| Project/Area Number |
21390055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
WAGURI Satoshi 福島県立医科大学, 医学部, 教授 (30244908)
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| Co-Investigator(Kenkyū-buntansha) |
KAMETAKA Satoshi 福島県立医科大学, 医学部, 講師 (10303950)
YAMAMOTO Masaya 福島県立医科大学, 医学部, 准教授 (20446115)
SAWADA Naoki 福島県立医科大学, 医学部, 博士研究員 (50452644)
UEMURA Takefumi 福島県立医科大学, 医学部, 助教 (80548925)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 細胞微細形態学 / クラスリン / 凝集体 / リソソーム分解 / クラスリンアダプター / GGA / AP-1 / p56 / EGFR / ショウジョウバエ / Notchシグナル / クラスリンアダプタータンパク質 / aftiphilin / ノックアウトマウス / 細胞内凝集物 / M6PR / TGN46 |
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| Research Abstract |
To elucidate physiological functions of Golgi/endosome-localized clathrin adaptors, GGAs and AP1, we performed extensive functional analysis using mammalian and drosophila model systems. We found that GGAs and AP1 are involved in the intracellular trafficking of epidermal growth factor receptor and Notch, respectively, by evading their degradations. Therefore, we propose new function of GGAs/AP1 in cell proliferation and differentiation, which would potentially be useful for developing new cancer therapy.
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