Bone marrow cell abnormality and diabetic complications

• Project/Area Number: 21390054
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Sapporo Medical University
• Principal Investigator: FUJIMIYA Mineko 札幌医科大学, 医学部, 教授 (10199359)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 細胞分化 / 組織形成 / 糖尿病 / 臓器障害 / 骨髄幹細胞 / 細胞融合 / 骨髄ニッチ / 腎障害 / 糖尿病合併症 / 骨髄顆粒球 / イマチニブ / TNFα / 合併症 / 骨髄細胞 / ストレプトゾトシン / プロインスリン / GFPマウス

Research Abstract

We successfully demonstrated that diabetic complications are derived from abnormality in bone marrow stem cells, and this finding leads the therapeutic strategies for diabetic complications by replacement of bone marrow niche.

Research Products

• [Journal Article] Bone Marrow Stem Cell Abnormality and Diabetic Complications (2012)
  • Author(s): Fujimiya M, Nagaishi K, Yamashita T, Ataka K.
  • Journal Title: Anat Rec Volume: (in press) Issue: 6 Pages: 917-21
  • DOI: 10.1002/ar.22445
  • NAID: 40019474228
  • Peer Reviewed
• [Journal Article] Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy (2012)
  • Author(s): Yamashita T, Fujimiya M, Nagaishi K, Ataka K, Tanaka M, Yoshida H, Tsuchihashi K, Shimamoto K, Miura T.
  • Journal Title: FASEB J Volume: 26 Pages: 1559-68
  • URL: http://www.fasebj.org/content/26/4/1559.long
  • Peer Reviewed
• [Journal Article] Metallothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics (2012)
  • Author(s): Oki G, Wada T, Iba K, Aiki H, Sasaki K, Imai S, Sohma H, Matsumoto K, Yamaguchi M, Fujimiya M, Yamashita T, Kokai Y.
  • Journal Title: Pain Volume: 153 Pages: 532-9
  • Peer Reviewed
• [Journal Article] Regulation of gastroduodenal motility : acyl ghrelin, des-acyl ghrelin and obestatin and hypothalamic peptides (2012)
  • Author(s): Fujimiya M, Ataka K, Asakawa A, Chen CY, Kato I, Inui A.
  • Journal Title: Digestion Volume: 85 Pages: 90-4
  • URL: http://content.karger.com/ProdukteDB/produkte.asp?id=doi%3A10.1159%2F000334654
  • Peer Reviewed
• [Journal Article] Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy (2012)
  • Author(s): Yamashita T, Fujimiya M, et al
  • Journal Title: FASEB J Volume: 26 Pages: 1559-1568
  • Peer Reviewed
• [Journal Article] Metallothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics (2012)
  • Author(s): Oki G, Wada T, Fujimiya M, et al
  • Journal Title: Pain Volume: 153 Pages: 532-539
  • Peer Reviewed
• [Journal Article] Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat (2011)
  • Author(s): Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sasaki Y, Fujimiya M, Imai K, Shinomura Y.
  • Journal Title: J Gastroenterol Volume: 46 Pages: 143-52
  • NAID: 10029027000
  • URL: http://www.springerlink.com/content/737w51v35p3633r5/?MUD=MP
  • Peer Reviewed
• [Journal Article] Transfer of Bone Marrow Progenitors Prevents Coronary Insufficiency and Systolic Dysfunction in the Mechanical Unloaded Heart in Mice (2011)
  • Author(s): Koike M, Kojima H, Fujimiya M, Matsubayashi K, Aimi Y, Kimura H, Asai T.
  • Journal Title: J Surg Res Volume: 171 Pages: 47-57
  • Peer Reviewed
• [Journal Article] Investigation of the presence of ghrelin in the central nervous system of the rat and mouse (2011)
  • Author(s): Furness JB, Hunne B, Matsuda N, Yin L, Russo D, Kato I, Fujimiya M, Patterson M, McLeod J, Andrews ZB, Bron R.
  • Journal Title: Neuroscience Volume: 193 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility (2011)
  • Author(s): Fujimiya M, Ataka K, Asakawa A, Chen CY, Kato I, Inui A.
  • Journal Title: Peptides Volume: 32 Pages: 2348-51
  • Peer Reviewed
• [Journal Article] Transfer of Bone Marrow Progenitors Prevents Coronary Insufficiency and Systolic Dysfunction in the Mechanical Unloaded Heart in Mice. (2011)
  • Author(s): Koike M., Fujimiya M, et al.
  • Journal Title: J Surg Res. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Ghrelin, des-acyl ghrelin, and obestatin : regulatory roles on the gastrointestinal motility. (2011)
  • Author(s): Fujimiya M., et al.
  • Journal Title: Int J Pept. Volume: (In press)
  • NAID: 40017367769
  • Peer Reviewed
• [Journal Article] Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat. (2011)
  • Author(s): Tanaka H., Fujimiya M., et al.
  • Journal Title: J Gastroenterol. Volume: 46 Pages: 143-152
  • NAID: 10029027000
  • Peer Reviewed
• [Journal Article] Chronic foot-shock stress potentiates the influx of bone marrow-derived microglia into hippocampus (2010)
  • Author(s): Brevet M, Kojima H, Asakawa A, Atsuchi K, Ushikai M, Ataka K, Inui A, Kimura H, Sevestre H, Fujimiya M.
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1890-1897
  • URL: http://onlinelibrary.wiley.com/doi/10.1002/jnr.22362/abstract;jsessionid=B449EE6613C342DDEABFF776B96FC731.d01t02?systemMessage=Wiley+Online+Library+will+be+disrupted+on+9+June+from+10%3A00-12%3A00+BST+%2805%3A00-07%3A00+EDT%29+for+essential+maintenance
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3 (2010)
  • Author(s): Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I, Nanba H, Laviano A, Meguid MM, Inui A.
  • Journal Title: Psychoneuroendocrinology Volume: 35 Pages: 1178-1186
  • Peer Reviewed
• [Journal Article] Ghrelin, des-acyl ghrelin, and obestatin : regulatory roles on the gastrointestinal motility (2010)
  • Author(s): Fujimiya M, Asakawa A, Ataka K, Chen CY, Kato I, Inui A.
  • Journal Title: Int J Pept Volume: 2010
  • NAID: 40017367769
  • URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915652/?tool=pubmed
  • Peer Reviewed
• [Journal Article] Modulation of ingestive behavior and gastrointestinal motility by ghrelin in diabetic animals and humans. (2010)
  • Author(s): Chen C-Y, Fujimiya M., et al.
  • Journal Title: J Chin Med Assoc. Volume: 73 Pages: 225-229
  • Peer Reviewed
• [Journal Article] Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice. (2010)
  • Author(s): Atsuchi K., Fujimiya M., et al.
  • Journal Title: Neuroreport. Volume: 21 Pages: 1008-1011
  • Peer Reviewed
• [Journal Article] Immunosuppressive effect of prolactin-induced protein : a new insight into its local and systemic role in chronic allergic contact dermatitis. (2010)
  • Author(s): Sugiura S., Fujimiya M., et al.
  • Journal Title: Br J Dermatol. Volume: 162 Pages: 1286-1293
  • Peer Reviewed
• [Journal Article] 糖尿病治療の新しい展開 (2010)
  • Author(s): 藤宮峯子
  • Journal Title: 胆と膵 Volume: 31 Pages: 547-551
• [Journal Article] グレリン、デスアシルグレリン、オベスタチンによる上部消化管運動の制御と脳腸相関 (2010)
  • Author(s): 藤宮峯子
  • Journal Title: 医学のあゆみ Volume: 235 Pages: 951-953
• [Journal Article] Chronic foot-shock stress potentiates the influx of bone marrow-derived microglia into hippocampus. (2010)
  • Author(s): Brevet M, Fujimiya M., et al.
  • Journal Title: J Neurosci Res. (In press)
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3. (2010)
  • Author(s): Asakawa A, Fujimiya M., et al.
  • Journal Title: Psychoneuroendocrinology. (In press)
  • Peer Reviewed
• [Journal Article] Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver. (2009)
  • Author(s): Fujimiya T, Fujimiya M., et al
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. 297
  • Peer Reviewed
• [Journal Article] Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity. (2009)
  • Author(s): Yabana T, Fujimiya M., et al.
  • Journal Title: J.Pathol. 218 Pages: 350-359
  • Peer Reviewed
• [Journal Article] Ghrelin gene products and the regulation of food intake and gut motility. (2009)
  • Author(s): Chen CY, Fujimiya M., et al.
  • Journal Title: Pharmacol Rev. 61 Pages: 430-481
  • Peer Reviewed
• [Journal Article] New method of manometric measurement of gastroduodenal motility in conscious mice : Effects of ghrelin and Y2 depletion. (2009)
  • Author(s): Tanaka R, Fujimiya M., et al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. 297 Pages: 1028-1034
  • Peer Reviewed
• [Journal Article] Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH. (2009)
  • Author(s): Mizutani M, Fujimiya M., et al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. 297 Pages: 974-980
  • Peer Reviewed
• [Journal Article] 糖尿病合併症の原因となる異常骨髄細胞 (2009)
  • Author(s): 藤宮峯子
  • Journal Title: 医学のあゆみ 229 Pages: 294-295
• [Journal Article] 最先端の幹細胞研究 -膵β細胞の再生- (2009)
  • Author(s): 藤宮峯子
  • Journal Title: Surgery Frontier 16 Pages: 303-308
• [Presentation] 骨髄由来ミクログリアと脳腸相関 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第13回日本神経消化器病学会
  • Place of Presentation: 宇都宮(招待講演)
  • Year and Date: 2011-11-05
• [Presentation] 糖尿病でおこる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第1回細胞再生医療研究会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-31
• [Presentation] 糖尿病でおこる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第1回細胞再生医療研究会
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2011-07-31
• [Presentation] 糖尿病合併症の原因となる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第67回日本顕微鏡学会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-05-18
• [Presentation] 糖尿病合併症の原因となる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第67回日本顕微鏡学会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-16
• [Presentation] 視床下部ペプチドと消化管運動 -ミクログリアの役割に関する最近の知見- (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第21回 北海道消化管運動研究会
  • Place of Presentation: 札幌
  • Year and Date: 2011-02-25
• [Presentation] 骨髄幹細胞を標的にした糖尿病合併症の治療戦略 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第35回広島整形外科先端医学セミナー
  • Place of Presentation: 広島
  • Year and Date: 2010-11-17
• [Presentation] 再生医療や変性疾患の治療に大きな可能性を秘めた骨髄細胞 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第56回 日本解剖学会 東北北海道連合支部学術集会
  • Place of Presentation: 旭川
  • Year and Date: 2010-09-25
• [Presentation] 上部消化管運動と脳腸相関 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第42回 胃病態機能研究会
  • Place of Presentation: 札幌
  • Year and Date: 2010-08-06
• [Presentation] 骨髄由来ミクログリアと脳腸相関 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第42回消化管Motility研究会
  • Place of Presentation: 神戸
  • Year and Date: 2010-07-21
• [Presentation] 骨髄由来ミクログリアと脳腸相関 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第10回 消化管Motility研究会
  • Place of Presentation: 神戸
  • Year and Date: 2010-07-21
• [Presentation] 視床下部ペプチドと脳腸相関 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第14回 Gl cell Biology研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-17
• [Presentation] 糖尿病合併症の原因となる骨髄幹細胞 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第115回日本解剖学会
  • Place of Presentation: 岩手
  • Year and Date: 2010-03-28
• [Presentation] 糖尿病合併症の原因となる骨髄幹細胞 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第115回 日本解剖学会(招待講演)
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-28
• [Presentation] Different effects of ghrelin, des-acyl ghrelin and obestatin on gastro-duodenal motility in conscious rats. (2009)
  • Author(s): 藤宮峯子, et al.
  • Organizer: International symposium on ghrelin
  • Place of Presentation: 東京
  • Year and Date: 2009-11-18
• [Presentation] グレリン、デスアシルグレリン、オベスタチンを中心にした脳腸相関 (2009)
  • Author(s): 藤宮峯子
  • Organizer: 第7回千葉Digestive Disease Conference(招待講演)
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-13
• [Presentation] 再生と変性に大きな可能性を秘めた骨髄幹細胞 (2009)
  • Author(s): 藤宮峯子
  • Organizer: 第5回 山口ライフサイエンスセミナー(招待講演)
  • Place of Presentation: 宇部
  • Year and Date: 2009-10-23
• [Patent(Industrial Property Rights)] Replacement of bone marrow niche cells for treatment of various diseases (2012)
  • Inventor(s): 藤宮峯子、安宅弘司、千葉弘規
  • Industrial Property Rights Holder: 札幌医科大学
  • Filing Date: 2012-01-27
  • Overseas
• [Patent(Industrial Property Rights)] 特許出願 (2012)
  • Inventor(s): 藤宮峯子, 安宅弘司, 千葉弘規
  • Industrial Property Rights Holder: 札幌医科大学
  • Filing Date: 2012-01-26
• [Patent(Industrial Property Rights)] 特許出願 (2012)
  • Inventor(s): 藤宮峯子, 安宅弘司, 千葉弘規
  • Industrial Property Rights Holder: 札幌医科大学
  • Filing Date: 2012-01-26
  • Overseas