Regulation of hepatic lipid metabolism through ileal bile acid-FGF signaling
Project/Area Number |
21390039
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Tohoku University |
Principal Investigator |
YAMAZOE Yasushi 東北大学, 大学院・薬学研究科, 教授 (00112699)
|
Co-Investigator(Kenkyū-buntansha) |
YOSHINARI Kouichi 東北大学, 大学院・薬学研究科, 准教授 (60343399)
MIYATA Masaaki 東北大学, 大学院・薬学研究科, 助教 (90239418)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
Keywords | FGF15/19 / FXR / 脂質代謝 / 胆汁酸 / 腸内細菌 / トリグリセリド / CD36 / FGF15 / 19 / 抗菌薬 |
Research Abstract |
We studied on the bile acid-mediated regulation of ileal FGF15/19 expression and FGF15/19-mediated regulation of hepatic lipid metabolism. The suppression of enterobacteria-mediated bile acid conversion decreased ileal FGF15 levels resulting in the elevation of hepatic bile acid synthesis. Multiple FXR responsive elements that are involved in the bile acid-mediated transcriptional activation of FGF19 gene we re found in the promoter region. FGF19 treatment decreased hepatic triglyceride and free fatty acid levels in Fxr-null mice.
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Report
(4 results)
Research Products
(41 results)