| Project/Area Number |
21390037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TAKEDA Ken 東京理科大学, 薬学部・薬学科, 教授 (80054013)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIBANA Ken 東京理科大学, 薬学部・薬学科, 助教 (10400540)
YANAGITA Shinya 東京理科大学, 理工学部教養, 助教 (80461755)
SHINKAI Yusuke 東京理科大学, 薬学部, PD (80459734)
SUZUKI Kenichro 東京理科大学, 総合研究機構, PD (30548384)
UMEZAWA Masakazu 東京理科大学, 総合研究機構, PD (60615277)
SUGAMATA Masao 栃木臨床病理研究所, 所長 (50049863)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 環境衛生学 / ナノ粒子 / 酸化チタン / 胎仔期曝露 / 脳神経系 / 網羅的遺伝子発現解析 / 発達障害 / データマイニング / 酸化亜鉛 / モノアミン代謝 / ドーパミン / 脳発達障害 / ディーゼル排ガス微粒子 / マイクロアレイ |
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| Research Abstract |
The present study showed the effects of maternal exposure to nanomaterials on the development of cranial nerve system of offspring, using electron microscopic analysis, histological analysis, neurochemical(monoamine) analysis as well as gene expression analysis. The results indicated that exposure of pregnant mice to nanomaterial frequently used in nanotechnology induced alterations of microstructures, monoamine and its metabolism in the brain of offspring during the developmental period. Gene expression analysis using microarray showed an important clue of the mechanisms underlying the effects of maternal exposure to nanomaterials on the brain development.
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