Clarification and evaluation of regulation mechanism of uric acid
| Project/Area Number |
21390044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAMAI Ikumi 金沢大学, 薬学系, 教授 (20155237)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASAKA Yoshiyuki 金沢大学, 薬学系, 助教 (60453833)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 尿酸 / トランスポーター / 高尿酸血症 / 腎臓 / 消化管 / 尿酸値変動 / 再吸収 / URAT1 / URATv1 / 発現系 / 尿酸排泄促進薬 / ベンズブロマロン / ロサルタン / 薬物間相互作用 / OAT / in vitro発現系 |
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| Research Abstract |
Transporter molecule that control renal handling of uric acid and effect of uricosuric-and anti-uricosuric drugs were analyzed using in vitro and in vivo model. OAT2 was newly found as the uric acid transporter in kidney. As the animal model, uric transporters expressed in rats were characterized and found to be useful as the model of uric acid disposition. In addition, as the extra-renal elimination pathways of uric acid, intestinal secretion was found to be very important and the BCRP transporter was found to be responsible for that process. Furthermore, for in vivo analysis in human, the method for the synthesis of PET probe of uric acid was succeeded. It was preliminarily applied in PET analysis in rats. All these studies related to the mechanism and evaluation method of uric acid disposition is useful for future development of drugs that can control serum uric acid level and physiological and pathological significance of uric acid.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Synthesis of[^<11> C] uric acid, using[^<11> C] phosgene, as a possible biomarker in PET imaging for diagnosis of gout2012
Author(s)
Yashio K., Katayama Y., Takashima T., Ishiguro N., Doi H, Suzuki M., Wada Y., Tamai I., Watanabe Y.
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Journal Title
Bioorg Med Chem Lett
Volume: 22(1)
Pages: 115-9
NAID
Related Report
Peer Reviewed
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[Journal Article] Synthesis of [^<11>C]uric acid, using [^<11>C] phosgene, as a possible biomarker in PET imaging for diagnosis of gout2012
Author(s)
Yashio K, Katayama Y, Takashima T, Ishiguro N, Doi H, Suzuki M, Wada Y, Tamai I, Watanabe Y
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Journal Title
Bioorg Med Chem Lett
Volume: 22(1)
Issue: 1
Pages: 115-9
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Uric Acid Transporter-Mediated Uricosuric Effect of RDEA594, A Metab olite of Antiviral Agent RDEA8062010
Author(s)
Mayuko Yoshifuji, Masanobu Sato, Li-Tain Yeh, Kohei Ohya, Yoshiyuki Shirasaka, Takeo Nakanishi, Ikumi Tamai
Organizer
Globalization of Pharmaceutics Education Network (GPEN) Meeting
Place of Presentation
University of North Carolina,チャペルヒル,NC,米国
Year and Date
2010-11-11
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