| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
Analysis of protein functions has been indispensable for disclose of unknown cellar phenomena and drug development. Our purpose in this research is the development of methodologies for catalytic decomposition of proteins, which leads to the uncovering protein functions. We have developed a wide variety of chemical devise for elucidation of peptides-and proteins-associated events, including stimulus-responsive amino acids, peptide mimetics, and nonhydrolyzable phosphoamino acids. On the basis of these researches, we have developed several chemical means for the catalytic protein decomposition.
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