| Project/Area Number |
21390056
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
SAKAI Hideki 富山大学, 大学院・医学薬学研究部(薬学), 教授 (60242509)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORII Magotoshi 鈴鹿医療科学大学, 薬学部, 教授 (60019130)
SHIMIZU Takahiro 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (40353437)
FUJII Takuto 富山大学, 大学院・医学薬学研究(薬学), 助教 (50567980)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Keywords | 胃酸分泌細胞 / 細胞防御 / ホメオスタシス / イオンチャネル / 塩化物イオン / トランスポーター / 塩素イオン / SLC26A7 / SLC26A9 / プロスタグランジン / ピロリ菌 / インターロイキン |
|---|
| Research Abstract |
The gastric parietal cell secretes strong acid, but the cell is not digested by acid. Therefore, it is thought that the parietal cell possesses the sophisticated cytoprotective mechanism. So far, we found that function of a cytoprotective Cl^-channel is essential for the mechanism. In this study, we tried to clarify physiological function of two kinds of Cl^-channels, SLC26A7 and SLC26A9, in the parietal cell. We found that SLC26A7 is an essential molecule for maintaining the function of cytoprotective Cl^-channel, and that SLC26A9 is activated by acidic pH and inhibited by hyperosmolality
|
