| Project/Area Number |
21390038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
AOKI Yasunobu 独立行政法人国立環境研究所, 環境リスク研究センター, 副センター長 (20159297)
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| Co-Investigator(Kenkyū-buntansha) |
NOUMI Takehiko 国立医薬品食品衛生研究所, 変異遺伝部, 部長 (30150890)
KAGEYAMA Shiho 郡山女子大学, 家政学部, 講師 (00514316)
MATSUMOTO Michi 独立行政法人国立環境研究所, 環境リスク研究センター, 主任研究員 (60132867)
NAKAJIMA Daisuke 独立行政法人国立環境研究所, 環境リスク研究センター, 主任研究員 (10281411)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | 環境系薬学 / 有害大気汚染物質 / 体内変異原性 / 肺 / 精巣 / 多環芳香族炭化水素 / In vivo mutation / gpt deltaマウス / 経気道曝露 / ディーゼルナノ粒子 / 点突然変異 / 環境質定量化・予測 / 人間生活環境 / 有害化学物質 / 遺伝子 / 癌 |
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| Research Abstract |
We evaluated mutagenesis induced in the target organs, such as the lung, by exposure of total suspended particulate matter(TSP) in ambient air using a model transgenic rodent for detecting in mutations, named gpt delta mouse. Consequently, in vivo mutagenicity of TSP extract obtained in Tsukuba City was estimated as 0.76 x 10^<-5>/mg. Compounds causing in vivo mutagenisis in Tar have not been identified, but several observations suggest that any potent mutagens other than polycyclic aromatic hydrocarbons exist in ambient air.
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