| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
|---|
| Research Abstract |
The lysophospholipid mediator sphingosine-1-phosphate(S1P) exerts a facilitative effect on atherosclerosis via S1P2 receptor in macrophages, regulatory effects on angiogenesis including tumor angiogenesis via multiple receptors, and modulatory effects on vascular barrier function. S1P also is involved in cardiac remodeling. Phosphatidylinositol 3-kinase class II, which produces phosphatidylinositol 3-phosphate, plays the crucial role in angiogenesis through a novel mechanism. These observations suggest the possibility that the functional lipids S1P and phosphatidylinositol 3-phosphate could be potential novel therapeutic targets for cardiovascular diseases.
|
