホール
• [Presentation] 1,3-ジカルボニル化合物のF3TBSIに対する立体選択的マンニッヒ型反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 第38回有機典型元素化学討論会
  • Place of Presentation: 石川県立音楽堂邦楽ホール
• [Presentation] α-トリフルオロメチルスルホンの脱炭酸型アリル化反応 (2011)
  • Author(s): 福士和伸
  • Organizer: 第38回有機典型元素化学討論会
  • Place of Presentation: 石川県立音楽堂邦楽ホール
• [Presentation] インドール類に対するFBSMを用いた求核置換反応 (2011)
  • Author(s): 松崎浩平
  • Organizer: 第38回有機典型元素化学討論会
  • Place of Presentation: 石川県立音楽堂邦楽ホール
• [Presentation] Environmentally benign organic synthesis based on fluorine chemistry (2011)
  • Author(s): Norio Shibata
  • Organizer: 23rd International Conference on ORGANIC PROCESS RESEARCH & DEVELOPMENT
  • Place of Presentation: Florida, USA
• [Presentation] 環固定型サリドマイドの合成とその安定性に関する考察 (2011)
  • Author(s): 山本剛嗣
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] Baylis-Hillman Carbonateに対するフルオロアルキル化反応の開発研究 (2011)
  • Author(s): 古川達也
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 新規求電子的ブロモジフルオロメチル化試薬の開発 (2011)
  • Author(s): 森悟
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 含フッ素サリドマイド誘導体の設計とその生理活性について (2011)
  • Author(s): 徳永恵津子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] アルケニルケトンに対する不斉トリフルオロメチル化反応および光学活性アリールヘテロアリールトリフルオロメチルカルビノール群の合成 (2011)
  • Author(s): 河合洋幸
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] 新規求電子的ブロモジフルオロメチル化試薬の開発研究 (2011)
  • Author(s): 劉国凱
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] 不斉Lewis酸触媒を用いた5-endo-dig環化反応 (2011)
  • Author(s): 鈴木悟
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] 1,3-双極子環化付加反応によるトリフルオロメチル基含有化合物のジアステレオ選択的合成 (2011)
  • Author(s): 猪飼英典
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] α-トリフルオロメチルアクリレートを用いたアゾメチンイミンに対する無触媒下での1,3-双極子環化付加反応の開発 (2011)
  • Author(s): 西峯貴之
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] エイズ治療薬Efavirenzの触媒的不斉合成法の開発 (2011)
  • Author(s): 北山卓
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] カラムクロマトグラフィーにおけるサリドマイドの自己不均一化現象 (2011)
  • Author(s): 前野万也香
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] 含フッ素化合物の選択的合成法 (2010)
  • Author(s): 柴田哲男
  • Organizer: 2010臭素化学懇話会年会
  • Place of Presentation: 山口
  • Year and Date: 2010-11-26
• [Presentation] 医薬品、農薬、機能性材料の合成に有用なトリフルオロメチル化合物の合成方法 (2010)
  • Author(s): 柴田哲男
  • Organizer: 名古屋工業大学新技術説明会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-12
• [Presentation] 環状型モノフルオロメチル化試薬FBDTを用いたアルデヒドに対する求核付加反応 (2010)
  • Author(s): 古川達也
  • Organizer: 第25回農薬デザイン研究会
  • Place of Presentation: ホテルクラウンパレス浜松
  • Year and Date: 2010-11-05
• [Presentation] ジアリールスルホニウム塩構造を有する求電子的ブロモジフルオロメチル化試薬の開発 (2010)
  • Author(s): 森悟
  • Organizer: 第25回農薬デザイン研究会
  • Place of Presentation: ホテルクラウンパレス浜松
  • Year and Date: 2010-11-05
• [Presentation] 1,3-双極子環化付加反応を用いたトリフルオロメチル基含有複素環の立体選択的合成 (2010)
  • Author(s): 猪飼英典
  • Organizer: 第25回農薬デザイン研究会
  • Place of Presentation: ホテルクラウンパレス浜松
  • Year and Date: 2010-11-05
• [Presentation] サリドマイド誘導体のキラリティと生物活性について (2010)
  • Author(s): 徳永恵津子
  • Organizer: 第25回農薬デザイン研究会
  • Place of Presentation: ホテルクラウンパレス浜松
  • Year and Date: 2010-11-05
• [Presentation] 新規フッ素系溶剤ソルカン365mfcを溶媒に用いるトリフルオロメチル化反応の開発とその応用 (2010)
  • Author(s): 楠田旭弘
  • Organizer: フルオラス科学研究会第3回シンポジウム
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2010-10-08
• [Presentation] 新規フッ素系溶剤ソルカン365mfcを溶媒に用いるグラーゼルカップリング反応 (2010)
  • Author(s): 除修華
  • Organizer: フルオラス科学研究会第3回シンポジウム
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2010-10-08
• [Presentation] ソルカン365mfcを溶媒に用いるFriedel-Crafts反応の開発 (2010)
  • Author(s): 楠田旭弘
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] DBFOX-Ph/金属錯体触媒を用いた不斉フッ素化反応における不斉増幅現象 (2010)
  • Author(s): 鈴木悟
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] クリックケミストリーを用いたビスシンコナアルカロイドの合成および不斉触媒としての利用 (2010)
  • Author(s): 安井宏有貴
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] アリルジアセテートに対する不斉モノフルオロメチル化反応 (2010)
  • Author(s): 古川達也
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] 新型Yagupolskii-梅本タイプ試薬の合成:トリフルオロメタンスルホン酸を用いたortho-Ethynylaryltrifluoromethylsulfanの分子内環化反応 (2010)
  • Author(s): 則竹瞬
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] 含フッ素化合物のシリカゲルカラムクロマトグラフィーでの自己不均一化 (2010)
  • Author(s): 西峯貴之
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] サリドマイドの水中における自己不均一化現象 (2010)
  • Author(s): 伊藤絵美
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] トリプルクリック反応を用いた風車型フタロシアニンの設計と合成 (2010)
  • Author(s): 梅田将司
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2010-07-03
• [Presentation] Self-disproportion of Enantiomers of Thalidomide on chrmatography with a non-chiral system (2010)
  • Author(s): Mayaka Maeno
  • Organizer: GLOBAL COE-RCMS International Symposium on Organic Chemistry and 7th Yoshimasa Hirata Memorial Lecture
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2010-03-17
• [Presentation] Catalytic Enantioselective Trifluoromethylation of Alkynyl Ketones and Synthesis of Aryl Heteroaryl Trifluoromethyl Carbinols (2010)
  • Author(s): Hiroyuki Kawai
  • Organizer: GLOBAL COE-RCMS International Symposium on Organic Chemistry and 7th Yoshimasa Hirata Memorial Lecture
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2010-03-17
• [Presentation] Asymmetric Allylic Fluoroalkylation using FBSM (2010)
  • Author(s): Tatsuya Furukawa
  • Organizer: GLOBAL COE-RCMS International Symposium on Organic Chemistry and 7th Yoshimasa Hirata Memorial Lecture
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2010-03-17
• [Presentation] Design and synthesis of novel electrophilic bromodifluoromethylating reagents (2010)
  • Author(s): Satoru Mori
  • Organizer: GLOBAL COE-RCMS International Symposium on Organic Chemistry and 7th Yoshimasa Hirata Memorial Lecture
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2010-03-17
• [Presentation] Catalytic Asymmetric Synthesis of Efavirenz, an HIV-1 Reverse Transcriptase Inhibitor (2010)
  • Author(s): Takashi Kitayama
  • Organizer: GLOBAL COE-RCMS International Symposium on Organic Chemistry and 7th Yoshimasa Hirata Memorial Lecture
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2010-03-17
• [Presentation] Chiral Lewis Acid Catalysts for Enantioselective Reaction of β-Trifluoromethylated Acrylates with Pyrroles (2010)
  • Author(s): Satoru Suzuki
  • Organizer: GLOBAL COE-RCMS International Symposium on Organic Chemistry and 7th Yoshimasa Hirata Memorial Lecture
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2010-03-17
• [Presentation] Expeditious Synthesis of Trifluoromethylated Heterocycles by Noncatalytic 1,3-Dipolar Cyclization (2010)
  • Author(s): Takayuki Nishimine
  • Organizer: GLOBAL COE-RCMS International Symposium on Organic Chemistry and 7th Yoshimasa Hirata Memorial Lecture
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2010-03-17
• [Presentation] Enantiocontrolled Synthesis of Fluoro-organic Compounds (2010)
  • Author(s): Norio Shibata
  • Organizer: Catalytic Asymmetric Synthesis-2010
  • Place of Presentation: Beijing, China
• [Presentation] Development of Novel Reagents for Fluoro-organic Chemistry (2010)
  • Author(s): 柴田哲男
  • Organizer: 第8回日中フッ素化学工業会議
  • Place of Presentation: 東京
• [Presentation] Trifluoroethoxy-Coated Subphthalocyanines : Synthesis, Characterization, Reactivity and Solubility (2010)
  • Author(s): Norio Shibata
  • Organizer: Sixth International Conference on Porphyrins and Phthalocyanines (ICPP-6)
  • Place of Presentation: New Mexico, USA
• [Presentation] Asymmetric Trifluoromethylation Reaction (2010)
  • Author(s): Norio Shibata
  • Organizer: The Perugia Fluorine Days Symposium
  • Place of Presentation: Perugia, Italy
• [Presentation] Chiral Amplification in Enantioselective Fluorinations Using DBFOX-Ph/Metal salts (2010)
  • Author(s): Satoru Suzuki
  • Organizer: 22nd International Symposium on Chirality (Chirality 2010; ISCD-22)
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Self-disproportionation of enantiomers of the fluorinated compounds on chromatography with a non-chiral system (2010)
  • Author(s): Takayuki Nishimine
  • Organizer: 22nd International Symposium on Chirality (Chirality 2010; ISCD-22)
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Enantiocontrolled Synthesis of Fluoro-organic Compounds : Building Brock Approach (2010)
  • Author(s): Norio Shibata
  • Organizer: 16th European Symposium on Fluorine Chemistry
  • Place of Presentation: Ljubljana, Slovenia
• [Presentation] Synthesis and Properties of Trifluoroethoxy-Coated Subphthalocyanines (2010)
  • Author(s): Norio Shibata
  • Organizer: 3rd Korea-Japan-China Joint Seminar on Fluorine Chemistry
  • Place of Presentation: Daejeon, Korea
• [Presentation] SHELF-STABLE ELECTROPHILIC TRIFLUOROMETHYLATING REAGENTS (2010)
  • Author(s): Norio Shibata
  • Organizer: 11th National Meeting on Fluorine Chemistry
  • Place of Presentation: Daejeon, Korea
• [Presentation] 新しい求電子的トリフルオロメチル化試薬の開発 (2010)
  • Author(s): 則竹瞬
  • Organizer: 第34回フッ素化学討論会
  • Place of Presentation: 札幌サンプラザ
• [Presentation] FBSMを用いた求核的モノフルオロメチル化反応 (2010)
  • Author(s): 楠田旭弘
  • Organizer: 第34回フッ素化学討論会
  • Place of Presentation: 札幌サンプラザ
• [Presentation] 求電子的モノフルオロメチル化試薬の開発 (2010)
  • Author(s): 野村佳則
  • Organizer: 第34回フッ素化学討論会
  • Place of Presentation: 札幌サンプラザ
• [Presentation] 求電子的ブロモジフルオロメチル化試薬の開発 (2010)
  • Author(s): 森悟
  • Organizer: 第34回フッ素化学討論会
  • Place of Presentation: 札幌サンプラザ
• [Presentation] ピロールとss-トリフルオロメチルアクリル酸エステルとの不斉Friedel-Crafts反応 (2010)
  • Author(s): 鈴木悟
  • Organizer: 第34回フッ素化学討論会
  • Place of Presentation: 札幌サンプラザ
• [Presentation] モノフルオロメチル化反応の開発研究 (2010)
  • Author(s): 古川達也
  • Organizer: 第36回反応と合成の進歩シンポジウム
  • Place of Presentation: ウインクあいち
• [Presentation] 新型Yagupolskii-梅本タイプトリフルオロメチル化試薬の合成と反応 (2010)
  • Author(s): 則竹瞬
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] (トリフルオロメチル)トリメチルシランを用いた不斉トリフルオロメチル化反応の開発 (2010)
  • Author(s): 河合洋幸
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] FBSMおよびFBDTを用いたモノフルオロメチル化反応の開発 (2010)
  • Author(s): 古川達也
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] サリドマイドおよびその誘導体の自己不均一化現象 (2010)
  • Author(s): 伊藤絵美
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] α-トリフルオロメチルアクリレートを用いたアゾメチンイミンに対する1,3-双極子環化付加反応の開発 (2010)
  • Author(s): 西峯貴之
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] 新しい求電子的ブロモジフルオロメチル化試薬の開発 (2010)
  • Author(s): 劉国凱
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] 1,3-双極子の環化付加を用いた立体選択的含トリフルオロメチル基化合物の合成 (2010)
  • Author(s): 猪飼英典
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] ソルカン365mfcを溶媒に用いたトリフルオロピルビン酸エチル及びグリオキサル酸エチルへのエナンチオ選択的Friedel-Crafts反応の開発 (2010)
  • Author(s): 楠田旭弘
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] ルイス酸触媒を用いた不斉5-endo-dig環化反応 (2010)
  • Author(s): 鈴木悟
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] DBFOX-Ph金属錯体を用いたアセチルチアゾリジノン類に対する触媒的不斉水酸化反応の開発 (2010)
  • Author(s): 鈴木由香
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] サリドマイドおよびそのフッ素化体における自己不均一化現象 (2010)
  • Author(s): 伊藤絵美
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都テルサ
• [Presentation] Resent progress of monofluoromethylation reactions using FBSM and FBDT as synthetic equivalents for monofluoromethide species (2010)
  • Author(s): Norio Shibata
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Enantioselective Friedel-Crafts Reaction of ss-Trifluoromethylated Acrylates with Pyrroles (2010)
  • Author(s): Satoru Suzuki
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Simple synthesis of fluorine-containing heterocyles by noncatalytic 1,3-dipolar cyclization of azomethine imines with tert-butyl-(α-trifluoromethy) acrylate (MAF-TBE) (2010)
  • Author(s): Takayuki Nishimine
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, Hawaii, USA