Role of functionallipids in cardiovascular homeostasis and diseases

• Project/Area Number: 21390057
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Kanazawa University
• Principal Investigator: TAKUWA Yoh 金沢大学, 医学系, 教授 (60171592)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Kazuaki 金沢大学, 医学系, 助教 (80333368)
• Co-Investigator(Renkei-kenkyūsha): TAKUWA Noriko 石川県立看護大学, 看護学部, 教授 (70150290)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: スフィンゴシン-1-リン酸 / PI3キナーゼ / 脂質 / 心血管 / ホメオスターシス / 病態生理

Research Abstract

The lysophospholipid mediator sphingosine-1-phosphate(S1P) exerts a facilitative effect on atherosclerosis via S1P2 receptor in macrophages, regulatory effects on angiogenesis including tumor angiogenesis via multiple receptors, and modulatory effects on vascular barrier function. S1P also is involved in cardiac remodeling. Phosphatidylinositol 3-kinase class II, which produces phosphatidylinositol 3-phosphate, plays the crucial role in angiogenesis through a novel mechanism. These observations suggest the possibility that the functional lipids S1P and phosphatidylinositol 3-phosphate could be potential novel therapeutic targets for cardiovascular diseases.

Research Products

• [Journal Article] Protein-coupled sphingosine-1-phosphate receptors : potential molecular targets for angiogenic and anti-angiogenic therapies (2011)
  • Author(s): Takuwa N, Okamoto Y, Yoshioka K, Takuwa Y.
  • Journal Title: Biomed Rev Volume: 22 Pages: 15-29
  • URL: http://www.eurochicago.com/wp-content/uploads/2012/03/BMR-22-2011.pdf#page=22
  • Peer Reviewed
• [Journal Article] Crucial role of membrane type 1 matrix metalloproteinase(MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells (2011)
  • Author(s): Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y.
  • Journal Title: J Atheroscler Thromb Volume: 18(9) Pages: 762-73
  • URL: http://www.jstage.jst.go.jp/article/jat/18/9/18_6783/_pdf
  • Peer Reviewed
• [Journal Article] Tumor-suppressive Sphingosine-1-phosphate Receptor-2 Counteracting Tumor-promoting Sphingosine-1-phosphate Receptor-1 and Sphingosine Kinase 1-Jekyll Hidden behind Hyde (2011)
  • Author(s): Takuwa N, Du W, Kaneko E, Okamoto Y, Yoshioka K Takuwa Y.
  • Journal Title: Am J Cancer Res Volume: 1(4) Pages: 460-481
  • URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186046/?tool=pubmed
  • Peer Reviewed
• [Journal Article] Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate spastic radial artery in coronary artery bypass grafting surgery (2011)
  • Author(s): Takagi T, Okamoto Y, Tomita S, Sato A, Yamaguchi S, Takuwa Y, Watanabe G.
  • Journal Title: J Thorac Cardiovasc Surg Volume: 142(2) Pages: 59-65
  • URL: http://dx.doi.org/10.1016/j.jtcvs.2011.01.055
  • Peer Reviewed
• [Journal Article] Effects of gomisin A on vascular contraction in rat aortic rings Naunyn-Schmiedeberg (2011)
  • Author(s): Seok YM, Choi YW, Kim GD, Kim HY, Takuwa Y, Kim IK.
  • Journal Title: Archives of Pharmacology Volume: 383(1) Issue: 1 Pages: 45-56
  • DOI: 10.1007/s00210-010-0571-0
  • Peer Reviewed
• [Journal Article] Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis Pharmaceuticals (2011)
  • Author(s): Okamoto Y, Wang F, Yoshioka K, Takuwa N, Takuwa Y.
  • Journal Title: Atherosclerosis Pharmaceuticals Volume: 4 Issue: 1 Pages: 117-137
  • DOI: 10.3390/ph4010117
  • Peer Reviewed
• [Journal Article] Involvement of membrane type1-matrix metalloproteinase(MT1-MMP) in rage activation signalingpathways (2011)
  • Author(s): Kamioka M, Ishibashi T, Ohkawara H, Eguchi R, Sugimoto K, Uekita H, Matsui T, Yamagishi SI, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y.
  • Journal Title: J Cell Physiol Volume: 226(6) Issue: 6 Pages: 1554-1563
  • DOI: 10.1002/jcp.22492
  • Peer Reviewed
• [Journal Article] Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats (2011)
  • Author(s): Suzuki H, Hashimoto H, Kawasaki M, Watanabe M, Otsubo H, Ishikura T, Fujihara H, Ohnishi H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Nakamura T, Ueta Y.
  • Journal Title: Int J Cancer Volume: 128 Issue: 9 Pages: 2215-2223
  • DOI: 10.1002/ijc.25535
  • Peer Reviewed
• [Journal Article] Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate spastic radial artery in coronary artery bypass grafting surgery (2011)
  • Author(s): Takagi T
  • Journal Title: J Thorac Cardiovasc Surg Volume: 142 Issue: 2 Pages: e59-e65
  • DOI: 10.1016/j.jtcvs.2011.01.055
  • Peer Reviewed
• [Journal Article] Tumor-suppressive Sphingosine-1-phosphate Receptor-2 Counteracting Tumor-promoting Sphingosine-1-phosphate Receptor-1 and Sphingosine Kinase 1-Jekyll Hidden behind Hyde (2011)
  • Author(s): Takuwa N
  • Journal Title: Am J Cancer Res Volume: 1 Pages: 460-481
  • Peer Reviewed
• [Journal Article] Crucial role of membrane type 1 matrix metalloproteinase (MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells (2011)
  • Author(s): Ando K
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 762-773
  • Peer Reviewed
• [Journal Article] G Protein-coupled sphingosine-1-phosphate receptors : potential molecular targets for angiogenic and anti-angiogenic therapies (2011)
  • Author(s): Takuwa N
  • Journal Title: Biomed Rev Volume: 22 Pages: 15-29
  • Peer Reviewed
• [Journal Article] スフィンゴシン-1-リン酸と炎症 (2011)
  • Author(s): 多久和陽
  • Journal Title: 感染・炎症・免疫 Volume: 41 Pages: 14-25
• [Journal Article] Sphingosme-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis (2011)
  • Author(s): Y Okamoto
  • Journal Title: Pharmaceuticals Volume: 4 Pages: 117-137
  • Peer Reviewed
• [Journal Article] Enhanced Ca2+-Dependent Activation of PI3KC2 alpha Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats (2010)
  • Author(s): Seok YM, Azam MA, Okamoto Y, Sato A, Yoshioka K, Maeda M, Kim IK, Takuw Y.
  • Journal Title: Hypertension Volume: 56(5) Issue: 5 Pages: 934-941
  • DOI: 10.1161/hypertensionaha.110.160853
  • Peer Reviewed
• [Journal Article] Roles of sphingosine-1-phosphate signaling in angiogenesis (2010)
  • Author(s): Takuwa Y, Du W, Qi X, Okamoto Y, Takuwa N, Yoshioka K.
  • Journal Title: World J Biol Chem Volume: 1(10) Pages: 298-306
  • URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083935/
  • Peer Reviewed
• [Journal Article] Preventive effects of pravastatin on thrombintriggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo (2010)
  • Author(s): Ohkawara H, Ishibashi T, Saitoh S, Inoue N, Sugimoto K, Kamioka M, Uekita H, Kaneshiro T, Ando K, Takuwa Y, Maruyama Y, Takeishi Y.
  • Journal Title: Cardiovasc Res Volume: 88(3) Issue: 3 Pages: 492-501
  • DOI: 10.1093/cvr/cvq221
  • Peer Reviewed
• [Journal Article] Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice (2010)
  • Author(s): Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, Yoshioka K, Du W, Sugimoto N, Yatomi Y, Takuwa N, Takuwa Y.
  • Journal Title: Eur J Pharmacol Volume: 634(1-3) Issue: 1-3 Pages: 121-131
  • DOI: 10.1016/j.ejphar.2010.02.038
  • NAID: 120002086439
  • Peer Reviewed
• [Journal Article] S1P2, the G protein-coupledreceptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice (2010)
  • Author(s): Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y.
  • Journal Title: Cancer Res Volume: 70(2) Issue: 2 Pages: 772-781
  • DOI: 10.1158/0008-5472.can-09-2722
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma (2010)
  • Author(s): Yoshida Y, Nakada M, Sugimoto N, Harada T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y, Yachie A, Takuwa Y, Hamada JI.
  • Journal Title: Int J Cancer Volume: 126(10) Issue: 10 Pages: 2341-2352
  • DOI: 10.1002/ijc.24933
  • Peer Reviewed
• [Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species (2010)
  • Author(s): Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y
  • Journal Title: Cardiovasc Res Volume: 85(3) Issue: 3 Pages: 484-493
  • DOI: 10.1093/cvr/cvp312
  • NAID: 120001939472
  • Peer Reviewed
• [Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. (2010)
  • Author(s): N.Takuwa
  • Journal Title: Cardiovasc Res Volume: 85 Pages: 484-493
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferat ion and correlates with survival of patients with glioblastoma. (2010)
  • Author(s): Y.Yoshida
  • Journal Title: Int J Cancer Volume: 126 Pages: 2341-2352
  • Peer Reviewed
• [Journal Article] S1P2, the G protein-coupled receptor for sphingosine-1-phosphate,negatively regulates tumor angiogenesis and tumor growth in vivo in mice. (2010)
  • Author(s): W Du
  • Journal Title: Cancer Res Volume: 70 Pages: 772-781
  • Peer Reviewed
• [Journal Article] Sustained delivery of sphingosine-1-phosphate using poly(lactic co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. (2010)
  • Author(s): X Qi
  • Journal Title: Eur J Pharmacol Volume: 634 Pages: 121-131
  • Peer Reviewed
• [Journal Article] Similar changes of hypothalamic feeding-regulating peptides mRNAs an d plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats. (2010)
  • Author(s): H Suzuki
  • Journal Title: Int J Cancer. Volume: 128 Pages: 2215-2223
  • Peer Reviewed
• [Journal Article] Preventive effects of pravastatin on thrombintriggered vascular response s via Akt/eNOS and RhoA/Racl pathways in vivo. (2010)
  • Author(s): H Ohkawara
  • Journal Title: I Cardiovasc Res. Volume: 88 Pages: 492-501
  • Peer Reviewed
• [Journal Article] Roles of sphingosine-1-phosphate signaling in angiogenesis. (2010)
  • Author(s): Y Takuwa
  • Journal Title: World J Biol Chem. Volume: 1 Pages: 298-306
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in Apoe-deficient mice. (2010)
  • Author(s): F Wang
  • Journal Title: J Clin Invest. Volume: 120 Pages: 3979-3995
  • Peer Reviewed
• [Journal Article] Enhanced Ca2^+-Dependent Activation of PI3KC2 alpha Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats. (2010)
  • Author(s): YM Seok
  • Journal Title: Hypertension Volume: 56 Pages: 934-941
  • Peer Reviewed
• [Journal Article] Involvement of membrane type1-matrix metalloproteinase (MT1-MMP) in rage activation signalingpathways. (2010)
  • Author(s): M Kamioka
  • Journal Title: J Cell Physionl. Volume: (In press)
  • Peer Reviewed
• [Journal Article] 脂質性成長因子SIPは、2型受容体を介してマクロファージ泡沫化および動脈硬化に関与する (2010)
  • Author(s): 王飛
  • Journal Title: 実験医学 Volume: 29 Pages: 3979-3995
  • Peer Reviewed
• [Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species (2010)
  • Author(s): 多久和陽
  • Journal Title: Cardiovasc Res 85 Pages: 484-493
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma (2010)
  • Author(s): Y.Yoshida
  • Journal Title: Int J Cancer 126 Pages: 2341-2352
  • Peer Reviewed
• [Journal Article] S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice (2010)
  • Author(s): W Du
  • Journal Title: Cancer Res 70 Pages: 772-781
  • Peer Reviewed
• [Journal Article] Sustained delivery of sphingosine-1-phosphate using poly (lactic-co-glycolicacid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice (2010)
  • Author(s): X Qi
  • Journal Title: Eur J Pharmacol 634 Pages: 121-131
  • Peer Reviewed
• [Journal Article] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits (2009)
  • Author(s): Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto T, Maruyama Y, Takeishi Y.
  • Journal Title: J Atheroscler Thromb Volume: 16(6) Pages: 846-856
  • Peer Reviewed
• [Journal Article] Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated polyester stent-graft (2009)
  • Author(s): Zhong H, Matsui O, Xu K, Ogi T, Sanada J, Okamoto Y, Tabata Y, Takuwa Y.
  • Journal Title: J Vasc Surg Volume: 50(6) Pages: 1433-1443
  • URL: http://www.jstage.jst.go.jp/article/jat/16/6/16_2394/_pdf
  • Peer Reviewed
• [Journal Article] LOX-1-LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-d nsity lipoprotein in endothelial cells (2009)
  • Author(s): Sugimoto K, Ishibashi T, Sawamura T, Inoue N, Kamioka M, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y.
  • Journal Title: Cardiovasc Res Volume: 84(1) Issue: 1 Pages: 127-136
  • DOI: 10.1093/cvr/cvp177
  • Peer Reviewed
• [Journal Article] Involvement of sphingosine-1-phosphate and S1P(1) in angiogenesis : Analyses using a new S1P(1) antagonist of non-sphingosine-1-phosphate analog (2009)
  • Author(s): Yonesu K, Kawase Y, Inoue T, Takagi N, Tsuchida J, Takuwa Y, Kumakura S, Nara F.
  • Journal Title: Biochem Pharmacol Volume: 15 ; 77(6) Pages: 1011-1020
  • URL: http://dx.doi.org/10.1016/j.bcp.2008.12.007
  • Peer Reviewed
• [Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc42 (2009)
  • Author(s): Shiratsuchi A, Ichiki M, Okamoto Y, Ueda N, Sugimoto N, Takuwa Y, Nakanishi Y.
  • Journal Title: J Biochem Volume: 145(1) Issue: 1 Pages: 43-50
  • DOI: 10.1093/jb/mvn139
  • Peer Reviewed
• [Journal Article] LOX-1-LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation in duced by oxidized low-d nsity lipoprotein in endothelial cells (2009)
  • Author(s): K.Sugimoto
  • Journal Title: Cardiovasc Res. 84 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Gene transduction into aortic wall using plasmid-loaded cationized gelat in hydrogel-coated polyester stent-graft (2009)
  • Author(s): H.Zhong
  • Journal Title: J Vasc Surg 50 Pages: 1433-1443
  • Peer Reviewed
• [Journal Article] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits (2009)
  • Author(s): H Ohkawara
  • Journal Title: J Atheroscler Thromb 16 Pages: 846-856
  • Peer Reviewed
• [Journal Article] 生体におけるスフィンゴシン-1-リン酸シグナル系の機能 (2009)
  • Author(s): 多久和陽
  • Journal Title: 実験医学 27 Pages: 2068-2073
  • Peer Reviewed
• [Presentation] スフィンゴシン-1-リン酸による血管内皮細胞遊走におけるクラスII型PI3キナーゼC2αの役割 (2012)
  • Author(s): Kuntal Biswas、吉岡和晃、多久和典子、岡本安雄、多久和陽
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 日長野県松本文化会館(長野)
• [Presentation] クラスII型PI3キナーゼC2αノックアウトマウスにおける血管障壁機能の異常 (2012)
  • Author(s): 吉岡和晃、吉田耕太朗、崔弘、安藝翔、Kuntal Biswas,趙娟娟、多久和典子、岡本安雄、多久和陽
  • Organizer: 89回日本生理学会大会
  • Place of Presentation: 日長野県松本文化会館(長野)
• [Presentation] クラスII型PI3キナーゼC2αノックアウトマウスにおける血管障壁機能の異常 (2012)
  • Author(s): 吉岡和晃
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)(招待講演)
• [Presentation] スフィンゴシン-1-リン酸による血管内皮細胞遊走におけるクラスII型PI3キナーゼC2αの役割 (2012)
  • Author(s): Kuntal Biswas
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 野県松本文化会館(長野県)
• [Presentation] 血管平滑筋収縮における新しいCa2+標的-ミオシン軽鎖ホスファターゼ (2011)
  • Author(s): 多久和陽
  • Organizer: 第27回スパズム・シンポジウム
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-07-30
• [Presentation] 血管平滑筋収縮における新しいCa2+標的-ミオシン軽鎖ホスファターゼ (2011)
  • Author(s): 多久和陽
  • Organizer: 第27回スパズム・シンポジウム
  • Place of Presentation: 国立京都国際会館(京都府)(招待講演)
  • Year and Date: 2011-07-30
• [Presentation] クラスII型PI3キナーゼC2αは血管新生と障壁機能に必須である (2011)
  • Author(s): 吉岡和晃、吉田耕太郎、崔弘、安藝翔、Kuntal Biswas、多久和典子、岡本安雄、多久和陽
  • Organizer: 第88回日本生理学会ポスター
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-03-29
• [Presentation] SIP2受容体遺伝子欠損はマクロファージの炎症活性を抑え、apoE欠損マウスにおける粥状動脈硬化を抑制する (2011)
  • Author(s): 岡本安雄
  • Organizer: 第88回日本生理学会
  • Place of Presentation: パシフィコ横浜・会議センター誌上開催
  • Year and Date: 2011-03-29
• [Presentation] クラスII型PI3キナーゼC2αは血管新生と障壁機能に必須である (2011)
  • Author(s): 吉岡和晃
  • Organizer: 第88回日本生理学会
  • Place of Presentation: パシフィコ横浜・会議センター誌上開催
  • Year and Date: 2011-03-28
• [Presentation] A novel Ca2+-and phosphoinositide 3-kinase-depend mechanism for myosin phosphatase inhibition and Ca2+-sensitization in vascular smooth muscle (2011)
  • Author(s): Yoh Takuwa
  • Organizer: Winter workshop「Plenary Lecture」
  • Place of Presentation: 光州(Gwanjn韓国)
  • Year and Date: 2011-01-25
• [Presentation] Function role of sphingosine-1-phosphate signaling in angiogenesis (2011)
  • Author(s): Yasuo Okamoto, Xun Qi, Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yoh Takuwa
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京)
• [Presentation] Role of Lysophospholipid Mediator Sphingosine-1-phosphate in Cardiac Fibrosis 1st Meeting of Asian-Pacific Federation of Inflammation and Regeneration (2011)
  • Author(s): Yoh Takuwa, Noriko Takuwa, Seiichiro Ohkura, Shin-ichiro Takashima, Soichiro Usui2, Shuichi Kaneko, Yasuo Okamoto, Kazuaki Yoshioka
  • Organizer: 第32回日本日本炎症・再生医学会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] ポリ乳酸-グリコール酸共重合体を基材としたスフィンゴシン-1-リン酸徐放微粒子製剤による持続性放出はマウス虚血肢においてAkt/ERK-eNOSを介して血管新生および血管成熟を促進し血流を回復させる (2011)
  • Author(s): 戚〓、岡本安雄、吉岡和晃、王飛、崔弘、Biswas Kuntal、安藝翔、Dandar Erdembileg、多久和典子、多久和陽
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂(金沢)
• [Presentation] Endothelial class II PI3K-Ca2a has an essential role for physiological and pathological angiogenesis (2011)
  • Author(s): Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Xun Qi, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Kazushi Sugihara, Sho Aki, Kuntal Biswas, Masahide Asano, Yoh Takuwa
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂(金沢)
• [Presentation] Endothelial class II PI3K-Ca2a has an essential role for physiological and pathological angiogenesis (2011)
  • Author(s): Kazuaki Yoshioka
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂(石川県)
• [Presentation] ポリ乳酸-グリコール酸共重合体を基材としたスフィンゴシン-1-リン酸徐放微粒子製剤による持続性放出はマウス虚血肢においてAkt/ERK-eNOSを介して血管新生および血管成熟を促進し血流を回復させる (2011)
  • Author(s): 戚勲
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂(石川県)
• [Presentation] Role of Lysophospholipid Mediator Sphingosine-1-phosphate in Cardiac Fibrosis (2011)
  • Author(s): Yoh Takuwa
  • Organizer: 1st Meeting of Asian-Pacific Federation of Inflammation and Regeneration and第32回日本日本炎症・再生医学会シンポジウム
  • Place of Presentation: 国立京都国際会館(京都府)(招待講演)
• [Presentation] Function role of sphingosine-1-phosphate signaling in angiogenesis (2011)
  • Author(s): Yasuo Okamoto
  • Organizer: The 1st Asia-Pacific Vascular Biology Meeting and第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京都)(招待講演)
• [Presentation] スフィンゴシン-1-リン酸と血管新生の制御 (2010)
  • Author(s): 多久和陽
  • Organizer: 第43回加齢医学研究所シンポジウム
  • Place of Presentation: 東北大学加齢医学研究所(仙台)
  • Year and Date: 2010-03-24
• [Presentation] スフィンゴシン-1-リン酸と血管新生の制御 (2010)
  • Author(s): 多久和陽
  • Organizer: 第43回加齢医学研究所シンポジウム
  • Place of Presentation: 加齢医学研究所 (宮城県)
  • Year and Date: 2010-03-24
• [Presentation] クラスIIα型PI3キナーゼC2αは血管新生及びバリアー機能に必須である (2010)
  • Author(s): 吉岡和晃、多久和典子、岡本安雄、多久和陽
  • Organizer: 第18回血管生物医学会
  • Place of Presentation: 梅田スカイビル(大阪)
• [Presentation] S1P2受容体によるがん血管新生抑制とそのメカニズム (2010)
  • Author(s): 多久和典子、杜娃、吉岡和晃、岡本安雄、多久和陽
  • Organizer: 日本脂質生化学会
  • Place of Presentation: 森秋旅館(群馬伊香保)
• [Presentation] Sphingosine-1-phosphate receptor-2 inhibits tumor angiogenesis and tumor growth in vivo in mice Keystone Symposia Bioactive Lipids (2010)
  • Author(s): Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, and Yoh Takuwa
  • Organizer: Biochemistry and Diseases
  • Place of Presentation: ウエステン都ホテル京都(京都)
• [Presentation] Signaling of vascular smooth muscle contraction (2010)
  • Author(s): Yoh Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa.
  • Organizer: 1st International Conference on Biorheology
  • Place of Presentation: 和光市
• [Presentation] クラスII型PI3キナーゼC2αの血管形成における生理的役割:コンディショナルKOマウスを用いた解析 (2010)
  • Author(s): 吉岡和晃、吉田耕太朗、安藝翔、Kuntal Biswas、Wa Du、Xun Qi、Fei Wang、多久和典子、岡本安雄、多久和陽
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 日盛岡市民文化ホールいわて県民情報交流センター(岩手)
• [Presentation] Development of Cardiac Fibrosis in Sphingosine Kinase 1 Transgenic Mice through an S1P3 Receptor-mediated Reactive Oxygen Species-dependent Process (2010)
  • Author(s): Noriko Takuwa, Seiichiro Ohkura, Shinichiro Takashima, Keisuke Ohtani, Yasuo Okamoto, Soichiro Usui, Kazuaki Yoshioka, Masayuki Takamura, Shuichi Kaneko, Yoh Takuwa
  • Organizer: 第74回日本循環器学会総会
• [Presentation] Sphingosine-1-phosphate receptor-2 deletion inhibits macrophage proinfla mmatory activities and atherosclerosis in mice (2010)
  • Author(s): 王飛
  • Organizer: 第18回血管生物医学会
  • Place of Presentation: 梅田スカイビル(大阪)
• [Presentation] クラスIIα型PI3キナーゼC2αは血管新生及びバリアー機能に必須である第18回血管生物医学会 (2010)
  • Author(s): 吉岡和晃
  • Organizer: 第18回血管生物医学会
  • Place of Presentation: 梅田スカイビル(大阪)
• [Presentation] 腫瘍血管新生におけるスフィンゴシン-1-リン酸受容体S1P2の役割 (2009)
  • Author(s): Wa Du
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] S1P2 IS AN ANGIOGENESIS-SUPPRESSIVE RECEPTOR (2009)
  • Author(s): 多久和陽
  • Organizer: International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 学術総合センター (東京都)
  • Year and Date: 2009-05-27
• [Presentation] 心筋リモデリングにおけるスフィンゴシン-1-リン酸情報伝達系の病態生理学的役割-スフィンゴシンキナーゼ1トランスジェニックマウスを用いた検討- (2009)
  • Author(s): 多久和典子,大倉誓一郎,高島伸一郎,大谷啓輔,薄井荘一郎,岡本安雄,王飛,杜娃,吉岡和晃,多久和陽
  • Organizer: 第56回中部日本生理学会
  • Place of Presentation: 石川県立音楽堂(金沢)
• [Presentation] 血管内皮細胞のTGFb1-Smadシグナル伝達系におけるクラスIIa型PI3キナーゼC2aの役割 (2009)
  • Author(s): 安藝翔,吉岡和晃,岡本安雄,多久和陽
  • Organizer: 第56回中部日本生理学会
  • Place of Presentation: 石川県立音楽堂(金沢)
• [Presentation] 腫瘍血管新生におけるスフィンゴシンー1-リン酸受容体S1P2の役割 (2009)
  • Author(s): Wa Du,多久和典子,吉岡和晃,岡本安雄, Xun Qi, Fei Wang, Hong Cui, Kuntal Biswas,杉原一司,浅野雅秀,多久和陽
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] マウス後肢虚血モデルにおける徐放化S1P製剤を用いた血管新生療法 (2009)
  • Author(s): 戚〓、岡本安雄、村川智美、王飛、尾山治、吉岡和晃、杜娃、多久和典子、多久和陽
  • Organizer: 第17回日本血管生物医学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] RHOMLC PHOSPHATASE PATHWAY IN HYPERTENSION (2009)
  • Author(s): Yasuo Okamoto, Mohammed Ali Azam, Kazuaki Yoshioka, Yoh Takuwa
  • Organizer: The 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] INVOLVEMENT OF THE Ca2+-PI3K-C2ALPHARHO-MLC PHOSPHATASE PATHWAY IN HYPERTENSION (2009)
  • Author(s): Yasuo Okamoto, Mohammed Ali Azam, Kazuaki Yoshioka, Yoh Takuwa
  • Organizer: The 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] Atsusi Sato Noriko Takuwa The pathophysiolosical roles of phosphoinositide 3-kinase(PI3K) class II a-isoform, a Ca2+-dependent regulator of Rho in vascular smooth blood pressure regulation Post-Genomic Advances in the Physiology of Smooth (2009)
  • Author(s): Yoh Takuwa, Kazuaki Yoshioka, Yasuo Okamoto Mohammed Ali Azam, Young Mi Seok
  • Organizer: Muscle Satellite Symposium of IUPS 2009
  • Place of Presentation: 名古屋市立大学病院(名古屋)
• [Presentation] 血管平滑筋のシグナル伝達 (2009)
  • Author(s): 多久和陽
  • Organizer: 第24回日本ショック学会
  • Place of Presentation: 金沢市文化ホール(金沢)
• [Presentation] HOST CELL S1P2 RECEPTOR NEGATIVELY REGULATES TUMOR GROWTH AND ANGIOGENESIS IN VIVO (2009)
  • Author(s): Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Masahide Asano and Yoh Takuwa.
  • Organizer: International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 学術総合センター(東京)
• [Presentation] S1P2 IS AN ANGIOGENESIS-SUPPRESSIVE RECEPTOR (2009)
  • Author(s): Yoh Takuwa
  • Organizer: International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 学術総合センター(東京)
• [Remarks]
  • URL: http://physiology1.w3.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://physiologyl.w3.kanazawa-u.ac.jp/
• [Patent(Industrial Property Rights)] S1P2受容体アンタゴニストを含む、粥状動脈硬化治療薬 (2011)
  • Inventor(s): 多久和陽、王飛、岡本安雄
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2011-01-13
• [Patent(Industrial Property Rights)] SIP_2受容体アンタゴニストを含む、粥状動脈硬化治療薬 (2011)
  • Inventor(s): 多久和陽、王飛、岡本安雄
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2011-01-13
• [Patent(Industrial Property Rights)] 非ヒトノックアウト動物、並びにその用途およびその作製方法 (2010)
  • Inventor(s): 吉岡和晃、多久和陽
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2010-04-09