Elucidation of functions of genes involved in cell polarity in vivo
| Project/Area Number |
21390050
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Ken 群馬大学, 生体調節研究所, 教授 (30311343)
SATO Takashi 群馬大学, 生体調節研究所, 准教授 (70344934)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 細胞極性 / ノックアウトマウス / 極性輸送 / 線虫 / Rab8 / 線毛 |
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| Research Abstract |
To elucidate the molecular mechanism of cell polarity, we knocked out genes involved in polarized transport. In addition, we tried to find out novel genes involved in cell polarity using the worm, C.elegans. As we found various phenotypes in our knockout mice, we are preparing manuscripts for the analyses of knockout mice. We finished screening of C.elegans in search of novel genes. We are now making knockout mice for some of the novel genes now.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] The role of VAMP7/TI-VAMP in cell polarity and lysosomal exocytosis in vivo.2011
Author(s)
Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Sato K, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A.
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Journal Title
Traffic
Volume: 12
Issue: 10
Pages: 1383-1393
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.2009
Author(s)
Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F.
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Journal Title
Journal of Immunology
Volume: 182
Issue: 5
Pages: 3243-3251
DOI
Related Report
Peer Reviewed
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[Journal Article] SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.2009
Author(s)
Sadakata H, Okazawa H, Sato T, Supriatna Y, Ohnishi H, Kusakari S, Murata Y, Ito T, Nishiyama U, Minegishi T, Harada A, Matozaki T.
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Journal Title
Genes to Cells
Volume: 14
Issue: 3
Pages: 295-308
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.2009
Author(s)
Akiyama H, Gotoh A, Shin RW, Koga T, Ohashi T, Sakamoto W, Harada A, Arai H, Sawa A, Uchida C, Uchida T.
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Journal Title
Journal of Biological Chemistry
Volume: 284
Issue: 47
Pages: 32695-32699
DOI
Related Report
Peer Reviewed
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