Effects of nanomaterial exposure on cranial nerve system of offspring

• Project/Area Number: 21390037
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental pharmacy
• Research Institution: Tokyo University of Science
• Principal Investigator: TAKEDA Ken 東京理科大学, 薬学部・薬学科, 教授 (80054013)
• Co-Investigator(Renkei-kenkyūsha): TACHIBANA Ken 東京理科大学, 薬学部・薬学科, 助教 (10400540) ; YANAGITA Shinya 東京理科大学, 理工学部教養, 助教 (80461755) ; SHINKAI Yusuke 東京理科大学, 薬学部, PD (80459734) ; SUZUKI Kenichro 東京理科大学, 総合研究機構, PD (30548384) ; UMEZAWA Masakazu 東京理科大学, 総合研究機構, PD (60615277) ; SUGAMATA Masao 栃木臨床病理研究所, 所長 (50049863)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
• Keywords: 環境衛生学 / ナノ粒子 / 酸化チタン / 胎仔期曝露 / 脳神経系 / 網羅的遺伝子発現解析 / 発達障害 / データマイニング / 酸化亜鉛 / モノアミン代謝 / ドーパミン / 脳発達障害 / ディーゼル排ガス微粒子 / マイクロアレイ

Research Abstract

The present study showed the effects of maternal exposure to nanomaterials on the development of cranial nerve system of offspring, using electron microscopic analysis, histological analysis, neurochemical(monoamine) analysis as well as gene expression analysis. The results indicated that exposure of pregnant mice to nanomaterial frequently used in nanotechnology induced alterations of microstructures, monoamine and its metabolism in the brain of offspring during the developmental period. Gene expression analysis using microarray showed an important clue of the mechanisms underlying the effects of maternal exposure to nanomaterials on the brain development.

Research Products

• [Journal Article] ナノマテリアルの次世代健康影響-妊娠期曝露の子に及ぼす影響 (2011)
  • Author(s): 武田健、新海雄介、鈴木健一郎、柳田信也、梅澤雅和、横田理、田井中均、押尾茂、井原智美、菅又昌雄
  • Journal Title: YAKUGAKU ZASSHI Volume: 131(2) Pages: 229-236
  • NAID: 130000451456
• [Journal Article] ナノマテリアルの次世代健康影響-妊娠期曝露の子に及ぼす影響 (2011)
  • Author(s): 武田健、新海雄介、鈴木健一郎、柳田信也、梅澤雅和、横田理、田
  • Journal Title: YAKUGAKU ZASSHI Volume: 131 Pages: 229-239
  • NAID: 130000451456
  • Peer Reviewed
• [Journal Article] What does carbon nanomaterial cause in human health? (Chapter 6) (2011)
  • Author(s): Umezawa, M., Takeda, K.
  • Journal Title: Carbon Black : Production and Uses Pages: 133-135
  • Peer Reviewed
• [Journal Article] ナノマテリアルの次世代影響-脳神経系及び雄性生殖系を中心に (2010)
  • Author(s): 武田健、鈴木健一郎、入江美代子、押尾茂、井原智美、菅又昌雄
  • Journal Title: ナノ材料のリスク評価と安全性対策 Volume: No.15 Pages: 54-59
• [Journal Article] Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice (2010)
  • Author(s): Takahashi, Y., Mizuo, K., Shinkai, Y., Oshio, S., Takeda, K
  • Journal Title: J. Toxicol. Sci. Volume: 35(5) Pages: 749-756
  • NAID: 10026669347
• [Journal Article] In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice (2010)
  • Author(s): Suzuki, T., Oshio, S., Iwata, M., Saburi, H., Odagiri, T., Udagawa, T., Sugawara, I., Umezawa, M., Takeda, K
  • Journal Title: Part. Fibre Toxicol. Volume: 7 Pages: 7-7
• [Journal Article] Novel insights into the pathogenesis of endometriosis from a disease model induced by autotransplantation of endometrium (2010)
  • Author(s): Umezawa, M., Takeda, K., Ihara, T., Sugamata, M
  • Journal Title: Inflamm. Regen. Volume: 30(2) Pages: 115-119
• [Journal Article] ナノマテリアルの次世代影響-脳神経系及び雄性生殖系を中心に (2010)
  • Author(s): 武田健、鈴木健一郎、入江美代子、押尾茂、井原智美、菅又昌雄
  • Journal Title: フロンティア出版 Volume: 15 Pages: 54-59
  • Peer Reviewed
• [Journal Article] Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice. (2010)
  • Author(s): Takahashi Y, Mizuo K, Shinkai Y, Oshio S, Takeda K.
  • Journal Title: J.Toxicol.Sci. Volume: 35 Pages: 749-756
  • NAID: 10026669347
  • Peer Reviewed
• [Journal Article] In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice. (2010)
  • Author(s): Suzuki T, Oshio S, Iwata M, Saburi H, Odagiri T, Udagawa T, Sugawara I, Umezawa M, Takeda K.
  • Journal Title: Part.Fibre Toxicol. Volume: 7 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Novel insights into the pathogenesis of endometriosis from a disease model induced by autotransplantation of endometrium.Inflamm. (2010)
  • Author(s): Umezawa M, Takeda K, Ihara T, Sugamata M.
  • Journal Title: Inflamm.Regen. Volume: 30 Pages: 115-119
  • Peer Reviewed
• [Journal Article] Perinatal exposure to diesel exhaust affects gene expression in mouse cerebrum (2009)
  • Author(s): Tsukue, N., Watanabe, M., Kumamoto, T., Takano, H., Takeda, K
  • Journal Title: Arch. Toxicol. Volume: 83 Pages: 985-1000
• [Journal Article] Maternal exposure to nanoparticulate titanium dioxide during the perinatal period alters gene expression related to brain development in the mice (2009)
  • Author(s): Shimizu, M., Tainaka, H., Oba, T., Mizuo, K., Umezawa, M., Takeda, K
  • Journal Title: Part. Fibre Toxicol. Volume: 6 Pages: 20-20
• [Journal Article] ナノマテリアルの次世代健康影響-脆弱性集団への影響 (2009)
  • Author(s): 新海雄介、梅澤雅和、武田健
  • Journal Title: 医学のあゆみ Volume: 230(8) Pages: 8438-8442
• [Journal Article] Prenatal diesel exhaust causes neurodegenerative diseases in adults (2009)
  • Author(s): Sugamata, M., Ihara, T., Takeda, K
  • Journal Title: MEDIMOND : New Trends in Alzheimer and Parkinson Disorders Pages: 21-24
• [Journal Article] 未知なる遭遇-ナノマテリアルの健康影響次世代影響を中心に (2009)
  • Author(s): 武田健、菅又昌雄
  • Journal Title: ファルマシア Volume: 45(3) Pages: 245-250
• [Journal Article] Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems (2009)
  • Author(s): Takeda, K., Suzuki, K., Ishihara, A., Kubo-Irie, M., Fujimoto, R., Tabata, M., Oshio, S., Nihei, Y., Ihara, T., Sugamata M
  • Journal Title: J. Health Sci. Volume: 55(1) Pages: 95-102
  • NAID: 110007055924
• [Journal Article] Caused by Malnutrition and Environmental Chemical Substances (2009)
  • Author(s): Xu, G., Umezawa, M., Takeda, K
  • Journal Title: J. Health Sci. Volume: 55(1) Pages: 11-19
• [Journal Article] Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice (2009)
  • Author(s): Yokota, S., Mizuo, K., Moriya, N., Oshio, S., Sugawara, I., Takeda, K
  • Journal Title: Neurosci. Lett. Volume: 449(1) Pages: 38-41
• [Journal Article] Perinatal exposure to diesel exhaust affects gene expression in mouse cerebrum (2009)
  • Author(s): Tsukue, N., Watanabe, M., Kumamoto, T., Takano, H., Takeda, K.
  • Journal Title: Arch Toxicol. 83 Pages: 985-1000
  • Peer Reviewed
• [Journal Article] Maternal exposure to nanoparticulate titanium dioxide during the perinatal period alters gene expression related to brain development in the mice (2009)
  • Author(s): Shimizu, M., Tainaka, H., Oba, T., Mizuo, K., Umezawa, M., Takeda, K.
  • Journal Title: Part.Fibre.Toxicol. 6 Pages: 20-28
  • Peer Reviewed
• [Journal Article] ナノマテリアルの次世代健康影―脆弱性集団への影響 (2009)
  • Author(s): 新海雄介, 梅澤雅和, 武田健
  • Journal Title: 医学のあゆみ 230巻8号 Pages: 8438-8442
  • Peer Reviewed
• [Journal Article] Prenatal diesel exhaust causes neurodegenerative diseases in adults (2009)
  • Author(s): Sugamata, M., Ihara, T., Takeda, K.
  • Journal Title: Medimond, New Trends in Alzheimer and Parkinson Disorders Pages: 21-24
  • Peer Reviewed
• [Journal Article] 未知なる遺遇・ナノマテリアルの健康影響 次世代影響を中心に (2009)
  • Author(s): 武田健, 菅又昌雄
  • Journal Title: ファルマシア Vol.45 No.3 Pages: 245-250
  • Peer Reviewed
• [Journal Article] Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems (2009)
  • Author(s): Takeda, K., Suzuki, K., Ishihara A., Kubo-Irie, M., Fujimoto, R., Tabata, M., Oshio, S., Nihei, Y., Ihara, T., sugamata.M.
  • Journal Title: J.Health Sci. Vol.55 No.1 Pages: 95-102
  • NAID: 110007055924
  • Peer Reviewed
• [Journal Article] Early Development Origins of Adult Disease Caused by Malnutrition and Environmental Chemical Substances (2009)
  • Author(s): Xu G., Umezawa M., Takeda K.
  • Journal Title: J.Health Sci. Vol.55 No.1 Pages: 11-19
  • NAID: 110007055942
  • Peer Reviewed
• [Journal Article] Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice (2009)
  • Author(s): Yokota, S., Mizuo, K., Moriya, N., Oshio, S., Sugawara, I., Takeda, K.
  • Journal Title: Neurosci Lett. 449 Pages: 38-41
  • Peer Reviewed
• [Presentation] (2012)
  • Author(s): 立花研, 高柳皓平, 秋本純芽, 新海雄介, 武田健
  • Organizer: 日本薬学会第132年会
  • Year and Date: 2012-03-30
• [Presentation] ディーゼル排ガス胎仔期曝露によるDNAメチル化異常の網羅的解析 (2012)
  • Author(s): 立花研, 高柳皓平, 秋本純芽, 新海雄介, 武田健
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 高等教育推進機構他(札幌)
  • Year and Date: 2012-03-30
• [Presentation] 次世代健康科学・健康教育を考える (2012)
  • Author(s): 武田健
  • Organizer: 日本幼少児健康教育学会第30回記念大会
  • Year and Date: 2012-02-18
• [Presentation] 血中miRNAを利用したナノ粒子の次世代健康影響評価系の検討 (2011)
  • Author(s): 黒岩法子、立花研、小平伊織、新海雄介、武田健
  • Organizer: 3回日本RNAi研究会
  • Year and Date: 2011-08-26
• [Presentation] 血中miRNAを利用したナノ粒子の次世代健康影響評価系の検討 (2011)
  • Author(s): 黒岩法子、立花研、小平伊織、新海雄介、武田健
  • Organizer: 第3回日本RNAi研究会
  • Place of Presentation: グランドプリンスホテル(広島)
  • Year and Date: 2011-08-26
• [Presentation] ナノマテリアルの次世代健康影響～胎仔期曝露の脳神経系及び生殖系への影響を中心に (2011)
  • Author(s): 武田健
  • Organizer: トキシンシンポジウム
  • Year and Date: 2011-07-07
• [Presentation] 脳発達期における脂肪酸を吸着したアルブミンナノ粒子の脳内移行 (2011)
  • Author(s): 川島奈津子、鈴木健一郎、横田理、大嶋秀明、武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡県立大学他
  • Year and Date: 2011-03-30
• [Presentation] 胎仔期ディーゼル排気微粒子曝露が不安情動性と認知機能に及ぼす影響 (2011)
  • Author(s): 横田理、佐藤央、杉戸雄四郎、柳田信也、武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡県立大学他
  • Year and Date: 2011-03-30
• [Presentation] 胎仔期にディーゼル排ガスに曝露されたマウスにおけるDNAメチル化状態の網羅的解析 (2011)
  • Author(s): 高柳皓平、立花研、秋本純芽、新海雄介、武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡県立大学他
  • Year and Date: 2011-03-30
• [Presentation] ナノマテリアルの次世代健康科学～新しい衛生薬学研究領域の開拓 (2011)
  • Author(s): 武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡県立大学他
  • Year and Date: 2011-03-29
• [Presentation] A novel analysis tool to interpret microarray results using multiple gene annotation. (2011)
  • Author(s): Umezawa M, Sera M, Takeda K.
  • Organizer: BICoB-2011
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2011-03-23
• [Presentation] 薬学会学術貢献賞受賞講演、ナノマテリアルの次世代健康科学～新しい衛生薬学研究領域の開拓 (2011)
  • Author(s): 武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 脳発達期における脂肪酸を吸着したアルブミンナノ粒子の脳内移行 (2011)
  • Author(s): 川島奈津子、鈴木健一郎、横田理、大嶋秀明、武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 胎仔期ディーゼル排気微粒子曝露が不安情動性と認知機能に及ぼす影響 (2011)
  • Author(s): 横田理、佐藤央、杉戸雄四郎、柳田信也、武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 胎仔期にディーゼル排ガスに曝露されたマウスにおけるDNAメチル化状態の網羅的解析 (2011)
  • Author(s): 高柳皓平、立花研、秋本純芽、新海雄介、武田健
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] A novel analysis tool to interpret microarray results using multiple gene annotation (2011)
  • Author(s): Umezawa M, Sera M, Takeda K
  • Organizer: 第3回バイオインフォマティクス及びコンピュータ生物学学会(BICoB-2011)
  • Place of Presentation: ニューオーリンズ・米国ルイジアナ
• [Presentation] 遺伝子アノテーションを用いた新しいマイクロアレイデータ解析法の確立 (2010)
  • Author(s): 梅澤雅和、世良実穂、武田健
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] Maternal exposure to nanoparticulate titanium dioxide alters gene expression related to brain development of offspring in the mouse (2010)
  • Author(s): Shimizu M, Umezawa M, Tainaka H, Takeda K
  • Organizer: Nanosafe 2010
  • Place of Presentation: Grenoble, France
  • Year and Date: 2010-11-17
• [Presentation] Maternal exposure to nanoparticulate titanium dioxide alters gene expression related to brain development of offspring in the mouse. (2010)
  • Author(s): Shimizu M, Umezawa M, Tainaka H, Takeda K.
  • Organizer: Nanosafe 2010
  • Place of Presentation: Grenoble, France
  • Year and Date: 2010-11-17
• [Presentation] Novel approach to analysis brain plasticity by biomolecule-designed nanoparticles. (2010)
  • Author(s): Yokota S, Suzuki K, Ishibashi R, Shinotsuka T, Sugito Y, Takeda K.
  • Organizer: Neuroscience 2010
  • Place of Presentation: San-Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] Effects of exposure to titanium dioxide nanoparticles on activation of corticotrophin-releasing hormone neurons in pregnant rats and its offspring. (2010)
  • Author(s): Yanagita S, Kanemaru J, Umezawa M, Yokota S, Takeda K.
  • Organizer: Neuroscience 2010
  • Place of Presentation: San-Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] Current research and prospect for health effects of nanoparticles on offspring. (2010)
  • Author(s): Umezawa M, Takeda K.
  • Organizer: 第3回国際セラミックス学会
  • Place of Presentation: グランキュープ大阪
  • Year and Date: 2010-11-16
• [Presentation] ディーゼル排気微粒子胎仔期曝露が老齢マウスのコリン神経系に影響を及ぼす (2010)
  • Author(s): 横田理、柳田信也、武田健
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] りん脂質修飾ナノ粒子を用いたマウス脳神経の脂質代謝の分析 (2010)
  • Author(s): 杉戸雄四郎、篠塚崇徳、横田理、鈴木健一郎、武田健
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] りん脂質修飾ナノ粒子の制御とそのマウス脳内における特異的分布 (2010)
  • Author(s): 篠塚崇徳、杉戸雄四郎、横田理、鈴木健一郎、武田健
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Prenatal exposure to diesel exhaust particles affected cholinergic systems in senile mice. (2010)
  • Author(s): Yokota S, Yanagita S, Takeda K.
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Effects of prenatal exposure to zinc oxide nanoparticles on monoaminergic systems in mice. (2010)
  • Author(s): Okada Y, Shinotsuka T, Tachibana K, Takeda K.
  • Organizer: Nanotoxicology 2010
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2010-06-03
• [Presentation] ナノマテリアルの次世代健康影響―妊娠期曝露は子に重大な影響を及ぼす (2010)
  • Author(s): 武田健, 新海雄介, 鈴木健一郎, 柳田信也, 梅澤雅和, 横田理, 押尾茂, 井原智美, 菅又昌雄
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] 遺伝子アノテーションを用いた新しいマイクロアレイデータ解析法の確立 (2010)
  • Author(s): 梅澤雅和、世良実穂、武田健
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Novel approach to analysis brain plasticity by biomolecule-designed nanoparticles (2010)
  • Author(s): Yokota S, Suzuki K, Ishibashi R, Shinotsuka T, Sugito Y, Takeda K
  • Organizer: Neuroscience 2010(Society for Neuroscience, 40th Annual Meeting)
  • Place of Presentation: San-Diego(USA)
• [Presentation] Effects of exposure to titanium dioxide nanoparticles on activation of corticotrophin-releasing hormone neurons in pregnant rats and its offspring (2010)
  • Author(s): Yanagita S, Kanemaru J, Umezawa M, Yokota S, Takeda K
  • Organizer: Neuroscience 2010(Society for Neuroscience, 40th Annual Meeting)
  • Place of Presentation: San-Diego(USA)
• [Presentation] Current research and prospect for health effects of nanoparticles on offspring (2010)
  • Author(s): Umezawa M, Takeda K
  • Organizer: 第3回国際セラミックス学会
  • Place of Presentation: 大阪
• [Presentation] 酸化チタンの胎児期曝露が視床下部室傍核CRH神経の活動に及ぼす影響 (2010)
  • Author(s): 柳田信也、金丸次郎、梅澤雅和、沼崎理英、武田健
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] ディーゼル排気微粒子胎仔期曝露が老齢マウスのコリン神経系に影響を及ぼす (2010)
  • Author(s): 横田理、柳田信也、武田健
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] りん脂質修飾ナノ粒子を用いたマウス脳神経の脂質代謝の分析 (2010)
  • Author(s): 杉戸雄四郎、篠塚崇徳、横田理、鈴木健一郎、武田健
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] りん脂質修飾ナノ粒子の制御とそのマウス脳内における特異的分布 (2010)
  • Author(s): 篠塚崇徳、杉戸雄四郎、横田理、鈴木健一郎、武田健
  • Organizer: 第33回日本神経科学会
  • Place of Presentation: 神戸
• [Presentation] Effects of prenatal exposure to zinc oxide nanoparticles on monoaminergic systems in mice (2010)
  • Author(s): Okada Y, Shinotsuka T, Tachibana K, Takeda K
  • Organizer: Nanotoxicology 2010
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] ナノマテリアルの次世代健康影響-妊娠期曝露は子に重大な影響を及ぼす (2010)
  • Author(s): 武田健、新海雄介、鈴木健一郎、柳田信也、梅澤雅和、横田理、押尾茂、井原智美、菅又昌雄
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] 酸化チタンナノ粒子胎仔期曝露がドパミン神経系に及ぼす影響 (2010)
  • Author(s): 大庭太郎、岡田悠佳、高橋雄大、黒岩法子、水尾圭祐、立花研、武田健
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] 酸化亜鉛ナノ粒子胎仔期曝露がドパミン神経系に及ぼす影響 (2010)
  • Author(s): 岡田悠佳、篠塚崇徳、高橋雄大、武田健
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] 酸化チタンナノ粒子の胎児期曝露が中枢神経系に及ぼす影響 (2010)
  • Author(s): 清水碧、梅澤雅和、大庭太郎、水尾圭祐、田井中均、武田健
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] 酸化チタンの胎児期曝露が視床下部室傍核CRH神経の活動に及ぼす影響 (2010)
  • Author(s): 柳田信也、金丸次郎、梅澤雅和、沼崎理英、武田健
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] Titanium dioxide nanoparticles transferred from pregnant mice to their offspring affect the genital and cranial nerve systems (2009)
  • Author(s): Takeda, K., Suzuki, K., Ishihara, A., Kubo-Irie, M., Fujimoto, R., Tabata, M., Oshio, S., Nihei, N., Ihara, T., Sugamata, M.
  • Organizer: PPTOXII, a CCT Meeting of Society of Toxicology
  • Place of Presentation: Miami Beach, Florida, USA
  • Year and Date: 2009-12-08
• [Presentation] Prenatal exposure to diesel exhaust affects dopaminergic system (2009)
  • Author(s): Yokota S, Mizuo K, Oshio S, Takeda K
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, Illinois, U.S.A.
  • Year and Date: 2009-10-21
• [Presentation] ディーゼル排気微粒子曝露が次世代の脳機能に及ぼす影響―行動評価試験法を組み合わせた毒性学的アプローチ― (2009)
  • Author(s): 横田理, 佐藤央, 杉戸雄四郎, 水尾圭祐, 武田健
  • Organizer: 第36回日本トキシコロジー学会学術年会
  • Place of Presentation: 岩手
  • Year and Date: 2009-07-06
• [Presentation] Titanium dioxide nanoparticles trans-ferred from pregnant mice to their offspring affect the genital and cranial nerve systems (2009)
  • Author(s): Takeda K, Suzuki K, Ishihara A, Kubo-Irie M, Fujimoto R, Tabata M, Oshio S, Nihei N, Ihara T, Sugamata M
  • Organizer: PPTOXII, a CCT Meeting of Society of Toxicology
  • Place of Presentation: Miami Beach, Florida, USA
• [Presentation] Prenatal exposure to diesel exhaust affects dopaminergic system (2009)
  • Author(s): Yokota S, Mizuo K, Oshio S, Takeda K
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, Illinois, U. S. A.
• [Presentation] 酸化チタンナノ粒子の胎仔期投与が脳の遺伝子発現に及ぼす影響 (2009)
  • Author(s): 清水碧、水尾圭祐、田井中均、梅澤雅和、武田健
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 胎仔期ディーゼル排気微粒子曝露により次世代の空間学習・記憶能が障害される (2009)
  • Author(s): 横田理、水尾圭祐、佐藤央、杉戸雄四郎、武田健
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Prenatal exposure to diesel exhaust particles produce learning deficits associated with impairment of NMDA receptor (2009)
  • Author(s): Yokota S, Sato A, Mizuo K, Akiyama K, Sutoo D, Takeda K
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
• [Presentation] ディーゼル排気微粒子曝露が次世代の脳機能に及ぼす影響-行動評価試験法を組み合わせた毒性学的アプローチ- (2009)
  • Author(s): 横田理、佐藤央、杉戸雄四郎、水尾圭祐、武田健
  • Organizer: 第36回日本トキシコロジー学会学術年会
  • Place of Presentation: 岩手
• [Book] Encyclopedia on Environmental Health. Auto-mobile exhaust : Detrimental effects of exposure to automobile exhaust on pul-monary and extrapulmonary tissues and offspring (2011)
  • Author(s): Umezawa, M., Takeda, K
• [Book] Endometriosis : Symptoms, Diagnosis and Treatments. Advantages and disadvantages of each animal model of endometriosis (2011)
  • Author(s): Umezawa, M., Takeda, K., Ihara, T., Sugamata, M
• [Book] Automobile exhaust : Detrimental effects of exposure to automobile exhaust on pulmonary and extrapulmonary tissues and offspring (2011)
  • Author(s): Umezawa, M., Takeda, K.
  • Publisher: Encyclopedia on Environmental Health
• [Book] Advantages and disadvantages of each animal model of endometriosis (2011)
  • Author(s): Umezawa, M., Takeda, K., Ihara, T., Sugamata, M.
  • Publisher: Endometriosis : Symptoms, Diagnosis and Treatments
• [Patent(Industrial Property Rights)] 分散物及び脳神経変性疾患治療薬 (2011)
  • Inventor(s): 鈴木健一郎、武田健
  • Industrial Property Rights Holder: 鈴木健一郎、武田健
  • Filing Date: 2011-08-09